Methods for predicting and monitoring mucosal healing

ABSTRACT

The present invention provides methods for predicting the likelihood of mucosal healing in an individual with a disease such as inflammatory bowel disease (IBD). In addition, the present invention provides methods for monitoring the progression of mucosal healing in an individual with a disease such as IBD. Information on mucosal healing status derived from the use of the present invention can also aid in optimizing therapy and/or monitoring the therapeutic efficiency of an anti-TNFα inhibitor drug.

CROSS-REFERENCES TO RELATED APPLICATIONS

This application is a continuation of PCT/IB2013/059077, filed Oct. 2,2013, which application claims priority to U.S. Provisional ApplicationNo. 61/710,491, filed Oct. 5, 2012, and U.S. Provisional Application No.61/824,959, filed May 17, 2013, the disclosures of which are herebyincorporated by reference in their entirety for all purposes.

BACKGROUND OF THE INVENTION

Inflammatory bowel disease (IBD) which includes Crohn's disease (CD) andulcerative colitis (UC) is a chronic idiopathic inflammatory disorderaffecting the gatrointestine tract. Disease progression of CD and UCincludes repeated episodes of inflammation and ulceration of theintestine, leading to complications requiring hospitalization, surgeryand escalation of therapy (Peyrin-Biroulet et al., Am. J.Gastroenterol., 105: 289-297 (2010); Langholz E., Dan. Med. Bull., 46:400-415 (1999)). Current treatments such as anti-tumor necrosisfactor-alpha (TNF-α) biologics (e.g., infliximab (IFX), etanercept,adalimumab (ADL) and certolizumab pegol), thiopurine drugs (e.g.,azathioprine (AZA), 6-mercaptopurin (6-MP)), anti-inflammatory drugs(e.g., mesalazine), and steroids (e.g., corticosteroids) have been shownto reduce disease activity. In some clinical trials of CD, mucosalhealing (MH) which is described as the absence of intestinal ulcers, wasinduced in patients receiving combination therapy of corticosteroids andIFX or ADL. Furthermore, MH was maintained in patients receiving IFX.

Other studies have shown that mucosal healing can be a hallmark ofsuppression of bowel inflammation and can predict long-term diseaseremission (Froslie et al., Gastroenterology, 133: 412-422 (2007); Baertet al., Gastroenterology, (2010)). Long-term mucosal healing has beenassociated with a decreased risk of colectomy and colorectal cancer inUC patients, a decreased need for corticosteroid treatment in CDpatients, and possibly a decreased need for hospitalization (Dave etal., Gastroenterology & Hepatology, 8(1): 29-38 (2012)).

The process of mucosal healing can be divided into three phase,beginning with bleeding (e.g., degradation of the endothelial layers ofthe blood vessels) and inflammation, then progression to cell and tissueproliferation, and finally tissue remodeling. At the inflammation stage,cytokines, chemokines and other inflammatory signaling molecules aresecreted by immune cells in the gut mucosa. During proliferation, tissuerepair and remodeling growth factors activate intestinal epithelialcells to proliferate, migrate to the sites of injury and repair thedamaged tissue. At the remodeling phase, structural and functionalimprovements occur to the intestinal mucosal barrier. The presentinvention is based on the identification of novel markers of mucosalhealing that are predictive of the phases of the process.

There is an unmet need in the art for non-invasive methods forpredicting the likelihood of mucosal healing and/or monitoring theprogression of mucosal healing in patients with IBD or otherinflammatory diseases. This information enables the personalizedtherapeutic management of the disease, such as allowing for appropriateselection and/or administration of therapy. The present inventionsatisfies this need and provides related advantages as well.

BRIEF SUMMARY OF THE INVENTION

Provided herein is a method for predicting the likelihood of mucosalhealing in a subject. The method comprises the steps of: (a) measuring afirst set of markers to form an inflammatory phase marker score; (b)measuring a second set of markers to form a proliferation phase markerscore; (c) comparing the inflammatory phase marker score to theproliferation phase marker score; and (d) predicting the likelihood ofmucosal healing based upon the comparison in step (c).

In some embodiments, the subject has an inflammatory bowel disease(IBD). In some instances, the inflammatory bowel disease is Crohn'sdisease or ulcerative colitis.

In some embodiments, the first set of markers comprises one or more ofTWEAK, CRP, ICAM, SAA, VCAM, IL-2, IL-8, IL-12p70, IL-1β, GMCSF, IFNγ,IL-6, TNFα, ASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, an anti-drugantibody (ADA), and combinations thereof. In some instances, the firstset of markers comprises one or more of GMCSF, IL-2, and VCAM.

In some embodiments, the second set of markers comprises one or more ofAREG, EREG, HBEGF, HGF, HRGB, BTC, EGF, TGFA, FGF1, FGF2, FGF4, FGF7,FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC, VEGFD,TGFB1, IL-10, and an anti-TNFα antibody. In some instances, the secondset of markers comprises HGF.

In some embodiments, each marker is assigned a value of from 0 to 6based upon the concentration or level of the marker.

In some embodiments, the concentration or level of the marker isrelative to the level of the same marker in a patient population withoutmucosal healing.

In some embodiments, the value for each marker in the first set ofmarkers is summed to form the inflammatory phase marker score. In someembodiments, the value for each marker in the second set of markers issummed to form the proliferation phase marker score.

In some embodiments, the comparison in step (c) comprises applying analgorithm incorporating the inflammatory phase marker score and theproliferation phase marker score.

In some embodiments, the algorithm comprises subtracting theinflammatory phase marker score from the proliferation phase markerscore to form a biomarker score of the subject.

In some embodiments, the subject has an increased likelihood of havingcomplete improvement of mucosal healing without relapse when thebiomarker score of the subject is higher than the biomarker score of apatient population without mucosal healing.

In some embodiments, the algorithm predicts the likelihood of mucosalhealing independent of clinical confounders. In some instances, theclinical confounders comprise one or more selected from the groupconsisting of age of diagnosis, age of last sample, disease location,anal involvement, smoking, and surgery.

In some embodiments, the algorithm predicts the likelihood of mucosalhealing by excluding serology markers. In other words, the algorithm canpredict the likelihood of mucosal healing without the use of serologymarkers. In particular embodiments, the excluded serology markerscomprise one or more selected from the group consisting of ASCA-A,ASCA-G, CBir1, Fla2, FlaX, and OmpC.

In some embodiments, the subject is receiving an anti-TNFα antibody. Insome embodiments, the anti-TNFα antibody comprises one or more ofREMICADE™ (infliximab), ENBREL™ (etanercept), HUMIRA™ (adalimumab), andCIMZIA® (certolizumab pegol).

In some embodiments, the marker is measured in a sample selected fromthe group consisting of serum, plasma, whole blood, stool, peripheralblood mononuclear cells (PBMC), polymorphonuclear (PMN) cells, a tissuebiopsy, and combinations thereof.

Also provided herein is a method for monitoring the progression ofmucosal healing in a subject. The method comprises the steps of: (a)measuring a first set of markers at a plurality of time points to form aplurality of inflammatory phase marker scores; (b) measuring a secondset of markers at a plurality of time points to form a plurality ofproliferation phase marker scores; (c) comparing the inflammatory phasemarker score to the proliferation phase marker score at each time pointand across the plurality of time points; and (d) monitoring theprogression of mucosal healing based upon the comparison in step (c).

In some embodiments, the subject has an inflammatory bowel disease(IBD). In some instances, the inflammatory bowel disease is Crohn'sdisease or ulcerative colitis.

In some embodiments, the first set of markers comprises one or more ofTWEAK, CRP, ICAM, SAA, VCAM, IL-2, IL-8, IL-12p70, IL-1β, GMCSF, IFNγ,IL-6, TNFα, ASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, and an anti-drugantibody (ADA). In some instances, the first set of markers comprisesone or more of GMCSF, IL-2, and VCAM.

In some embodiments, the second set of markers comprises one or more ofAREG, EREG, HBEGF, HGF, HRGB, BTC, EGF, TGFA, FGF1, FGF2, FGF4, FGF7,FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC, VEGFD,TGFB1, IL-10, and an anti-TNFα antibody. In some instances, the secondset of markers comprises HGF.

In some embodiments, each marker is assigned a value of from 0 to 6based upon the concentration or level of the marker.

In some embodiments, the concentration or level of the marker isrelative to the level of the same marker in a patient population withoutmucosal healing.

In some embodiments, the value for each marker in the first set ofmarkers is summed to form the inflammatory phase marker score. In someembodiments, the value for each marker in the second set of markers issummed to form the proliferation phase marker score.

In some embodiments, the comparison in step (c) comprises applying analgorithm incorporating the inflammatory phase marker score and theproliferation phase marker score.

In some embodiments, the algorithm comprises subtracting theinflammatory phase marker score from the proliferation phase markerscore to form a biomarker score of the subject at each time point.

In some embodiments, the subject is progressing through the phases ofmucosal healing when the biomarker score of the subject increases ateach time point over the plurality of time points. In some instances,the subject is progressing from a phase of mucosal healing selected froman inflammatory phase and a proliferation phase onto the next phase ofmucosal healing.

In some embodiments, the algorithm monitors the progression of mucosalhealing independent of clinical confounders. In some instances, theclinical confounders comprise one or more selected from the groupconsisting of age of diagnosis, age of last sample, disease location,anal involvement, smoking, surgery, and combinations thereof.

In some embodiments, the algorithm monitors the progression of mucosalhealing by excluding serology markers. In other words, the algorithm canpredict the progression of mucosal healing without the use of serologymarkers. In certain embodiments, the excluded serology markers compriseone or more selected from the group consisting of ASCA-A, ASCA-G, CBir1,Fla2, FlaX, and OmpC.

In some embodiments, the subject is receiving an anti-TNFα antibody. Insome embodiments, the anti-TNFα antibody comprises one or more ofREMICADE™ (infliximab), ENBREL™ (etanercept), HUMIRA™ (adalimumab), andCIMZIA® (certolizumab pegol).

In some embodiments, the marker at each time point is measured in asample selected from the group consisting of serum, plasma, whole blood,stool, peripheral blood mononuclear cells (PBMC), polymorphonuclear(PMN) cells, and a tissue biopsy.

In some embodiments, the method further comprises optimizing therapeuticefficacy of an anti-TNFα antibody therapy based upon the progression ofmucosal healing in the subject.

In yet other embodiments, the method further comprises selecting anappropriate therapeutic regimen based upon the progression of mucosalhealing in the subject.

Other objects, features, and advantages of the present invention will beapparent to one of skill in the art from the following detaileddescription and figures.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 illustrates the three phases of mucosal healing—inflammatoryphase, proliferation phase and remodeling phase.

FIGS. 2A-B show representative data of clinical outcome for anindividual who exhibited mucosal improvement (FIG. 2A) and an individualwho experienced relapse after exhibiting complete improvement (FIG. 2B).

FIGS. 3A-B depict the clinical status of individuals who have healed(FIG. 3A) and individuals who have never healed (FIG. 3B).

FIG. 4 shows the marker distributions between two extremes in themucosal healing continuum—individuals who have never healed andindividuals who have completely healed.

FIG. 5 depicts a table of inflammatory markers that are associated withmucosal healing. For GM-CSF, IL2, VCAM and HGF, lower marker values arepredictive of mucosal healing.

FIGS. 6A-B show a schematic of the individual patient analysis strategythat compares the expression of various markers in “true” healedindividuals (FIG. 6A) to not healed individuals (FIG. 6B).

FIGS. 7A-F show inflammatory marker data used to identify “true” healedindividuals. Individuals exhibiting low inflammation were selected forthe individual patient analysis study.

FIGS. 8A-D show clinical data (e.g., ATI and/or IFX status) and thelevels (e.g., concentration) of repair factor markers in samples fromPatient #1, a “true” healed individual.

FIGS. 9 A-D show data of inflammatory, anti-inflammatory and serologymarkers for Patient #1.

FIGS. 10 A-D show clinical data and the levels of repair factor markersin samples from Patient #2, a “true” healed individual.

FIGS. 11 A-D show data of inflammatory, anti-inflammatory and serologymarkers for Patient #2.

FIGS. 12 A-D show clinical data and the levels of repair factor markersin samples from Patient #3, a “true” healed individual.

FIGS. 13 A-D show data of inflammatory, anti-inflammatory and serologymarkers for Patient #3.

FIGS. 14 A-D show clinical data and the levels of repair factor markersin samples from Patient #4, a “true” healed individual.

FIGS. 15 A-D show data of inflammatory, anti-inflammatory and serologymarkers for Patient #4.

FIGS. 16 A-D shows clinical data and the levels of repair factor markersin samples from Patient #5, a not healed individual.

FIGS. 17 A-D show data of inflammatory, anti-inflammatory and serologymarkers for Patient #5.

FIGS. 18 A-D show clinical data and the levels of repair factor markersin samples from Patient #6, a not healed individual.

FIGS. 19 A-D show data of inflammatory, anti-inflammatory and serologymarkers for Patient #6.

FIGS. 20 A-D show clinical data and the levels of repair factor markersin samples from Patient #7, a not healed individual.

FIGS. 21 A-D show data of inflammatory, anti-inflammatory and serologymarkers for Patient #7.

FIGS. 22 A-D show clinical data and the levels of repair factor markersin samples from Patient #8, a not healed individual.

FIGS. 23 A-D show data of inflammatory, anti-inflammatory and serologymarkers for Patient #8.

FIGS. 24 A-D show illustrative data of repair factor markers (e.g., HERligands, FGFs, PDGFs, and VEGFs) and clinical outcome from a theoreticalpatient progressing from the inflammatory phase (year 1), proliferationphase (year 2), and remodeling phase (year 3).

FIGS. 25 A-C show illustrative data of inflammatory andanti-inflammatory markers (e.g., markers detected by CEER andinflammatory markers) and clinical outcome from a theoretical patientprogressing from the inflammatory phase (year 1), proliferation phase(year 2), and remodeling phase (year 3).

FIG. 26 shows the number of individuals in the study missing aparticular marker.

FIG. 27 is a graph of the distribution of biomarker scores in thepatient population of the study.

FIG. 28 shows that the biomarker score was predictive of having completeimprovement without relapse.

FIG. 29 shows that after controlling for potential clinical confounders,the biomarker score was predictive of having complete improvementwithout relapse.

FIG. 30 shows the distribution of the biomarker scores for the twopopulations analyzed: individuals with complete improvement withoutrelapse and individuals who never healed.

FIG. 31 shows that the biomarker score, determined without serologymarker data was predictive of having complete improvement withoutrelapse.

FIG. 32 shows that after controlling for potential clinical confounders,the biomarker score of FIG. 31 was predictive of having completeimprovement without relapse.

FIG. 33 shows the distribution of the biomarker scores of FIG. 32 forthe two populations analyzed.

FIGS. 34A-C show statistical data from the combined marker analysiswherein removal of a single marker from the marker set was tested.

DETAILED DESCRIPTION OF THE INVENTION I. Introduction

Anti-TNFα drugs such as infliximab (IFX) and adalimumab (ADA), promotemucosal healing in inflammatory bowel disease (IBD) patients. In fact,in clinical trials, endoscopic mucosal healing is a marker of theanti-inflammatory action of biological anti-TNFα drugs.

One underlying principle of the present invention is that IBD such asCrohn's disease and ulcerative colitis is better understood when viewedas a wound of the intestinal mucosal. Like other wounds of epithelialtissue, three phases of healing occur. As is shown in FIG. 1, a subjecthaving IBD and being treated with an anti-TNF a drug, will progressthrough an inflammatory phase, a proliferation phase, and finally aremodeling phase. This mucosal healing mechanism occurs over time and isfacilitated by anti-TNF a drugs while being treated.

The inflammatory phase occurs first and during this phase, bacteria andforeign debris are removed from the wound. Inflammatory markers arepresent at their highest concentration levels during this phase. Next,the proliferative phase is characterized by tissue formation,epithelialization, and wound contraction. In this phase, epithelialcells that are activated by growth factors and repair factorsproliferate and provide cover for the new tissue. During the remodelingphase, the wound contracts and is made smaller by the action ofmyofibroblasts, which establish a grip on the wound edges and contractthemselves, thereby healing the wound. A person just beginning therapywill most likely be in the inflammation phase and progress with a propertherapeutic regimen to the remodeling phase. And eventually, theintestinal mucosa will be restored.

Using the invention provided herein, it is possible to identify anddetermine the “phase” a particular subject is in at any particular timeand predict the likelihood of mucosal healing (e.g., progression throughthe phases of mucosal healing towards complete improvement thereof). Inaddition, the present invention can be used to monitor a subject'sprogression through the phases of mucosal healing over a plurality oftime points. The present invention can also be used to determine whethera patient has an increased likelihood of having complete improvement ofmucosal healing without relapse. Furthermore, the present inventionprovides methods for optimizing therapeutic efficiency for an anti-TNFαantibody therapy and for selecting an appropriate therapeutic regimenbased on the progression of mucosal healing in the subject.

II. Definitions

As used herein, the following terms have the meanings ascribed to themunless specified otherwise.

The term “mucosal healing” refers to restoration of normal mucosalappearance of a previously inflamed region, and complete absence ofulceration and inflammation at the endoscopic and microscopic levels.Mucosal healing includes repair and restoration of the mucosa,submucosa, and muscularis layers. It can also include neuronal andlymphangiogenic elements of the intestinal wall.

The term “progression of mucosal healing” refers to a transition throughthe phases (e.g., stages) of mucosal healing from inflammatory phase,proliferation phase and remodeling phase towards complete improvement(e.g., complete repair) of the intestinal mucosa.

The term “complete improvement of mucosal healing without relapse”refers to a disease state wherein a patient having a disease such as IBDis undergoing or has undergone complete repair of the mucosa such thatit is free of inflammation and/or an ulceration.

The terms “marker” and “biomarker” include any biochemical markers,serological markers, protein markers, genetic markers, and/or otherclinical or echographic characteristics, that can be measured in asample. In certain embodiments, a marker of the invention can be used todetect mucosal healing in a sample from an individual with a diseasesuch as IBD including Crohn's disease and ulcerative colitis.

The term “marker score” or “biomarker score” includes an empiricallyderived score that is based upon an analysis of a plurality of markerssuch as, e.g., inflammatory markers, anti-inflammatory markers, repairfactor markers, serology markers, level of anti-TNFα antibody, and levelof anti-drug antibody. In one aspect, a first set of markers such as theconcentration of the markers or their measured concentration values aretransformed into an inflammatory phase marker score by an algorithmresident on a computer. In another aspect, a second set of markers suchas the concentration of the markers or their measured concentrationvalues are transformed into a proliferation phase marker score by analgorithm resident on a computer. A marker score can be determinedmultiple times over the course of different time points. In certainaspects, the marker score comprises or corresponds to a synthetic orhuman derived output, value, or cut off value(s) which expresses thebiological data in numerical terms.

The term “TNFα” is intended to include a human cytokine that exists as a17 kDa secreted form and a 26 kDa membrane associated form, thebiologically active form of which is composed of a trimer ofnoncovalently bound 17 kDa molecules. The structure of TNFα is describedfurther in, for example, Jones et al., Nature, 338:225-228 (1989). Theterm TNFα is intended to include human TNFα, a recombinant human TNFα(rhTNF-α), or TNFα that is at least about 80% identity to the human TNFαprotein. Human TNFα consists of a 35 amino acid (aa) cytoplasmic domain,a 21 aa transmembrane segment, and a 177 aa extracellular domain (ECD)(Pennica, D. et al. (1984) Nature 312:724). Within the ECD, human TNFαshares 97% aa sequence identity with rhesus TNFα, and 71% to 92% aasequence identity with bovine, canine, cotton rat, equine, feline,mouse, porcine, and rat TNFα. TNFα can be prepared by standardrecombinant expression methods or purchased commercially (R & D Systems,Catalog No. 210-TA, Minneapolis, Minn.).

In certain embodiments, “TNFα” is an “antigen,” which includes amolecule or a portion of the molecule capable of being bound by ananti-TNF-α drug. TNFα can have one or more than one epitope. In certaininstances, TNFα will react, in a highly selective manner, with ananti-TNFα antibody. Preferred antigens that bind antibodies, fragments,and regions of anti-TNFα antibodies include at least 5 amino acids ofhuman TNFα. In certain instances, TNFα is a sufficient length having anepitope of TNFα that is capable of binding anti-TNFα antibodies,fragments, and regions thereof.

The terms “TNF inhibitor”, “TNF-α inhibitor,” “TNFα inhibitor” and antiTNFα drug” are intended to encompass agents including proteins,antibodies, antibody fragments, fusion proteins (e.g., Ig fusionproteins or Fc fusion proteins), multivalent binding proteins (e.g., DVDIg), small molecule TNF-α antagonists and similar naturally- ornonnaturally-occurring molecules, and/or recombinant and/or engineeredforms thereof, that, directly or indirectly, inhibits TNF a activity,such as by inhibiting interaction of TNF-α with a cell surface receptorfor TNF-α, inhibiting TNF-α protein production, inhibiting TNF-α geneexpression, inhibiting TNFα secretion from cells, inhibiting TNF-αreceptor signaling or any other means resulting in decreased TNF-αactivity in a subject. The term “TNFα inhibitor” preferably includesagents which interfere with TNF-α activity. Examples of TNF-α inhibitors(anti-TNFα drug) include etanercept (ENBREL™, Amgen), infliximab(REMICADE™, Johnson and Johnson), human anti-TNF monoclonal antibodyadalimumab (D2E7/HUMIRA™, Abbott Laboratories), CDP 571 (Celltech), andCDP 870 (Celltech), as well as other compounds which inhibit TNF-αactivity, such that when administered to a subject suffering from or atrisk of suffering from a disorder in which TNF-α activity is detrimental(e.g., IBD), the disorder is treated.

The terms “anti-drug antibody” and “ADA” are intended to encompass ahuman anti-chimeric antibody (HACA), a human anti-humanized antibody(HAHA), a human anti-mouse antibody (HAMA). The terms “antibodies toinfliximab” and “ATI” refer to antibodies against the anti-TNFα antibodydrug infliximab.

The term “subject,” “patient,” or “individual” typically refers tohumans, but also to other animals including, e.g., other primates,rodents, canines, felines, equines, ovines, porcines, and the like.

The term “patient population without mucosal healing” includes a groupof patients wherein the patient has IBD and inflammation and/or anulceration in the intestinal mucosa. In some instances, the intestinalmucosa of such a patient has not or has never healed. For example, thepatient can be in the inflammatory phase of mucosal healing.

The term “clinical confounder” refers to an extraneous variable based onclinical observations that can be statistically related to or correlatedwith an independent variable, e.g., the concentration or level of amarker. Clinical confounders for predicting mucosal healing ininflammatory bowel disease patients can include one or more of age ofdiagnosis, age of last sample, disease location, anal involvement,smoking, surgery, socioeconomic status, gender, diet, etc.

The term “sample” as used herein includes any biological specimenobtained from a patient. Samples include, without limitation, wholeblood, plasma, serum, red blood cells, white blood cells (e.g.,peripheral blood mononuclear cells (PBMC), polymorphonuclear (PMN)cells), ductal lavage fluid, nipple aspirate, lymph (e.g., disseminatedtumor cells of the lymph node), bone marrow aspirate, saliva, urine,stool (i.e., feces), sputum, bronchial lavage fluid, tears, fine needleaspirate (e.g., harvested by random periareolar fine needle aspiration),any other bodily fluid, a tissue sample such as a biopsy of a site ofinflammation (e.g., needle biopsy), and cellular extracts thereof. Insome embodiments, the sample is whole blood or a fractional componentthereof such as plasma, serum, or a cell pellet. In other embodiments,the sample is obtained by isolating PBMCs and/or PMN cells using anytechnique known in the art. In other embodiments, the sample is a tissuebiopsy, e.g., tissue obtained from a site of inflammation such as aportion of the gastrointestinal tract or synovial tissue.

III. Description of the Embodiments

The methods described herein can be used for predicting the likelihoodof mucosal healing in a subject. In some embodiments, the subject has aninflammatory bowel disease. In some instances, the inflammatory boweldisease is Crohn's disease or ulcerative colitis.

In one aspect of the invention provided herein, the method includes (a)measuring a first set of markers to form an inflammatory phase markerscore; (b) measuring a second set of markers to form a proliferationphase marker score; (c) comparing the inflammatory phase marker score tothe proliferation phase marker score; and (d) predicting the likelihoodof mucosal healing based upon the comparison in step (c).

In some embodiments, the first set of markers includes one or more ofTWEAK, CRP, ICAM, SAA, VCAM, IL-2, IL-8, IL-12p70, IL-1β, GMCSF, IFNγ,IL-6, TNFα, ASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, an anti-drugantibody (ADA), and combinations thereof. In one embodiment, the firstset of markers includes one or more of GMCSF, IL-2, VCAM, andcombinations thereof.

In some embodiments, the second set of markers includes one or more ofAREG, EREG, HBEGF, HGF, HRGB, BTC, EGF, TGFA, FGF1, FGF2, FGF4, FGF7,FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC, VEGFD,TGFB1, IL-10, an anti-TNFα antibody, and combinations thereof. In oneembodiment, the second set of markers includes HGF.

In some embodiments, the anti-drug antibody (ADA) is a member selectedfrom the group consisting of a human anti-chimeric antibody (HACA), ahuman anti-humanized antibody (HAHA), a human anti-mouse antibody(HAMA), and combinations thereof.

In some embodiments, the anti-TNFα antibody is a member selected fromthe group consisting of REMICADE™ (infliximab), ENBREL™ (etanercept),HUMIRA™ (adalimumab), CIMZIA® (certolizumab pegol), and combinationsthereof.

Each marker of the first set and/or the second set may be assigned avalue based upon the concentration or level of the marker. In particularembodiments, each marker of the first set and/or the second set isassigned a value of from 0 to 6 based upon the concentration or level ofthe marker.

In some embodiments, one or more markers selected from the groupconsisting of EGF, AREG, EREG, HBEGF, HGF, HRGB, BTC, TGFA, FGF1, FGF2,FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC,VEGFD, TGFB1, and TWEAK is measured using a CEER assay. In certainembodiments, the value of the marker is based upon 6 standard samplesfor each marker.

In some embodiments, one or more markers selected from the groupconsisting of an anti-TNFα antibody and ADA is measured using ahomogeneous mobility shift assay (HMSA). In certain embodiments, thevalue of the marker is based on a quantile level for each marker.

In some embodiments, one or more markers selected from the groupconsisting of IL10, CRP, ICAM, SAA, VCAM, IL2, IL8, IL12p70, IL1B,GMCSF, IFNγ, IL6, TNFα, ASCAA, ASCAG, CBir1, Fla2, FlaX, and OmpC ismeasured using an immunoassay. In some instances, the value of themarker is based on a quantile level for each marker.

In some embodiments, the concentration or level of the marker isrelative to the level of the same marker in a patient population withoutmucosal healing (e.g., an IBD patient population without mucosalhealing). The value for each marker in the first set of markers can besummed to form the inflammatory phase marker score. The value for eachmarker in the second set of markers can be summed to form theproliferation phase marker score.

In some embodiments, the comparison in step (c) includes applying analgorithm incorporating the inflammatory phase marker score and theproliferation phase marker score. In some instances, the algorithmincludes subtracting the inflammatory phase marker score from theproliferation phase marker score to form a biomarker score of thesubject.

In some embodiments, if the biomarker score of the subject is higherthan the biomarker score of a patient population without mucosalhealing, the subject has an increased likelihood of having completeimprovement of mucosal healing without relapse.

In some embodiments, the algorithm predicts the likelihood of mucosalhealing independent of clinical confounders. In some instances, theclinical confounders include one or more selected from the groupconsisting of age of diagnosis, age of last sample, disease location,anal involvement, smoking, surgery, and combinations thereof.

In other embodiments, the algorithm predicts the likelihood of mucosalhealing by excluding serology markers. In some embodiments, the excludedserology markers include one or more selected from the group consistingof ASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, and combinations thereof.For example, in some embodiments, the algorithm used for predicting thelikelihood of mucosal healing does not include (e.g., excludes, iswithout, or is independent of) values (e.g., scores or measurements,such as, concentrations, amounts or levels) of serology markers, such asASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, or combinations thereof.

In some embodiments, the subject is receiving an anti-TNFα antibody. Insome instances, the anti-TNFα antibody includes one or more of REMICADE™(infliximab), ENBREL™ (etanercept), HUMIRA™ (adalimumab), CIMZIA®(certolizumab pegol), and combinations thereof.

In some embodiments, the marker is measured in a sample from the subjectselected from the group consisting of serum, plasma, whole blood, stool,peripheral blood mononuclear cells (PBMC), polymorphonuclear (PMN)cells, a tissue biopsy, and combinations thereof.

Also, the methods provided herein can be used for monitoring theprogression of mucosal healing in a subject. In some embodiments, thesubject has an inflammatory bowel disease. In some instances, theinflammatory bowel disease is Crohn's disease or ulcerative colitis.

In one aspect of the invention provided herein, the method includes thesteps of: (a) measuring a first set of markers at a plurality of timepoints to form a plurality of inflammatory phase marker scores; (b)measuring a second set of markers at a plurality of time points to forma plurality of proliferation phase marker scores; (c) comparing theinflammatory phase marker score to the proliferation phase marker scoreat each time point and across the plurality of time points; and (d)monitoring the progression of mucosal healing based upon the comparisonin step (c).

In some embodiments, the first set of markers includes one or more ofTWEAK, CRP, ICAM, SAA, VCAM, IL-2, IL-8, IL-12p70, IL-1β, GMCSF, IFNγ,IL-6, TNFα, ASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, an anti-drugantibody (ADA), and combinations thereof. In some instances, the firstset of markers includes one or more of GMCSF, IL-2, VCAM, andcombinations thereof.

In some embodiments, the second set of markers includes one or more ofAREG, EREG, HBEGF, HGF, HRGB, BTC, EGF, TGFA, FGF1, FGF2, FGF4, FGF7,FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC, VEGFD,TGFB1, IL-10, an anti-TNFα antibody, and combinations thereof. In someinstances, the second set of markers includes HGF.

In some embodiments, the anti-drug antibody (ADA) is a member selectedfrom the group consisting of a human anti-chimeric antibody (HACA), ahuman anti-humanized antibody (HAHA), a human anti-mouse antibody(HAMA), and combinations thereof.

In some embodiments, the anti-TNFα antibody is a member selected fromthe group consisting of REMICADE™ (infliximab), ENBREL™ (etanercept),HUMIRA™ (adalimumab), CIMZIA® (certolizumab pegol), and combinationsthereof.

Each marker of the first set and/or the second set may be assigned avalue based upon the concentration or level of the marker. In particularembodiments, each marker of the first set and/or the second set isassigned a value of from 0 to 6 based upon the concentration or level ofthe marker.

In some embodiments, one or more markers selected from the groupconsisting of EGF, AREG, EREG, HBEGF, HGF, HRGB, BTC, TGFA, FGF1, FGF2,FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC,VEGFD, TGFB1, and TWEAK is measured using a CEER assay. In certainembodiments, the value of the marker is based upon 6 standard samplesfor each marker.

In some embodiments, one or more markers selected from the groupconsisting of an anti-TNFα antibody and ADA is measured using ahomogeneous mobility shift assay (HMSA). In certain embodiments, thevalue of the marker is based on a quantile level for each marker.

In some embodiments, one or more markers selected from the groupconsisting of IL10, CRP, ICAM, SAA, VCAM, IL2, IL8, IL12p70, IL1B,GMCSF, IFNγ, IL6, TNFα, ASCAA, ASCAG, CBir1, Fla2, FlaX, and OmpC ismeasured using an immunoassay. In some instances, the value of themarker is based on a quantile level for each marker.

In some embodiments, the concentration or level of the marker isrelative to the level of the same marker in a patient population withoutmucosal healing (e.g., an IBD patient population without mucosalhealing). The value for each marker in the first set of markers can besummed to form the inflammatory phase marker score. The value for eachmarker in the second set of markers can be summed to form theproliferation phase marker score.

In some embodiments, the comparison in step (c) includes applying analgorithm incorporating the inflammatory phase marker score and theproliferation phase marker score. In some instances, the algorithmincludes subtracting the inflammatory phase marker score from theproliferation phase marker score to form a biomarker score of thesubject at each time point.

In some embodiments, the subject is progressing through the phases ofmucosal healing when the biomarker score of the subject increases ateach time point over the plurality of time points. In some instances,the subject is progressing from a phase of mucosal healing selected froman inflammatory phase and a proliferation phase onto the next phase ofmucosal healing.

The algorithm of the method provided herein can monitor the progressionof mucosal healing independent of clinical confounders. In someinstances, the clinical confounders include one or more selected fromthe group consisting of age of diagnosis, age of last sample, diseaselocation, anal involvement, smoking, surgery, and combinations thereof.

In other embodiments, the algorithm monitors the progression of mucosalhealing by excluding serology markers. In some embodiments, the excludedserology markers include one or more selected from the group consistingof ASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, and combinations thereof.For example, in some instances, the algorithm used for monitoring theprogression of mucosal healing does not include (e.g., excludes, iswithout, or is independent of) values (e.g., scores or measurements,such as, concentrations, amounts or levels) of serology markers, such asASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, or combinations thereof.

The subject of the methods provided herein can be receiving an anti-TNFαantibody. In some instances, the anti-TNFα antibody includes one or moreof REMICADE™ (infliximab), ENBREL™ (etanercept), HUMIRA™ (adalimumab),CIMZIA® (certolizumab pegol), and combinations thereof.

In some embodiments, the marker at each time point is measured in asample selected from the group consisting of serum, plasma, whole blood,stool, peripheral blood mononuclear cells (PBMC), polymorphonuclear(PMN) cells, a tissue biopsy, and combinations thereof.

In some embodiments, the plurality of time points comprises at least 2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30,35, 40, 45, 50, or more time points.

In some embodiments, the method further includes optimizing therapeuticefficacy of an anti-TNFα antibody therapy based upon the progression ofmucosal healing in the subject.

In yet other embodiments, the method further includes selecting anappropriate therapeutic regimen based upon the progression of mucosalhealing in the subject.

A. Additional Embodiments of the Invention

The methods described herein are also useful for identifying the phaseof mucosal healing, such as an inflammatory phase, a proliferationphase, or a remodeling phase, in a subject, (e.g., an individual havingIBD and receiving anti-TNFα therapy). As such, in one embodiment, themethod can be further used to select or administer an appropriatetherapy.

In some embodiments, the method includes the steps of: (a) measuring afirst set of markers to form an inflammatory phase marker score; (b)measuring a second set of markers to form a proliferation phase markerscore; (c) identifying the phase of mucosal healing of the subject byusing an algorithm incorporating the inflammatory phase marker score andthe proliferation phase marker score; and (d) selecting an appropriatetherapy based upon the phase of mucosal healing of the subject.

In some embodiments, the subject has inflammatory bowel disease. In someaspects, inflammatory bowel disease is Crohn's disease or ulcerativecolitis.

In some embodiments, the first set of markers comprises one or moreselected from the group consisting of TWEAK, CRP, ICAM, SAA, VCAM, IL2,IL8, IL12p70, IL1β, GMCSF, IFNγ, IL6, TNFα, ASCAA, ASCAG, CBir1, Fla2,FlaX, OmpC, an anti-drug antibody (ADA), and combinations thereof. Insome embodiments, the second set of markers comprises one or moreselected from the group consisting of AREG, EREG, HBEGF, HGF, HRGB, BTC,EGF, TGFA, FGF1, FGF2, FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB,PDGFC, VEGFA, VEGFB, VEGFC, VEGFD, TGFB1, IL10, an anti-TNFα antibody,and combinations thereof.

In some embodiments, the anti-drug antibody (ADA) is a member selectedfrom the group consisting of a human anti-chimeric antibody (HACA), ahuman anti-humanized antibody (HAHA), a human anti-mouse antibody(HAMA), and combinations thereof.

In some embodiments, the anti-TNFα antibody is a member selected fromthe group consisting of REMICADE™ (infliximab), ENBREL™ (etanercept),HUMIRA™ (adalimumab), CIMZIA® (certolizumab pegol), and combinationsthereof.

Each marker of the first set and/or the second set may be assigned avalue based upon the concentration or level of the marker. In particularembodiments, each marker of the first set and/or the second set isassigned a value of from 0 to 6 based upon the concentration or level ofthe marker.

In some embodiments, one or more markers selected from the groupconsisting of EGF, AREG, EREG, HBEGF, HGF, HRGB, BTC, TGFA, FGF1, FGF2,FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC,VEGFD, TGFB1, and TWEAK is measured using a CEER assay. In someinstances, the value of the marker described herein is based upon 6standard samples for each marker.

In some embodiments, one or more markers selected from the groupconsisting of an anti-TNFα antibody and ADA is measured using ahomogeneous mobility shift assay (HMSA). In some instances, the value ofthe marker is based on a quantile level for each marker.

In some embodiments, one or more markers selected from the groupconsisting of IL10, CRP, ICAM, SAA, VCAM, IL2, IL8, IL12p70, IL1B,GMCSF, IFNγ, IL6, TNFα, ASCAA, ASCAG, CBir1, Fla2, FlaX, and OmpC ismeasured using an immunoassay. In some instances, the value of themarker is based on a quantile level for each marker.

In some embodiments, each marker is measured in a sample selected fromthe group consisting of serum, plasma, whole blood, stool, peripheralblood mononuclear cells (PBMC), polymorphonuclear (PMN) cells, a tissuebiopsy, and combinations thereof.

In some embodiments, the concentration or level of the marker isrelative to the level of the same marker in a patient population withoutmucosal healing (e.g., an IBD patient population without mucosalhealing). The value for each marker in the first set of markers can besummed to form the inflammatory phase marker score. The value for eachmarker in the second set of markers can be summed to form theproliferation phase marker score. In some embodiments, the algorithm isthe summation of the proliferation phase marker values minus thesummation of the inflammatory phase marker values.

The algorithm of the method provided herein can identify the phase ofmucosal healing independent of clinical confounders. In some instances,the clinical confounders include one or more selected from the groupconsisting of age of diagnosis, age of last sample, disease location,anal involvement, smoking, surgery, and combinations thereof.

In other embodiments, the algorithm identifies the phase of mucosalhealing by excluding serology markers. In some embodiments, the excludedserology markers include one or more selected from the group consistingof ASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, and combinations thereof.For example, in some instances, the algorithm used for identifying thephase of mucosal healing does not include (e.g., excludes, is without,or is independent of) values (e.g., scores or measurements, such as,concentrations, amounts or levels) of serology markers, such as ASCA-A,ASCA-G, CBir1, Fla2, FlaX, OmpC, or combinations thereof.

In certain embodiments, the method of identifying the phase of mucosalhealing in a subject can be used to select or administer an anti-TNFαantibody. In some instances, the anti-TNFα antibody includes one or moreof REMICADE™ (infliximab), ENBREL™ (etanercept), HUMIRA™ (adalimumab),CIMZIA® (certolizumab pegol), and combinations thereof.

In addition, the methods provided herein can be used for monitoringmucosal healing in a subject in order to optimize therapeutic efficacy.In some embodiments, the method includes (a) measuring a first set ofmarkers to form an inflammatory phase marker score; (b) measuring asecond set of markers to form a proliferation phase marker score; (c)monitoring mucosal healing in the subject by using an algorithmincorporating the inflammatory phase marker score and the proliferationphase marker score; and (d) optimizing therapeutic efficacy of ananti-TNFα antibody therapy based upon the mucosal healing in thesubject.

In some embodiments, the subject has inflammatory bowel disease. In someaspects, inflammatory bowel disease is Crohn's disease or ulcerativecolitis.

In some embodiments, the first set of markers comprises one or moreselected from the group consisting of TWEAK, CRP, ICAM, SAA, VCAM, IL2,IL8, IL12p70, IL1β, GMCSF, IFNγ, IL6, TNFα, ASCAA, ASCAG, CBir1, Fla2,FlaX, OmpC, an anti-drug antibody (ADA), and combinations thereof. Insome embodiments, the second set of markers comprises one or moreselected from the group consisting of AREG, EREG, HBEGF, HGF, HRGB, BTC,EGF, TGFA, FGF1, FGF2, FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB,PDGFC, VEGFA, VEGFB, VEGFC, VEGFD, TGFB1, IL10, an anti-TNFα antibody,and combinations thereof.

In some embodiments, the anti-drug antibody (ADA) is a member selectedfrom the group consisting of a human anti-chimeric antibody (HACA), ahuman anti-humanized antibody (HAHA), a human anti-mouse antibody(HAMA), and combinations thereof.

In some embodiments, the anti-TNFα antibody is a member selected fromthe group consisting of REMICADE™ (infliximab), ENBREL™ (etanercept),HUMIRA™ (adalimumab), CIMZIA® (certolizumab pegol), and combinationsthereof.

Each marker of the first set and/or the second set may be assigned avalue based upon the concentration or level of the marker. In particularembodiments, each marker of the first set and/or the second set isassigned a value of from 0 to 6, e.g., 0, 1, 2, 3, 4, 5, or 6, basedupon the concentration or level of the marker.

In some embodiments, one or more markers selected from the groupconsisting of EGF, AREG, EREG, HBEGF, HGF, HRGB, BTC, TGFA, FGF1, FGF2,FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC,VEGFD, TGFB1, and TWEAK is measured using a CEER assay. In someinstances, the value of the marker described herein is based upon 6standard samples for each marker.

In some embodiments, one or more markers selected from the groupconsisting of an anti-TNFα antibody and ADA is measured using ahomogeneous mobility shift assay (HMSA). In some instances, the value ofthe marker is based on a quantile level for each marker.

In some embodiments, one or more markers selected from the groupconsisting of IL-10, CRP, ICAM, SAA, VCAM, IL-2, IL-8, IL-12p70, IL-1β,GMCSF, IFNγ, IL-6, TNFα, ASCA-A, ASCA-G, CBir1, Fla2, FlaX, and OmpC ismeasured using an immunoassay. In some instances, the value of themarker is based on a quantile level for each marker.

In some embodiments, each marker is measured in a sample selected fromthe group consisting of serum, plasma, whole blood, stool, peripheralblood mononuclear cells (PBMC), polymorphonuclear (PMN) cells, and atissue biopsy.

In some embodiments, the concentration or level of the marker isrelative to the level of the same marker in a patient population withoutmucosal healing (e.g., an IBD patient population without mucosalhealing). The value for each marker in the first set of markers can besummed to form the inflammatory phase marker score. The value for eachmarker in the second set of markers can be summed to form theproliferation phase marker score. In some embodiments, the algorithm isthe summation of the proliferation phase marker values minus thesummation of the inflammatory phase marker values.

The algorithm of the method provided herein can monitor mucosal healingindependent of clinical confounders. In some instances, the clinicalconfounders include one or more selected from the group consisting ofage of diagnosis, age of last sample, disease location, analinvolvement, smoking, surgery, and combinations thereof.

In other embodiments, the algorithm monitors mucosal healing byexcluding serology markers. In some embodiments, the excluded serologymarkers include one or more selected from the group consisting ofASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, and combinations thereof. Forexample, in some instances, the algorithm used for monitoring mucosalhealing does not include (e.g., excludes, is without, or is independentof) values (e.g., scores or measurements, such as, concentrations,amounts or levels) of serology markers, such as ASCA-A, ASCA-G, CBir1,Fla2, FlaX, OmpC, or combinations thereof.

In certain embodiments, the method of monitoring mucosal healing in asubject can be used to optimize therapeutic efficacy by selecting oradministering an appropriate anti-TNFα antibody. In some instances, theanti-TNFα antibody includes one or more of REMICADE™ (infliximab),ENBREL™ (etanercept), HUMIRA™ (adalimumab), CIMZIA® (certolizumabpegol), and combinations thereof.

Also, the methods provided herein are useful for selecting a therapeuticregimen for a subject by monitoring mucosal healing. In someembodiments, the method includes the steps of: (a) measuring a first setof markers to form an inflammatory phase marker score, wherein theinflammatory phase marker score is measured at a plurality of timepoints over the course of therapy; (b) measuring a second set of markersto form a proliferation phase marker score, wherein the proliferationphase marker score is measured at a plurality of time points over thecourse of therapy; (c) monitoring mucosal healing in the subject byusing an algorithm incorporating the inflammatory phase marker score andthe proliferation phase marker score; and (d) selecting an appropriatetherapeutic regimen for the individual, wherein the therapeutic regimenpromotes mucosal healing and is based upon the algorithm.

In some embodiments, the subject has inflammatory bowel disease. In someaspects, inflammatory bowel disease is Crohn's disease or ulcerativecolitis.

In some embodiments, the first set of markers is one or more selectedfrom the group consisting of TWEAK, CRP, ICAM, SAA, VCAM, IL-2, IL-8,IL-12p70, IL1-β, GMCSF, IFNγ, IL6, TNFα, ASCA-A, ASCA-G, CBir1, Fla2,FlaX, OmpC, an anti-drug antibody (ADA), and combinations thereof. Insome embodiments, the second set of markers is one or more selected fromthe group consisting of AREG, EREG, HBEGF, HGF, HRGB, BTC, EGF, TGFA,FGF1, FGF2, FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA,VEGFB, VEGFC, VEGFD, TGFB1, IL-10, an anti-TNFα antibody, andcombinations thereof.

In some embodiments, the anti-drug antibody (ADA) is a member selectedfrom the group consisting of a human anti-chimeric antibody (HACA), ahuman anti-humanized antibody (HAHA), a human anti-mouse antibody(HAMA), and combinations thereof.

In some embodiments, the anti-TNFα antibody is a member selected fromthe group consisting of REMICADE™ (infliximab), ENBREL™ (etanercept),HUMIRA™ (adalimumab), CIMZIA® (certolizumab pegol), and combinationsthereof.

Each marker of the first set and/or the second set may be assigned avalue based upon the concentration or level of the marker. In particularembodiments, each marker of the first set and/or the second set isassigned a value of from 0 to 6 based upon the concentration or level ofthe marker.

In some embodiments, one or more markers selected from the groupconsisting of EGF, AREG, EREG, HBEGF, HGF, HRGB, BTC, TGFA, FGF1, FGF2,FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC,VEGFD, TGFB1, and TWEAK is measured using a CEER assay. In someinstances, the value of the marker described herein is based upon 6standard samples for each marker.

In some embodiments, one or more markers selected from the groupconsisting of an anti-TNFα antibody and ADA is measured using ahomogeneous mobility shift assay (HMSA). In some instances, the value ofthe marker is based on a quantile level for each marker.

In some embodiments, one wherein one or more markers selected from thegroup consisting of IL10, CRP, ICAM, SAA, VCAM, IL-2, IL-8, IL-12p70,IL-1β, GMCSF, IFNγ, IL-6, TNFα, ASCA-A, ASCA-G, CBir1, Fla2, FlaX, andOmpC is measured using an immunoassay. In some instances, the value ofthe marker is based on a quantile level for each marker.

In some embodiments, each marker is measured in a sample selected fromthe group consisting of serum, plasma, whole blood, stool, peripheralblood mononuclear cells (PBMC), polymorphonuclear (PMN) cells, and atissue biopsy.

In some embodiments, the concentration or level of the marker isrelative to the level of the same marker in a patient population withoutmucosal healing (e.g., an IBD patient population without mucosalhealing). The value for each marker in the first set of markers can besummed to form the inflammatory phase marker score. The value for eachmarker in the second set of markers can be summed to form theproliferation phase marker score. In some embodiments, the algorithm isthe summation of the proliferation phase marker values minus thesummation of the inflammatory phase marker values.

The algorithm of the method provided herein can monitor mucosal healingindependent of clinical confounders. In some instances, the clinicalconfounders include one or more selected from the group consisting ofage of diagnosis, age of last sample, disease location, analinvolvement, smoking, surgery, and combinations thereof.

In other embodiments, the algorithm monitors mucosal healing byexcluding serology markers. In some embodiments, the excluded serologymarkers include one or more selected from the group consisting ofASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, and combinations thereof. Forexample, in some instances, the algorithm used for monitoring mucosalhealing does not include (e.g., excludes, is without, or is independentof) values (e.g., scores or measurements, such as, concentrations,amounts or levels) of serology markers, such as ASCA-A, ASCA-G, CBir1,Fla2, FlaX, OmpC, or combinations thereof.

In certain embodiments, the method of monitoring mucosal healing in asubject can be used to select an appropriate anti-TNFα antibody for thesubject. In some instances, the anti-TNFα antibody includes one or moreof REMICADE™ (infliximab), ENBREL™ (etanercept), HUMIRA™ (adalimumab),CIMZIA® (certolizumab pegol), and combinations thereof.

In some embodiments, the plurality of time points comprises at least 2,3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30,35, 40, 45, 50, or more time points.

In addition, the methods provided herein are useful for predicting thelikelihood of mucosal healing in a subject. In some embodiments, themethod includes the steps of: (a) measuring a first set of markers toform an inflammatory phase marker score; (b) measuring a second set ofmarkers to form a proliferation phase marker score; (c) monitoringmucosal healing in the subject by using an algorithm incorporating theinflammatory phase marker score and the proliferation phase markerscore; and (d) predicting the likelihood of mucosal healing based uponthe algorithm.

In some embodiments, the subject has inflammatory bowel disease. In someaspects, inflammatory bowel disease is Crohn's disease or ulcerativecolitis.

In some embodiments, the first set of markers is one or more selectedfrom the group consisting of TWEAK, CRP, ICAM, SAA, VCAM, IL-2, IL-8,IL-12p70, IL1-β, GMCSF, IFNγ, IL6, TNFα, ASCA-A, ASCA-G, CBir1, Fla2,FlaX, OmpC, an anti-drug antibody (ADA), and combinations thereof. Insome embodiments, the second set of markers is one or more selected fromthe group consisting of AREG, EREG, HBEGF, HGF, HRGB, BTC, EGF, TGFA,FGF1, FGF2, FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA,VEGFB, VEGFC, VEGFD, TGFB1, IL-10, an anti-TNFα antibody, andcombinations thereof.

In some embodiments, the anti-drug antibody (ADA) is a member selectedfrom the group consisting of a human anti-chimeric antibody (HACA), ahuman anti-humanized antibody (HAHA), a human anti-mouse antibody(HAMA), and combinations thereof.

In some embodiments, the anti-TNFα antibody is a member selected fromthe group consisting of REMICADE™ (infliximab), ENBREL™ (etanercept),HUMIRA™ (adalimumab), CIMZIA® (certolizumab pegol), and combinationsthereof.

Each marker of the first set and/or the second set may be assigned avalue based upon the concentration or level of the marker. In particularembodiments, each marker of the first set and/or the second set isassigned a value of from 0 to 6, e.g., 0, 1, 2, 3, 4, 5, or 6, basedupon the concentration or level of the marker.

In some embodiments, one or more markers selected from the groupconsisting of EGF, AREG, EREG, HBEGF, HGF, HRGB, BTC, TGFA, FGF1, FGF2,FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC,VEGFD, TGFB1, and TWEAK is measured using a CEER assay. In someinstances, the value of the marker described herein is based upon 6standard samples for each marker.

In some embodiments, one or more markers selected from the groupconsisting of an anti-TNFα antibody and ADA is measured using ahomogeneous mobility shift assay (HMSA). In some instances, the value ofthe marker is based on a quantile level for each marker.

In some embodiments, one or more markers selected from the groupconsisting of IL10, CRP, ICAM, SAA, VCAM, IL-2, IL-8, IL-12p70, IL1B,GMCSF, IFNγ, IL-6, TNFα, ASCA-A, ASCA-G, CBir1, Fla2, FlaX, and OmpC ismeasured using an immunoassay. In some instances, the value of themarker is based on a quantile level for each marker.

In some embodiments, each marker is measured in a sample selected fromthe group consisting of serum, plasma, whole blood, stool, peripheralblood mononuclear cells (PBMC), polymorphonuclear (PMN) cells, and atissue biopsy.

In some embodiments, the concentration or level of the marker isrelative to the level of the same marker in a patient population withoutmucosal healing (e.g., an IBD patient population without mucosalhealing). The value for each marker in the first set of markers can besummed to form the inflammatory phase marker score. The value for eachmarker in the second set of markers can be summed to form theproliferation phase marker score. In some embodiments, the algorithm isthe summation of the proliferation phase marker values minus thesummation of the inflammatory phase marker values.

The algorithm of the method provided herein can predict the likelihoodof mucosal healing independent of clinical confounders. In someinstances, the clinical confounders include one or more selected fromthe group consisting of age of diagnosis, age of last sample, diseaselocation, anal involvement, smoking, surgery, and combinations thereof.

In other embodiments, the algorithm predicts the likelihood of mucosalhealing by excluding serology markers. In some embodiments, the excludedserology markers include one or more selected from the group consistingof ASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, and combinations thereof.For example, in some instances, the algorithm used for predicting thelikelihood of mucosal healing does not include (e.g., excludes, iswithout, or is independent of) values (e.g., scores or measurements,such as, concentrations, amounts or levels) of serology markers, such asASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, or combinations thereof.

In certain embodiments, the method of predicting the likelihood ofmucosal healing in a subject can be used to select an appropriatetherapeutic regimen such as an anti-TNFα antibody. In some instances,the anti-TNFα antibody includes one or more of REMICADE™ (infliximab),ENBREL™ (etanercept), HUMIRA™ (adalimumab), CIMZIA® (certolizumabpegol), and combinations thereof.

In some embodiments, the algorithm is used to predict relapse of adisease.

The methods described herein can be used to evaluate the phase ofmucosal healing, such as an inflammatory phase, a proliferation phase,or a remodeling phase, in an IBD individual receiving anti-TNFα therapy.In certain aspects, in both UC and CD patients, as shown herein, mucosalhealing can change the natural course of the disease by decreasingrelapse rates, and/or the need for surgery. Still further, mucosalhealing can reduce the development of long-term disease complications,such as bowel damage in CD and colorectal cancer in UC. Thus, it isimportant to continually monitor a subject while on therapies to ensurethe progress of mucosal healing.

B. Measuring Markers

As described herein, the methods for assessing mucosal healing in asubject include measuring the concentration or level of a first set ofmarkers used to form the inflammatory phase marker score, wherein atleast one or a plurality (e.g., at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 13, 14, 15, 16, 17, 18, 19, or 20) of the markers are selected fromthe group consisting of TWEAK, CRP, ICAM, SAA, VCAM, IL-2, IL-8,IL-12p70, IL-1β, GMCSF, IFNγ, IL-6, TNFα, ASCA-A, ASCA-G, CBir1, Fla2,FlaX, OmpC, an anti-drug antibody (ADA), and combinations thereof. Insome embodiments, the methods include measuring a combination of atleast two markers selected from the group consisting of TWEAK, CRP,ICAM, SAA, VCAM, IL-2, IL-8, IL-12p70, IL-1β, GMCSF, IFNγ, IL-6, TNFα,ASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, and an ADA, e.g., TWEAK andCRP, TWEAK and ICAM, TWEAK and SAA, TWEAK and VCAM, TWEAK and IL-2,TWEAK and IL-8, TWEAK and IL-12p70, TWEAK and IL-1β, TWEAK and GMCSF,TWEAK and IFNγ, TWEAK and IL-6, TWEAK and TNFα, TWEAK and ASCA-A, TWEAKand ASCA-G, TWEAK and CBir1, TWEAK and Fla2, TWEAK and FlaX, TWEAK andOmpC, TWEAK and ADA, CRP and ICAM, CRP and SAA, CRP and VCAM, CRP andIL-2, CRP and IL-8, CRP and IL-12p70, CRP and IL-1β, CRP and GMCSF, CRPand IFNγ, CRP and IL-6, CRP and TNFα, CRP and ASCA-A, CRP and ASCA-G,CRP and CBir1, CRP and Fla2, CRP and FlaX, CRP and OmpC, CRP and ADA,ICAM and SAA, ICAM and VCAM, ICAM and IL-2, ICAM and IL-8, ICAM andIL-12p70, ICAM and IL-1β, ICAM and GMCSF, ICAM and IFNγ, ICAM and IL-6,ICAM and TNFα, ICAM and ASCA-A, ICAM and ASCA-G, ICAM and CBir1, ICAMand Fla2, ICAM and FlaX, ICAM and OmpC, ICAM and ADA, SAA and VCAM, SAAand IL-2, IL-8, SAA and IL-12p70, SAA and IL-1β, SAA and GMCSF, SAA andIFNγ, SAA and IL-6, SAA and TNFα, SAA and ASCA-A, SAA and ASCA-G, SAAand CBir1, SAA and Fla2, SAA and FlaX, SAA and OmpC, SAA and ADA, VCAMand IL-2, VCAM and IL-8, VCAM and IL-12p70, VCAM and IL-1β, VCAM andGMCSF, VCAM and IFNγ, VCAM and IL-6, VCAM and TNFα, VCAM and ASCA-A,VCAM and ASCA-G, VCAM and CBir1, VCAM and Fla2, VCAM and FlaX, VCAM andOmpC, VCAM and ADA, IL-2 and IL-8, IL-2 and IL-12p70, IL-2 and IL-1β,IL-2 and GMCSF, IL-2 and IFNγ, IL-2 and IL-6, IL-2 and TNFα, IL-2 andASCA-A, IL-2 and ASCA-G, IL-2 and CBir1, IL-2 and Fla2, IL-2 and FlaX,IL-2 and OmpC, IL-2 and ADA, IL-8 and IL-12p70, IL-8 and IL-1β, IL-8 andGMCSF, IL-8 and IFNγ, IL-8 and IL-6, IL-8 and TNFα, IL-8 and ASCA-A,IL-8 and ASCA-G, IL-8 and CBir1, IL-8 and Fla2, IL-8 and FlaX, IL-8 andOmpC, IL-8 and ADA, IL-12p70 and IL-1β, IL-12p70 and GMCSF, IL-12p70 andIFNγ, IL-12p70 and IL-6, IL-12p70 and TNFα, IL-12p70 and ASCA-A,IL-12p70 and ASCA-G, IL-12p70 and CBir1, IL-12p70 and Fla2, IL-12p70 andFlaX, IL-12p70 and OmpC, IL-12p70 and ADA, IL-1β and GMCSF, IL-1β andIFNγ, IL-1β and IL-6, IL-1β and TNFα, IL-1β and ASCA-A, IL-1β andASCA-G, IL-1β and CBir1, IL-1β and Fla2, IL-1β and FlaX, IL-1β and OmpC,IL-1β and ADA, GMCSF and IFNγ, GMCSF and IL-6, GMCSF and TNFα, GMCSF andASCA-A, GMCSF and ASCA-G, GMCSF and CBir1, GMCSF and Fla2, GMCSF andFlaX, GMCSF and OmpC, GMCSF and ADA, IFNγ and IL-6, IFNγ and TNFα, IFNγand ASCA-A, IFNγ and ASCA-G, IFNγ and CBir1, IFNγ and Fla2, IFNγ andFlaX, IFNγ and OmpC, IFNγ and ADA, IL-6 and TNFα, IL-6 and ASCA-A, IL-6and ASCA-G, IL-6 and CBir1, IL-6 and Fla2, IL-6 and FlaX, IL-6 and OmpC,IL-6 and ADA, TNFα and ASCA-A, TNFα and ASCA-G, TNFα and CBir1, TNFα andFla2, TNFα and FlaX, TNFα and OmpC, TNFα and ADA, ASCA-A and ASCA-G,ASCA-A and CBir1, ASCA-A and Fla2, ASCA-A and FlaX, ASCA-A and OmpC,ASCA-A and ADA, ASCA-G and CBir1, ASCA-G and Fla2, ASCA-G and FlaX,ASCA-G and OmpC, ASCA-G and ADA, CBir1 and Fla2, CBir1 and FlaX, CBir1and OmpC, CBir1 and ADA, Fla2 and FlaX, Fla2 and OmpC, Fla2 and ADA,FlaX and OmpC, FlaX and ADA, OmpC and ADA, and the like. In someinstances, the combination of at least two markers can further includeat least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, or18 of the other markers selected from the first set of markers to forman inflammatory phase marker score.

In some embodiments, the methods include measuring a combination of atleast three markers selected from the group consisting of TWEAK, CRP,ICAM, SAA, VCAM, IL-2, IL-8, IL-12p70, IL-1β, GMCSF, IFNγ, IL-6, TNFα,ASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC, and an ADA, e.g., TWEAK, CRPand ICAM; TWEAK, CRP and SAA; TWEAK, CRP and VCAM; TWEAK, CRP and IL-2;TWEAK, CRP and IL-8; TWEAK, CRP and IL-12p70; TWEAK, CRP and IL-1β;TWEAK, CRP and GMCSF; TWEAK, CRP and IFNγ; TWEAK, CRP and IL-6; TWEAK,CRP and TNFα; TWEAK, CRP and ASCA-A; TWEAK, CRP and ASCA-G; TWEAK, CRPand CBir1; TWEAK, CRP and Fla2; TWEAK, CRP and FlaX; TWEAK, CRP andOmpC; TWEAK, CRP and ADA; TWEAK, ICAM and SAA; TWEAK, ICAM and VCAM;TWEAK, ICAM and IL-2; TWEAK, ICAM and IL-8; TWEAK, ICAM and IL-12p70;TWEAK, ICAM and IL-1β; TWEAK, ICAM and GMCSF; TWEAK, ICAM and IFNγ;TWEAK, ICAM and IL-6; TWEAK, ICAM and TNFα; TWEAK, ICAM and ASCA-A;TWEAK, ICAM and ASCA-G; TWEAK, ICAM and CBir1; TWEAK, ICAM and Fla2;TWEAK, ICAM and FlaX; TWEAK, ICAM and OmpC; TWEAK, ICAM and ADA; TWEAK,SAA and VCAM; TWEAK, SAA and IL-2; TWEAK, SAA and IL-8; TWEAK, SAA andIL-12p70; TWEAK, SAA and IL-1β; TWEAK, SAA and GMCSF; TWEAK, SAA andIFNγ; TWEAK, SAA and IL-6; TWEAK, SAA and TNFα; TWEAK, SAA and ASCA-A;TWEAK, SAA and ASCA-G; TWEAK, SAA and CBir1; TWEAK, SAA and Fla2; TWEAK,SAA and FlaX; TWEAK, SAA and OmpC; TWEAK, SAA and ADA; TWEAK, VCAM andIL-2; TWEAK, VCAM and IL-8; TWEAK, VCAM and IL-12p70; TWEAK, VCAM andIL-1β; TWEAK, VCAM and GMCSF; TWEAK, VCAM and IFNγ; TWEAK, VCAM andIL-6; TWEAK, VCAM and TNFα; TWEAK, VCAM and ASCA-A; TWEAK, VCAM andASCA-G; TWEAK, VCAM and CBir1; TWEAK, VCAM and Fla2; TWEAK, VCAM andFlaX; TWEAK, VCAM and OmpC; TWEAK, VCAM and ADA; TWEAK, IL-2 and IL-8;TWEAK, IL-2 and IL-12p70; TWEAK, IL-2 and IL-1β; TWEAK, IL-2 and GMCSF;TWEAK, IL-2 and IFNγ; TWEAK, IL-2 and IL-6; TWEAK, IL-2 and TNFα; TWEAK,IL-2 and ASCA-A; TWEAK, IL-2 and ASCA-G; TWEAK, IL-2 and CBir1; TWEAK,IL-2 and Fla2; TWEAK, IL-2 and FlaX; TWEAK, IL-2 and OmpC; TWEAK, IL-2and ADA; TWEAK, IL-8 and IL-12p70; TWEAK, IL-8 and IL-1β; TWEAK, IL-8and GMCSF; TWEAK, IL-8 and IFNγ; TWEAK, IL-8 and IL-6; TWEAK, IL-8 andTNFα; TWEAK, IL-8 and ASCA-A; TWEAK, IL-8 and ASCA-G; TWEAK, IL-8 andCBir1; TWEAK, IL-8 and Fla2; TWEAK, IL-8 and FlaX; TWEAK, IL-8 and OmpC;TWEAK, IL-8 and ADA; TWEAK, IL-12p70 and IL-1β; TWEAK, IL-12p70 andGMCSF; TWEAK, IL-12p70 and IFNγ; TWEAK, IL-12p70 and IL-6; TWEAK,IL-12p70 and TNFα; TWEAK, IL-12p70 and ASCA-A; TWEAK, IL-12p70 andASCA-G; TWEAK, IL-12p70 and CBir1; TWEAK, IL-12p70 and Fla2; TWEAK,IL-12p70 and FlaX; TWEAK, IL-12p70 and OmpC; TWEAK, IL-12p70 and ADA;TWEAK, IL-1β and GMCSF; TWEAK, IL-1β and IFNγ; TWEAK, IL-1β and IL-6;TWEAK, IL-1β and TNFα; TWEAK, IL-1β and ASCA-A; TWEAK, IL-1β and ASCA-G;TWEAK, IL-1β and CBir1; TWEAK, IL-1β and Fla2; TWEAK, IL-1β and FlaX;TWEAK, IL-1β and OmpC; TWEAK, IL-1β and ADA; TWEAK, GMCSF and IFNγ;TWEAK, GMCSF and IL-6; TWEAK, GMCSF and TNFα; TWEAK, GMCSF and ASCA-A;TWEAK, GMCSF and ASCA-G; TWEAK, GMCSF and CBir1; TWEAK, GMCSF and Fla2;TWEAK, GMCSF and FlaX; TWEAK, GMCSF and OmpC; TWEAK, GMCSF and ADA;TWEAK, IFNγ and IL-6; TWEAK, IFNγ and TNFα; TWEAK, IFNγ and ASCA-A;TWEAK, IFNγ and ASCA-G; TWEAK, IFNγ and CBir1; TWEAK, IFNγ and Fla2;TWEAK, IFNγ and FlaX; TWEAK, IFNγ and OmpC; TWEAK, IFNγ and ADA; TWEAK,IL-6 and TNFα; TWEAK, IL-6 and ASCA-A; TWEAK, IL-6 and ASCA-G; TWEAK,IL-6 and CBir1; TWEAK, IL-6 and Fla2; TWEAK, IL-6 and FlaX; TWEAK, IL-6and OmpC; TWEAK, IL-6 and ADA; TWEAK, TWEAK, TNFα and ASCA-A; TWEAK,TNFα and ASCA-G; TWEAK, TNFα and CBir1; TWEAK, TNFα and Fla2; TWEAK,TNFα and FlaX; TWEAK, TNFα and OmpC; TWEAK, TNFα and ADA; TWEAK, ASCA-Aand ASCA-G; TWEAK, ASCA-A and CBir1; TWEAK, ASCA-A and Fla2; TWEAK,ASCA-A and FlaX; TWEAK, ASCA-A and OmpC; TWEAK, ASCA-A and ADA; TWEAK,ASCA-G and CBir1; TWEAK, ASCA-G and Fla2; TWEAK, ASCA-G and FlaX; TWEAK,ASCA-G and OmpC; TWEAK, ASCA-G and ADA; TWEAK, CBir1 and Fla2; TWEAK,CBir1 and FlaX; TWEAK, CBir1 and OmpC; TWEAK, CBir1 and ADA; TWEAK, Fla2and FlaX; TWEAK, Fla2 and OmpC; TWEAK, Fla2 and ADA; TWEAK, FlaX andOmpC; TWEAK, FlaX and ADA; TWEAK, OmpC and ADA; CRP, TWEAK and ICAM;CRP, TWEAK and SAA; CRP, TWEAK and VCAM; CRP, TWEAK and IL-2; CRP, TWEAKand IL-8; CRP, TWEAK and IL-12p70; CRP, TWEAK and IL-1β; CRP, TWEAK andGMCSF; CRP, TWEAK and IFNγ; CRP, TWEAK and IL-6; CRP, TWEAK and TNFα;CRP, TWEAK and ASCA-A; CRP, TWEAK and ASCA-G; CRP, TWEAK and CBir1; CRP,TWEAK and Fla2; CRP, TWEAK and FlaX; CRP, TWEAK and OmpC; CRP, TWEAK andADA; CRP, ICAM and SAA; CRP, ICAM and VCAM; CRP, ICAM and IL-2; CRP,ICAM and IL-8; CRP, ICAM and IL-12p70; CRP, ICAM and IL-1β; CRP, ICAMand GMCSF; CRP, ICAM and IFNγ; CRP, ICAM and IL-6; CRP, ICAM and TNFα;CRP, ICAM and ASCA-A; CRP, ICAM and ASCA-G; CRP, ICAM and CBir1; CRP,ICAM and Fla2; CRP, ICAM and FlaX; CRP, ICAM and OmpC; CRP, ICAM andADA; CRP, SAA and VCAM; CRP, SAA and IL-2; CRP, SAA and IL-8; CRP, SAAand IL-12p70; CRP, SAA and IL-1β; CRP, SAA and GMCSF; CRP, SAA and IFNγ;CRP, SAA and IL-6; CRP, SAA and TNFα; CRP, SAA and ASCA-A; CRP, SAA andASCA-G; CRP, SAA and CBir1; CRP, SAA and Fla2; CRP, SAA and FlaX; CRP,SAA and OmpC; CRP, SAA and ADA; CRP, VCAM and IL-2; CRP, VCAM and IL-8;CRP, VCAM and IL-12p70; CRP, VCAM and IL-1β; CRP, VCAM and GMCSF; CRP,VCAM and IFNγ; CRP, VCAM and IL-6; CRP, VCAM and TNFα; CRP, VCAM andASCA-A; CRP, VCAM and ASCA-G; CRP, VCAM and CBir1; CRP, VCAM and Fla2;CRP, VCAM and FlaX; CRP, VCAM and OmpC; CRP, VCAM and ADA; CRP, IL-2 andIL-8; CRP, IL-2 and IL-12p70; CRP, IL-2 and IL-1β; CRP, IL-2 and GMCSF;CRP, IL-2 and IFNγ; CRP, IL-2 and IL-6; CRP, IL-2 and TNFα; CRP, IL-2and ASCA-A; CRP, IL-2 and ASCA-G; CRP, IL-2 and CBir1; CRP, IL-2 andFla2; CRP, IL-2 and FlaX; CRP, IL-2 and OmpC; CRP, IL-2 and ADA; CRP,IL-8 and IL-12p70; CRP, IL-8 and IL-1β; CRP, IL-8 and GMCSF; CRP, IL-8and IFNγ; CRP, IL-8 and IL-6; CRP, IL-8 and TNFα; CRP, IL-8 and ASCA-A;CRP, IL-8 and ASCA-G; CRP, IL-8 and CBir1; CRP, IL-8 and Fla2; CRP, IL-8and FlaX; CRP, IL-8 and OmpC; CRP, IL-8 and ADA; CRP, IL-12p70 andIL-1β; CRP, IL-12p70 and GMCSF; CRP, IL-12p70 and IFNγ; CRP, IL-12p70and IL-6; CRP, IL-12p70 and TNFα; CRP, IL-12p70 and ASCA-A; CRP,IL-12p70 and ASCA-G; CRP, IL-12p70 and CBir1; CRP, IL-12p70 and Fla2;CRP, IL-12p70 and FlaX; CRP, IL-12p70 and OmpC; CRP, IL-12p70 and ADA;CRP, IL-1β and GMCSF; CRP, IL-1β and IFNγ; CRP, IL-1β and IL-6; CRP,IL-1β and TNFα; CRP, IL-1β and ASCA-A; CRP, IL-1β and ASCA-G; CRP, IL-1βand CBir1; CRP, IL-1β and Fla2; CRP, IL-1β and FlaX; CRP, IL-1β andOmpC; CRP, IL-1β and ADA; CRP, GMCSF and IFNγ; CRP, GMCSF and IL-6; CRP,GMCSF and TNFα; CRP, GMCSF and ASCA-A; CRP, GMCSF and ASCA-G; CRP, GMCSFand CBir1; CRP, GMCSF and Fla2; CRP, GMCSF and FlaX; CRP, GMCSF andOmpC; CRP, GMCSF and ADA; CRP, IFNγ and IL-6; CRP, IFNγ and TNFα; CRP,IFNγ and ASCA-A; CRP, IFNγ and ASCA-G; CRP, IFNγ and CBir1; CRP, IFNγand Fla2; CRP, IFNγ and FlaX; CRP, IFNγ and OmpC; CRP, IFNγ and ADA;CRP, IL-6 and TNFα; CRP, IL-6 and ASCA-A; CRP, IL-6 and ASCA-G; CRP,IL-6 and CBir1; CRP, IL-6 and Fla2; CRP, IL-6 and FlaX; CRP, IL-6 andOmpC; CRP, IL-6 and ADA; CRP, TNFα and ASCA-A; CRP, TNFα and ASCA-G;CRP, TNFα and CBir1; CRP, TNFα and Fla2; CRP, TNFα and FlaX; CRP, TNFαand OmpC; CRP, TNFα and ADA; CRP, ASCA-A and ASCA-G; CRP, ASCA-A andCBir1; CRP, ASCA-A and Fla2; CRP, ASCA-A and FlaX; CRP, ASCA-A and OmpC;CRP, ASCA-A and ADA; CRP, ASCA-G and CBir1; CRP, ASCA-G and Fla2; CRP,ASCA-G and FlaX; CRP, ASCA-G and OmpC; CRP, ASCA-G and ADA; CRP, CBir1and Fla2; CRP, CBir1 and FlaX; CRP, CBir1 and OmpC; CRP, CBir1 and ADA;CRP, Fla2 and FlaX; CRP, Fla2 and OmpC; CRP, Fla2 and ADA; CRP, FlaX andOmpC; CRP, FlaX and ADA; CRP, OmpC and ADA; ICAM, TWEAK and CRP; ICAM,TWEAK and SAA; ICAM, TWEAK and VCAM; ICAM, TWEAK and IL-2; ICAM, TWEAKand IL-8; ICAM, TWEAK and IL-12p70; ICAM, TWEAK and IL-1β; ICAM, TWEAKand GMCSF; ICAM, TWEAK and IFNγ; ICAM, TWEAK and IL-6; ICAM, TWEAK andTNFα; ICAM, TWEAK and ASCA-A; ICAM, TWEAK and ASCA-G; ICAM, TWEAK andCBir1; ICAM, TWEAK and Fla2; ICAM, TWEAK and FlaX; ICAM, TWEAK and OmpC;ICAM, TWEAK and ADA; ICAM, CRP and SAA; ICAM, CRP and VCAM; ICAM, CRPand IL-2; ICAM, CRP and IL-8; ICAM, CRP and IL-12p70; ICAM, CRP andIL-1β; ICAM, CRP and GMCSF; ICAM, CRP and IFNγ; ICAM, CRP and IL-6;ICAM, CRP and TNFα; ICAM, CRP and ASCA-A; ICAM, CRP and ASCA-G; ICAM,CRP and CBir1; ICAM, CRP and Fla2; ICAM, CRP and FlaX; ICAM, CRP andOmpC; ICAM, CRP and ADA; ICAM, SAA and VCAM; ICAM, SAA and IL-2; ICAM,SAA and IL-8; ICAM, SAA and IL-12p70; ICAM, SAA and IL-1β; ICAM, SAA andGMCSF; ICAM, SAA and IFNγ; ICAM, SAA and IL-6; ICAM, SAA and TNFα; ICAM,SAA and ASCA-A; ICAM, SAA and ASCA-G; ICAM, SAA and CBir1; ICAM, SAA andFla2; ICAM, SAA and FlaX; ICAM, SAA and OmpC; ICAM, SAA and ADA; ICAM,VCAM and IL-2; ICAM, VCAM and IL-8; ICAM, VCAM and IL-12p70; ICAM, VCAMand IL-1β; ICAM, VCAM and GMCSF; ICAM, VCAM and IFNγ; ICAM, VCAM andIL-6; ICAM, VCAM and TNFα; ICAM, VCAM and ASCA-A; ICAM, VCAM and ASCA-G;ICAM, VCAM and CBir1; ICAM, VCAM and Fla2; ICAM, VCAM and FlaX; ICAM,VCAM and OmpC; ICAM, VCAM and ADA; ICAM, IL-2 and IL-8; ICAM, IL-2 andIL-12p70; ICAM, IL-2 and IL-1β; ICAM, IL-2 and GMCSF; ICAM, IL-2 andIFNγ; ICAM, IL-2 and IL-6; ICAM, IL-2 and TNFα; ICAM, IL-2 and ASCA-A;ICAM, IL-2 and ASCA-G; ICAM, IL-2 and CBir1; ICAM, IL-2 and Fla2; ICAM,IL-2 and FlaX; ICAM, IL-2 and OmpC; ICAM, IL-2 and ADA; ICAM, IL-8 andIL-12p70; ICAM, IL-8 and IL-1β; ICAM, IL-8 and GMCSF; ICAM, IL-8 andIFNγ; ICAM, IL-8 and IL-6; ICAM, IL-8 and TNFα; ICAM, IL-8 and ASCA-A;ICAM, IL-8 and ASCA-G; ICAM, IL-8 and CBir1; ICAM, IL-8 and Fla2; ICAM,IL-8 and FlaX; ICAM, IL-8 and OmpC; ICAM, IL-8 and ADA; ICAM, IL-12p70and IL-1β; ICAM, IL-12p70 and GMCSF; ICAM, IL-12p70 and IFNγ; ICAM,IL-12p70 and IL-6; ICAM, IL-12p70 and TNFα; ICAM, IL-12p70 and ASCA-A;ICAM, IL-12p70 and ASCA-G; ICAM, IL-12p70 and CBir1; ICAM, IL-12p70 andFla2; ICAM, IL-12p70 and FlaX; ICAM, IL-12p70 and OmpC; ICAM, IL-12p70and ADA; CAM, IL-1β and GMCSF; ICAM, IL-1β and IFNγ; ICAM, IL-1β andIL-6; ICAM, IL-1β and TNFα; ICAM, IL-1β and ASCA-A; ICAM, IL-1β andASCA-G; ICAM, IL-1β and CBir1; ICAM, IL-1β and Fla2; ICAM, IL-1β andFlaX; ICAM, IL-1β and OmpC; ICAM, IL-1β and ADA; ICAM, GMCSF and IFNγ;ICAM, GMCSF and IL-6; ICAM, GMCSF and TNFα; ICAM, GMCSF and ASCA-A;ICAM, GMCSF and ASCA-G; ICAM, GMCSF and CBir1; ICAM, GMCSF and Fla2;ICAM, GMCSF and FlaX; ICAM, GMCSF and OmpC; ICAM, GMCSF and ADA; ICAM,IFNγ and IL-6; ICAM, IFNγ and TNFα; ICAM, IFNγ and ASCA-A; ICAM, IFNγand ASCA-G; ICAM, IFNγ and CBir1; ICAM, IFNγ and Fla2; ICAM, IFNγ andFlaX; ICAM, IFNγ and OmpC; ICAM, IFNγ and ADA; ICAM, IL-6 and TNFα;ICAM, IL-6 and ASCA-A; ICAM, IL-6 and ASCA-G; ICAM, IL-6 and CBir1;ICAM, IL-6 and Fla2; ICAM, IL-6 and FlaX; ICAM, IL-6 and OmpC; ICAM,IL-6 and ADA; ICAM, TNFα and ASCA-A; ICAM, TNFα and ASCA-G; ICAM, TNFαand CBir1; ICAM, TNFα and Fla2; ICAM, TNFα and FlaX; ICAM, TNFα andOmpC; ICAM, TNFα and ADA; ICAM, ASCA-A and ASCA-G; ICAM, ASCA-A andCBir1; ICAM, ASCA-A and Fla2; ICAM, ASCA-A and FlaX; ICAM, ASCA-A andOmpC; ICAM, ASCA-A and ADA; ICAM, ASCA-G and CBir1; ICAM, ASCA-G andFla2; ICAM, ASCA-G and FlaX; ICAM, ASCA-G and OmpC; ICAM, ASCA-G andADA; ICAM, CBir1 and Fla2; ICAM, CBir1 and FlaX; ICAM, CBir1 and OmpC;ICAM, CBir1 and ADA; ICAM, Fla2 and FlaX; ICAM, Fla2 and OmpC; ICAM,Fla2 and ADA; ICAM, FlaX and OmpC; ICAM, FlaX and ADA; ICAM, OmpC andADA; SAA, TWEAK and CRP; SAA, TWEAK and ICAM; SAA, TWEAK and SAA; SAA,TWEAK and VCAM; SAA, TWEAK and IL-2; SAA, TWEAK and IL-8; SAA, TWEAK andIL-12p70; SAA, TWEAK and IL-1β; SAA, TWEAK and GMCSF; SAA, TWEAK andIFNγ; SAA, TWEAK and IL-6; SAA, TWEAK and TNFα; SAA, TWEAK and ASCA-A;SAA, TWEAK and ASCA-G; SAA, TWEAK and CBir1; SAA, TWEAK and Fla2; SAA,TWEAK and FlaX; SAA, TWEAK and OmpC; SAA, TWEAK and ADA; SAA, CRP andICAM; SAA, CRP and VCAM; SAA, CRP and IL-2; SAA, CRP and IL-8; SAA, CRPand IL-12p70; SAA, CRP and IL-1β; SAA, CRP and GMCSF; SAA, CRP and IFNγ;SAA, CRP and IL-6; SAA, CRP and TNFα; SAA, CRP and ASCA-A; SAA, CRP andASCA-G; SAA, CRP and CBir1; SAA, CRP and Fla2; SAA, CRP and FlaX; SAA,CRP and OmpC; SAA, CRP and ADA; SAA, ICAM and VCAM; SAA, ICAM and IL-2;SAA, ICAM and IL-8; SAA, ICAM and IL-12p70; SAA, ICAM and IL-1β; SAA,ICAM and GMCSF; SAA, ICAM and IFNγ; SAA, ICAM and IL-6; SAA, ICAM andTNFα; SAA, ICAM and ASCA-A; SAA, ICAM and ASCA-G; SAA, ICAM and CBir1;SAA, ICAM and Fla2; SAA, ICAM and FlaX; SAA, ICAM and OmpC; SAA, ICAMand ADA; SAA, VCAM and IL-2; SAA, VCAM and IL-8; SAA, VCAM and IL-12p70;SAA, VCAM and IL-1β; SAA, VCAM and GMCSF; SAA, VCAM and IFNγ; SAA, VCAMand IL-6; SAA, VCAM and TNFα; SAA, VCAM and ASCA-A; SAA, VCAM andASCA-G; SAA, VCAM and CBir1; SAA, VCAM and Fla2; SAA, VCAM and FlaX;SAA, VCAM and OmpC; SAA, VCAM and ADA; SAA, IL-2 and IL-8; SAA, IL-2 andIL-12p70; SAA, IL-2 and IL-1β; SAA, IL-2 and GMCSF; SAA, IL-2 and IFNγ;SAA, IL-2 and IL-6; SAA, IL-2 and TNFα; SAA, IL-2 and ASCA-A; SAA, IL-2and ASCA-G; SAA, IL-2 and CBir1; SAA, IL-2 and Fla2; SAA, IL-2 and FlaX;SAA, IL-2 and OmpC; SAA, IL-2 and ADA; SAA, IL-8 and IL-12p70; SAA, IL-8and IL-1β; SAA, IL-8 and GMCSF; SAA, IL-8 and IFNγ; SAA, IL-8 and IL-6;SAA, IL-8 and TNFα; SAA, IL-8 and ASCA-A; SAA, IL-8 and ASCA-G; SAA,IL-8 and CBir1; SAA, IL-8 and Fla2; SAA, IL-8 and FlaX; SAA, IL-8 andOmpC; SAA, IL-8 and ADA; SAA, IL-12p70 and IL-1β; SAA, IL-12p70 andGMCSF; SAA, IL-12p70 and IFNγ; SAA, IL-12p70 and IL-6; SAA, IL-12p70 andTNFα; SAA, IL-12p70 and ASCA-A; SAA, IL-12p70 and ASCA-G; SAA, IL-12p70and CBir1; SAA, IL-12p70 and Fla2; SAA, IL-12p70 and FlaX; SAA, IL-12p70and OmpC; SAA, IL-12p70 and ADA; SAA, IL-1β and GMCSF; SAA, IL-1β andIFNγ; SAA, IL-1β and IL-6; SAA, IL-1β and TNFα; SAA, IL-1β and ASCA-A;SAA, IL-1β and ASCA-G; SAA, IL-1β and CBir1; SAA, IL-1β and Fla2; SAA,IL-1β and FlaX; SAA, IL-1β and OmpC; SAA, IL-1β and ADA; SAA, GMCSF andIFNγ; SAA, GMCSF and IL-6; SAA, GMCSF and TNFα; SAA, GMCSF and ASCA-A;SAA, GMCSF and ASCA-G; SAA, GMCSF and CBir1; SAA, GMCSF and Fla2; SAA,GMCSF and FlaX; SAA, GMCSF and OmpC; SAA, GMCSF and ADA; SAA, IFNγ andIL-6; SAA, IFNγ and TNFα; SAA, IFNγ and ASCA-A; SAA, IFNγ and ASCA-G;SAA, IFNγ and CBir1; SAA, IFNγ and Fla2; SAA, IFNγ and FlaX; SAA, IFNγand OmpC; SAA, IFNγ and ADA; SAA, IL-6 and TNFα; SAA, IL-6 and ASCA-A;SAA, IL-6 and ASCA-G; SAA, IL-6 and CBir1; SAA, IL-6 and Fla2; SAA, IL-6and FlaX; SAA, IL-6 and OmpC; SAA, IL-6 and ADA; SAA, TNFα and ASCA-A;SAA, TNFα and ASCA-G; SAA, TNFα and CBir1; SAA, TNFα and Fla2; SAA, TNFαand FlaX; SAA, TNFα and OmpC; SAA, TNFα and ADA; SAA, ASCA-A and ASCA-G;SAA, ASCA-A and CBir1; SAA, ASCA-A and Fla2; SAA, ASCA-A and FlaX; SAA,ASCA-A and OmpC; SAA, ASCA-A and ADA; SAA, ASCA-G and CBir1; SAA, ASCA-Gand Fla2; SAA, ASCA-G and FlaX; SAA, ASCA-G and OmpC; SAA, ASCA-G andADA; SAA, CBir1 and Fla2; SAA, CBir1 and FlaX; SAA, CBir1 and OmpC; SAA,CBir1 and ADA; SAA, Fla2 and FlaX; SAA, Fla2 and OmpC; SAA, Fla2 andADA; SAA, FlaX and OmpC; SAA, FlaX and ADA; SAA, OmpC and ADA; VCAM,TWEAK and CRP; VCAM, TWEAK and ICAM; VCAM, TWEAK and SAA; VCAM, TWEAKand IL-2; VCAM, TWEAK and IL-8; VCAM, TWEAK and IL-12p70; VCAM, TWEAKand IL-1β; VCAM, TWEAK and GMCSF; VCAM, TWEAK and IFNγ; VCAM, TWEAK andIL-6; VCAM, TWEAK and TNFα; VCAM, TWEAK and ASCA-A; VCAM, TWEAK andASCA-G; VCAM, TWEAK and CBir1; VCAM, TWEAK and Fla2; VCAM, TWEAK andFlaX; VCAM, TWEAK and OmpC; VCAM, TWEAK and ADA; VCAM, CRP and ICAM;VCAM, CRP and SAA; VCAM, CRP and IL-2; VCAM, CRP and IL-8; VCAM, CRP andIL-12p70; VCAM, CRP and IL-1β; VCAM, CRP and GMCSF; VCAM, CRP and IFNγ;VCAM, CRP and IL-6; VCAM, CRP and TNFα; VCAM, CRP and ASCA-A; VCAM, CRPand ASCA-G; VCAM, CRP and CBir1; VCAM, CRP and Fla2; VCAM, CRP and FlaX;VCAM, CRP and OmpC; VCAM, CRP and ADA; VCAM, ICAM and SAA; VCAM, ICAMand IL-2; VCAM, ICAM and IL-8; VCAM, ICAM and IL-12p70; VCAM, ICAM andIL-1β; VCAM, ICAM and GMCSF; VCAM, ICAM and IFNγ; VCAM, ICAM and IL-6;VCAM, ICAM and TNFα; VCAM, ICAM and ASCA-A; VCAM, ICAM and ASCA-G; VCAM,ICAM and CBir1; VCAM, ICAM and Fla2; VCAM, ICAM and FlaX; VCAM, ICAM andOmpC; VCAM, ICAM and ADA; VCAM, SAA and IL-2; VCAM, SAA and IL-8; VCAM,SAA and IL-12p70; VCAM, SAA and IL-1β; VCAM, SAA and GMCSF; VCAM, SAAand IFNγ; VCAM, SAA and IL-6; VCAM, SAA and TNFα; VCAM, SAA and ASCA-A;VCAM, SAA and ASCA-G; VCAM, SAA and CBir1; VCAM, SAA and Fla2; VCAM, SAAand FlaX; VCAM, SAA and OmpC; VCAM, SAA and ADA; VCAM, IL-2 and IL-8;VCAM, IL-2 and IL-12p70; VCAM, IL-2 and IL-1β; VCAM, IL-2 and GMCSF;VCAM, IL-2 and IFNγ; VCAM, IL-2 and IL-6; VCAM, IL-2 and TNFα; VCAM,IL-2 and ASCA-A; VCAM, IL-2 and ASCA-G; VCAM, IL-2 and CBir1; VCAM, IL-2and Fla2; VCAM, IL-2 and FlaX; VCAM, IL-2 and OmpC; VCAM, IL-2 and ADA;VCAM, IL-8 and IL-12p70; VCAM, IL-8 and IL-1β; VCAM, IL-8 and GMCSF;VCAM, IL-8 and IFNγ; VCAM, IL-8 and IL-6; VCAM, IL-8 and TNFα; VCAM,IL-8 and ASCA-A; VCAM, IL-8 and ASCA-G; VCAM, IL-8 and CBir1; VCAM, IL-8and Fla2; VCAM, IL-8 and FlaX; VCAM, IL-8 and OmpC; VCAM, IL-8 and ADA;VCAM, IL-12p70 and IL-1β; VCAM, IL-12p70 and GMCSF; VCAM, IL-12p70 andIFNγ; VCAM, IL-12p70 and IL-6; VCAM, IL-12p70 and TNFα; VCAM, IL-12p70and ASCA-A; VCAM, IL-12p70 and ASCA-G; VCAM, IL-12p70 and CBir1; VCAM,IL-12p70 and Fla2; VCAM, IL-12p70 and FlaX; VCAM, IL-12p70 and OmpC;VCAM, IL-12p70 and ADA; VCAM, IL-1β and GMCSF; VCAM, IL-1β and IFNγ;VCAM, IL-1β and IL-6; VCAM, IL-1β and TNFα; VCAM, IL-1β and ASCA-A;VCAM, IL-1β and ASCA-G; VCAM, IL-1β and CBir1; VCAM, IL-1β and Fla2;VCAM, IL-1β and FlaX; VCAM, IL-1β and OmpC; VCAM, IL-1β and ADA; VCAM,GMCSF and IFNγ; VCAM, GMCSF and IL-6; VCAM, GMCSF and TNFα; VCAM, GMCSFand ASCA-A; VCAM, GMCSF and ASCA-G; VCAM, GMCSF and CBir1; VCAM, GMCSFand Fla2; VCAM, GMCSF and FlaX; VCAM, GMCSF and OmpC; VCAM, GMCSF andADA; VCAM, IFNγ and IL-6; VCAM, IFNγ and TNFα; VCAM, IFNγ and ASCA-A;VCAM, IFNγ and ASCA-G; VCAM, IFNγ and CBir1; VCAM, IFNγ and Fla2; VCAM,IFNγ and FlaX; VCAM, IFNγ and OmpC; VCAM, IFNγ and ADA; VCAM, IL-6 andTNFα; VCAM, IL-6 and ASCA-A; VCAM, IL-6 and ASCA-G; VCAM, IL-6 andCBir1; VCAM, IL-6 and Fla2; VCAM, IL-6 and FlaX; VCAM, IL-6 and OmpC;VCAM, IL-6 and ADA; VCAM, TNFα and ASCA-A; VCAM, TNFα and ASCA-G; VCAM,TNFα and CBir1; VCAM, TNFα and Fla2; VCAM, TNFα and FlaX; VCAM, TNFα andOmpC; VCAM, TNFα and ADA; VCAM, ASCA-A and ASCA-G; VCAM, ASCA-A andCBir1; VCAM, ASCA-A and Fla2; VCAM, ASCA-A and FlaX; VCAM, ASCA-A andOmpC; VCAM, ASCA-A and ADA; VCAM, ASCA-G and CBir1; VCAM, ASCA-G andFla2; VCAM, ASCA-G and FlaX; VCAM, ASCA-G and OmpC; VCAM, ASCA-G andADA; VCAM, CBir1 and Fla2; VCAM, CBir1 and FlaX; VCAM, CBir1 and OmpC;VCAM, CBir1 and ADA; VCAM, Fla2 and FlaX; VCAM, Fla2 and OmpC; VCAM,Fla2 and ADA; VCAM, FlaX and OmpC; VCAM, FlaX and ADA; VCAM, OmpC andADA; IL-2, TWEAK and CRP; IL-2, TWEAK and ICAM; IL-2, TWEAK and SAA;IL-2, TWEAK and VCAM; IL-2, TWEAK and IL-8; IL-2, TWEAK and IL-12p70;IL-2, TWEAK and IL-1β; IL-2, TWEAK and GMCSF; IL-2, TWEAK and IFNγ;IL-2, TWEAK and IL-6; IL-2, TWEAK and TNFα; IL-2, TWEAK and ASCA-A;IL-2, TWEAK and ASCA-G; IL-2, TWEAK and CBir1; IL-2, TWEAK and Fla2;IL-2, TWEAK and FlaX; IL-2, TWEAK and OmpC; IL-2, TWEAK and ADA; IL-2,CRP and ICAM; IL-2, CRP and SAA; IL-2, CRP and VCAM; IL-2, CRP and IL-8;IL-2, CRP and IL-12p70; IL-2, CRP and IL-1β; IL-2, CRP and GMCSF; IL-2,CRP and IFNγ; IL-2, CRP and IL-6; IL-2, CRP and TNFα; IL-2, CRP andASCA-A; IL-2, CRP and ASCA-G; IL-2, CRP and CBir1; IL-2, CRP and Fla2;IL-2, CRP and FlaX; IL-2, CRP and OmpC; IL-2, CRP and ADA; IL-2, ICAMand SAA; IL-2, ICAM and VCAM; IL-2, ICAM and IL-8; IL-2, ICAM andIL-12p70; IL-2, ICAM and IL-1β; IL-2, ICAM and GMCSF; IL-2, ICAM andIFNγ; IL-2, ICAM and IL-6; IL-2, ICAM and TNFα; IL-2, ICAM and ASCA-A;IL-2, ICAM and ASCA-G; IL-2, ICAM and CBir1; IL-2, ICAM and Fla2; IL-2,ICAM and FlaX; IL-2, ICAM and OmpC; IL-2, ICAM and ADA; IL-2, SAA andVCAM; IL-2, SAA and IL-8; IL-2, SAA and IL-12p70; IL-2, SAA and IL-1β;IL-2, SAA and GMCSF; IL-2, SAA and IFNγ; IL-2, SAA and IL-6; IL-2, SAAand TNFα; IL-2, SAA and ASCA-A; IL-2, SAA and ASCA-G; IL-2, SAA andCBir1; IL-2, SAA and Fla2; IL-2, SAA and FlaX; IL-2, SAA and OmpC; IL-2,SAA and ADA; IL-2, VCAM and IL-8; IL-2, VCAM and IL-12p70; IL-2, VCAMand IL-1β; IL-2, VCAM and GMCSF; IL-2, VCAM and IFNγ; IL-2, VCAM andIL-6; IL-2, VCAM and TNFα; IL-2, VCAM and ASCA-A; IL-2, VCAM and ASCA-G;IL-2, VCAM and CBir1; IL-2, VCAM and Fla2; IL-2, VCAM and FlaX; IL-2,VCAM and OmpC; IL-2, VCAM and ADA; IL-2, IL-8 and IL-12p70; IL-2, IL-8and IL-1β; IL-2, IL-8 and GMCSF; IL-2, IL-8 and IFNγ; IL-2, IL-8 andIL-6; IL-2, IL-8 and TNFα; IL-2, IL-8 and ASCA-A; IL-2, IL-8 and ASCA-G;IL-2, IL-8 and CBir1; IL-2, IL-8 and Fla2; IL-2, IL-8 and FlaX; IL-2,IL-8 and OmpC; IL-2, IL-8 and ADA; IL-2, IL-12p70 and IL-1β; IL-2,IL-12p70 and GMCSF; IL-2, IL-12p70 and IFNγ; IL-2, IL-12p70 and IL-6;IL-2, IL-12p70 and TNFα; IL-2, IL-12p70 and ASCA-A; IL-2, IL-12p70 andASCA-G; IL-2, IL-12p70 and CBir1; IL-2, IL-12p70 and Fla2; IL-2,IL-12p70 and FlaX; IL-2, IL-12p70 and OmpC; IL-2, IL-12p70 and ADA;IL-2, IL-1β and GMCSF; IL-2, IL-1β and IFNγ; IL-2, IL-1β and IL-6; IL-2,IL-1β and TNFα; IL-2, IL-1β and ASCA-A; IL-2, IL-1β and ASCA-G; IL-2,IL-1β and CBir1; IL-2, IL-1β and Fla2; IL-2, IL-1β and FlaX; IL-2, IL-1βand OmpC; IL-2, IL-1β and ADA; IL-2, GMCSF and IFNγ; IL-2, GMCSF andIL-6; IL-2, GMCSF and TNFα; IL-2, GMCSF and ASCA-A; IL-2, GMCSF andASCA-G; IL-2, GMCSF and CBir1; IL-2, GMCSF and Fla2; IL-2, GMCSF andFlaX; IL-2, GMCSF and OmpC; IL-2, GMCSF and ADA; IL-2, IFNγ and IL-6;IL-2, IFNγ and TNFα; IL-2, IFNγ and ASCA-A; IL-2, IFNγ and ASCA-G; IL-2,IFNγ and CBir1; IL-2, IFNγ and Fla2; IL-2, IFNγ and FlaX; IL-2, IFNγ andOmpC; IL-2, IFNγ and ADA; IL-2, IL-6 and TNFα; IL-2, IL-6 and ASCA-A;IL-2, IL-6 and ASCA-G; IL-2, IL-6 and CBir1; IL-2, IL-6 and Fla2; IL-2,IL-6 and FlaX; IL-2, IL-6 and OmpC; IL-2, IL-6 and ADA; IL-2, TNFα andASCA-A; IL-2, TNFα and ASCA-G; IL-2, TNFα and CBir1; IL-2, TNFα andFla2; IL-2, TNFα and FlaX; IL-2, TNFα and OmpC; IL-2, TNFα and ADA;IL-2, ASCA-A and ASCA-G; IL-2, ASCA-A and CBir1; IL-2, ASCA-A and Fla2;IL-2, ASCA-A and FlaX; IL-2, ASCA-A and OmpC; IL-2, ASCA-A and ADA;IL-2, ASCA-G and CBir1; IL-2, ASCA-G and Fla2; IL-2, ASCA-G and FlaX;IL-2, ASCA-G and OmpC; IL-2, ASCA-G and ADA; IL-2, CBir1 and Fla2; IL-2,CBir1 and FlaX; IL-2, CBir1 and OmpC; IL-2, CBir1 and ADA; IL-2, Fla2and FlaX; IL-2, Fla2 and OmpC; IL-2, Fla2 and ADA; IL-2, FlaX and OmpC;IL-2, FlaX and ADA; IL-2, OmpC and ADA; IL-8, TWEAK and CRP; IL-8, TWEAKand ICAM; IL-8, TWEAK and SAA; IL-8, TWEAK and VCAM; IL-8, TWEAK andIL-2; IL-8, TWEAK and IL-12p70; IL-8, TWEAK and IL-1β; IL-8, TWEAK andGMCSF; IL-8, TWEAK and IFNγ; IL-8, TWEAK and IL-6; IL-8, TWEAK and TNFα;IL-8, TWEAK and ASCA-A; IL-8, TWEAK and ASCA-G; IL-8, TWEAK and CBir1;IL-8, TWEAK and Fla2; IL-8, TWEAK and FlaX; IL-8, TWEAK and OmpC; IL-8,TWEAK and ADA; IL-8, CRP and ICAM; IL-8, CRP and SAA; IL-8, CRP andVCAM; IL-8, CRP and IL-2; IL-8, CRP and IL-12p70; IL-8, CRP and IL-1β;IL-8, CRP and GMCSF; IL-8, CRP and IFNγ; IL-8, CRP and IL-6; IL-8, CRPand TNFα; IL-8, CRP and ASCA-A; IL-8, CRP and ASCA-G; IL-8, CRP andCBir1; IL-8, CRP and Fla2; IL-8, CRP and FlaX; IL-8, CRP and OmpC; IL-8,CRP and ADA; IL-8, ICAM and SAA; IL-8, ICAM and VCAM; IL-8, ICAM andIL-2; IL-8, ICAM and IL-12p70; IL-8, ICAM and IL-1β; IL-8, ICAM andGMCSF; IL-8, ICAM and IFNγ; IL-8, ICAM and IL-6; IL-8, ICAM and TNFα;IL-8, ICAM and ASCA-A; IL-8, ICAM and ASCA-G; IL-8, ICAM and CBir1;IL-8, ICAM and Fla2; IL-8, ICAM and FlaX; IL-8, ICAM and OmpC; IL-8,ICAM and ADA; IL-8, SAA and VCAM; IL-8, SAA and IL-2; IL-8, SAA andIL-12p70; IL-8, SAA and IL-1β; IL-8, SAA and GMCSF; IL-8, SAA and IFNγ;IL-8, SAA and IL-6; IL-8, SAA and TNFα; IL-8, SAA and ASCA-A; IL-8, SAAand ASCA-G; IL-8, SAA and CBir1; IL-8, SAA and Fla2; IL-8, SAA and FlaX;IL-8, SAA and OmpC; IL-8, SAA and ADA; IL-8, VCAM and IL-2; IL-8, VCAMand IL-12p70; IL-8, VCAM and IL-1β; IL-8, VCAM and GMCSF; IL-8, VCAM andIFNγ; IL-8, VCAM and IL-6; IL-8, VCAM and TNFα; IL-8, VCAM and ASCA-A;IL-8, VCAM and ASCA-G; IL-8, VCAM and CBir1; IL-8, VCAM and Fla2; IL-8,VCAM and FlaX; IL-8, VCAM and OmpC; IL-8, VCAM and ADA; IL-8, IL-2 andIL-12p70; IL-8, IL-2 and IL-1β; IL-8, IL-2 and GMCSF; IL-8, IL-2 andIFNγ; IL-8, IL-2 and IL-6; IL-8, IL-2 and TNFα; IL-8, IL-2 and ASCA-A;IL-8, IL-2 and ASCA-G; IL-8, IL-2 and CBir1; IL-8, IL-2 and Fla2; IL-8,IL-2 and FlaX; IL-8, IL-2 and OmpC; IL-8, IL-2 and ADA; IL-8, IL-12p70and IL-1β; IL-8, IL-12p70 and GMCSF; IL-8, IL-12p70 and IFNγ; IL-8,IL-12p70 and IL-6; IL-8, IL-12p70 and TNFα; IL-8, IL-12p70 and ASCA-A;IL-8, IL-12p70 and ASCA-G; IL-8, IL-12p70 and CBir1; IL-8, IL-12p70 andFla2; IL-8, IL-12p70 and FlaX; IL-8, IL-12p70 and OmpC; IL-8, IL-12p70and ADA; IL-8, IL-1β and GMCSF; IL-8, IL-1β and IFNγ; IL-8, IL-1β andIL-6; IL-8, IL-1β and TNFα; IL-8, IL-1β and ASCA-A; IL-8, IL-1β andASCA-G; IL-8, IL-1β and CBir1; IL-8, IL-1β and Fla2; IL-8, IL-1β andFlaX; IL-8, IL-1β and OmpC; IL-8, IL-1β and ADA; IL-8, GMCSF and IFNγ;IL-8, GMCSF and IL-6; IL-8, GMCSF and TNFα; IL-8, GMCSF and ASCA-A;IL-8, GMCSF and ASCA-G; IL-8, GMCSF and CBir1; IL-8, GMCSF and Fla2;IL-8, GMCSF and FlaX; IL-8, GMCSF and OmpC; IL-8, GMCSF and ADA; IL-8,IFNγ and IL-6; IL-8, IFNγ and TNFα; IL-8, IFNγ and ASCA-A; IL-8, IFNγand ASCA-G; IL-8, IFNγ and CBir1; IL-8, IFNγ and Fla2; IL-8, IFNγ andFlaX; IL-8, IFNγ and OmpC; IL-8, IFNγ and ADA; IL-8, IL-6 and TNFα;IL-8, IL-6 and ASCA-A; IL-8, IL-6 and ASCA-G; IL-8, IL-6 and CBir1;IL-8, IL-6 and Fla2; IL-8, IL-6 and FlaX; IL-8, IL-6 and OmpC; IL-8,IL-6 and ADA; IL-8, TNFα and ASCA-A; IL-8, TNFα and ASCA-G; IL-8, TNFαand CBir1; IL-8, TNFα and Fla2; IL-8, TNFα and FlaX; IL-8, TNFα andOmpC; IL-8, TNFα and ADA; IL-8, ASCA-A and ASCA-G; IL-8, ASCA-A andCBir1; IL-8, ASCA-A and Fla2; IL-8, ASCA-A and FlaX; IL-8, ASCA-A andOmpC; IL-8, ASCA-A and ADA; IL-8, ASCA-G and CBir1; IL-8, ASCA-G andFla2; IL-8, ASCA-G and FlaX; IL-8, ASCA-G and OmpC; IL-8, ASCA-G andADA; IL-8, CBir1 and Fla2; IL-8, CBir1 and FlaX; IL-8, CBir1 and OmpC;IL-8, CBir1 and ADA; IL-8, Fla2 and FlaX; IL-8, Fla2 and OmpC; IL-8,Fla2 and ADA; IL-8, FlaX and OmpC; IL-8, FlaX and ADA; IL-8, OmpC andADA; IL-12p70, TWEAK and CRP; IL-12p70, TWEAK and ICAM; IL-12p70, TWEAKand SAA; IL-12p70, TWEAK and VCAM; IL-12p70, TWEAK and IL-2; IL-12p70,TWEAK and IL-8; IL-12p70, TWEAK and IL-1β; IL-12p70, TWEAK and GMCSF;IL-12p70, TWEAK and IFNγ; IL-12p70, TWEAK and IL-6; IL-12p70, TWEAK andTNFα; IL-12p70, TWEAK and ASCA-A; IL-12p70, TWEAK and ASCA-G; IL-12p70,TWEAK and CBir1; IL-12p70, TWEAK and Fla2; IL-12p70, TWEAK and FlaX;IL-12p70, TWEAK and OmpC; IL-12p70, TWEAK and ADA; IL-12p70, CRP andICAM; IL-12p70, CRP and SAA; IL-12p70, CRP and VCAM; IL-12p70, CRP andIL-2; IL-12p70, CRP and IL-8; IL-12p70, CRP and IL-1β; IL-12p70, CRP andGMCSF; IL-12p70, CRP and IFNγ; IL-12p70, CRP and IL-6; IL-12p70, CRP andTNFα; IL-12p70, CRP and ASCA-A; IL-12p70, CRP and ASCA-G; IL-12p70, CRPand CBir1; IL-12p70, CRP and Fla2; IL-12p70, CRP and FlaX; IL-12p70, CRPand OmpC; IL-12p70, CRP and ADA; IL-12p70, ICAM and SAA; IL-12p70, ICAMand VCAM; IL-12p70, ICAM and IL-2; IL-12p70, ICAM and IL-8; IL-12p70,ICAM and IL-1β; IL-12p70, ICAM and GMCSF; IL-12p70, ICAM and IFNγ;IL-12p70, ICAM and IL-6; IL-12p70, ICAM and TNFα; IL-12p70, ICAM andASCA-A; IL-12p70, ICAM and ASCA-G; IL-12p70, ICAM and CBir1; IL-12p70,ICAM and Fla2; IL-12p70, ICAM and FlaX; IL-12p70, ICAM and OmpC;IL-12p70, ICAM and ADA; IL-12p70, SAA and VCAM; IL-12p70, SAA and IL-2;IL-12p70, SAA and IL-8; IL-12p70, SAA and IL-1β; IL-12p70, SAA andGMCSF; IL-12p70, SAA and IFNγ; IL-12p70, SAA and IL-6; IL-12p70, SAA andTNFα; IL-12p70, SAA and ASCA-A; IL-12p70, SAA and ASCA-G; IL-12p70, SAAand CBir1; IL-12p70, SAA and Fla2; IL-12p70, SAA and FlaX; IL-12p70, SAAand OmpC; IL-12p70, SAA and ADA; IL-12p70, VCAM and IL-2; IL-12p70, VCAMand IL-8; IL-12p70, VCAM and IL-1β; IL-12p70, VCAM and GMCSF; IL-12p70,VCAM and IFNγ; IL-12p70, VCAM and IL-6; IL-12p70, VCAM and TNFα;IL-12p70, VCAM and ASCA-A; IL-12p70, VCAM and ASCA-G; IL-12p70, VCAM andCBir1; IL-12p70, VCAM and Fla2; IL-12p70, VCAM and FlaX; IL-12p70, VCAMand OmpC; IL-12p70, VCAM and ADA; IL-12p70, IL-2 and IL-8; IL-12p70,IL-2 and IL-1β; IL-12p70, IL-2 and GMCSF; IL-12p70, IL-2 and IFNγ;IL-12p70, IL-2 and IL-6; IL-12p70, IL-2 and TNFα; IL-12p70, IL-2 andASCA-A; IL-12p70, IL-2 and ASCA-G; IL-12p70, IL-2 and CBir1; IL-12p70,IL-2 and Fla2; IL-12p70, IL-2 and FlaX; IL-12p70, IL-2 and OmpC;IL-12p70, IL-2 and ADA; IL-12p70, IL-8 and IL-1β; IL-12p70, IL-8 andGMCSF; IL-12p70, IL-8 and IFNγ; IL-12p70, IL-8 and IL-6; IL-12p70, IL-8and TNFα; IL-12p70, IL-8 and ASCA-A; IL-12p70, IL-8 and ASCA-G;IL-12p70, IL-8 and CBir1; IL-12p70, IL-8 and Fla2; IL-12p70, IL-8 andFlaX; IL-12p70, IL-8 and OmpC; IL-12p70, IL-8 and ADA; IL-12p70, IL-1βand GMCSF; IL-12p70, IL-1β and IFNγ; IL-12p70, IL-1β and IL-6; IL-12p70,IL-1β and TNFα; IL-12p70, IL-1β and ASCA-A; IL-12p70, IL-1β and ASCA-G;IL-12p70, IL-1β and CBir1; IL-12p70, IL-1β and Fla2; IL-12p70, IL-1β andFlaX; IL-12p70, IL-1β and OmpC; IL-12p70, IL-1β and ADA; IL-12p70, GMCSFand IFNγ; IL-12p70, GMCSF and IL-6; IL-12p70, GMCSF and TNFα; IL-12p70,GMCSF and ASCA-A; IL-12p70, GMCSF and ASCA-G; IL-12p70, GMCSF and CBir1;IL-12p70, GMCSF and Fla2; IL-12p70, GMCSF and FlaX; IL-12p70, GMCSF andOmpC; IL-12p70, GMCSF and ADA; IL-12p70, IFNγ and IL-6; IL-12p70, IFNγand TNFα; IL-12p70, IFNγ and ASCA-A; IL-12p70, IFNγ and ASCA-G;IL-12p70, IFNγ and CBir1; IL-12p70, IFNγ and Fla2; IL-12p70, IFNγ andFlaX; IL-12p70, IFNγ and OmpC; IL-12p70, IFNγ and ADA; IL-12p70, IL-6and TNFα; IL-12p70, IL-6 and ASCA-A; IL-12p70, IL-6 and ASCA-G;IL-12p70, IL-6 and CBir1; IL-12p70, IL-6 and Fla2; IL-12p70, IL-6 andFlaX; IL-12p70, IL-6 and OmpC; IL-12p70, IL-6 and ADA; IL-12p70, TNFαand ASCA-A; IL-12p70, TNFα and ASCA-G; IL-12p70, TNFα and CBir1;IL-12p70, TNFα and Fla2; IL-12p70, TNFα and FlaX; IL-12p70, TNFα andOmpC; IL-12p70, TNFα and ADA; IL-12p70, ASCA-A and ASCA-G; IL-12p70,ASCA-A and CBir1; IL-12p70, ASCA-A and Fla2; IL-12p70, ASCA-A and FlaX;IL-12p70, ASCA-A and OmpC; IL-12p70, ASCA-A and ADA; IL-12p70, ASCA-Gand CBir1; IL-12p70, ASCA-G and Fla2; IL-12p70, ASCA-G and FlaX;IL-12p70, ASCA-G and OmpC; IL-12p70, ASCA-G and ADA; IL-12p70, CBir1 andFla2; IL-12p70, CBir1 and FlaX; IL-12p70, CBir1 and OmpC; IL-12p70,CBir1 and ADA; IL-12p70, Fla2 and FlaX; IL-12p70, Fla2 and OmpC;IL-12p70, Fla2 and ADA; IL-12p70, FlaX and OmpC; IL-12p70, FlaX and ADA;IL-12p70, OmpC and ADA; IL-1β, TWEAK and CRP; IL-1β, TWEAK and ICAM;IL-1β, TWEAK and SAA; IL-1β, TWEAK and VCAM; IL-1β, TWEAK and IL-2;IL-1β, TWEAK and IL-8; IL-1β, TWEAK and IL-12p70; IL-11β b, TWEAK andGMCSF; IL-1β, TWEAK and IFNγ; IL-1β, TWEAK and IL-6; IL-1β, TWEAK andTNFα; IL-1b, TWEAK and ASCA-A; IL-1β, TWEAK and ASCA-G; IL-1β, TWEAK andCBir1; IL-1β, TWEAK and Fla2; IL-1β, TWEAK and FlaX; IL-1β, TWEAK andOmpC; IL-1β, TWEAK and ADA; IL-1β, CRP and ICAM; IL-1β, CRP and SAA;IL-1β, CRP and VCAM; IL-1β, CRP and IL-2; IL-1β, CRP and IL-8; IL-1β,CRP and IL-12p70; IL-1b, CRP and GMCSF; IL-1b, CRP and IFNγ; IL-1β, CRPand IL-6; IL-1β, CRP and TNFα; IL-1β, CRP and ASCA-A; IL-1b, CRP andASCA-G; IL-1β, CRP and CBir1; IL-1β, CRP and Fla2; IL-1β, CRP and FlaX;IL-1β, CRP and OmpC; IL-1β, CRP and ADA; IL-1β, ICAM and SAA; IL-1β,ICAM and VCAM; IL-1β, ICAM and IL-2; IL-1β, ICAM and IL-8; IL-1β, ICAMand IL-12p70; IL-1β, ICAM and GMCSF; IL-1β, ICAM and IFNγ; IL-1β, ICAMand IL-6; IL-1β, ICAM and TNFα; IL-1β, ICAM and ASCA-A; IL-1β, ICAM andASCA-G; IL-1β, ICAM and CBir1; IL-1β, ICAM and Fla2; IL-1β, ICAM andFlaX; IL-1β, ICAM and OmpC; IL-1β, ICAM and ADA; IL-1β, SAA and VCAM;IL-1β, SAA and IL-2; IL-1β, SAA, and IL-8; IL-1β, SAA and IL-12p70;IL-1β, SAA and GMCSF; IL-1β, SAA and IFNγ; IL-1β, SAA and IL-6; IL-1β,SAA and TNFα; IL-1β, SAA and ASCA-A; IL-1β, SAA and ASCA-G; IL-1β, SAAand CBir1; IL-1β, SAA and Fla2; IL-1β, SAA and FlaX; IL-1β, SAA andOmpC; IL-1β, SAA and ADA; IL-1β, VCAM and IL-2; IL-1β, VCAM and IL-8;IL-1β, VCAM and IL-12p70; IL-1β, VCAM and GMCSF; IL-1β, VCAM and IFNγ;IL-1β, VCAM and IL-6; IL-1β, VCAM and TNFα; IL-1β, VCAM and ASCA-A;IL-1β, VCAM and ASCA-G; IL-1β, VCAM and CBir1; IL-1β, VCAM and Fla2;IL-1β, VCAM and FlaX; IL-1β, VCAM and OmpC; IL-1β, VCAM and ADA; IL-1β,IL-2 and IL-8; IL-1β, IL-2 and IL-12p70; IL-1β, IL-2 and GMCSF; IL-1β,IL-2 and IFNγ; IL-1β, IL-2 and IL-6; IL-1β, IL-2 and TNFα; IL-1β, IL-2and ASCA-A; IL-1β, IL-2 and ASCA-G; IL-1β, IL-2 and CBir1; IL-1β, IL-2and Fla2; IL-1β, IL-2 and FlaX; IL-1β, IL-2 and OmpC; IL-1β, IL-2 andADA; IL-1β, IL-8 and IL-12p70; IL-1β, IL-8 and GMCSF; IL-1β, IL-8 andIFNγ; IL-1β, IL-8 and IL-6; IL-1β, IL-8 and TNFα; IL-1β, IL-8 andASCA-A; IL-1β, IL-8 and ASCA-G; IL-1β, IL-8 and CBir1; IL-1β, IL-8 andFla2; IL-1β, IL-8 and FlaX; IL-1β, IL-8 and OmpC; IL-1β, IL-8 and ADA;IL-1β, IL-12p70 and GMCSF; IL-1β, IL-12p70 and IFNγ; IL-1β, IL-12p70 andIL-6; IL-1β, IL-12p70 and TNFα; IL-1β, IL-12p70 and ASCA-A; IL-1β,IL-12p70 and ASCA-G; IL-1β, IL-12p70 and CBir1; IL-1β, IL-12p70 andFla2; IL-1β, IL-12p70 and FlaX; IL-1β, IL-12p70 and OmpC; IL-1β,IL-12p70 and ADA; IL-1β, GMCSF and IFNγ; IL-1β, GMCSF and IL-6; IL-1β,GMCSF and TNFα; IL-1β, GMCSF and ASCA-A; IL-1β, GMCSF and ASCA-G; IL-1β,GMCSF and CBir1; IL-1β, GMCSF and Fla2; IL-1β, GMCSF and FlaX; IL-1β,GMCSF and OmpC; IL-1β, GMCSF and ADA; IL-1β, IFNγ and IL-6; IL-1β, IFNγand TNFα; IL-1β, IFNγ and ASCA-A; IL-1β, IFNγ and ASCA-G; IL-1β, IFNγand CBir1; IL-1β, IFNγ and Fla2; IL-1β, IFNγ and FlaX; IL-1β, IFNγ andOmpC; IL-1β, IFNγ and ADA; IL-1β, IL-6 and TNFα; IL-1β, IL-6 and ASCA-A;IL-1β, IL-6 and ASCA-G; IL-1β, IL-6 and CBir1; IL-1β, IL-6 and Fla2;IL-1β, IL-6 and FlaX; IL-1β, IL-6 and OmpC; IL-1β, IL-6 and ADA; IL-1β,TNFα and ASCA-A; IL-1β, TNFα and ASCA-G; IL-1β, TNFα and CBir1; IL-1β,TNFα and Fla2; IL-1β, TNFα and FlaX; IL-1β, TNFα and OmpC; IL-1β, TNFαand ADA; IL-1β, ASCA-A and ASCA-G; IL-1β, ASCA-A and CBir1; IL-1β,ASCA-A and Fla2; IL-1β, ASCA-A and FlaX; IL-1β, ASCA-A and OmpC; IL-1β,ASCA-A and ADA; IL-1β, ASCA-G and CBir1; IL-1β, ASCA-G and Fla2; IL-1β,ASCA-G and FlaX; IL-1β, ASCA-G and OmpC; IL-1β, ASCA-G and ADA; IL-1β,CBir1 and Fla2; IL-1β, CBir1 and FlaX; IL-1β, CBir1 and OmpC; IL-1β,CBir1 and ADA; IL-1β, Fla2 and FlaX; IL-1β, Fla2 and OmpC; IL-1β, Fla2and ADA; IL-1β, FlaX and OmpC; IL-1β, FlaX and ADA; IL-1β, OmpC and ADA;GMCSF, TWEAK and CRP; GMCSF, TWEAK and ICAM; GMCSF, TWEAK and SAA;GMCSF, TWEAK and VCAM; GMCSF, TWEAK and IL-2; GMCSF, TWEAK and IL-8;GMCSF, TWEAK and IL-12p70; GMCSF, TWEAK and IL-1β; GMCSF, TWEAK andIFNγ; GMCSF, TWEAK and IL-6; GMCSF, TWEAK and TNFα; GMCSF, TWEAK andASCA-A; GMCSF, TWEAK and ASCA-G; GMCSF, TWEAK and CBir1; GMCSF, TWEAKand Fla2; GMCSF, TWEAK and FlaX; GMCSF, TWEAK and OmpC; GMCSF, TWEAK andADA; GMCSF, CRP and ICAM; GMCSF, CRP and SAA; GMCSF, CRP and VCAM;GMCSF, CRP and IL-2; GMCSF, CRP and IL-8; GMCSF, CRP and IL-12p70;GMCSF, CRP and IL-1β; GMCSF, CRP and IFNγ; GMCSF, CRP and IL-6; GMCSF,CRP and TNFα; GMCSF, CRP and ASCA-A; GMCSF, CRP and ASCA-G; GMCSF, CRPand CBir1; GMCSF, CRP and Fla2; GMCSF, CRP and FlaX; GMCSF, CRP andOmpC; GMCSF, CRP and ADA; GMCSF, ICAM and SAA; GMCSF, ICAM and VCAM;GMCSF, ICAM and IL-2; GMCSF, ICAM and IL-8; GMCSF, ICAM and IL-12p70;GMCSF, ICAM and IL-1β; GMCSF, ICAM and IFNγ; GMCSF, ICAM and IL-6;GMCSF, ICAM and TNFα; GMCSF, ICAM and ASCA-A; GMCSF, ICAM and ASCA-G;GMCSF, ICAM and CBir1; GMCSF, ICAM and Fla2; GMCSF, ICAM and FlaX;GMCSF, ICAM and OmpC; GMCSF, ICAM and ADA; GMCSF, SAA and VCAM; GMCSF,SAA and IL-2; GMCSF, SAA and IL-8; GMCSF, SAA and IL-12p70; GMCSF, SAAand IL-1β; GMCSF, SAA and IFNγ; GMCSF, SAA and IL-6; GMCSF, SAA andTNFα; GMCSF, SAA and ASCA-A; GMCSF, SAA and ASCA-G; GMCSF, SAA andCBir1; GMCSF, SAA and Fla2; GMCSF, SAA and FlaX; GMCSF, SAA and OmpC;GMCSF, SAA and ADA; GMCSF, VCAM and IL-2; GMCSF, VCAM and IL-8; GMCSF,VCAM and IL-12p70; GMCSF, VCAM and IL-1β; GMCSF, VCAM and IFNγ; GMCSF,VCAM and IL-6; GMCSF, VCAM and TNFα; GMCSF, VCAM and ASCA-A; GMCSF, VCAMand ASCA-G; GMCSF, VCAM and CBir1; GMCSF, VCAM and Fla2; GMCSF, VCAM andFlaX; GMCSF, VCAM and OmpC; GMCSF, VCAM and ADA; GMCSF, IL-2 and IL-8;GMCSF, IL-2 and IL-12p70; GMCSF, IL-2 and IL-1β; GMCSF, IL-2 and IFNγ;GMCSF, IL-2 and IL-6; GMCSF, IL-2 and TNFα; GMCSF, IL-2 and ASCA-A;GMCSF, IL-2 and ASCA-G; GMCSF, IL-2 and CBir1; GMCSF, IL-2 and Fla2;GMCSF, IL-2 and FlaX; GMCSF, IL-2 and OmpC; GMCSF, IL-2 and ADA; GMCSF,IL-8 and IL-12p70; GMCSF, IL-8 and IL-1β; GMCSF, IL-8 and IFNγ; GMCSF,IL-8 and IL-6; GMCSF, IL-8 and TNFα; GMCSF, IL-8 and ASCA-A; GMCSF, IL-8and ASCA-G; GMCSF, IL-8 and CBir1; GMCSF, IL-8 and Fla2; GMCSF, IL-8 andFlaX; GMCSF, IL-8 and OmpC; GMCSF, IL-8 and ADA; GMCSF, IL-12p70 andIL-1β; GMCSF, IL-12p70 and IFNγ; GMCSF, IL-12p70 and IL-6; GMCSF,IL-12p70 and TNFα; GMCSF, IL-12p70 and ASCA-A; GMCSF, IL-12p70 andASCA-G; GMCSF, IL-12p70 and CBir1; GMCSF, IL-12p70 and Fla2; GMCSF,IL-12p70 and FlaX; GMCSF, IL-12p70 and OmpC; GMCSF, IL-12p70 and ADA;GMCSF, IL-1β and IFNγ; GMCSF, IL-1β and IL-6; GMCSF, IL-1β and TNFα;GMCSF, IL-1β and ASCA-A; GMCSF, IL-1β and ASCA-G; GMCSF, IL-1β andCBir1; GMCSF, IL-1β and Fla2; GMCSF, IL-1β and FlaX; GMCSF, IL-1β andOmpC; GMCSF, IL-1β and ADA; GMCSF, IFNγ and IL-6; GMCSF, IFNγ and TNFα;GMCSF, IFNγ and ASCA-A; GMCSF, IFNγ and ASCA-G; GMCSF, IFNγ and CBir1;GMCSF, IFNγ and Fla2; GMCSF, IFNγ and FlaX; GMCSF, IFNγ and OmpC; GMCSF,IFNγ and ADA; GMCSF, IL-6 and TNFα; GMCSF, IL-6 and ASCA-A; GMCSF, IL-6and ASCA-G; GMCSF, IL-6 and CBir1; GMCSF, IL-6 and Fla2; GMCSF, IL-6 andFlaX; GMCSF, IL-6 and OmpC; GMCSF, IL-6 and ADA; GMCSF, TNFα and ASCA-A;GMCSF, TNFα and ASCA-G; GMCSF, TNFα and CBir1; GMCSF, TNFα and Fla2;GMCSF, TNFα and FlaX; GMCSF, TNFα and OmpC; GMCSF, TNFα and ADA; GMCSF,ASCA-A and ASCA-G; GMCSF, ASCA-A and CBir1; GMCSF, ASCA-A and Fla2;GMCSF, ASCA-A and FlaX; GMCSF, ASCA-A and OmpC; GMCSF, ASCA-A and ADA;GMCSF, ASCA-G and CBir1; GMCSF, ASCA-G and Fla2; GMCSF, ASCA-G and FlaX;GMCSF, ASCA-G and OmpC; GMCSF, ASCA-G and ADA; GMCSF, CBir1 and Fla2;GMCSF, CBir1 and FlaX; GMCSF, CBir1 and OmpC; GMCSF, CBir1 and ADA;GMCSF, Fla2 and FlaX; GMCSF, Fla2 and OmpC; GMCSF, Fla2 and ADA; GMCSF,FlaX and OmpC; GMCSF, FlaX and ADA; GMCSF, OmpC and ADA; IFNγ, TWEAK andCRP; IFNγ, TWEAK and ICAM; IFNγ, TWEAK and SAA; IFNγ, TWEAK and VCAM;IFNγ, TWEAK and IL-2; IFNγ, TWEAK and IL-8; IFNγ, TWEAK and IL-12p70;IFNγ, TWEAK and IL-1β; IFNγ, TWEAK and GMCSF; IFNγ, TWEAK and IL-6;IFNγ, TWEAK and TNFα; IFNγ, TWEAK and ASCA-A; IFNγ, TWEAK and ASCA-G;IFN, TWEAK and CBir1; IFNγ, TWEAK and Fla2; IFNγ, TWEAK and FlaX; IFNγ,TWEAK and OmpC; IFNγ, TWEAK and ADA; IFNγ, CRP and ICAM; IFNγ, CRP andSAA; IFNγ, CRP and VCAM; IFNγ, CRP and IL-2; IFNγ, CRP and IL-8; IFNγ,CRP and IL-12p70; IFNγ, CRP and IL-1β; IFNγ, CRP and GMCSF; IFNγ, CRPand IL-6; IFNγ, CRP and TNFα; IFNγ, CRP and ASCA-A; IFNγ, CRP andASCA-G; IFNγ, CRP and CBir1; IFNγ, CRP and Fla2; IFNγ, CRP and FlaX;IFNγ, CRP and OmpC; IFNγ, CRP and ADA; IFNγ, ICAM and SAA; IFNγ, ICAMand VCAM; IFNγ, ICAM and IL-2; IFNγ, ICAM and IL-8; IFNγ, ICAM andIL-12p70; IFNγ, ICAM and IL-1β; IFNγ, ICAM and GMCSF; IFNγ, ICAM andIL-6; IFNγ, ICAM and TNFα; IFNγ, ICAM and ASCA-A; IFNγ, ICAM and ASCA-G;IFNγ, ICAM and CBir1; IFNγ, ICAM and Fla2; IFNγ, ICAM and FlaX; IFNγ,ICAM and OmpC; IFNγ, ICAM and ADA; IFNγ, SAA and VCAM; IFNγ, SAA andIL-2; IFNγ, SAA and IL-8; IFNγ, SAA and IL-12p70; IFNγ, SAA and IL-1β;IFNγ, SAA and GMCSF; IFNγ, SAA and IL-6; IFNγ, SAA and TNFα; IFNγ, SAAand ASCA-A; IFNγ, SAA and ASCA-G; IFNγ, SAA and CBir1; IFNγ, SAA andFla2; IFNγ, SAA and FlaX; IFN, SAA and OmpC; IFNγ, SAA and ADA; IFNγ,VCAM and IL-2; IFNγ, VCAM and IL-8; IFNγ, VCAM and IL-12p70; IFNγ, VCAMand IL-1β; IFNγ, VCAM and GMCSF; IFNγ, VCAM and IL-6; IFNγ, VCAM andTNFα; IFNγ, VCAM and ASCA-A; IFNγ, VCAM and ASCA-G; IFNγ, VCAM andCBir1; IFNγ, VCAM and Fla2; IFNγ, VCAM and FlaX; IFNγ, VCAM and OmpC;IFNγ, VCAM and ADA; IFNγ, IL-2 and IL-8; IFNγ, IL-2 and IL-12p70; IFNγ,IL-2 and IL-1β; IFNγ, IL-2 and GMCSF; IFNγ, IL-2 and IL-6; IFNγ, IL-2and TNFα; IFNγ, IL-2 and ASCA-A; IFNγ, IL-2 and ASCA-G; IFNγ, IL-2 andCBir1; IFNγ, IL-2 and Fla2; IFNγ, IL-2 and FlaX; IFNγ, IL-2 and OmpC;IFNγ, IL-2 and ADA; IFNγ, IL-8 and IL-12p70; IFNγ, IL-8 and IL-1β; IFNγ,IL-8 and GMCSF; IFNγ, IL-8 and IL-6; IFNγ, IL-8 and TNFα; IFNγ, IL-8 andASCA-A; IFNγ, IL-8 and ASCA-G; IFNγ, IL-8 and CBir1; IFNγ, IL-8 andFla2; IFNγ, IL-8 and FlaX; IFNγ, IL-8 and OmpC; IFNγ, IL-8 and ADA;IFNγ, IL-12p70 and IL-1β; IFNγ, IL-12p70 and GMCSF; IFNγ, IL-12p70 andIL-6; IFNγ, IL-12p70 and TNFα; IFNγ, IL-12p70 and ASCA-A; IFNγ, IL-12p70and ASCA-G; IFNγ, IL-12p70 and CBir1; IFNγ, IL-12p70 and Fla2; IFNγ,IL-12p70 and FlaX; IFNγ, IL-12p70 and OmpC; IFNγ, IL-12p70 and ADA;IFNγ, IL-1β and GMCSF; IFNγ, IL-1β and IL-6; IFNγ, IL-1β and TNFα; IFNγ,IL-1β and ASCA-A; IFNγ, IL-1β and ASCA-G; IFNγ, IL-1β and CBir1; IFNγ,IL-1β and Fla2; IFNγ, IL-1β and FlaX; IFNγ, IL-1β and OmpC; IFNγ, IL-1βand ADA; IFNγ, GMCSF and IL-6; IFNγ, GMCSF and TNFα; IFNγ, GMCSF andASCA-A; IFNγ, GMCSF and ASCA-G; IFNγ, GMCSF and CBir1; IFNγ, GMCSF andFla2; IFNγ, GMCSF and FlaX; IFNγ, GMCSF and OmpC; IFNγ, GMCSF and ADA;IFNγ, IL-6 and TNFα; IFNγ, IL-6 and ASCA-A; IFNγ, IL-6 and ASCA-G; IFNγ,IL-6 and CBir1; IFNγ, IL-6 and Fla2; IFNγ, IL-6 and FlaX; IFNγ, IL-6 andOmpC; IFNγ, IL-6 and ADA; IFNγ, TNFα and ASCA-A; IFNγ, TNFα and ASCA-G;IFNγ, TNFα and CBir1; IFNγ, TNFα and Fla2; IFNγ, TNFα and FlaX; IFNγ,TNFα and OmpC; IFNγ, TNFα and ADA; IFNγ, ASCA-A and ASCA-G; IFNγ, ASCA-Aand CBir1; IFNγ, ASCA-A and Fla2; IFNγ, ASCA-A and FlaX; IFNγ, ASCA-Aand OmpC; IFNγ, ASCA-A and ADA; IFNγ, ASCA-G and CBir1; IFNγ, ASCA-G andFla2; IFNγ, ASCA-G and FlaX; IFNγ, ASCA-G and OmpC; IFNγ, ASCA-G andADA; IFNγ, CBir1 and Fla2; IFNγ, CBir1 and FlaX; IFNγ, CBir1 and OmpC;IFNγ, CBir1 and ADA; IFNγ, Fla2 and FlaX; IFNγ, Fla2 and OmpC; IFNγ,Fla2 and ADA; IFNγ, FlaX and OmpC; IFNγ, FlaX and ADA; IFNγ, OmpC andADA; IL-6, TWEAK and CRP; IL-6, TWEAK and ICAM; IL-6, TWEAK and SAA;IL-6, TWEAK and VCAM; IL-6, TWEAK and IL-2; IL-6, TWEAK and IL-8; IL-6,TWEAK and IL-12p70; IL-6, TWEAK and IL-1β; IL-6, TWEAK and GMCSF; IL-6,TWEAK and IFNγ; TWEAK and TNFα; IL-6, TWEAK and ASCA-A; IL-6, TWEAK andASCA-G; IL-6, TWEAK and CBir1; IL-6, TWEAK and Fla2; IL-6, TWEAK andFlaX; IL-6, TWEAK and OmpC; IL-6, TWEAK and ADA; IL-6, CRP and ICAM;IL-6, CRP and SAA; IL-6, CRP and VCAM; IL-6, CRP and IL-2; IL-6, CRP andIL-8; IL-6, CRP and IL-12p70; IL-6, CRP and IL-1β; IL-6, CRP and GMCSF;IL-6, CRP and IFNγ; IL-6, CRP and TNFα; IL-6, CRP and ASCA-A; IL-6, CRPand ASCA-G; IL-6, CRP and CBir1; IL-6, CRP and Fla2; IL-6, CRP and FlaX;IL-6, CRP and OmpC; IL-6, CRP and ADA; IL-6, ICAM and SAA; IL-6, ICAMand VCAM; IL-6, ICAM and IL-2; IL-6, ICAM and IL-8; IL-6, ICAM andIL-12p70; IL-6, ICAM and IL-1β; IL-6, ICAM and GMCSF; IL-6, ICAM andIFNγ; IL-6, ICAM and TNFα; IL-6, ICAM and ASCA-A; IL-6, ICAM and ASCA-G;IL-6, ICAM and CBir1; IL-6, ICAM and Fla2; IL-6, ICAM and FlaX; IL-6,ICAM and OmpC; IL-6, ICAM and ADA; IL-6, SAA and VCAM; IL-6, SAA andIL-2; IL-6, IL-8; IL-6, SAA and IL-12p70; IL-6, SAA and IL-1β; IL-6, SAAand GMCSF; IL-6, SAA and IFNγ; IL-6, SAA and TNFα; IL-6, SAA and ASCA-A;IL-6, SAA and ASCA-G; IL-6, SAA and CBir1; IL-6, SAA and Fla2; IL-6, SAAand FlaX; IL-6, SAA and OmpC; IL-6, SAA and ADA; IL-6, VCAM and IL-2;IL-6, VCAM and IL-8; IL-6, VCAM and IL-12p70; IL-6, VCAM and IL-1β;IL-6, VCAM and GMCSF; IL-6, VCAM and IFNγ; IL-6, VCAM and TNFα; IL-6,VCAM and ASCA-A; IL-6, VCAM and ASCA-G; IL-6, VCAM and CBir1; IL-6, VCAMand Fla2; IL-6, VCAM and FlaX; IL-6, VCAM and OmpC; IL-6, VCAM and ADA;IL-6, IL-2 and IL-8; IL-6, IL-2 and IL-12p70; IL-6, IL-2 and IL-1β;IL-6, IL-2 and GMCSF; IL-6, IL-2 and IFNγ; IL-6, IL-2 and TNFα; IL-6,IL-2 and ASCA-A; IL-6, IL-2 and ASCA-G; IL-6, IL-2 and CBir1; IL-6, IL-2and Fla2; IL-6, IL-2 and FlaX; IL-6, IL-2 and OmpC; IL-6, IL-2 and ADA;IL-6, IL-8 and IL-12p70; IL-6, IL-8 and IL-1β; IL-6, IL-8 and GMCSF;IL-6, IL-8 and IFNγ; IL-6, IL-8 and TNFα; IL-6, IL-8 and ASCA-A; IL-6,IL-8 and ASCA-G; IL-6, IL-8 and CBir1; IL-6, IL-8 and Fla2; IL-6, IL-8and FlaX; IL-6, IL-8 and OmpC; IL-6, IL-8 and ADA; IL-6, IL-12p70 andIL-1β; IL-6, IL-12p70 and GMCSF; IL-6, IL-12p70 and IFNγ; IL-6, IL-12p70and TNFα; IL-6, IL-12p70 and ASCA-A; IL-6, IL-12p70 and ASCA-G; IL-6,IL-12p70 and CBir1; IL-6, IL-12p70 and Fla2; IL-6, IL-12p70 and FlaX;IL-6, IL-12p70 and OmpC; IL-6, IL-12p70 and ADA; IL-6, IL-1β and GMCSF;IL-6, IL-1β and IFNγ; IL-6, IL-1β and TNFα; IL-6, IL-1β and ASCA-A;IL-6, IL-1β and ASCA-G; IL-6, IL-1β and CBir1; IL-6, IL-1β and Fla2;IL-6, IL-1β and FlaX; IL-6, IL-1β and OmpC; IL-6, IL-1β and ADA; IL-6,GMCSF and IFNγ; IL-6, GMCSF and TNFα; IL-6, GMCSF and ASCA-A; IL-6,GMCSF and ASCA-G; IL-6, GMCSF and CBir1; IL-6, GMCSF and Fla2; IL-6,GMCSF and FlaX; IL-6, GMCSF and OmpC; IL-6, GMCSF and ADA; IL-6, IFNγand TNFα; IL-6, IFNγ and ASCA-A; IL-6, IFNγ and ASCA-G; IL-6, IFNγ andCBir1; IL-6, IFNγ and Fla2; IL-6, IFNγ and FlaX; IL-6, IFNγ and OmpC;IL-6, IFNγ and ADA; IL-6, TNFα and ASCA-A; IL-6, TNFα and ASCA-G; IL-6,TNFα and CBir1; IL-6, TNFα and Fla2; IL-6, TNFα and FlaX; IL-6, TNFα andOmpC; IL-6, TNFα and ADA; IL-6, ASCA-A and ASCA-G; IL-6, ASCA-A andCBir1; IL-6, ASCA-A and Fla2; IL-6, ASCA-A and FlaX; IL-6, ASCA-A andOmpC; IL-6, ASCA-A and ADA; IL-6, ASCA-G and CBir1; IL-6, ASCA-G andFla2; IL-6, ASCA-G and FlaX; IL-6, ASCA-G and OmpC; IL-6, ASCA-G andADA; IL-6, CBir1 and Fla2; IL-6, CBir1 and FlaX; IL-6, CBir1 and OmpC;IL-6, CBir1 and ADA; IL-6, Fla2 and FlaX; IL-6, Fla2 and OmpC; IL-6,Fla2 and ADA; IL-6, FlaX and OmpC; IL-6, FlaX and ADA; IL-6, OmpC andADA; TNFα, TWEAK and CRP; TNFα, TWEAK and ICAM; TNFα, TWEAK and SAA;TNFα, TWEAK and VCAM; TNFα, TWEAK and IL-2; TNFα, TWEAK and IL-8; TNFα,TWEAK and IL-12p70; TNFα, TWEAK and IL-1β; TNFα, TWEAK and GMCSF; TNFα,TWEAK and IFNγ; TNFα, TWEAK and IL-6; TNFα, TWEAK and ASCA-A; TNFα,TWEAK and ASCA-G; TNFα, TWEAK and CBir1; TNFα, TWEAK and Fla2; TNFα,TWEAK and FlaX; TNFα, TWEAK and OmpC; TNFα, TWEAK and ADA; TNFα, CRP andICAM; TNFα, CRP and SAA; TNFα, CRP and VCAM; TNFα, CRP and IL-2; TNFα,CRP and IL-8; TNFα, CRP and IL-12p70; TNFα, CRP and IL-1β; TNFα, CRP andGMCSF; TNFα, CRP and IFNγ; TNFα, CRP and IL-6; TNFα, CRP and TNFα; TNFα,CRP and ASCA-A; TNFα, CRP and ASCA-G; TNFα, CRP and CBir1; TNFα, CRP andFla2; TNFα, CRP and FlaX; TNFα, CRP and OmpC; TNFα, CRP and ADA; TNFα,ICAM and SAA; TNFα, ICAM and VCAM; TNFα, ICAM and IL-2; TNFα, ICAM andIL-8; TNFα, ICAM and IL-12p70; TNFα, ICAM and IL-1β; TNFα, ICAM andGMCSF; TNFα, ICAM and IFNγ; TNFα, ICAM and IL-6; TNFα, ICAM and ASCA-A;TNFα, ICAM and ASCA-G; TNFα, ICAM and CBir1; TNFα, ICAM and Fla2; TNFα,ICAM and FlaX; TNFα, ICAM and OmpC; TNFα, ICAM and ADA; TNFα, SAA andVCAM; TNFα, SAA and IL-2; TNFα, SAA and IL-8; TNFα, SAA and IL-12p70;TNFα, SAA and IL-1β; TNFα, SAA and GMCSF; TNFα, SAA and IFNγ; TNFα, SAAand IL-6; TNFα, SAA and ASCA-A; TNFα, SAA and ASCA-G; TNFα, SAA andCBir1; TNFα, SAA and Fla2; TNFα, SAA and FlaX; TNFα, SAA and OmpC; TNFα,SAA and ADA; TNFα, VCAM and IL-2; TNFα, VCAM and IL-8; TNFα, VCAM andIL-12p70; TNFα, VCAM and IL-1β; TNFα, VCAM and GMCSF; TNFα, VCAM andIFNγ; TNFα, VCAM and IL-6; TNFα, VCAM and ASCA-A; TNFα, VCAM and ASCA-G;TNFα, VCAM and CBir1; TNFα, VCAM and Fla2; TNFα, VCAM and FlaX; TNFα,VCAM and OmpC; TNFα, VCAM and ADA; TNFα, IL-2 and IL-8; TNFα, IL-2 andIL-12p70; TNFα, IL-2 and IL-1β; TNFα, IL-2 and GMCSF; TNFα, IL-2 andIFNγ; TNFα, IL-2 and IL-6; TNFα, IL-2 and ASCA-A; TNFα, IL-2 and ASCA-G;TNFα, IL-2 and CBir1; TNFα, IL-2 and Fla2; TNFα, IL-2 and FlaX; TNFα,IL-2 and OmpC; TNFα, IL-2 and ADA; TNFα, IL-8 and IL-12p70; TNFα, IL-8and IL-1β; TNFα, IL-8 and GMCSF; TNFα, IL-8 and IFNγ; TNFα, IL-8 andIL-6; TNFα, IL-8 and ASCA-A; TNFα, IL-8 and ASCA-G; TNFα, IL-8 andCBir1; TNFα, IL-8 and Fla2; TNFα, IL-8 and FlaX; TNFα, IL-8 and OmpC;TNFα, IL-8 and ADA; TNFα, IL-12p70 and IL-1β; TNFα, IL-12p70 and GMCSF;TNFα, IL-12p70 and IFNγ; TNFα, IL-12p70 and IL-6; TNFα, IL-12p70 andASCA-A; TNFα, IL-12p70 and ASCA-G; TNFα, IL-12p70 and CBir1; TNFα,IL-12p70 and Fla2; TNFα, IL-12p70 and FlaX; TNFα, IL-12p70 and OmpC;TNFα, IL-12p70 and ADA; TNFα, IL-1β and GMCSF; TNFα, IL-1β and IFNγ;TNFα, IL-1β and IL-6; TNFα, IL-1β and ASCA-A; TNFα, IL-1β and ASCA-G;TNFα, IL-1β and CBir1; TNFα, IL-1β and Fla2; TNFα, IL-1β and FlaX; TNFα,IL-1β and OmpC; TNFα, IL-1β and ADA; TNFα, GMCSF and IFNγ; TNFα, GMCSFand IL-6; TNFα, GMCSF and TNFα; TNFα, GMCSF and ASCA-A; TNFα, GMCSF andASCA-G; TNFα, GMCSF and CBir1; TNFα, GMCSF and Fla2; TNFα, GMCSF andFlaX; TNFα, GMCSF and OmpC; TNFα, GMCSF and ADA; TNFα, IFNγ and IL-6;TNFα, IFNγ and ASCA-A; TNFα, IFNγ and ASCA-G; TNFα, IFNγ and CBir1;TNFα, IFNγ and Fla2; TNFα, IFNγ and FlaX; TNFα, IFNγ and OmpC; TNFα,IFNγ and ADA; TNFα, IL-6 and ASCA-A; TNFα, IL-6 and ASCA-G; TNFα, IL-6and CBir1; TNFα, IL-6 and Fla2; TNFα, IL-6 and FlaX; TNFα, IL-6 andOmpC; TNFα, IL-6 and ADA; TNFα, ASCA-A and ASCA-G; TNFα, ASCA-A andCBir1; TNFα, ASCA-A and Fla2; TNFα, ASCA-A and FlaX; TNFα, ASCA-A andOmpC; TNFα, ASCA-A and ADA; TNFα, ASCA-G and CBir1; TNFα, ASCA-G andFla2; TNFα, ASCA-G and FlaX; TNFα, ASCA-G and OmpC; TNFα, ASCA-G andADA; TNFα, CBir1 and Fla2; TNFα, CBir1 and FlaX; TNFα, CBir1 and OmpC;TNFα, CBir1 and ADA; TNFα, Fla2 and FlaX; TNFα, Fla2 and OmpC; TNFα,Fla2 and ADA; TNFα, FlaX and OmpC; TNFα, FlaX and ADA; TNFα, OmpC andADA; ASCA-A, TWEAK and CRP; ASCA-A, TWEAK and ICAM; ASCA-A, TWEAK andSAA; ASCA-A, TWEAK and VCAM; ASCA-A, TWEAK and IL-2; ASCA-A, TWEAK andIL-8; ASCA-A, TWEAK and IL-12p70; ASCA-A, TWEAK and IL-1β; ASCA-A, TWEAKand GMCSF; ASCA-A, TWEAK and IFNγ; ASCA-A, TWEAK and IL-6; ASCA-A, TWEAKand TNFα; ASCA-A, TWEAK and ASCA-G; ASCA-A, TWEAK and CBir1; ASCA-A,TWEAK and Fla2; ASCA-A, TWEAK and FlaX; ASCA-A, TWEAK and OmpC; ASCA-A,TWEAK and ADA; ASCA-A, CRP and ICAM; ASCA-A, CRP and SAA; ASCA-A, CRPand VCAM; ASCA-A, CRP and IL-2; ASCA-A, CRP and IL-8; ASCA-A, CRP andIL-12p70; ASCA-A, CRP and IL-1β; ASCA-A, CRP and GMCSF; ASCA-A, CRP andIFNγ; ASCA-A, CRP and IL-6; ASCA-A, CRP and TNFα; ASCA-A, CRP andASCA-G; ASCA-A, CRP and CBir1; ASCA-A, CRP and Fla2; ASCA-A, CRP andFlaX; ASCA-A, CRP and OmpC; ASCA-A, CRP and ADA; ASCA-A, ICAM and SAA;ASCA-A, ICAM and VCAM; ASCA-A, ICAM and IL-2; ASCA-A, ICAM and IL-8;ASCA-A, ICAM and IL-12p70; ASCA-A, ICAM and IL-1β; ASCA-A, ICAM andGMCSF; ASCA-A, ICAM and IFNγ; ASCA-A, ICAM and IL-6; ASCA-A, ICAM andTNFα; ASCA-A, ICAM and ASCA-G; ASCA-A, ICAM and CBir1; ASCA-A, ICAM andFla2; ASCA-A, ICAM and FlaX; ASCA-A, ICAM and OmpC; ASCA-A, ICAM andADA; ASCA-A, SAA and VCAM; ASCA-A, SAA and IL-2; ASCA-A, SAA and IL-8;ASCA-A, SAA and IL-12p70; ASCA-A, SAA and IL-1β; ASCA-A, SAA and GMCSF;ASCA-A, SAA and IFNγ; ASCA-A, SAA and IL-6; ASCA-A, SAA and TNFα;ASCA-A, SAA and ASCA-G; ASCA-A, SAA and CBir1; ASCA-A, SAA and Fla2;ASCA-A, SAA and FlaX; ASCA-A, SAA and OmpC; ASCA-A, SAA and ADA; ASCA-A,VCAM and IL-2; ASCA-A, VCAM and IL-8; ASCA-A, VCAM and IL-12p70; ASCA-A,VCAM and IL-1β; ASCA-A, VCAM and GMCSF; ASCA-A, VCAM and IFNγ; ASCA-A,VCAM and IL-6; ASCA-A, VCAM and TNFα; ASCA-A, VCAM and ASCA-A; ASCA-A,VCAM and CBir1; ASCA-A, VCAM and Fla2; ASCA-A, VCAM and FlaX; ASCA-A,VCAM and OmpC; ASCA-A, VCAM and ADA; ASCA-A, IL-2 and IL-8; ASCA-A, IL-2and IL-12p70; ASCA-A, IL-2 and IL-1β; ASCA-A, IL-2 and GMCSF; ASCA-A,IL-2 and IFNγ; ASCA-A, IL-2 and IL-6; ASCA-A, IL-2 and TNFα; ASCA-A,IL-2 and ASCA-G; ASCA-A, IL-2 and CBir1; ASCA-A, IL-2 and Fla2; ASCA-A,IL-2 and FlaX; ASCA-A, IL-2 and OmpC; ASCA-A, IL-2 and ADA; ASCA-A, IL-8and IL-12p70; ASCA-A, IL-8 and IL-1β; ASCA-A, IL-8 and GMCSF; ASCA-A,IL-8 and IFNγ; ASCA-A, IL-8 and IL-6; ASCA-A, IL-8 and TNFα; ASCA-A,IL-8 and ASCA-G; ASCA-A, IL-8 and CBir1; ASCA-A, IL-8 and Fla2; ASCA-A,IL-8 and FlaX; ASCA-A, IL-8 and OmpC; ASCA-A, IL-8 and ADA; ASCA-A,IL-12p70 and IL-1β; ASCA-A, IL-12p70 and GMCSF; ASCA-A, IL-12p70 andIFNγ; ASCA-A, IL-12p70 and IL-6; ASCA-A, IL-12p70 and TNFα; ASCA-A,IL-12p70 and ASCA-G; ASCA-A, IL-12p70 and CBir1; ASCA-A, IL-12p70 andFla2; ASCA-A, IL-12p70 and FlaX; ASCA-A, IL-12p70 and OmpC; ASCA-A,IL-12p70 and ADA; ASCA-A, IL-1β and GMCSF; ASCA-A, IL-1β and IFNγ;ASCA-A, IL-1β and IL-6; ASCA-A, IL-1β and TNFα; ASCA-A, IL-1β andASCA-G; ASCA-A, IL-1β and CBir1; ASCA-A, IL-1β and Fla2; ASCA-A, IL-1βand FlaX; ASCA-A, IL-1β and OmpC; ASCA-A, IL-1β and ADA; ASCA-A, GMCSFand IFNγ; ASCA-A, GMCSF and IL-6; ASCA-A, GMCSF and TNFα; ASCA-A, GMCSFand ASCA-G; ASCA-A, GMCSF and CBir1; ASCA-A, GMCSF and Fla2; ASCA-A,GMCSF and FlaX; ASCA-A, GMCSF and OmpC; ASCA-A, GMCSF and ADA; ASCA-A,IFNγ and IL-6; ASCA-A, IFNγ and TNFα; ASCA-A, IFNγ and ASCA-G; ASCA-A,IFNγ and CBir1; ASCA-A, IFNγ and Fla2; ASCA-A, IFNγ and FlaX; ASCA-A,IFNγ and OmpC; ASCA-A, IFNγ and ADA; ASCA-A, IL-6 and TNFα; ASCA-A, IL-6and ASCA-G; ASCA-A, IL-6 and CBir1; ASCA-A, IL-6 and Fla2; ASCA-A, IL-6and FlaX; ASCA-A, IL-6 and OmpC; ASCA-A, IL-6 and ADA; ASCA-A, ASCA-Gand CBir1; ASCA-A, ASCA-G and Fla2; ASCA-A, ASCA-G and FlaX; ASCA-A,ASCA-G and OmpC; ASCA-A, ASCA-G and ADA; ASCA-A, CBir1 and Fla2; ASCA-A,CBir1 and FlaX; ASCA-A, CBir1 and OmpC; ASCA-A, CBir1 and ADA; ASCA-A,Fla2 and FlaX; ASCA-A, Fla2 and OmpC; ASCA-A, Fla2 and ADA; ASCA-A, FlaXand OmpC; ASCA-A, FlaX and ADA; ASCA-A, OmpC and ADA; ASCA-G, TWEAK andCRP; ASCA-G, TWEAK and ICAM; ASCA-G, TWEAK and SAA; ASCA-G, TWEAK andVCAM; ASCA-G, TWEAK and IL-2; ASCA-G, TWEAK and IL-8; ASCA-G, TWEAK andIL-12p70; ASCA-G, TWEAK and IL-1β; ASCA-G, TWEAK and GMCSF; ASCA-G,TWEAK and IFNγ; ASCA-G, TWEAK and IL-6; ASCA-G, TWEAK and TNFα; ASCA-G,TWEAK and ASCA-A; ASCA-G, TWEAK and CBir1; ASCA-G, TWEAK and Fla2;ASCA-G, TWEAK and FlaX; ASCA-G, TWEAK and OmpC; ASCA-G, TWEAK and ADA;ASCA-G, CRP and ICAM; ASCA-G, CRP and SAA; ASCA-G, CRP and VCAM; ASCA-G,CRP and IL-2; ASCA-G, CRP and IL-8; ASCA-G, CRP and IL-12p70; ASCA-G,CRP and IL-1β; ASCA-G, CRP and GMCSF; ASCA-G, CRP and IFNγ; ASCA-G, CRPand IL-6; ASCA-G, CRP and TNFα; ASCA-G, CRP and ASCA-A; ASCA-G, CRP andCBir1; ASCA-G, CRP and Fla2; ASCA-G, CRP and FlaX; ASCA-G, CRP and OmpC;ASCA-G, CRP and ADA; ASCA-G, ICAM and SAA; ASCA-G, ICAM and VCAM;ASCA-G, ICAM and IL-2; ASCA-G, ICAM and IL-8; ASCA-G, ICAM and IL-12p70;ASCA-G, ICAM and IL-1β; ASCA-G, ICAM and GMCSF; ASCA-G, ICAM and IFNγ;ASCA-G, ICAM and IL-6; ASCA-G, ICAM and TNFα; ASCA-G, ICAM and ASCA-A;ASCA-G, ICAM and CBir1; ASCA-G, ICAM and Fla2; ASCA-G, ICAM and FlaX;ASCA-G, ICAM and OmpC; ASCA-G, ICAM and ADA; ASCA-G, SAA and VCAM;ASCA-G, SAA and IL-2; ASCA-G, SAA and IL-8; ASCA-G, SAA and IL-12p70;ASCA-G, SAA and IL-1β; ASCA-G, SAA and GMCSF; ASCA-G, SAA and IFNγ;ASCA-G, SAA and IL-6; ASCA-G, SAA and TNFα; ASCA-G, SAA and ASCA-A;ASCA-G, SAA and CBir1; ASCA-G, SAA and Fla2; ASCA-G, SAA and FlaX;ASCA-G, SAA and OmpC; ASCA-G, SAA and ADA; ASCA-G, VCAM and IL-2;ASCA-G, VCAM and IL-8; ASCA-G, VCAM and IL-12p70; ASCA-G, VCAM andIL-1β; ASCA-G, VCAM and GMCSF; ASCA-G, VCAM and IFNγ; ASCA-G, VCAM andIL-6; ASCA-G, VCAM and TNFα; ASCA-G, VCAM and ASCA-A; ASCA-G, VCAM andCBir1; ASCA-G, VCAM and Fla2; ASCA-G, VCAM and FlaX; ASCA-G, VCAM andOmpC; ASCA-G, VCAM and ADA; ASCA-G, IL-2 and IL-8; ASCA-G, IL-2 andIL-12p70; ASCA-G, IL-2 and IL-1β; ASCA-G, IL-2 and GMCSF; ASCA-G, IL-2and IFNγ; ASCA-G, IL-2 and IL-6; ASCA-G, IL-2 and TNFα; ASCA-G, IL-2 andASCA-A; ASCA-G, IL-2 and CBir1; ASCA-G, IL-2 and Fla2; ASCA-G, IL-2 andFlaX; ASCA-G, IL-2 and OmpC; ASCA-G, IL-2 and ADA; ASCA-G, IL-8 andIL-12p70; ASCA-G, IL-8 and IL-1β; ASCA-G, IL-8 and GMCSF; ASCA-G, IL-8and IFNγ; ASCA-G, IL-8 and IL-6; ASCA-G, IL-8 and TNFα; ASCA-G, IL-8 andASCA-A; ASCA-G, IL-8 and CBir1; ASCA-G, IL-8 and Fla2; ASCA-G, IL-8 andFlaX; ASCA-G, IL-8 and OmpC; ASCA-G, IL-8 and ADA; ASCA-G, IL-12p70 andIL-1β; ASCA-G, IL-12p70 and GMCSF; ASCA-G, IL-12p70 and IFNγ; ASCA-G,IL-12p70 and IL-6; ASCA-G, IL-12p70 and TNFα; ASCA-G, IL-12p70 andASCA-A; ASCA-G, IL-12p70 and CBir1; ASCA-G, IL-12p70 and Fla2; ASCA-G,IL-12p70 and FlaX; ASCA-G, IL-12p70 and OmpC; ASCA-G, IL-12p70 and ADA;ASCA-G, IL-1β and GMCSF; ASCA-G, IL-1β and IFNγ; ASCA-G, IL-1β and IL-6;ASCA-G, IL-1β and TNFα; ASCA-G, IL-1β and ASCA-A; ASCA-G, IL-1β andASCA-G; ASCA-G, IL-1β and CBir1; ASCA-G, IL-1β and Fla2; ASCA-G, IL-1βand FlaX; ASCA-G, IL-1β and OmpC; ASCA-G, IL-1β and ADA; ASCA-G, GMCSFand IFNγ; ASCA-G, GMCSF and IL-6; ASCA-G, GMCSF and TNFα; ASCA-G, GMCSFand ASCA-A; ASCA-G, GMCSF and ASCA-G; ASCA-G, GMCSF and CBir1; ASCA-G,GMCSF and Fla2; ASCA-G, GMCSF and FlaX; ASCA-G, GMCSF and OmpC; ASCA-G,GMCSF and ADA; ASCA-G, IFNγ and IL-6; ASCA-G, IFNγ and TNFα; ASCA-G,IFNγ and ASCA-A; ASCA-G, IFNγ and CBir1; ASCA-G, IFNγ and Fla2; ASCA-G,IFNγ and FlaX; ASCA-G, IFNγ and OmpC; ASCA-G, IFNγ and ADA; ASCA-G, IL-6and TNFα; ASCA-G, IL-6 and ASCA-A; ASCA-G, IL-6 and CBir1; ASCA-G, IL-6and Fla2; ASCA-G, IL-6 and FlaX; ASCA-G, IL-6 and OmpC; ASCA-G, IL-6 andADA; ASCA-G, TNFα and ASCA-A; ASCA-G, TNFα and CBir1; ASCA-G, TNFα andFla2; ASCA-G, TNFα and FlaX; ASCA-G, TNFα and OmpC; ASCA-G, TNFα andADA; ASCA-G, ASCA-A and CBir1; ASCA-G, ASCA-A and Fla2; ASCA-G, ASCA-Aand FlaX; ASCA-G, ASCA-A and OmpC; ASCA-G, ASCA-A and ADA; ASCA-G, CBir1and Fla2; ASCA-G, CBir1 and FlaX; ASCA-G, CBir1 and OmpC; ASCA-G, CBir1and ADA; ASCA-G, Fla2 and FlaX; ASCA-G, Fla2 and OmpC; ASCA-G, Fla2 andADA; ASCA-G, FlaX and OmpC; ASCA-G, FlaX and ADA; ASCA-G, OmpC and ADA;CBir1, TWEAK and CRP; CBir1, TWEAK and ICAM; CBir1, TWEAK and SAA;CBir1, TWEAK and VCAM; CBir1, TWEAK and IL-2; CBir1, TWEAK and IL-8;CBir1, TWEAK and IL-12p70; CBir1, TWEAK and IL-1β; CBir1, TWEAK andGMCSF; CBir1, TWEAK and IFNγ; CBir1, TWEAK and IL-6; CBir1, TWEAK andTNFα; CBir1, TWEAK and ASCA-A; CBir1, TWEAK and ASCA-G; CBir1, TWEAK andFla2; CBir1, TWEAK and FlaX; CBir1, TWEAK and OmpC; CBir1, TWEAK andADA; CBir1, CRP and ICAM; CBir1, CRP and SAA; CBir1, CRP and VCAM;CBir1, CRP and IL-2; CBir1, CRP and IL-8; CBir1, CRP and IL-12p70;CBir1, CRP and IL-1β; CBir1, CRP and GMCSF; CBir1, CRP and IFNγ; CBir1,CRP and IL-6; CBir1, CRP and TNFα; CBir1, CRP and ASCA-A; CBir1, CRP andASCA-G; CBir1, CRP and Fla2; CBir1, CRP and FlaX; CBir1, CRP and OmpC;CBir1, CRP and ADA; CBir1, ICAM and SAA; CBir1, ICAM and VCAM; CBir1,ICAM and IL-2; CBir1, ICAM and IL-8; CBir1, ICAM and IL-12p70; CBir1,ICAM and IL-1β; CBir1, ICAM and GMCSF; CBir1, ICAM and IFNγ; CBir1, ICAMand IL-6; CBir1, ICAM and TNFα; CBir1, ICAM and ASCA-A; CBir1, ICAM andASCA-G; CBir1, ICAM and Fla2; CBir1, ICAM and FlaX; CBir1, ICAM andOmpC; CBir1, ICAM and ADA; CBir1, SAA and VCAM; CBir1, SAA and IL-2;CBir1, IL-8; CBir1, SAA and IL-12p70; CBir1, SAA and IL-1β; CBir1, SAAand GMCSF; CBir1, SAA and IFNγ; CBir1, SAA and IL-6; CBir1, SAA andTNFα; CBir1, SAA and ASCA-A; CBir1, SAA and ASCA-G; CBir1, SAA and Fla2;CBir1, SAA and FlaX; CBir1, SAA and OmpC; CBir1, SAA and ADA; CBir1,VCAM and IL-2; CBir1, VCAM and IL-8; CBir1, VCAM and IL-12p70; CBir1,VCAM and IL-1β; CBir1, VCAM and GMCSF; CBir1, VCAM and IFNγ; CBir1, VCAMand IL-6; CBir1, VCAM and TNFα; CBir1, VCAM and ASCA-A; CBir1, VCAM andASCA-G; CBir1, VCAM and Fla2; CBir1, VCAM and FlaX; CBir1, VCAM andOmpC; CBir1, VCAM and ADA; CBir1, IL-2 and IL-8; CBir1, IL-2 andIL-12p70; CBir1, IL-2 and IL-1β; CBir1, IL-2 and GMCSF; CBir1, IL-2 andIFNγ; CBir1, IL-2 and IL-6; CBir1, IL-2 and TNFα; CBir1, IL-2 andASCA-A; CBir1, IL-2 and ASCA-G; CBir1, IL-2 and Fla2; CBir1, IL-2 andFlaX; CBir1, IL-2 and OmpC; CBir1, IL-2 and ADA; CBir1, IL-8 andIL-12p70; CBir1, IL-8 and IL-1β; CBir1, IL-8 and GMCSF; CBir1, IL-8 andIFNγ; CBir1, IL-8 and IL-6; CBir1, IL-8 and TNFα; CBir1, IL-8 andASCA-A; CBir1, IL-8 and ASCA-G; CBir1, IL-8 and Fla2; CBir1, IL-8 andFlaX; CBir1, IL-8 and OmpC; CBir1, IL-8 and ADA; CBir1, IL-12p70 andIL-1β; CBir1, IL-12p70 and GMCSF; CBir1, IL-12p70 and IFNγ; CBir1,IL-12p70 and IL-6; CBir1, IL-12p70 and TNFα; CBir1, IL-12p70 and ASCA-A;CBir1, IL-12p70 and ASCA-G; CBir1, IL-12p70 and Fla2; CBir1, IL-12p70and FlaX; CBir1, IL-12p70 and OmpC; CBir1, IL-12p70 and ADA; CBir1,IL-1β and GMCSF; CBir1, IL-1β and IFNγ; CBir1, IL-1β and IL-6; CBir1,IL-1β and TNFα; CBir1, IL-1β and ASCA-A; CBir1, IL-1β and ASCA-G; CBir1,IL-1β and Fla2; CBir1, IL-1β and FlaX; CBir1, IL-1β and OmpC; CBir1,IL-1β and ADA; CBir1, GMCSF and IFNγ; CBir1, GMCSF and IL-6; CBir1,GMCSF and TNFα; CBir1, GMCSF and ASCA-A; CBir1, GMCSF and ASCA-G; CBir1,GMCSF and Fla2; CBir1, GMCSF and FlaX; CBir1, GMCSF and OmpC; CBir1,GMCSF and ADA; CBir1, IFNγ and IL-6; CBir1, IFNγ and TNFα; CBir1, IFNγand ASCA-A; CBir1, IFNγ and ASCA-G; CBir1, IFNγ and Fla2; CBir1, IFNγand FlaX; CBir1, IFNγ and OmpC; CBir1, IFNγ and ADA; CBir1, IL-6 andTNFα; CBir1, IL-6 and ASCA-A; CBir1, IL-6 and ASCA-G; CBir1, IL-6 andFla2; CBir1, IL-6 and FlaX; CBir1, IL-6 and OmpC; CBir1, IL-6 and ADA;CBir1, TNFα and ASCA-A; CBir1, TNFα and ASCA-G; CBir1, TNFα and CBir1;CBir1, TNFα and Fla2; CBir1, TNFα and FlaX; CBir1, TNFα and OmpC; CBir1,TNFα and ADA; CBir1, ASCA-A and ASCA-G; CBir1, ASCA-A and Fla2; CBir1,ASCA-A and FlaX; CBir1, ASCA-A and OmpC; CBir1, ASCA-A and ADA; CBir1,ASCA-G and Fla2; CBir1, ASCA-G and FlaX; CBir1, ASCA-G and OmpC; CBir1,ASCA-G and ADA; CBir1, Fla2 and FlaX; CBir1, Fla2 and OmpC; CBir1, Fla2and ADA; CBir1, FlaX and OmpC; CBir1, FlaX and ADA; CBir1, OmpC and ADA;Fla2, TWEAK and CRP; Fla2, TWEAK and ICAM; Fla2, TWEAK and SAA; Fla2,TWEAK and VCAM; Fla2, TWEAK and IL-2; Fla2, TWEAK and IL-8; Fla2, TWEAKand IL-12p70; Fla2, TWEAK and IL-1β; Fla2, TWEAK and GMCSF; Fla2, TWEAKand IFNγ; Fla2, TWEAK and IL-6; Fla2, TWEAK and TNFα; Fla2, TWEAK andASCA-A; Fla2, TWEAK and ASCA-G; Fla2, TWEAK and CBir1; Fla2, TWEAK andFlaX; Fla2, TWEAK and OmpC; Fla2, TWEAK and ADA; Fla2, CRP and ICAM;Fla2, CRP and SAA; Fla2, CRP and VCAM; Fla2, CRP and IL-2; Fla2, CRP andIL-8; Fla2, CRP and IL-12p70; Fla2, CRP and IL-1β; Fla2, CRP and GMCSF;Fla2, CRP and IFNγ; Fla2, CRP and IL-6; Fla2, CRP and TNFα; Fla2, CRPand ASCA-A; Fla2, CRP and ASCA-G; Fla2, CRP and CBir1; Fla2, CRP andFlaX; Fla2, CRP and OmpC; Fla2, CRP and ADA; Fla2, ICAM and SAA; Fla2,ICAM and VCAM; Fla2, ICAM and IL-2; Fla2, ICAM and IL-8; Fla2, ICAM andIL-12p70; Fla2, ICAM and IL-1β; Fla2, ICAM and GMCSF; Fla2, ICAM andIFNγ; Fla2, ICAM and IL-6; Fla2, ICAM and TNFα; Fla2, ICAM and ASCA-A;Fla2, ICAM and ASCA-G; Fla2, ICAM and CBir1; Fla2, ICAM and FlaX; Fla2,ICAM and OmpC; Fla2, ICAM and ADA; Fla2, SAA and VCAM; Fla2, SAA andIL-2; Fla2, SAA, and IL-8; Fla2, SAA and IL-12p70; Fla2, SAA and IL-1β;Fla2, SAA and GMCSF; Fla2, SAA and IFNγ; Fla2, SAA and IL-6; Fla2, SAAand TNFα; Fla2, SAA and ASCA-A; Fla2, SAA and ASCA-G; Fla2, SAA andCBir1; Fla2, SAA and FlaX; Fla2, SAA and OmpC; Fla2, SAA and ADA; Fla2,VCAM and IL-2; Fla2, VCAM and IL-8; Fla2, VCAM and IL-12p70; Fla2, VCAMand IL-1β; Fla2, VCAM and GMCSF; Fla2, VCAM and IFNγ; Fla2, VCAM andIL-6; Fla2, VCAM and TNFα; Fla2, VCAM and ASCA-A; Fla2, VCAM and ASCA-G;Fla2, VCAM and CBir1; Fla2, VCAM and FlaX; Fla2, VCAM and OmpC; Fla2,VCAM and ADA; Fla2, IL-2 and IL-8; Fla2, IL-2 and IL-12p70; Fla2, IL-2and IL-1β; Fla2, IL-2 and GMCSF; Fla2, IL-2 and IFNγ; Fla2, IL-2 andIL-6; Fla2, IL-2 and TNFα; Fla2, IL-2 and ASCA-A; Fla2, IL-2 and ASCA-G;Fla2, IL-2 and CBir1; Fla2, IL-2 and FlaX; Fla2, IL-2 and OmpC; Fla2,IL-2 and ADA; Fla2, IL-8 and IL-12p70; Fla2, IL-8 and IL-1β; Fla2, IL-8and GMCSF; Fla2, IL-8 and IFNγ; Fla2, IL-8 and IL-6; Fla2, IL-8 andTNFα; Fla2, IL-8 and ASCA-A; Fla2, IL-8 and ASCA-G; Fla2, IL-8 andCBir1; Fla2, IL-8 and FlaX; Fla2, IL-8 and OmpC; Fla2, IL-8 and ADA;Fla2, IL-12p70 and IL-1β; Fla2, IL-12p70 and GMCSF; Fla2, IL-12p70 andIFNγ; Fla2, IL-12p70 and IL-6; Fla2, IL-12p70 and TNFα; Fla2, IL-12p70and ASCA-A; Fla2, IL-12p70 and ASCA-G; Fla2, IL-12p70 and CBir1; Fla2,IL-12p70 and FlaX; Fla2, IL-12p70 and OmpC; Fla2, IL-12p70 and ADA;Fla2, IL-1β and GMCSF; Fla2, IL-1β and IFNγ; Fla2, IL-1β and IL-6; Fla2,IL-1β and TNFα; Fla2, IL-1β and ASCA-A; Fla2, IL-1β and ASCA-G; Fla2,IL-1β and CBir1; Fla2, IL-1β and FlaX; Fla2, IL-1β and OmpC; Fla2, IL-1βand ADA; Fla2, GMCSF and IFNγ; Fla2, GMCSF and IL-6; Fla2, GMCSF andTNFα; Fla2, GMCSF and ASCA-A; Fla2, GMCSF and ASCA-G; Fla2, GMCSF andCBir1; Fla2, GMCSF and FlaX; Fla2, GMCSF and OmpC; Fla2, GMCSF and ADA;Fla2, IFNγ and IL-6; Fla2, IFNγ and TNFα; Fla2, IFNγ and ASCA-A; Fla2,IFNγ and ASCA-G; Fla2, IFNγ and CBir1; Fla2, IFNγ and FlaX; Fla2, IFNγand OmpC; Fla2, IFNγ and ADA; Fla2, IL-6 and TNFα; Fla2, IL-6 andASCA-A; Fla2, IL-6 and ASCA-G; Fla2, IL-6 and CBir1; Fla2, IL-6 andFlaX; Fla2, IL-6 and OmpC; Fla2, IL-6 and ADA; Fla2, TNFα and ASCA-A;Fla2, TNFα and ASCA-G; Fla2, TNFα and CBir1; Fla2, TNFα and FlaX; Fla2,TNFα and OmpC; Fla2, TNFα and ADA; Fla2, ASCA-A and ASCA-G; Fla2, ASCA-Aand CBir1; Fla2, ASCA-A and FlaX; Fla2, ASCA-A and OmpC; Fla2, ASCA-Aand ADA; Fla2, ASCA-G and CBir1; Fla2, ASCA-G and FlaX; Fla2, ASCA-G andOmpC; Fla2, ASCA-G and ADA; Fla2, CBir1 and FlaX; Fla2, CBir1 and OmpC;Fla2, CBir1 and ADA; Fla2, FlaX and OmpC; Fla2, FlaX and ADA; Fla2, OmpCand ADA; FlaX, TWEAK and CRP; FlaX, TWEAK and ICAM; FlaX, TWEAK and SAA;FlaX, TWEAK and VCAM; FlaX, TWEAK and IL-2; FlaX, TWEAK and IL-8; FlaX,TWEAK and IL-12p70; FlaX, TWEAK and IL-1β; FlaX, TWEAK and GMCSF; FlaX,TWEAK and IFNγ; FlaX, TWEAK and IL-6; FlaX, TWEAK and TNFα; FlaX, TWEAKand ASCA-A; FlaX, TWEAK and ASCA-G; FlaX, TWEAK and CBir1; FlaX, TWEAKand Fla2; FlaX, TWEAK and OmpC; FlaX, TWEAK and ADA; FlaX, CRP and ICAM;FlaX, CRP and SAA; FlaX, CRP and VCAM; FlaX, CRP and IL-2; FlaX, CRP andIL-8; FlaX, CRP and IL-12p70; FlaX, CRP and IL-1β; FlaX, CRP and GMCSF;FlaX, CRP and IFNγ; FlaX, CRP and IL-6; FlaX, CRP and TNFα; FlaX, CRPand ASCA-A; FlaX, CRP and ASCA-G; FlaX, CRP and CBir1; FlaX, CRP andFla2; FlaX, CRP and OmpC; FlaX, CRP and ADA; FlaX, ICAM and SAA; FlaX,ICAM and VCAM; FlaX, ICAM and IL-2; FlaX, ICAM and IL-8; FlaX, ICAM andIL-12p70; FlaX, ICAM and IL-1β; FlaX, ICAM and GMCSF; FlaX, ICAM andIFNγ; FlaX, ICAM and IL-6; FlaX, ICAM and TNFα; FlaX, ICAM and ASCA-A;FlaX, ICAM and ASCA-G; FlaX, ICAM and CBir1; FlaX, ICAM and Fla2; FlaX,ICAM and OmpC; FlaX, ICAM and ADA; FlaX, SAA and VCAM; FlaX, SAA andIL-2; FlaX, SAA, and IL-8; FlaX, SAA and IL-12p70; FlaX, SAA and IL-1β;FlaX, SAA and GMCSF; FlaX, SAA and IFNγ; FlaX, SAA and IL-6; FlaX, SAAand TNFα; FlaX, SAA and ASCA-A; FlaX, SAA and ASCA-G; FlaX, SAA andCBir1; FlaX, SAA and Fla2; FlaX, SAA and OmpC; FlaX, SAA and ADA; FlaX,VCAM and IL-2; FlaX, VCAM and IL-8; FlaX, VCAM and IL-12p70; FlaX, VCAMand IL-1β; FlaX, VCAM and GMCSF; FlaX, VCAM and IFNγ; FlaX, VCAM andIL-6; FlaX, VCAM and TNFα; FlaX, VCAM and ASCA-A; FlaX, VCAM and ASCA-G;FlaX, VCAM and CBir1; FlaX, VCAM and Fla2; FlaX, VCAM and OmpC; FlaX,VCAM and ADA; FlaX, IL-2 and IL-8; FlaX, IL-2 and IL-12p70; FlaX, IL-2and IL-1β; FlaX, IL-2 and GMCSF; FlaX, IL-2 and IFNγ; FlaX, IL-2 andIL-6; FlaX, IL-2 and TNFα; FlaX, IL-2 and ASCA-A; FlaX, IL-2 and ASCA-G;FlaX, IL-2 and CBir1; FlaX, IL-2 and Fla2; FlaX, IL-2 and OmpC; FlaX,IL-2 and ADA; FlaX, IL-8 and IL-12p70; FlaX, IL-8 and IL-1β; FlaX, IL-8and GMCSF; FlaX, IL-8 and IFNγ; FlaX, IL-8 and IL-6; FlaX, IL-8 andTNFα; FlaX, IL-8 and ASCA-A; FlaX, IL-8 and ASCA-G; FlaX, IL-8 andCBir1; FlaX, IL-8 and Fla2; FlaX, IL-8 and OmpC; FlaX, IL-8 and ADA;FlaX, IL-12p70 and IL-1β; FlaX, IL-12p70 and GMCSF; FlaX, IL-12p70 andIFNγ; FlaX, IL-12p70 and IL-6; FlaX, IL-12p70 and TNFα; FlaX, IL-12p70and ASCA-A; FlaX, IL-12p70 and ASCA-G; FlaX, IL-12p70 and CBir1; FlaX,IL-12p70 and Fla2; FlaX, IL-12p70 and OmpC; FlaX, IL-12p70 and ADA;FlaX, IL-1β and GMCSF; FlaX, IL-1β and IFNγ; FlaX, IL-1β and IL-6; FlaX,IL-1β and TNFα; FlaX, IL-1β and ASCA-A; FlaX, IL-1β and ASCA-G; FlaX,IL-1β and CBir1; FlaX, IL-1β and Fla2; FlaX, IL-1β and OmpC; FlaX, IL-1βand ADA; FlaX, GMCSF and IFNγ; FlaX, GMCSF and IL-6; FlaX, GMCSF andTNFα; FlaX, GMCSF and ASCA-A; FlaX, GMCSF and ASCA-G; FlaX, GMCSF andCBir1; FlaX, GMCSF and Fla2; FlaX, GMCSF and OmpC; FlaX, GMCSF and ADA;FlaX, IFNγ and IL-6; FlaX, IFNγ and TNFα; FlaX, IFNγ and ASCA-A; FlaX,IFNγ and ASCA-G; FlaX, IFNγ and CBir1; FlaX, IFNγ and Fla2; FlaX, IFNγand FlaX; FlaX, IFNγ and OmpC; FlaX, IFNγ and ADA; FlaX, IL-6 and TNFα;FlaX, IL-6 and ASCA-A; FlaX, IL-6 and ASCA-G; FlaX, IL-6 and CBir1;FlaX, IL-6 and Fla2; FlaX, IL-6 and OmpC; FlaX, IL-6 and ADA; FlaX, TNFαand ASCA-A; FlaX, TNFα and ASCA-G; FlaX, TNFα and CBir1; FlaX, TNFα andFla2; FlaX, TNFα and OmpC; FlaX, TNFα and ADA; FlaX, ASCA-A and ASCA-G;FlaX, ASCA-A and CBir1; FlaX, ASCA-A and Fla2; FlaX, ASCA-A and OmpC;FlaX, ASCA-A and ADA; FlaX, ASCA-G and CBir1; FlaX, ASCA-G and Fla2;FlaX, ASCA-G and FlaX; FlaX, ASCA-G and OmpC; FlaX, ASCA-G and ADA;FlaX, CBir1 and Fla2; FlaX, CBir1 and FlaX; FlaX, CBir1 and OmpC; FlaX,CBir1 and ADA; FlaX, Fla2 and FlaX; FlaX, Fla2 and OmpC; FlaX, Fla2 andADA; FlaX, OmpC and ADA; OmpC, TWEAK and CRP; OmpC, TWEAK and ICAM;OmpC, TWEAK and SAA; OmpC, TWEAK and VCAM; OmpC, TWEAK and IL-2; OmpC,TWEAK and IL-8; OmpC, TWEAK and IL-12p70; OmpC, TWEAK and IL-1β; OmpC,TWEAK and GMCSF; OmpC, TWEAK and IFNγ; OmpC, TWEAK and IL-6; OmpC, TWEAKand TNFα; OmpC, TWEAK and ASCA-A; OmpC, TWEAK and ASCA-G; OmpC, TWEAKand CBir1; OmpC, TWEAK and Fla2; OmpC, TWEAK and FlaX; OmpC, TWEAK andADA; OmpC, CRP and ICAM; OmpC, CRP and SAA; OmpC, CRP and VCAM; OmpC,CRP and IL-2; OmpC, CRP and IL-8; OmpC, CRP and IL-12p70; OmpC, CRP andIL-1β; OmpC, CRP and GMCSF; OmpC, CRP and IFNγ; OmpC, CRP and IL-6;OmpC, CRP and TNFα; OmpC, CRP and ASCA-A; OmpC, CRP and ASCA-G; OmpC,CRP and CBir1; OmpC, CRP and Fla2; OmpC, CRP and FlaX; OmpC, CRP andADA; OmpC, ICAM and SAA; OmpC, ICAM and VCAM; OmpC, ICAM and IL-2; OmpC,ICAM and IL-8; OmpC, ICAM and IL-12p70; OmpC, ICAM and IL-1β; OmpC, ICAMand GMCSF; OmpC, ICAM and IFNγ; OmpC, ICAM and IL-6; OmpC, ICAM andTNFα; OmpC, ICAM and ASCA-A; OmpC, ICAM and ASCA-G; OmpC, ICAM andCBir1; OmpC, ICAM and Fla2; OmpC, ICAM and FlaX; OmpC, ICAM and ADA;OmpC, SAA and VCAM; OmpC, SAA and IL-2; OmpC, SAA, and IL-8; OmpC, SAAand IL-12p70; OmpC, SAA and IL-1β; OmpC, SAA and GMCSF; OmpC, SAA andIFNγ; OmpC, SAA and IL-6; OmpC, SAA and TNFα; OmpC, SAA and ASCA-A;OmpC, SAA and ASCA-G; OmpC, SAA and CBir1; OmpC, SAA and Fla2; OmpC, SAAand FlaX; OmpC, SAA and ADA; OmpC, VCAM and IL-2; OmpC, VCAM and IL-8;OmpC, VCAM and IL-12p70; OmpC, VCAM and IL-1β; OmpC, VCAM and GMCSF;OmpC, VCAM and IFNγ; OmpC, VCAM and IL-6; OmpC, VCAM and TNFα; OmpC,VCAM and ASCA-A; OmpC, VCAM and ASCA-G; OmpC, VCAM and CBir1; OmpC, VCAMand Fla2; OmpC, VCAM and FlaX; OmpC, VCAM and ADA; OmpC, IL-2 and IL-8;OmpC, IL-2 and IL-12p70; OmpC, IL-2 and IL-1β; OmpC, IL-2 and GMCSF;OmpC, IL-2 and IFNγ; OmpC, IL-2 and IL-6; OmpC, IL-2 and TNFα; OmpC,IL-2 and ASCA-A; OmpC, IL-2 and ASCA-G; OmpC, IL-2 and CBir1; OmpC, IL-2and Fla2; OmpC, IL-2 and FlaX; OmpC, IL-2 and ADA; OmpC, IL-8 andIL-12p70; OmpC, IL-8 and IL-1β; OmpC, IL-8 and GMCSF; OmpC, IL-8 andIFNγ; OmpC, IL-8 and IL-6; OmpC, IL-8 and TNFα; OmpC, IL-8 and ASCA-A;OmpC, IL-8 and ASCA-G; OmpC, IL-8 and CBir1; OmpC, IL-8 and Fla2; OmpC,IL-8 and FlaX; OmpC, IL-8 and ADA; OmpC, IL-12p70 and IL-1β; OmpC,IL-12p70 and GMCSF; OmpC, IL-12p70 and IFNγ; OmpC, IL-12p70 and IL-6;OmpC, IL-12p70 and TNFα; OmpC, IL-12p70 and ASCA-A; OmpC, IL-12p70 andASCA-G; OmpC, IL-12p70 and CBir1; OmpC, IL-12p70 and Fla2; OmpC,IL-12p70 and FlaX; OmpC, IL-12p70 and ADA; OmpC, IL-1β and GMCSF; OmpC,IL-1β and IFNγ; OmpC, IL-1β and IL-6; OmpC, IL-1β and TNFα; OmpC, IL-1βand ASCA-A; OmpC, IL-1β and ASCA-G; OmpC, IL-1β and CBir1; OmpC, IL-1βand Fla2; OmpC, IL-1β and FlaX; OmpC, IL-1β and ADA; OmpC, GMCSF andIFNγ; OmpC, GMCSF and IL-6; OmpC, GMCSF and TNFα; OmpC, GMCSF andASCA-A; OmpC, GMCSF and ASCA-G; OmpC, GMCSF and CBir1; OmpC, GMCSF andFla2; OmpC, GMCSF and FlaX; OmpC, GMCSF and ADA; OmpC, IFNγ and IL-6;OmpC, IFNγ and TNFα; OmpC, IFNγ and ASCA-A; OmpC, IFNγ and ASCA-G; OmpC,IFNγ and CBir1; OmpC, IFNγ and Fla2; OmpC, IFNγ and FlaX; OmpC, IFNγ andADA; OmpC, IL-6 and TNFα; OmpC, IL-6 and ASCA-A; OmpC, IL-6 and ASCA-G;OmpC, IL-6 and CBir1; OmpC, IL-6 and Fla2; OmpC, IL-6 and FlaX; OmpC,IL-6 and ADA; OmpC, TNFα and ASCA-A; OmpC, TNFα and ASCA-G; OmpC, TNFαand CBir1; OmpC, TNFα and Fla2; OmpC, TNFα and FlaX; OmpC, TNFα and ADA;OmpC, ASCA-A and ASCA-G; OmpC, ASCA-A and CBir1; OmpC, ASCA-A and Fla2;OmpC, ASCA-A and FlaX; OmpC, ASCA-A and ADA; OmpC, ASCA-G and CBir1;OmpC, ASCA-G and Fla2; OmpC, ASCA-G and FlaX; OmpC, ASCA-G and ADA;OmpC, CBir1 and Fla2; OmpC, CBir1 and FlaX; OmpC, CBir1 and ADA; OmpC,Fla2 and FlaX; OmpC, Fla2 and ADA; OmpC, FlaX and ADA; ADA, TWEAK andCRP; ADA, TWEAK and ICAM; ADA, TWEAK and SAA; ADA, TWEAK and VCAM; ADA,TWEAK and IL-2; ADA, TWEAK and IL-8; ADA, TWEAK and IL-12p70; ADA, TWEAKand IL-1β; ADA, TWEAK and GMCSF; ADA, TWEAK and IFNγ; ADA, TWEAK andIL-6; ADA, TWEAK and TNFα; ADA, TWEAK and ASCA-A; ADA, TWEAK and ASCA-G;ADA, TWEAK and CBir1; ADA, TWEAK and Fla2; ADA, TWEAK and FlaX; ADA,TWEAK and OmpC; ADA, CRP and ICAM; ADA, CRP and SAA; ADA, CRP and VCAM;ADA, CRP and IL-2; ADA, CRP and IL-8; ADA, CRP and IL-12p70; ADA, CRPand IL-1β; ADA, CRP and GMCSF; ADA, CRP and IFNγ; ADA, CRP and IL-6;ADA, CRP and TNFα; ADA, CRP and ASCA-A; ADA, CRP and ASCA-G; ADA, CRPand CBir1; ADA, CRP and Fla2; ADA, CRP and FlaX; ADA, CRP and OmpC; ADA,ICAM and SAA; ADA, ICAM and VCAM; ADA, ICAM and IL-2; ADA, ICAM andIL-8; ADA, ICAM and IL-12p70; ADA, ICAM and IL-1β; ADA, ICAM and GMCSF;ADA, ICAM and IFNγ; ADA, ICAM and IL-6; ADA, ICAM and TNFα; ADA, ICAMand ASCA-A; ADA, ICAM and ASCA-G; ADA, ICAM and CBir1; ADA, ICAM andFla2; ADA, ICAM and FlaX; ADA, ICAM and OmpC; ADA, SAA and VCAM; ADA,SAA and IL-2; ADA, SAA and IL-8; ADA, SAA and IL-12p70; ADA, SAA andIL-1β; ADA, SAA and GMCSF; ADA, SAA and IFNγ; ADA, SAA and IL-6; ADA,SAA and TNFα; ADA, SAA and ASCA-A; ADA, SAA and ASCA-G; ADA, SAA andCBir1; ADA, SAA and Fla2; ADA, SAA and FlaX; ADA, SAA and OmpC; ADA,VCAM and IL-2; ADA, VCAM and IL-8; ADA, VCAM and IL-12p70; ADA, VCAM andIL-1β; ADA, VCAM and GMCSF; ADA, VCAM and IFNγ; ADA, VCAM and IL-6; ADA,VCAM and TNFα; ADA, VCAM and ASCA-A; ADA, VCAM and ASCA-G; ADA, VCAM andCBir1; ADA, VCAM and Fla2; ADA, VCAM and FlaX; ADA, VCAM and OmpC; ADA,IL-2 and IL-8; ADA, IL-2 and IL-12p70; ADA, IL-2 and IL-1β; ADA, IL-2and GMCSF; ADA, IL-2 and IFNγ; ADA, IL-2 and IL-6; ADA, IL-2 and TNFα;ADA, IL-2 and ASCA-A; ADA, IL-2 and ASCA-G; ADA, IL-2 and CBir1; ADA,IL-2 and Fla2; ADA, IL-2 and FlaX; ADA, IL-2 and OmpC; ADA, IL-8 andIL-12p70; ADA, IL-8 and IL-1β; ADA, IL-8 and GMCSF; ADA, IL-8 and IFNγ;ADA, IL-8 and IL-6; ADA, IL-8 and TNFα; ADA, IL-8 and ASCA-A; ADA, IL-8and ASCA-G; ADA, IL-8 and CBir1; ADA, IL-8 and Fla2; ADA, IL-8 and FlaX;ADA, IL-8 and OmpC; ADA, IL-12p70 and IL-1β; ADA, IL-12p70 and GMCSF;ADA, IL-12p70 and IFNγ; ADA, IL-12p70 and IL-6; ADA, IL-12p70 and TNFα;ADA, IL-12p70 and ASCA-A; ADA, IL-12p70 and ASCA-G; ADA, IL-12p70 andCBir1; ADA, IL-12p70 and Fla2; ADA, IL-12p70 and FlaX; ADA, IL-12p70 andOmpC; ADA, IL-1β and GMCSF; ADA, IL-1β and IFNγ; ADA, IL-1β and IL-6;ADA, IL-1β and TNFα; ADA, IL-1β and ASCA-A; ADA, IL-1β and ASCA-G; ADA,IL-1β and CBir1; ADA, IL-1β and Fla2; ADA, IL-1β and FlaX; ADA, IL-1βand OmpC; ADA, GMCSF and IFNγ; ADA, GMCSF and IL-6; ADA, GMCSF and TNFα;ADA, GMCSF and ASCA-A; ADA, GMCSF and ASCA-G; ADA, GMCSF and CBir1; ADA,GMCSF and Fla2; ADA, GMCSF and FlaX; ADA, GMCSF and OmpC; ADA, IFNγ andIL-6; ADA, IFNγ and TNFα; ADA, IFNγ and ASCA-A; ADA, IFNγ and ASCA-G;ADA, IFNγ and CBir1; ADA, IFNγ and Fla2; ADA, IFNγ and FlaX; ADA, IFNγand OmpC; ADA, IFNγ and ADA; ADA, IL-6 and TNFα; ADA, IL-6 and ASCA-A;ADA, IL-6 and ASCA-G; ADA, IL-6 and CBir1; ADA, IL-6 and Fla2; ADA, IL-6and FlaX; ADA, IL-6 and OmpC; ADA, TNFα and ASCA-A; ADA, TNFα andASCA-G; ADA, TNFα and CBir1; ADA, TNFα and Fla2; ADA, TNFα and FlaX;ADA, TNFα and OmpC; ADA, ASCA-A and ASCA-G; ADA, ASCA-A and CBir1; ADA,ASCA-A and Fla2; ADA, ASCA-A and FlaX; ADA, ASCA-A and OmpC; ADA, ASCA-Gand CBir1; ADA, ASCA-G and Fla2; ADA, ASCA-G and FlaX; ADA, ASCA-G andOmpC; ADA, CBir1 and Fla2; ADA, CBir1 and FlaX; ADA, CBir1 and OmpC;ADA, Fla2 and FlaX; ADA, Fla2 and OmpC; ADA, FlaX and OmpC, and thelike. In some instances, the combination of at least three markers canfurther include at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14,15, 16, or 17 of the other markers selected from the first set ofmarkers to form an inflammatory phase marker score.

As described herein, the methods for assessing mucosal healing in asubject include measuring the concentration or level of a second set ofmarkers used to form the proliferation phase marker score, wherein atleast one or a plurality (e.g., at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 11,12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, or 25) of themarkers are selected from the group consisting of AREG, EREG, HBEGF,HGF, HRGB, BTC, EGF, TGFA, FGF1, FGF2, FGF4, FGF7, FGF9, FGF19, SCF,PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC, VEGFD, TGFB1, IL-10, ananti-TNFα antibody, and combinations thereof. In some embodiments, themethods include measuring a combination of at least two markers selectedfrom the group consisting of AREG, EREG, HBEGF, HGF, HRGB, BTC, EGF,TGFA, FGF1, FGF2, FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC,VEGFA, VEGFB, VEGFC, VEGFD, TGFB1, IL-10, and an anti-TNFα antibody,e.g., AREG and EREG, AREG and HBEGF, AREG and HGF, AREG and HRGB, AREGand BTC, AREG and EGF, AREG and TGFA, AREG and FGF1, AREG and FGF2, AREGand FGF4, AREG and FGF7, AREG and FGF9, AREG and FGF19, AREG and SCF,AREG and PDGFA, AREG and PDGFB, AREG and PDGFC, AREG and VEGFA, AREG andVEGFB, AREG and VEGFC, AREG and VEGFD, AREG and TGFB1, AREG and IL-10,AREG and an anti-TNFα antibody, EREG and HBEGF, EREG and HGF, EREG andHRGB, EREG and BTC, EREG and EGF, EREG and TGFA, EREG and FGF1, EREG andFGF2, EREG and FGF4, EREG and FGF7, EREG and FGF9, EREG and FGF19, EREGand SCF, EREG and PDGFA, EREG and PDGFB, EREG and PDGFC, EREG and VEGFA,EREG and VEGFB, EREG and VEGFC, EREG and VEGFD, EREG and TGFB1, EREG andIL-10, EREG and an anti-TNFα antibody, HBEGF and HGF, HBEGF and HRGB,HBEGF and BTC, HBEGF and EGF, HBEGF and TGFA, HBEGF and FGF1, HBEGF andFGF2, HBEGF and FGF4, HBEGF and FGF7, HBEGF and FGF9, HBEGF and FGF19,HBEGF and SCF, HBEGF and PDGFA, HBEGF and PDGFB, HBEGF and PDGFC, HBEGFand VEGFA, HBEGF and VEGFB, HBEGF and VEGFC, HBEGF and VEGFD, HBEGF andTGFB1, HBEGF and IL-10, HBEGF and an anti-TNFα antibody, HGF and HRGB,HGF and BTC, HGF and EGF, HGF and TGFA, HGF and FGF1, HGF and FGF2, HGFand FGF4, HGF and FGF7, HGF and FGF9, HGF and FGF19, HGF and SCF, HGFand PDGFA, HGF and PDGFB, HGF and PDGFC, HGF and VEGFA, HGF and VEGFB,HGF and VEGFC, HGF and VEGFD, HGF and TGFB1, HGF and IL-10, HGF and ananti-TNFα antibody, HRGB and BTC, HRGB and EGF, HRGB and TGFA, HRGB andFGF1, HRGB and FGF2, HRGB and FGF4, HRGB and FGF7, HRGB and FGF9, HRGBand FGF19, HRGB and SCF, HRGB and PDGFA, HRGB and PDGFB, HRGB and PDGFC,HRGB and VEGFA, HRGB and VEGFB, HRGB and VEGFC, HRGB and VEGFD, HRGB andTGFB1, HRGB and IL-10, HRGB and an anti-TNFαantibody, BTC and EGF, BTCand TGFA, BTC and FGF1, BTC and FGF2, BTC and FGF4, BTC and FGF7, BTCand FGF9, BTC and FGF19, BTC and SCF, BTC and PDGFA, BTC and PDGFB, BTCand PDGFC, BTC and VEGFA, BTC and VEGFB, BTC and VEGFC, BTC and VEGFD,BTC and TGFB1, BTC and IL-10, BTC and an anti-TNFα antibody, EGF andTGFA, EGF and FGF1, EGF and FGF2, EGF and FGF4, EGF and FGF7, EGF andFGF9, EGF and FGF19, EGF and SCF, EGF and PDGFA, EGF and PDGFB, EGF andPDGFC, EGF and VEGFA, EGF and VEGFB, EGF and VEGFC, EGF and VEGFD, EGFand TGFB1, EGF and IL-10, EGF and an anti-TNFα antibody, TGFA and FGF1,TGFA and FGF2, TGFA and FGF4, TGFA and FGF7, TGFA and FGF9, TGFA andFGF19, TGFA and SCF, TGFA and PDGFA, TGFA and PDGFB, TGFA and PDGFC,TGFA and VEGFA, TGFA and VEGFB, TGFA and VEGFC, TGFA and VEGFD, TGFA andTGFB1, TGFA and IL-10, TGFA and an anti-TNFα antibody, FGF1 and FGF2,FGF1 and FGF4, FGF1 and FGF7, FGF1 and FGF9, FGF1 and FGF19, FGF1 andSCF, FGF1 and PDGFA, FGF1 and PDGFB, FGF1 and PDGFC, FGF1 and VEGFA,FGF1 and VEGFB, FGF1 and VEGFC, FGF1 and VEGFD, FGF1 and TGFB1, FGF1 andIL-10, FGF1 and an anti-TNFα antibody, FGF2 and FGF4, FGF2 and FGF7,FGF2 and FGF9, FGF2 and FGF19, FGF2 and SCF, FGF2 and PDGFA, FGF2 andPDGFB, FGF2 and PDGFC, FGF2 and VEGFA, FGF2 and VEGFB, FGF2 and VEGFC,FGF2 and VEGFD, FGF2 and TGFB1, FGF2 and IL-10, FGF2 and an anti-TNFαantibody, FGF4 and FGF7, FGF4 and FGF9, FGF4 and FGF19, FGF4 and SCF,FGF4 and PDGFA, FGF4 and PDGFB, FGF4 and PDGFC, FGF4 and VEGFA, FGF4 andVEGFB, FGF4 and VEGFC, FGF4 and VEGFD, FGF4 and TGFB1, FGF4 and IL-10,FGF4 and an anti-TNFα antibody, FGF7 and FGF9, FGF7 and FGF19, FGF7 andSCF, FGF7 and PDGFA, FGF7 and PDGFB, FGF7 and PDGFC, FGF7 and VEGFA,FGF7 and VEGFB, FGF7 and VEGFC, FGF7 and VEGFD, FGF7 and TGFB1, FGF7 andIL-10, FGF7 and an anti-TNFα antibody, FGF9 and FGF19, FGF9 and SCF,FGF9 and PDGFA, FGF9 and PDGFB, FGF9 and PDGFC, FGF9 and VEGFA, FGF9 andVEGFB, FGF9 and VEGFC, FGF9 and VEGFD, FGF9 and TGFB1, FGF9 and IL-10,FGF9 and an anti-TNFα antibody, FGF19 and SCF, FGF19 and PDGFA, FGF19and PDGFB, FGF19 and PDGFC, FGF19 and VEGFA, FGF19 and VEGFB, FGF19 andVEGFC, FGF19 and VEGFD, FGF19 and TGFB1, FGF19 and IL-10, FGF19 and ananti-TNFα antibody, SCF and PDGFA, SCF and PDGFB, SCF and PDGFC, SCF andVEGFA, SCF and VEGFB, SCF and VEGFC, SCF and VEGFD, SCF and TGFB1, SCFand IL-10, SCF and an anti-TNFα antibody, PDGFA and PDGFB, PDGFA andPDGFC, PDGFA and VEGFA, PDGFA and VEGFB, PDGFA and VEGFC, PDGFA andVEGFD, PDGFA and TGFB1, PDGFA and IL-10, PDGFA and an anti-TNFαantibody, PDGFB and PDGFC, PDGFB and VEGFA, PDGFB and VEGFB, PDGFB andVEGFC, PDGFB and VEGFD, PDGFB and TGFB1, PDGFB and IL-10, PDGFB and ananti-TNFα antibody, PDGFC and VEGFA, PDGFC and VEGFB, PDGFC and VEGFC,PDGFC and VEGFD, PDGFC and TGFB1, PDGFC and IL-10, PDGFC and ananti-TNFα antibody, VEGFA and VEGFB, VEGFA and VEGFC, VEGFA and VEGFD,VEGFA and TGFB1, VEGFA and IL-10, VEGFA and an anti-TNFα antibody, VEGFBand VEGFC, VEGFB and VEGFD, VEGFB and TGFB1, VEGFB and IL-10, VEGFB andan anti-TNFα antibody, VEGFC and VEGFD, VEGFC and TGFB1, VEGFC andIL-10, VEGFC and an anti-TNFα antibody, VEGFD and TGFB1, VEGFD andIL-10, VEGFD and an anti-TNFα antibody, TGFB1 and IL-10, TGFB1 and ananti-TNFα antibody, IL-10 and an anti-TNFα antibody, and the like. Insome instances, the combination of at least two markers can furtherinclude at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16,17, 18, 19, 20, 21, 22, or 23 of the other markers selected from thesecond set of markers to form a proliferation phase marker score.

In some embodiments, the methods include measuring a combination of atleast three markers selected from the group consisting of AREG, EREG,HBEGF, HGF, HRGB, BTC, EGF, TGFA, FGF1, FGF2, FGF4, FGF7, FGF9, FGF19,SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC, VEGFD, TGFB1, IL-10, andan anti-TNFα antibody, e.g., AREG, EREG and HBEGF; AREG, EREG and HGF;AREG, EREG and HRGB; AREG, EREG and BTC; AREG, EREG and EGF; AREG, EREGand TGFA; AREG, EREG and FGF1; AREG, EREG and FGF2; AREG, EREG and FGF4;AREG, EREG and FGF7; AREG, EREG and FGF9; AREG, EREG and FGF19; AREG,EREG and SCF; AREaG, EREG and PDGFA; AREG, EREG and PDGFB; AREG, EREGand PDGFC; AREG, EREG and VEGFA; AREG, EREG and VEGFB; AREG, EREG andVEGFC; AREG, EREG and VEGFD; AREG, EREG and TGFB1; AREG, EREG and IL-10;AREG, EREG and an anti-TNFα antibody; AREG, HBEGF and HGF; AREG, HBEGFand HRGB; AREG, HBEGF and BTC; AREG, HBEGF and EGF; AREG, HBEGF andTGFA; AREG, HBEGF and FGF1; AREG, HBEGF and FGF2; AREG, HBEGF and FGF4;AREG, HBEGF and FGF7; AREG, HBEGF and FGF9; AREG, HBEGF and FGF19; AREG,HBEGF and SCF; AREG, HBEGF and PDGFA; AREG, HBEGF and PDGFB; AREG, HBEGFand PDGFC; AREG, HBEGF and VEGFA; AREG, HBEGF and VEGFB; AREG, HBEGF andVEGFC; AREG, HBEGF and VEGFD; AREG, HBEGF and TGFB1; AREG, HBEGF andIL-10; AREG, HBEGF and an anti-TNFα antibody; AREG, HGF and HRGB; AREG,HGF and BTC; AREG, HGF and EGF; AREG, HGF and TGFA; AREG, HGF and FGF1;AREG, HGF and FGF2; AREG, HGF and FGF4; AREG, HGF and FGF7; AREG, HGFand FGF9; AREG, HGF and FGF19; AREG, HGF and SCF; AREG, HGF and PDGFA;AREG, HGF and PDGFB; AREG, HGF and PDGFC; AREG, HGF and VEGFA; AREG, HGFand VEGFB; AREG, HGF and VEGFC; AREG, HGF and VEGFD; AREG, HGF andTGFB1; AREG, HGF and IL-10; AREG, HGF and an anti-TNFα antibody; AREG,HRGB and BTC; AREG, HRGB and EGF; AREG, HRGB and TGFA; AREG, HRGB andFGF1; AREG, HRGB and FGF2; AREG, HRGB and FGF4; AREG, HRGB and FGF7;AREG, HRGB and FGF9; AREG, HRGB and FGF19; AREG, HRGB and SCF; AREG,HRGB and PDGFA; AREG, HRGB and PDGFB; AREG, HRGB and PDGFC; AREG, HRGBand VEGFA; AREG, HRGB and VEGFB; AREG, HRGB and VEGFC; AREG, HRGB andVEGFD; AREG, HRGB and TGFB1; AREG, HRGB and IL-10; AREG, HRGB and ananti-TNFα antibody; AREG, BTC and EGF; AREG, BTC and TGFA; AREG, BTC andFGF1; AREG, BTC and FGF2; AREG, BTC and FGF4; AREG, BTC and FGF7; AREG,BTC and FGF9; AREG, BTC and FGF19; AREG, BTC and SCF; AREG, BTC andPDGFA; AREG, BTC and PDGFB; AREG, BTC and PDGFC; AREG, BTC and VEGFA;AREG, BTC and VEGFB; AREG, BTC and VEGFC; AREG, BTC and VEGFD; AREG, BTCand TGFB1; AREG, BTC and IL-10; AREG, BTC and an anti-TNFα antibody;AREG, EGF and TGFA; AREG, EGF and FGF1; AREG, EGF and FGF2; AREG, EGFand FGF4; AREG, EGF and FGF7; AREG, EGF and FGF9; AREG, EGF and FGF19;AREG, EGF and SCF; AREG, EGF and PDGFA; AREG, EGF and PDGFB; AREG, EGFand PDGFC; AREG, EGF and VEGFA; AREG, EGF and VEGFB; AREG, EGF andVEGFC; AREG, EGF and VEGFD; AREG, EGF and TGFB1; AREG, EGF and IL-10;AREG, EGF and an anti-TNFα antibody; AREG, TGFA and FGF1; AREG, TGFA andFGF2; AREG, TGFA and FGF4; AREG, TGFA and FGF7; AREG, TGFA and FGF9;AREG, TGFA and FGF19; AREG, TGFA and SCF; AREG, TGFA and PDGFA; AREG,TGFA and PDGFB; AREG, TGFA and PDGFC; AREG, TGFA and VEGFA; AREG, TGFAand VEGFB; AREG, TGFA and VEGFC; AREG, TGFA and VEGFD; AREG, TGFA andTGFB1; AREG, TGFA and IL-10; AREG, TGFA and an anti-TNFα antibody; AREG,FGF1 and FGF2; AREG, FGF1 and FGF4; AREG, FGF1 and FGF7; AREG, FGF1 andFGF9; AREG, FGF1 and FGF19; AREG, FGF1 and SCF; AREG, FGF1 and PDGFA;AREG, FGF1 and PDGFB; AREG, FGF1 and PDGFC; AREG, FGF1 and VEGFA; AREG,FGF1 and VEGFB; AREG, FGF1 and VEGFC; AREG, FGF1 and VEGFD; AREG, FGF1and TGFB1; AREG, FGF1 and IL-10; AREG, FGF1 and an anti-TNFα antibody;AREG, FGF2 and FGF4; AREG, FGF2 and FGF7; AREG, FGF2 and FGF9; AREG,FGF2 and FGF19; AREG, FGF2 and SCF; AREG, FGF2 and PDGFA; AREG, FGF2 andPDGFB; AREG, FGF2 and PDGFC; AREG, FGF2 and VEGFA; AREG, FGF2 and VEGFB;AREG, FGF2 and VEGFC; AREG, FGF2 and VEGFD; AREG, FGF2 and TGFB1; AREG,FGF2 and IL-10; AREG, FGF2 and an anti-TNFα antibody; AREG, FGF4 andFGF7; AREG, FGF4 and FGF9; AREG, FGF4 and FGF19; AREG, FGF4 and SCF;AREG, FGF4 and PDGFA; AREG, FGF4 and PDGFB; AREG, FGF4 and PDGFC; AREG,FGF4 and VEGFA; AREG, FGF4 and VEGFB; AREG, FGF4 and VEGFC; AREG, FGF4and VEGFD; AREG, FGF4 and TGFB1; AREG, FGF4 and IL-10; AREG, FGF4 and ananti-TNFα antibody; AREG, FGF7 and FGF9; AREG, FGF7 and FGF19; AREG,FGF7 and SCF; AREG, FGF7 and PDGFA; AREG, FGF7 and PDGFB; AREG, FGF7 andPDGFC; AREG, FGF7 and VEGFA; AREG, FGF7 and VEGFB; AREG, FGF7 and VEGFC;AREG, FGF7 and VEGFD; AREG, FGF7 and TGFB1; AREG, FGF7 and IL-10; AREG,FGF7 and an anti-TNFα antibody; AREG, FGF9 and FGF19; AREG, FGF9 andSCF; AREG, FGF9 and PDGFA; AREG, FGF9 and PDGFB; AREG, FGF9 and PDGFC;AREG, FGF9 and VEGFA; AREG, FGF9 and VEGFB; AREG, FGF9 and VEGFC; AREG,FGF9 and VEGFD; AREG, FGF9 and TGFB1; AREG, FGF9 and IL-10; AREG, FGF9and an anti-TNFα antibody; AREG, FGF19 and SCF; AREG, FGF19 and PDGFA;AREG, FGF19 and PDGFB; AREG, FGF19 and PDGFC; AREG, FGF19 and VEGFA;AREG, FGF19 and VEGFB; AREG, FGF19 and VEGFC; AREG, FGF19 and VEGFD;AREG, FGF19 and TGFB1; AREG, FGF19 and IL-10; AREG, FGF19 and ananti-TNFα antibody; AREG, SCF and PDGFA; AREG, SCF and PDGFB; AREG, SCFand PDGFC; AREG, SCF and VEGFA; AREG, SCF and VEGFB; AREG, SCF andVEGFC; AREG, SCF and VEGFD; AREG, SCF and TGFB1; AREG, SCF and IL-10;AREG, SCF and an anti-TNFα antibody; AREG, PDGFA and PDGFB; AREG, PDGFAand PDGFC; AREG, PDGFA and VEGFA; AREG, PDGFA and VEGFB; AREG, PDGFA andVEGFC; AREG, PDGFA and VEGFD; AREG, PDGFA and TGFB1; AREG, PDGFA andIL-10; AREG, PDGFA and an anti-TNFα antibody; AREG, PDGFB and PDGFC;AREG, PDGFB and VEGFA; AREG, PDGFB and VEGFB; AREG, PDGFB and VEGFC;AREG, PDGFB and VEGFD; AREG, PDGFB and TGFB1; AREG, PDGFB and IL-10;AREG, PDGFB and an anti-TNFα antibody; AREG, PDGFC and VEGFA; AREG,PDGFC and VEGFB; AREG, PDGFC and VEGFC; AREG, PDGFC and VEGFD; AREG,PDGFC and TGFB1; AREG, PDGFC and IL-10; AREG, PDGFC and an anti-TNFαantibody; AREG, VEGFA and VEGFB; AREG, VEGFA and VEGFC; AREG, VEGFA andVEGFD; AREG, VEGFA and TGFB1; AREG, VEGFA and IL-10; AREG, VEGFA and ananti-TNFα antibody; AREG, VEGFB and VEGFC; AREG, VEGFB and VEGFD; AREG,VEGFB and TGFB1; AREG, VEGFB and IL-10; AREG, VEGFB and an anti-TNFαantibody; AREG, VEGFC and VEGFD; AREG, VEGFC and TGFB1; AREG, VEGFC andIL-10; AREG, VEGFC and an anti-TNFα antibody; AREG, VEGFD and TGFB1;AREG, VEGFD and IL-10; AREG, VEGFD and an anti-TNFα antibody; AREG,TGFB1 and IL-10; AREG, TGFB1 and an anti-TNFα antibody; AREG, IL-10 andan anti-TNFα antibody; EREG, AREG and HBEGF; EREG, AREG and HGF; EREG,AREG and HRGB; EREG, AREG and BTC; EREG, AREG and EGF; EREG, AREG andTGFA; EREG, AREG and FGF1; EREG, AREG and FGF2; EREG, AREG and FGF4;EREG, AREG and FGF7; EREG, AREG and FGF9; EREG, AREG and FGF19; EREG,AREG and SCF; EREG, AREG and PDGFA; EREG, AREG and PDGFB; EREG, AREG andPDGFC; EREG, AREG and VEGFA; EREG, AREG and VEGFB; EREG, AREG and VEGFC;EREG, AREG and VEGFD; EREG, AREG and TGFB1; EREG, AREG and IL-10; EREG,AREG and an anti-TNFα antibody; EREG, HBEGF and HGF; EREG, HBEGF andHRGB; EREG, HBEGF and BTC; EREG, HBEGF and EGF; EREG, HBEGF and TGFA;EREG, HBEGF and FGF1; EREG, HBEGF and FGF2; EREG, HBEGF and FGF4; EREG,HBEGF and FGF7; EREG, HBEGF and FGF9; EREG, HBEGF and FGF19; EREG, HBEGFand SCF; EREG, HBEGF and PDGFA; EREG, HBEGF and PDGFB; EREG, HBEGF andPDGFC; EREG, HBEGF and VEGFA; EREG, HBEGF and VEGFB; EREG, HBEGF andVEGFC; EREG, HBEGF and VEGFD; EREG, HBEGF and TGFB1; EREG, HBEGF andIL-10; EREG, HBEGF and an anti-TNFα antibody; EREG, HGF and HRGB; EREG,HGF and BTC; EREG, HGF and EGF; EREG, HGF and TGFA; EREG, HGF and FGF1;EREG, HGF and FGF2; EREG, HGF and FGF4; EREG, HGF and FGF7; EREG, HGFand FGF9; EREG, HGF and FGF19; EREG, HGF and SCF; EREG, HGF and PDGFA;EREG, HGF and PDGFB; EREG, HGF and PDGFC; EREG, HGF and VEGFA; EREG, HGFand VEGFB; EREG, HGF and VEGFC; EREG, HGF and VEGFD; EREG, HGF andTGFB1; EREG, HGF and IL-10; EREG, HGF and an anti-TNFα antibody; EREG,HRGB and BTC; EREG, HRGB and EGF; EREG, HRGB and TGFA; EREG, HRGB andFGF1; EREG, HRGB and FGF2; EREG, HRGB and FGF4; EREG, HRGB and FGF7;EREG, HRGB and FGF9; EREG, HRGB and FGF19; EREG, HRGB and SCF; EREG,HRGB and PDGFA; EREG, HRGB and PDGFB; EREG, HRGB and PDGFC; EREG, HRGBand VEGFA; EREG, HRGB and VEGFB; EREG, HRGB and VEGFC; EREG, HRGB andVEGFD; EREG, HRGB and TGFB1; EREG, HRGB and IL-10; EREG, HRGB and ananti-TNFα antibody; EREG, BTC and EGF; EREG, BTC and TGFA; EREG, BTC andFGF1; EREG, BTC and FGF2; EREG, BTC and FGF4; EREG, BTC and FGF7; EREG,BTC and FGF9; EREG, BTC and FGF19; EREG, BTC and SCF; EREG, BTC andPDGFA; EREG, BTC and PDGFB; EREG, BTC and PDGFC; EREG, BTC and VEGFA;EREG, BTC and VEGFB; EREG, BTC and VEGFC; EREG, BTC and VEGFD; EREG, BTCand TGFB1; EREG, BTC and IL-10; EREG, BTC and an anti-TNFα antibody;EREG, EGF and TGFA; EREG, EGF and FGF1; EREG, EGF and FGF2; EREG, EGFand FGF4; EREG, EGF and FGF7; EREG, EGF and FGF9; EREG, EGF and FGF19;EREG, EGF and SCF; EREG, EGF and PDGFA; EREG, EGF and PDGFB; EREG, EGFand PDGFC; EREG, EGF and VEGFA; EREG, EGF and VEGFB; EREG, EGF andVEGFC; EREG, EGF and VEGFD; EREG, EGF and TGFB1; EREG, EGF and IL-10;EREG, EGF and an anti-TNFα antibody; EREG, TGFA and FGF1; EREG, TGFA andFGF2; EREG, TGFA and FGF4; EREG, TGFA and FGF7; EREG, TGFA and FGF9;EREG, TGFA and FGF19; EREG, TGFA and SCF; EREG, TGFA and PDGFA; EREG,TGFA and PDGFB; EREG, TGFA and PDGFC; EREG, TGFA and VEGFA; EREG, TGFAand VEGFB; EREG, TGFA and VEGFC; EREG, TGFA and VEGFD; EREG, TGFA andTGFB1; EREG, TGFA and IL-10; EREG, TGFA and an anti-TNFα antibody; EREG,FGF1 and FGF2; EREG, FGF1 and FGF4; EREG, FGF1 and FGF7; EREG, FGF1 andFGF9; EREG, FGF1 and FGF19; EREG, FGF1 and SCF; EREG, FGF1 and PDGFA;EREG, FGF1 and PDGFB; EREG, FGF1 and PDGFC; EREG, FGF1 and VEGFA; EREG,FGF1 and VEGFB; EREG, FGF1 and VEGFC; EREG, FGF1 and VEGFD; EREG, FGF1and TGFB1; EREG, FGF1 and IL-10; EREG, FGF1 and an anti-TNFα antibody;EREG, FGF2 and FGF4; EREG, FGF2 and FGF7; EREG, FGF2 and FGF9; EREG,FGF2 and FGF19; EREG, FGF2 and SCF; EREG, FGF2 and PDGFA; EREG, FGF2 andPDGFB; EREG, FGF2 and PDGFC; EREG, FGF2 and VEGFA; EREG, FGF2 and VEGFB;EREG, FGF2 and VEGFC; EREG, FGF2 and VEGFD; EREG, FGF2 and TGFB1; EREG,FGF2 and IL-10; EREG, FGF2 and an anti-TNFα antibody; EREG, FGF4 andFGF7; EREG, FGF4 and FGF9; EREG, FGF4 and FGF19; EREG, FGF4 and SCF;EREG, FGF4 and PDGFA; EREG, FGF4 and PDGFB; EREG, FGF4 and PDGFC; EREG,FGF4 and VEGFA; EREG, FGF4 and VEGFB; EREG, FGF4 and VEGFC; EREG, FGF4and VEGFD; EREG, FGF4 and TGFB1; EREG, FGF4 and IL-10; EREG, FGF4 and ananti-TNFα antibody; EREG, FGF7 and FGF9; EREG, FGF7 and FGF19; EREG,FGF7 and SCF; EREG, FGF7 and PDGFA; EREG, FGF7 and PDGFB; EREG, FGF7 andPDGFC; EREG, FGF7 and VEGFA; EREG, FGF7 and VEGFB; EREG, FGF7 and VEGFC;EREG, FGF7 and VEGFD; EREG, FGF7 and TGFB1; EREG, FGF7 and IL-10; EREG,FGF7 and an anti-TNFα antibody; EREG, FGF9 and FGF19; EREG, FGF9 andSCF; EREG, FGF9 and PDGFA; EREG, FGF9 and PDGFB; EREG, FGF9 and PDGFC;EREG, FGF9 and VEGFA; EREG, FGF9 and VEGFB; EREG, FGF9 and VEGFC; EREG,FGF9 and VEGFD; EREG, FGF9 and TGFB1; EREG, FGF9 and IL-10; EREG, FGF9and an anti-TNFα antibody; EREG, FGF19 and SCF; EREG, FGF19 and PDGFA;EREG, FGF19 and PDGFB; EREG, FGF19 and PDGFC; EREG, FGF19 and VEGFA;EREG, FGF19 and VEGFB; EREG, FGF19 and VEGFC; EREG, FGF19 and VEGFD;EREG, FGF19 and TGFB1; EREG, FGF19 and IL-10; EREG, FGF19 and ananti-TNFα antibody; EREG, SCF and PDGFA; EREG, SCF and PDGFB; EREG, SCFand PDGFC; EREG, SCF and VEGFA; EREG, SCF and VEGFB; EREG, SCF andVEGFC; EREG, SCF and VEGFD; EREG, SCF and TGFB1; EREG, SCF and IL-10;EREG, SCF and an anti-TNFα antibody; EREG, PDGFA and PDGFB; EREG, PDGFAand PDGFC; EREG, PDGFA and VEGFA; EREG, PDGFA and VEGFB; EREG, PDGFA andVEGFC; EREG, PDGFA and VEGFD; EREG, PDGFA and TGFB1; EREG, PDGFA andIL-10; EREG, PDGFA and an anti-TNFα antibody; EREG, PDGFB and PDGFC;EREG, PDGFB and VEGFA; EREG, PDGFB and VEGFB; EREG, PDGFB and VEGFC;EREG, PDGFB and VEGFD; EREG, PDGFB and TGFB1; EREG, PDGFB and IL-10;EREG, PDGFB and an anti-TNFα antibody; EREG, PDGFC and VEGFA; EREG,PDGFC and VEGFB; EREG, PDGFC and VEGFC; EREG, PDGFC and VEGFD; EREG,PDGFC and TGFB1; EREG, PDGFC and IL-10; EREG, PDGFC and an anti-TNFαantibody; EREG, VEGFA and VEGFB; EREG, VEGFA and VEGFC; EREG, VEGFA andVEGFD; EREG, VEGFA and TGFB1; EREG, VEGFA and IL-10; EREG, VEGFA and ananti-TNFα antibody; EREG, VEGFB and VEGFC; EREG, VEGFB and VEGFD; EREG,VEGFB and TGFB1; EREG, VEGFB and IL-10; EREG, VEGFB and an anti-TNFαantibody; EREG, VEGFC and VEGFD; EREG, VEGFC and TGFB1; EREG, VEGFC andIL-10; EREG, VEGFC and an anti-TNFα antibody; EREG, VEGFD and TGFB1;EREG, VEGFD and IL-10; EREG, VEGFD and an anti-TNFα antibody; EREG,TGFB1 and IL-10; EREG, TGFB1 and an anti-TNFα antibody; EREG, IL-10 andan anti-TNFα antibody; HBEGF, AREG and EREG; HBEGF, AREG and HGF; HBEGF,AREG and HRGB; HBEGF, AREG and BTC; HBEGF, AREG and EGF; HBEGF, AREG andTGFA; HBEGF, AREG and FGF1; HBEGF, AREG and FGF2; HBEGF, AREG and FGF4;HBEGF, AREG and FGF7; HBEGF, AREG and FGF9; HBEGF, AREG and FGF19;HBEGF, AREG and SCF; HBEGF, AREG and PDGFA; HBEGF, AREG and PDGFB;HBEGF, AREG and PDGFC; HBEGF, AREG and VEGFA; HBEGF, AREG and VEGFB;HBEGF, AREG and VEGFC; HBEGF, AREG and VEGFD; HBEGF, AREG and TGFB1;HBEGF, AREG and IL-10; HBEGF, AREG and an anti-TNFα antibody; HBEGF,EREG and HBEGF; HBEGF, EREG and HGF; HBEGF, EREG and HRGB; HBEGF, EREGand BTC; HBEGF, EREG and EGF; HBEGF, EREG and TGFA; HBEGF, EREG andFGF1; HBEGF, EREG and FGF2; HBEGF, EREG and FGF4; HBEGF, EREG and FGF7;HBEGF, EREG and FGF9; HBEGF, EREG and FGF19; HBEGF, EREG and SCF; HBEGF,EREG and PDGFA; HBEGF, EREG and PDGFB; HBEGF, EREG and PDGFC; HBEGF,EREG and VEGFA; HBEGF, EREG and VEGFB; HBEGF, EREG and VEGFC; HBEGF,EREG and VEGFD; HBEGF, EREG and TGFB1; HBEGF, EREG and IL-10; HBEGF,EREG and an anti-TNFα antibody; HBEGF, HGF and HRGB; HBEGF, HGF and BTC;HBEGF, HGF and EGF; HBEGF, HGF and TGFA; HBEGF, HGF and FGF1; HBEGF, HGFand FGF2; HBEGF, HGF and FGF4; HBEGF, HGF and FGF7; HBEGF, HGF and FGF9;HBEGF, HGF and FGF19; HBEGF, HGF and SCF; HBEGF, HGF and PDGFA; HBEGF,HGF and PDGFB; HBEGF, HGF and PDGFC; HBEGF, HGF and VEGFA; HBEGF, HGFand VEGFB; HBEGF, HGF and VEGFC; HBEGF, HGF and VEGFD; HBEGF, HGF andTGFB1; HBEGF, HGF and IL-10; HBEGF, HGF and an anti-TNFα antibody;HBEGF, HRGB and BTC; HBEGF, HRGB and EGF; HBEGF, HRGB and TGFA; HBEGF,HRGB and FGF1; HBEGF, HRGB and FGF2; HBEGF, HRGB and FGF4; HBEGF, HRGBand FGF7; HBEGF, HRGB and FGF9; HBEGF, HRGB and FGF19; HBEGF, HRGB andSCF; HBEGF, HRGB and PDGFA; HBEGF, HRGB and PDGFB; HBEGF, HRGB andPDGFC; HBEGF, HRGB and VEGFA; HBEGF, HRGB and VEGFB; HBEGF, HRGB andVEGFC; HBEGF, HRGB and VEGFD; HBEGF, HRGB and TGFB1; HBEGF, HRGB andIL-10; HBEGF, HRGB and an anti-TNFα antibody; HBEGF, BTC and EGF; HBEGF,BTC and TGFA; HBEGF, BTC and FGF1; HBEGF, BTC and FGF2; HBEGF, BTC andFGF4; HBEGF, BTC and FGF7; HBEGF, BTC and FGF9; HBEGF, BTC and FGF19;HBEGF, BTC and SCF; HBEGF, BTC and PDGFA; HBEGF, BTC and PDGFB; HBEGF,BTC and PDGFC; HBEGF, BTC and VEGFA; HBEGF, BTC and VEGFB; HBEGF, BTCand VEGFC; HBEGF, BTC and VEGFD; HBEGF, BTC and TGFB1; HBEGF, BTC andIL-10; HBEGF, BTC and an anti-TNFα antibody; HBEGF, EGF and TGFA; HBEGF,EGF and FGF1; HBEGF, EGF and FGF2; HBEGF, EGF and FGF4; HBEGF, EGF andFGF7; HBEGF, EGF and FGF9; HBEGF, EGF and FGF19; HBEGF, EGF and SCF;HBEGF, EGF and PDGFA; HBEGF, EGF and PDGFB; HBEGF, EGF and PDGFC; HBEGF,EGF and VEGFA; HBEGF, EGF and VEGFB; HBEGF, EGF and VEGFC; HBEGF, EGFand VEGFD; HBEGF, EGF and TGFB1; HBEGF, EGF and IL-10; HBEGF, EGF and ananti-TNFα antibody; HBEGF, TGFA and FGF1; HBEGF, TGFA and FGF2; HBEGF,TGFA and FGF4; HBEGF, TGFA and FGF7; HBEGF, TGFA and FGF9; HBEGF, TGFAand FGF19; HBEGF, TGFA and SCF; HBEGF, TGFA and PDGFA; HBEGF, TGFA andPDGFB; HBEGF, TGFA and PDGFC; HBEGF, TGFA and VEGFA; HBEGF, TGFA andVEGFB; HBEGF, TGFA and VEGFC; HBEGF, TGFA and VEGFD; HBEGF, TGFA andTGFB1; HBEGF, TGFA and IL-10; HBEGF, TGFA and an anti-TNFα antibody;HBEGF, FGF1 and FGF2; HBEGF, FGF1 and FGF4; HBEGF, FGF1 and FGF7; HBEGF,FGF1 and FGF9; HBEGF, FGF1 and FGF19; HBEGF, FGF1 and SCF; HBEGF, FGF1and PDGFA; HBEGF, FGF1 and PDGFB; HBEGF, FGF1 and PDGFC; HBEGF, FGF1 andVEGFA; HBEGF, FGF1 and VEGFB; HBEGF, FGF1 and VEGFC; HBEGF, FGF1 andVEGFD; HBEGF, FGF1 and TGFB1; HBEGF, FGF1 and IL-10; HBEGF, FGF1 and ananti-TNFα antibody; HBEGF, FGF2 and FGF4; HBEGF, FGF2 and FGF7; HBEGF,FGF2 and FGF9; HBEGF, FGF2 and FGF19; HBEGF, FGF2 and SCF; HBEGF, FGF2and PDGFA; HBEGF, FGF2 and PDGFB; HBEGF, FGF2 and PDGFC; HBEGF, FGF2 andVEGFA; HBEGF, FGF2 and VEGFB; HBEGF, FGF2 and VEGFC; HBEGF, FGF2 andVEGFD; HBEGF, FGF2 and TGFB1; HBEGF, FGF2 and IL-10; HBEGF, FGF2 and ananti-TNFα antibody; HBEGF, FGF4 and FGF7; HBEGF, FGF4 and FGF9; HBEGF,FGF4 and FGF19; HBEGF, FGF4 and SCF; HBEGF, FGF4 and PDGFA; HBEGF, FGF4and PDGFB; HBEGF, FGF4 and PDGFC; HBEGF, FGF4 and VEGFA; HBEGF, FGF4 andVEGFB; HBEGF, FGF4 and VEGFC; HBEGF, FGF4 and VEGFD; HBEGF, FGF4 andTGFB1; HBEGF, FGF4 and IL-10; HBEGF, FGF4 and an anti-TNFα antibody;HBEGF, FGF7 and FGF9; HBEGF, FGF7 and FGF19; HBEGF, FGF7 and SCF; HBEGF,FGF7 and PDGFA; HBEGF, FGF7 and PDGFB; HBEGF, FGF7 and PDGFC; HBEGF,FGF7 and VEGFA; HBEGF, FGF7 and VEGFB; HBEGF, FGF7 and VEGFC; HBEGF,FGF7 and VEGFD; HBEGF, FGF7 and TGFB1; HBEGF, FGF7 and IL-10; HBEGF,FGF7 and an anti-TNFα antibody; HBEGF, FGF9 and FGF19; HBEGF, FGF9 andSCF; HBEGF, FGF9 and PDGFA; HBEGF, FGF9 and PDGFB; HBEGF, FGF9 andPDGFC; HBEGF, FGF9 and VEGFA; HBEGF, FGF9 and VEGFB; HBEGF, FGF9 andVEGFC; HBEGF, FGF9 and VEGFD; HBEGF, FGF9 and TGFB1; HBEGF, FGF9 andIL-10; HBEGF, FGF9 and an anti-TNFα antibody; HBEGF, FGF19 and SCF;HBEGF, FGF19 and PDGFA; HBEGF, FGF19 and PDGFB; HBEGF, FGF19 and PDGFC;HBEGF, FGF19 and VEGFA; HBEGF, FGF19 and VEGFB; HBEGF, FGF19 and VEGFC;HBEGF, FGF19 and VEGFD; HBEGF, FGF19 and TGFB1; HBEGF, FGF19 and IL-10;HBEGF, FGF19 and an anti-TNFα antibody; HBEGF, SCF and PDGFA; HBEGF, SCFand PDGFB; HBEGF, SCF and PDGFC; HBEGF, SCF and VEGFA; HBEGF, SCF andVEGFB; HBEGF, SCF and VEGFC; HBEGF, SCF and VEGFD; HBEGF, SCF and TGFB1;HBEGF, SCF and IL-10; HBEGF, SCF and an anti-TNFα antibody; HBEGF, PDGFAand PDGFB; HBEGF, PDGFA and PDGFC; HBEGF, PDGFA and VEGFA; HBEGF, PDGFAand VEGFB; HBEGF, PDGFA and VEGFC; HBEGF, PDGFA and VEGFD; HBEGF, PDGFAand TGFB1; HBEGF, PDGFA and IL-10; HBEGF, PDGFA and an anti-TNFαantibody; HBEGF, PDGFB and PDGFC; HBEGF, PDGFB and VEGFA; HBEGF, PDGFBand VEGFB; HBEGF, PDGFB and VEGFC; HBEGF, PDGFB and VEGFD; HBEGF, PDGFBand TGFB1; HBEGF, PDGFB and IL-10; HBEGF, PDGFB and an anti-TNFαantibody; HBEGF, PDGFC and VEGFA; HBEGF, PDGFC and VEGFB; HBEGF, PDGFCand VEGFC; HBEGF, PDGFC and VEGFD; HBEGF, PDGFC and TGFB1; HBEGF, PDGFCand IL-10; HBEGF, PDGFC and an anti-TNFα antibody; HBEGF, VEGFA andVEGFB; HBEGF, VEGFA and VEGFC; HBEGF, VEGFA and VEGFD; HBEGF, VEGFA andTGFB1; HBEGF, VEGFA and IL-10; HBEGF, VEGFA and an anti-TNFα antibody;HBEGF, VEGFB and VEGFC; HBEGF, VEGFB and VEGFD; HBEGF, VEGFB and TGFB1;HBEGF, VEGFB and IL-10; HBEGF, VEGFB and an anti-TNFα antibody; HBEGF,VEGFC and VEGFD; HBEGF, VEGFC and TGFB1; HBEGF, VEGFC and IL-10; HBEGF,VEGFC and an anti-TNFα antibody; HBEGF, VEGFD and TGFB1; HBEGF, VEGFDand IL-10; HBEGF, VEGFD and an anti-TNFα antibody; HBEGF, TGFB1 andIL-10; HBEGF, TGFB1 and an anti-TNFα antibody; HBEGF, IL-10 and ananti-TNFα antibody; HGF, AREG and EREG; HGF, AREG and HBEGF; HGF, AREGand HRGB; HGF, AREG and BTC; HGF, AREG and EGF; HGF, AREG and TGFA; HGF,AREG and FGF1; HGF, AREG and FGF2; HGF, AREG and FGF4; HGF, AREG andFGF7; HGF, AREG and FGF9; HGF, AREG and FGF19; HGF, AREG and SCF; HGF,AREG and PDGFA; HGF, AREG and PDGFB; HGF, AREG and PDGFC; HGF, AREG andVEGFA; HGF, AREG and VEGFB; HGF, AREG and VEGFC; HGF, AREG and VEGFD;HGF, AREG and TGFB1; HGF, AREG and IL-10; HGF, AREG and an anti-TNFαantibody; HGF, EREG and HBEGF; HGF, EREG and HRGB; HGF, EREG and BTC;HGF, EREG and EGF; HGF, EREG and TGFA; HGF, EREG and FGF1; HGF, EREG andFGF2; HGF, EREG and FGF4; HGF, EREG and FGF7; HGF, EREG and FGF9; HGF,EREG and FGF19; HGF, EREG and SCF; HGF, EREG and PDGFA; HGF, EREG andPDGFB; HGF, EREG and PDGFC; HGF, EREG and VEGFA; HGF, EREG and VEGFB;HGF, EREG and VEGFC; HGF, EREG and VEGFD; HGF, EREG and TGFB1; HGF, EREGand IL-10; HGF, EREG and an anti-TNFα antibody; HGF, HBEGF and HRGB;HGF, HBEGF and BTC; 00HGF, HBEGF and EGF; HGF, HBEGF and TGFA; HGF,HBEGF and FGF1; HGF, HBEGF and FGF2; HGF, HBEGF and FGF4; HGF, HBEGF andFGF7; HGF, HBEGF and FGF9; HGF, HBEGF and FGF19; HGF, HBEGF and SCF;HGF, HBEGF and PDGFA; HGF, HBEGF and PDGFB; HGF, HBEGF and PDGFC; HGF,HBEGF and VEGFA; HGF, HBEGF and VEGFB; HGF, HBEGF and VEGFC; HGF, HBEGFand VEGFD; HGF, HBEGF and TGFB1; HGF, HBEGF and IL-10; HGF, HBEGF and ananti-TNFα antibody; HGF, HRGB and BTC; HGF, HRGB and EGF; HGF, HRGB andTGFA; HGF, HRGB and FGF1; HGF, HRGB and FGF2; HGF, HRGB and FGF4; HGF,HRGB and FGF7; HGF, HRGB and FGF9; HGF, HRGB and FGF19; HGF, HRGB andSCF; HGF, HRGB and PDGFA; HGF, HRGB and PDGFB; HGF, HRGB and PDGFC; HGF,HRGB and VEGFA; HGF, HRGB and VEGFB; HGF, HRGB and VEGFC; HGF, HRGB andVEGFD; HGF, HRGB and TGFB1; HGF, HRGB and IL-10; HGF, HRGB and ananti-TNFα antibody; HGF, BTC and EGF; HGF, BTC and TGFA; HGF, BTC andFGF1; HGF, BTC and FGF2; HGF, BTC and FGF4; HGF, BTC and FGF7; HGF, BTCand FGF9; HGF, BTC and FGF19; HGF, BTC and SCF; HGF, BTC and PDGFA; HGF,BTC and PDGFB; HGF, BTC and PDGFC; HGF, BTC and VEGFA; HGF, BTC andVEGFB; HGF, BTC and VEGFC; HGF, BTC and VEGFD; HGF, BTC and TGFB1; HGF,BTC and IL-10; HGF, BTC and an anti-TNFα antibody; HGF, EGF and TGFA;HGF, EGF and FGF1; HGF, EGF and FGF2; HGF, EGF and FGF4; HGF, EGF andFGF7; HGF, EGF and FGF9; HGF, EGF and FGF19; HGF, EGF and SCF; HGF, EGFand PDGFA; HGF, EGF and PDGFB; HGF, EGF and PDGFC; HGF, EGF and VEGFA;HGF, EGF and VEGFB; HGF, EGF and VEGFC; HGF, EGF and VEGFD; HGF, EGF andTGFB1; HGF, EGF and IL-10; HGF, EGF and an anti-TNFα antibody; HGF, TGFAand FGF1; HGF, TGFA and FGF2; HGF, TGFA and FGF4; HGF, TGFA and FGF7;HGF, TGFA and FGF9; HGF, TGFA and FGF19; HGF, TGFA and SCF; HGF, TGFAand PDGFA; HGF, TGFA and PDGFB; HGF, TGFA and PDGFC; HGF, TGFA andVEGFA; HGF, TGFA and VEGFB; HGF, TGFA and VEGFC; HGF, TGFA and VEGFD;HGF, TGFA and TGFB1; HGF, TGFA and IL-10; HGF, TGFA and an anti-TNFαantibody; HGF, FGF1 and FGF2; HGF, FGF1 and FGF4; HGF, FGF1 and FGF7;HGF, FGF1 and FGF9; HGF, FGF1 and FGF19; HGF, FGF1 and SCF; HGF, FGF1and PDGFA; HGF, FGF1 and PDGFB; HGF, FGF1 and PDGFC; HGF, FGF1 andVEGFA; HGF, FGF1 and VEGFB; HGF, FGF1 and VEGFC; HGF, FGF1 and VEGFD;HGF, FGF1 and TGFB1; HGF, FGF1 and IL-10; HGF, FGF1 and an anti-TNFαantibody; HGF, FGF2 and FGF4; HGF, FGF2 and FGF7; HGF, FGF2 and FGF9;HGF, FGF2 and FGF19; HGF, FGF2 and SCF; HGF, FGF2 and PDGFA; HGF, FGF2and PDGFB; HGF, FGF2 and PDGFC; HGF, FGF2 and VEGFA; HGF, FGF2 andVEGFB; HGF, FGF2 and VEGFC; HGF, FGF2 and VEGFD; HGF, FGF2 and TGFB1;HGF, FGF2 and IL-10; HGF, FGF2 and an anti-TNFα antibody; HGF, FGF4 andFGF7; HGF, FGF4 and FGF9; HGF, FGF4 and FGF19; HGF, FGF4 and SCF; HGF,FGF4 and PDGFA; HGF, FGF4 and PDGFB; HGF, FGF4 and PDGFC; HGF, FGF4 andVEGFA; HGF, FGF4 and VEGFB; HGF, FGF4 and VEGFC; HGF, FGF4 and VEGFD;HGF, FGF4 and TGFB1; HGF, FGF4 and IL-10; HGF, FGF4 and an anti-TNFαantibody; HGF, FGF7 and FGF9; HGF, FGF7 and FGF19; HGF, FGF7 and SCF;HGF, FGF7 and PDGFA; HGF, FGF7 and PDGFB; HGF, FGF7 and PDGFC; HGF, FGF7and VEGFA; HGF, FGF7 and VEGFB; HGF, FGF7 and VEGFC; HGF, FGF7 andVEGFD; HGF, FGF7 and TGFB1; HGF, FGF7 and IL-10; HGF, FGF7 and ananti-TNFα antibody; HGF, FGF9 and FGF19; HGF, FGF9 and SCF; HGF, FGF9and PDGFA; HGF, FGF9 and PDGFB; HGF, FGF9 and PDGFC; HGF, FGF9 andVEGFA; HGF, FGF9 and VEGFB; HGF, FGF9 and VEGFC; HGF, FGF9 and VEGFD;HGF, FGF9 and TGFB1; HGF, FGF9 and IL-10; HGF, FGF9 and an anti-TNFαantibody; HGF, FGF19 and SCF; HGF, FGF19 and PDGFA; HGF, FGF19 andPDGFB; HGF, FGF19 and PDGFC; HGF, FGF19 and VEGFA; HGF, FGF19 and VEGFB;HGF, FGF19 and VEGFC; HGF, FGF19 and VEGFD; HGF, FGF19 and TGFB1; HGF,FGF19 and IL-10; HGF, FGF19 and an anti-TNFα antibody; HGF, SCF andPDGFA; HGF, SCF and PDGFB; HGF, SCF and PDGFC; HGF, SCF and VEGFA; HGF,SCF and VEGFB; HGF, SCF and VEGFC; HGF, SCF and VEGFD; HGF, SCF andTGFB1; HGF, SCF and IL-10; HGF, SCF and an anti-TNFα antibody; HGF,PDGFA and PDGFB; HGF, PDGFA and PDGFC; HGF, PDGFA and VEGFA; HGF, PDGFAand VEGFB; HGF, PDGFA and VEGFC; HGF, PDGFA and VEGFD; HGF, PDGFA andTGFB1; HGF, PDGFA and IL-10; HGF, PDGFA and an anti-TNFα antibody; HGF,PDGFB and PDGFC; HGF, PDGFB and VEGFA; HGF, PDGFB and VEGFB; HGF, PDGFBand VEGFC; HGF, PDGFB and VEGFD; HGF, PDGFB and TGFB1; HGF, PDGFB andIL-10; HGF, PDGFB and an anti-TNFα antibody; HGF, PDGFC and VEGFA; HGF,PDGFC and VEGFB; HGF, PDGFC and VEGFC; HGF, PDGFC and VEGFD; HGF, PDGFCand TGFB1; HGF, PDGFC and IL-10; HGF, PDGFC and an anti-TNFα antibody;HGF, VEGFA and VEGFB; HGF, VEGFA and VEGFC; HGF, VEGFA and VEGFD; HGF,VEGFA and TGFB1; HGF, VEGFA and IL-10; HGF, VEGFA and an anti-TNFαantibody; HGF, VEGFB and VEGFC; HGF, VEGFB and VEGFD; HGF, VEGFB andTGFB1; HGF, VEGFB and IL-10; HGF, VEGFB and an anti-TNFα antibody; HGF,VEGFC and VEGFD; HGF, VEGFC and TGFB1; HGF, VEGFC and IL-10; HGF, VEGFCand an anti-TNFα antibody; HGF, VEGFD and TGFB1; HGF, VEGFD and IL-10;HGF, VEGFD and an anti-TNFα antibody; HGF, TGFB1 and IL-10; HGF, TGFB1and an anti-TNFα antibody; HGF, IL-10 and an anti-TNFα antibody; HRGB,AREG and EREG; HRGB, AREG and HBEGF; HRGB, AREG and HGF; HRGB, AREG andBTC; HRGB, AREG and EGF; HRGB, AREG and TGFA; HRGB, AREG and FGF1; HRGB,AREG and FGF2; HRGB, AREG and FGF4; HRGB, AREG and FGF7; HRGB, AREG andFGF9; HRGB, AREG and FGF19; HRGB, AREG and SCF; HRGB, AREG and PDGFA;HRGB, AREG and PDGFB; HRGB, AREG and PDGFC; HRGB, AREG and VEGFA; HRGB,AREG and VEGFB; HRGB, AREG and VEGFC; HRGB, AREG and VEGFD; HRGB, AREGand TGFB1; HRGB, AREG and IL-10; HRGB, AREG and an anti-TNFα antibody;HRGB, EREG and HBEGF; HRGB, EREG and HGF; HRGB, EREG and BTC; HRGB, EREGand EGF; HRGB, EREG and TGFA; HRGB, EREG and FGF1; HRGB, EREG and FGF2;HRGB, EREG and FGF4; HRGB, EREG and FGF7; HRGB, EREG and FGF9; HRGB,EREG and FGF19; HRGB, EREG and SCF; HRGB, EREG and PDGFA; HRGB, EREG andPDGFB; HRGB, EREG and PDGFC; HRGB, EREG and VEGFA; HRGB, EREG and VEGFB;HRGB, EREG and VEGFC; HRGB, EREG and VEGFD; HRGB, EREG and TGFB1; HRGB,EREG and IL-10; HRGB, EREG and an anti-TNFα antibody; HRGB, HBEGF andHGF; HRGB, HBEGF and BTC; HRGB, HBEGF and EGF; HRGB, HBEGF and TGFA;HRGB, HBEGF and FGF1; HRGB, HBEGF and FGF2; HRGB, HBEGF and FGF4; HRGB,HBEGF and FGF7; HRGB, HBEGF and FGF9; HRGB, HBEGF and FGF19; HRGB, HBEGFand SCF; HRGB, HBEGF and PDGFA; HRGB, HBEGF and PDGFB; HRGB, HBEGF andPDGFC; HRGB, HBEGF and VEGFA; HRGB, HBEGF and VEGFB; HRGB, HBEGF andVEGFC; HRGB, HBEGF and VEGFD; HRGB, HBEGF and TGFB1; HRGB, HBEGF andIL-10; HRGB, HBEGF and an anti-TNFα antibody; HRGB, HGF and BTC; HRGB,HGF and EGF; HRGB, HGF and TGFA; HRGB, HGF and FGF1; HRGB, HGF and FGF2;HRGB, HGF and FGF4; HRGB, HGF and FGF7; HRGB, HGF and FGF9; HRGB, HGFand FGF19; HRGB, HGF and SCF; HRGB, HGF and PDGFA; HRGB, HGF and PDGFB;HRGB, HGF and PDGFC; HRGB, HGF and VEGFA; HRGB, HGF and VEGFB; HRGB, HGFand VEGFC; HRGB, HGF and VEGFD; HRGB, HGF and TGFB1; HRGB, HGF andIL-10; HRGB, HGF and an anti-TNFα antibody; HRGB, and an anti-TNFαantibody; HRGB, BTC and EGF; HRGB, BTC and TGFA; HRGB, BTC and FGF1;HRGB, BTC and FGF2; HRGB, BTC and FGF4; HRGB, BTC and FGF7; HRGB, BTCand FGF9; HRGB, BTC and FGF19; HRGB, BTC and SCF; HRGB, BTC and PDGFA;HRGB, BTC and PDGFB; HRGB, BTC and PDGFC; HRGB, BTC and VEGFA; HRGB, BTCand VEGFB; HRGB, BTC and VEGFC; HRGB, BTC and VEGFD; HRGB, BTC andTGFB1; HRGB, BTC and IL-10; HRGB, BTC and an anti-TNFα antibody; HRGB,EGF and TGFA; HRGB, EGF and FGF1; HRGB, EGF and FGF2; HRGB, EGF andFGF4; HRGB, EGF and FGF7; HRGB, EGF and FGF9; HRGB, EGF and FGF19; HRGB,EGF and SCF; HRGB, EGF and PDGFA; HRGB, EGF and PDGFB; HRGB, EGF andPDGFC; HRGB, EGF and VEGFA; HRGB, EGF and VEGFB; HRGB, EGF and VEGFC;HRGB, EGF and VEGFD; HRGB, EGF and TGFB1; HRGB, EGF and IL-10; HRGB, EGFand an anti-TNFα antibody; HRGB, TGFA and FGF1; HRGB, TGFA and FGF2;HRGB, TGFA and FGF4; HRGB, TGFA and FGF7; HRGB, TGFA and FGF9; HRGB,TGFA and FGF19; HRGB, TGFA and SCF; HRGB, TGFA and PDGFA; HRGB, TGFA andPDGFB; HRGB, TGFA and PDGFC; HRGB, TGFA and VEGFA; HRGB, TGFA and VEGFB;HRGB, TGFA and VEGFC; HRGB, TGFA and VEGFD; HRGB, TGFA and TGFB1; HRGB,TGFA and IL-10; HRGB, TGFA and an anti-TNFα antibody; HRGB, FGF1 andFGF2; HRGB, FGF1 and FGF4; HRGB, FGF1 and FGF7; HRGB, FGF1 and FGF9;HRGB, FGF1 and FGF19; HRGB, FGF1 and SCF; HRGB, FGF1 and PDGFA; HRGB,FGF1 and PDGFB; HRGB, FGF1 and PDGFC; HRGB, FGF1 and VEGFA; HRGB, FGF1and VEGFB; HRGB, FGF1 and VEGFC; HRGB, FGF1 and VEGFD; HRGB, FGF1 andTGFB1; HRGB, FGF1 and IL-10; HRGB, FGF1 and an anti-TNFα antibody; HRGB,FGF2 and FGF4; HRGB, FGF2 and FGF7; HRGB, FGF2 and FGF9; HRGB, FGF2 andFGF19; HRGB, FGF2 and SCF; HRGB, FGF2 and PDGFA; HRGB, FGF2 and PDGFB;HRGB, FGF2 and PDGFC; HRGB, FGF2 and VEGFA; HRGB, FGF2 and VEGFB; HRGB,FGF2 and VEGFC; HRGB, FGF2 and VEGFD; HRGB, FGF2 and TGFB1; HRGB, FGF2and IL-10; HRGB, FGF2 and an anti-TNFα antibody; HRGB, FGF4 and FGF7;HRGB, FGF4 and FGF9; HRGB, FGF4 and FGF19; HRGB, FGF4 and SCF; HRGB,FGF4 and PDGFA; HRGB, FGF4 and PDGFB; HRGB, FGF4 and PDGFC; HRGB, FGF4and VEGFA; HRGB, FGF4 and VEGFB; HRGB, FGF4 and VEGFC; HRGB, FGF4 andVEGFD; HRGB, FGF4 and TGFB1; HRGB, FGF4 and IL-10; HRGB, FGF4 and ananti-TNFα antibody; HRGB, FGF7 and FGF9; HRGB, FGF7 and FGF19; HRGB,FGF7 and SCF; HRGB, FGF7 and PDGFA; HRGB, FGF7 and PDGFB; HRGB, FGF7 andPDGFC; HRGB, FGF7 and VEGFA; HRGB, FGF7 and VEGFB; HRGB, FGF7 and VEGFC;HRGB, FGF7 and VEGFD; HRGB, FGF7 and TGFB1; HRGB, FGF7 and IL-10; HRGB,FGF7 and an anti-TNFα antibody; HRGB, FGF9 and FGF19; HRGB, FGF9 andSCF; HRGB, FGF9 and PDGFA; HRGB, FGF9 and PDGFB; HRGB, FGF9 and PDGFC;HRGB, FGF9 and VEGFA; HRGB, FGF9 and VEGFB; HRGB, FGF9 and VEGFC; HRGB,FGF9 and VEGFD; HRGB, FGF9 and TGFB1; HRGB, FGF9 and IL-10; HRGB, FGF9and an anti-TNFα antibody; HRGB, FGF19 and SCF; HRGB, FGF19 and PDGFA;HRGB, FGF19 and PDGFB; HRGB, FGF19 and PDGFC; HRGB, FGF19 and VEGFA;HRGB, FGF19 and VEGFB; HRGB, FGF19 and VEGFC; HRGB, FGF19 and VEGFD;HRGB, FGF19 and TGFB1; HRGB, FGF19 and IL-10; HRGB, FGF19 and ananti-TNFα antibody; HRGB, SCF and PDGFA; HRGB, SCF and PDGFB; HRGB, SCFand PDGFC; HRGB, SCF and VEGFA; HRGB, SCF and VEGFB; HRGB, SCF andVEGFC; HRGB, SCF and VEGFD; HRGB, SCF and TGFB1; HRGB, SCF and IL-10;HRGB, SCF and an anti-TNFα antibody; HRGB, PDGFA and PDGFB; HRGB, PDGFAand PDGFC; HRGB, PDGFA and VEGFA; HRGB, PDGFA and VEGFB; HRGB, PDGFA andVEGFC; HRGB, PDGFA and VEGFD; HRGB, PDGFA and TGFB1; HRGB, PDGFA andIL-10; HRGB, PDGFA and an anti-TNFα antibody; HRGB, PDGFB and PDGFC;HRGB, PDGFB and VEGFA; HRGB, PDGFB and VEGFB; HRGB, PDGFB and VEGFC;HRGB, PDGFB and VEGFD; HRGB, PDGFB and TGFB1; HRGB, PDGFB and IL-10;HRGB, PDGFB and an anti-TNFα antibody; HRGB, PDGFC and VEGFA; HRGB,PDGFC and VEGFB; HRGB, PDGFC and VEGFC; HRGB, PDGFC and VEGFD; HRGB,PDGFC and TGFB1; HRGB, PDGFC and IL-10; HRGB, PDGFC and an anti-TNFαantibody; HRGB, VEGFA and VEGFB; HRGB, VEGFA and VEGFC; HRGB, VEGFA andVEGFD; HRGB, VEGFA and TGFB1; HRGB, VEGFA and IL-10; HRGB, VEGFA and ananti-TNFα antibody; HRGB, VEGFB and VEGFC; HRGB, VEGFB and VEGFD; HRGB,VEGFB and TGFB1; HRGB, VEGFB and IL-10; HRGB, VEGFB and an anti-TNFαantibody; HRGB, VEGFC and VEGFD; HRGB, VEGFC and TGFB1; HRGB, VEGFC andIL-10; HRGB, VEGFC and an anti-TNFα antibody; HRGB, VEGFD and TGFB1;HRGB, VEGFD and IL-10; HRGB, VEGFD and an anti-TNFα antibody; HRGB,TGFB1 and IL-10; HRGB, TGFB1 and an anti-TNFα antibody; HRGB, IL-10 andan anti-TNFα antibody; BTC, AREG and EREG; BTC, AREG and HBEGF; BTC,AREG and HGF; BTC, AREG and HRGB; BTC, AREG and EGF; BTC, AREG and TGFA;BTC, AREG and FGF1; BTC, AREG and FGF2; BTC, AREG and FGF4; BTC, AREGand FGF7; BTC, AREG and FGF9; BTC, AREG and FGF19; BTC, AREG and SCF;BTC, AREG and PDGFA; BTC, AREG and PDGFB; BTC, AREG and PDGFC; BTC, AREGand VEGFA; BTC, AREG and VEGFB; BTC, AREG and VEGFC; BTC, AREG andVEGFD; BTC, AREG and TGFB1; BTC, AREG and IL-10; BTC, AREG and ananti-TNFα antibody; BTC, EREG and HBEGF; BTC, EREG and HGF; BTC, EREGand HRGB; BTC, EREG and EGF; BTC, EREG and TGFA; BTC, EREG and FGF1;BTC, EREG and FGF2; BTC, EREG and FGF4; BTC, EREG and FGF7; BTC, EREGand FGF9; BTC, EREG and FGF19; BTC, EREG and SCF; 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TGFA, VEGFB and an anti-TNFα antibody; TGFA,VEGFC and VEGFD; TGFA, VEGFC and TGFB1; TGFA, VEGFC and IL-10; TGFA,VEGFC and an anti-TNFα antibody; TGFA, VEGFD and TGFB1; TGFA, VEGFD andIL-10; TGFA, VEGFD and an anti-TNFα antibody; TGFA, TGFB1 and IL-10;TGFA, TGFB1 and an anti-TNFα antibody; TGFA, IL-10 and an anti-TNFαantibody; FGF1, AREG and EREG; FGF1, AREG and HBEGF; FGF1, AREG and HGF;FGF1, AREG and HRGB; FGF1, AREG and BTC; FGF1, AREG and EGF; FGF1, AREGand TGFA; FGF1, AREG and FGF1; FGF1, AREG and FGF2; FGF1, AREG and FGF4;FGF1, AREG and FGF7; FGF1, AREG and FGF9; FGF1, AREG and FGF19; FGF1,AREG and SCF; FGF1, AREG and PDGFA; FGF1, AREG and PDGFB; FGF1, AREG andPDGFC; FGF1, AREG and VEGFA; FGF1, AREG and VEGFB; FGF1, AREG and VEGFC;FGF1, AREG and VEGFD; FGF1, AREG and TGFB1; FGF1, AREG and IL-10; FGF1,AREG and an anti-TNFα antibody; FGF1, EREG and HBEGF; FGF1, EREG andHGF; FGF1, EREG and HRGB; FGF1, EREG and BTC; FGF1, EREG and EGF; FGF1,EREG and TGFA; FGF1, EREG and FGF1; FGF1, EREG and FGF2; FGF1, EREG andFGF4; FGF1, EREG and FGF7; FGF1, EREG and FGF9; FGF1, EREG and FGF19;FGF1, EREG and SCF; FGF1, EREG and PDGFA; FGF1, EREG and PDGFB; FGF1,EREG and PDGFC; FGF1, EREG and VEGFA; FGF1, EREG and VEGFB; FGF1, EREGand VEGFC; FGF1, EREG and VEGFD; FGF1, EREG and TGFB1; FGF1, EREG andIL-10; FGF1, EREG and an anti-TNFα antibody; FGF1, HBEGF and HGF; FGF1,HBEGF and HRGB; FGF1, HBEGF and BTC; FGF1, HBEGF and EGF; FGF1, HBEGFand TGFA; FGF1, HBEGF and FGF1; FGF1, HBEGF and FGF2; FGF1, HBEGF andFGF4; FGF1, HBEGF and FGF7; FGF1, HBEGF and FGF9; FGF1, HBEGF and FGF19;FGF1, HBEGF and SCF; FGF1, HBEGF and PDGFA; FGF1, HBEGF and PDGFB; FGF1,HBEGF and PDGFC; FGF1, HBEGF and VEGFA; FGF1, HBEGF and VEGFB; FGF1,HBEGF and VEGFC; FGF1, HBEGF and VEGFD; FGF1, HBEGF and TGFB1; FGF1,HBEGF and IL-10; FGF1, HBEGF and an anti-TNFα antibody; FGF1, HGF andHRGB; FGF1, HGF and BTC; FGF1, HGF and EGF; FGF1, HGF and TGFA; FGF1,HGF and FGF2; FGF1, HGF and FGF4; FGF1, HGF and FGF7; FGF1, HGF andFGF9; FGF1, HGF and FGF19; FGF1, HGF and SCF; FGF1, HGF and PDGFA; FGF1,HGF and PDGFB; FGF1, HGF and PDGFC; FGF1, HGF and VEGFA; FGF1, HGF andVEGFB; FGF1, HGF and VEGFC; FGF1, HGF and VEGFD; FGF1, HGF and TGFB1;FGF1, HGF and IL-10; FGF1, HGF and an anti-TNFα antibody; FGF1, HRGB andBTC; FGF1, HRGB and EGF; FGF1, HRGB and TGFA; FGF1, HRGB and FGF2; FGF1,HRGB and FGF4; FGF1, HRGB and FGF7; FGF1, HRGB and FGF9; FGF1, HRGB andFGF19; FGF1, HRGB and SCF; FGF1, HRGB and PDGFA; FGF1, HRGB and PDGFB;FGF1, HRGB and PDGFC; FGF1, HRGB and VEGFA; FGF1, HRGB and VEGFB; FGF1,HRGB and VEGFC; FGF1, HRGB and VEGFD; FGF1, HRGB and TGFB1; FGF1, HRGBand IL-10; FGF1, HRGB and an anti-TNFα antibody; FGF1, BTC and EGF;FGF1, BTC and TGFA; FGF1, BTC and FGF2; FGF1, BTC and FGF4; FGF1, BTCand FGF7; FGF1, BTC and FGF9; FGF1, BTC and FGF19; FGF1, BTC and SCF;FGF1, BTC and PDGFA; FGF1, BTC and PDGFB; FGF1, BTC and PDGFC; FGF1, BTCand VEGFA; FGF1, BTC and VEGFB; FGF1, BTC and VEGFC; FGF1, BTC andVEGFD; FGF1, BTC and TGFB1; FGF1, BTC and IL-10; FGF1, BTC and ananti-TNFα antibody; FGF1, EGF and TGFA; FGF1, EGF and FGF2; FGF1, EGFand FGF4; FGF1, EGF and FGF7; FGF1, EGF and FGF9; FGF1, EGF and FGF19;FGF1, EGF and SCF; FGF1, EGF and PDGFA; FGF1, EGF and PDGFB; FGF1, EGFand PDGFC; FGF1, EGF and VEGFA; FGF1, EGF and VEGFB; FGF1, EGF andVEGFC; FGF1, EGF and VEGFD; FGF1, EGF and TGFB1; FGF1, EGF and IL-10;FGF1, EGF and an anti-TNFα antibody; FGF1, TGFA and FGF2; FGF1, TGFA andFGF4; FGF1, TGFA and FGF7; FGF1, TGFA and FGF9; FGF1, TGFA and FGF19;FGF1, TGFA and SCF; FGF1, TGFA and PDGFA; FGF1, TGFA and PDGFB; FGF1,TGFA and PDGFC; FGF1, TGFA and VEGFA; FGF1, TGFA and VEGFB; FGF1, TGFAand VEGFC; FGF1, TGFA and VEGFD; FGF1, TGFA and TGFB1; FGF1, TGFA andIL-10; FGF1, TGFA and an anti-TNFα antibody; FGF1, FGF2 and FGF4; FGF1,FGF2 and FGF7; FGF1, FGF2 and FGF9; FGF1, FGF2 and FGF19; FGF1, FGF2 andSCF; FGF1, FGF2 and PDGFA; FGF1, FGF2 and PDGFB; FGF1, FGF2 and PDGFC;FGF1, FGF2 and VEGFA; FGF1, FGF2 and VEGFB; FGF1, FGF2 and VEGFC; FGF1,FGF2 and VEGFD; FGF1, FGF2 and TGFB1; FGF1, FGF2 and IL-10; FGF1, FGF2and an anti-TNFα antibody; FGF1, FGF4 and FGF7; FGF1, FGF4 and FGF9;FGF1, FGF4 and FGF19; FGF1, FGF4 and SCF; FGF1, FGF4 and PDGFA; FGF1,FGF4 and PDGFB; FGF1, FGF4 and PDGFC; FGF1, FGF4 and VEGFA; FGF1, FGF4and VEGFB; FGF1, FGF4 and VEGFC; FGF1, FGF4 and VEGFD; FGF1, FGF4 andTGFB1; FGF1, FGF4 and IL-10; FGF1, FGF4 and an anti-TNFα antibody; FGF1,FGF7 and FGF9; FGF1, FGF7 and FGF19; FGF1, FGF7 and SCF; FGF1, FGF7 andPDGFA; FGF1, FGF7 and PDGFB; FGF1, FGF7 and PDGFC; FGF1, FGF7 and VEGFA;FGF1, FGF7 and VEGFB; FGF1, FGF7 and VEGFC; FGF1, FGF7 and VEGFD; FGF1,FGF7 and TGFB1; FGF1, FGF7 and IL-10; FGF1, FGF7 and an anti-TNFαantibody; FGF1, FGF9 and FGF19; FGF1, FGF9 and SCF; FGF1, FGF9 andPDGFA; FGF1, FGF9 and PDGFB; FGF1, FGF9 and PDGFC; FGF1, FGF9 and VEGFA;FGF1, FGF9 and VEGFB; FGF1, FGF9 and VEGFC; FGF1, FGF9 and VEGFD; FGF1,FGF9 and TGFB1; FGF1, FGF9 and IL-10; FGF1, FGF9 and an anti-TNFαantibody; FGF1, FGF19 and SCF; FGF1, FGF19 and PDGFA; FGF1, FGF19 andPDGFB; FGF1, FGF19 and PDGFC; FGF1, FGF19 and VEGFA; FGF1, FGF19 andVEGFB; FGF1, FGF19 and VEGFC; FGF1, FGF19 and VEGFD; FGF1, FGF19 andTGFB1; FGF1, FGF19 and IL-10; FGF1, FGF19 and an anti-TNFα antibody;FGF1, SCF and PDGFA; FGF1, SCF and PDGFB; FGF1, SCF and PDGFC; FGF1, SCFand VEGFA; FGF1, SCF and VEGFB; FGF1, SCF and VEGFC; FGF1, SCF andVEGFD; FGF1, SCF and TGFB1; FGF1, SCF and IL-10; FGF1, SCF and ananti-TNFα antibody; FGF1, PDGFA and PDGFB; FGF1, PDGFA and PDGFC; FGF1,PDGFA and VEGFA; FGF1, PDGFA and VEGFB; FGF1, PDGFA and VEGFC; FGF1,PDGFA and VEGFD; FGF1, PDGFA and TGFB1; FGF1, PDGFA and IL-10; FGF1,PDGFA and an anti-TNFα antibody; FGF1, PDGFB and PDGFC; FGF1, PDGFB andVEGFA; FGF1, PDGFB and VEGFB; FGF1, PDGFB and VEGFC; FGF1, PDGFB andVEGFD; FGF1, PDGFB and TGFB1; FGF1, PDGFB and IL-10; FGF1, PDGFB and ananti-TNFα antibody; FGF1, PDGFC and VEGFA; FGF1, PDGFC and VEGFB; FGF1,PDGFC and VEGFC; FGF1, PDGFC and VEGFD; FGF1, PDGFC and TGFB1; FGF1,PDGFC and IL-10; FGF1, PDGFC and an anti-TNFα antibody; FGF1, VEGFA andVEGFB; FGF1, VEGFA and VEGFC; FGF1, VEGFA and VEGFD; FGF1, VEGFA andTGFB1; FGF1, VEGFA and IL-10; FGF1, VEGFA and an anti-TNFα antibody;FGF1, VEGFB and VEGFC; FGF1, VEGFB and VEGFD; FGF1, VEGFB and TGFB1;FGF1, VEGFB and IL-10; FGF1, VEGFB and an anti-TNFα antibody; FGF1,VEGFC and VEGFD; FGF1, VEGFC and TGFB1; FGF1, VEGFC and IL-10; FGF1,VEGFC and an anti-TNFα antibody; FGF1, VEGFD and TGFB1; FGF1, VEGFD andIL-10; FGF1, VEGFD and an anti-TNFα antibody; FGF1, TGFB1 and IL-10;FGF1, TGFB1 and an anti-TNFα antibody; FGF1, IL-10 and an anti-TNFαantibody; FGF2, AREG and EREG; FGF2, AREG and HBEGF; FGF2, AREG and HGF;FGF2, AREG and HRGB; FGF2, AREG and BTC; FGF2, AREG and EGF; FGF2, AREGand TGFA; FGF2, AREG and FGF1; FGF2, AREG and FGF4; FGF2, AREG and FGF7;FGF2, AREG and FGF9; FGF2, AREG and FGF19; FGF2, AREG and SCF; FGF2,AREG and PDGFA; FGF2, AREG and PDGFB; FGF2, AREG and PDGFC; FGF2, AREGand VEGFA; FGF2, AREG and VEGFB; FGF2, AREG and VEGFC; FGF2, AREG andVEGFD; FGF2, AREG and TGFB1; FGF2, AREG and IL-10; FGF2, AREG and ananti-TNFα antibody; FGF2, EREG and HBEGF; FGF2, EREG and HGF; FGF2, EREGand HRGB; FGF2, EREG and BTC; FGF2, EREG and EGF; FGF2, EREG and TGFA;FGF2, EREG and FGF1; FGF2, EREG and FGF4; FGF2, EREG and FGF7; FGF2,EREG and FGF9; FGF2, EREG and FGF19; FGF2, EREG and SCF; FGF2, EREG andPDGFA; FGF2, EREG and PDGFB; FGF2, EREG and PDGFC; FGF2, EREG and VEGFA;FGF2, EREG and VEGFB; FGF2, EREG and VEGFC; FGF2, EREG and VEGFD; FGF2,EREG and TGFB1; FGF2, EREG and IL-10; FGF2, EREG and an anti-TNFαantibody; FGF2, HBEGF and HGF; FGF2, HBEGF and HRGB; FGF2, HBEGF andBTC; FGF2, HBEGF and EGF; FGF2, HBEGF and TGFA; FGF2, HBEGF and FGF1;FGF2, HBEGF and FGF4; FGF2, HBEGF and FGF7; FGF2, HBEGF and FGF9; FGF2,HBEGF and FGF19; FGF2, HBEGF and SCF; FGF2, HBEGF and PDGFA; FGF2, HBEGFand PDGFB; FGF2, HBEGF and PDGFC; FGF2, HBEGF and VEGFA; FGF2, HBEGF andVEGFB; FGF2, HBEGF and VEGFC; FGF2, HBEGF and VEGFD; FGF2, HBEGF andTGFB1; FGF2, HBEGF and IL-10; FGF2, HBEGF and an anti-TNFα antibody;FGF2, HGF and HRGB; FGF2, HGF and BTC; FGF2, HGF and EGF; FGF2, HGF andTGFA; FGF2, HGF and FGF1; FGF2, HGF and FGF4; FGF2, HGF and FGF7; FGF2,HGF and FGF9; FGF2, HGF and FGF19; FGF2, HGF and SCF; FGF2, HGF andPDGFA; FGF2, HGF and PDGFB; FGF2, HGF and PDGFC; FGF2, HGF and VEGFA;FGF2, HGF and VEGFB; FGF2, HGF and VEGFC; FGF2, HGF and VEGFD; FGF2, HGFand TGFB1; FGF2, HGF and IL-10; FGF2, HGF and an anti-TNFα antibody;FGF2, HRGB and BTC; FGF2, HRGB and EGF; FGF2, HRGB and TGFA; FGF2, HRGBand FGF1; FGF2, HRGB and FGF4; FGF2, HRGB and FGF7; FGF2, HRGB and FGF9;FGF2, HRGB and FGF19; FGF2, HRGB and SCF; FGF2, HRGB and PDGFA; FGF2,HRGB and PDGFB; FGF2, HRGB and PDGFC; FGF2, HRGB and VEGFA; FGF2, HRGBand VEGFB; FGF2, HRGB and VEGFC; FGF2, HRGB and VEGFD; FGF2, HRGB andTGFB1; FGF2, HRGB and IL-10; FGF2, HRGB and an anti-TNFα antibody; FGF2,BTC and EGF; FGF2, BTC and TGFA; FGF2, BTC and FGF1; FGF2, BTC and FGF4;FGF2, BTC and FGF7; FGF2, BTC and FGF9; FGF2, BTC and FGF19; FGF2, BTCand SCF; FGF2, BTC and PDGFA; FGF2, BTC and PDGFB; FGF2, BTC and PDGFC;FGF2, BTC and VEGFA; FGF2, BTC and VEGFB; FGF2, BTC and VEGFC; FGF2, BTCand VEGFD; FGF2, BTC and TGFB1; FGF2, BTC and IL-10; FGF2, BTC and ananti-TNFα antibody; FGF2, EGF and TGFA; FGF2, EGF and FGF1; FGF2, EGFand FGF4; FGF2, EGF and FGF7; FGF2, EGF and FGF9; FGF2, EGF and FGF19;FGF2, EGF and SCF; FGF2, EGF and PDGFA; FGF2, EGF and PDGFB; FGF2, EGFand PDGFC; FGF2, EGF and VEGFA; FGF2, EGF and VEGFB; FGF2, EGF andVEGFC; FGF2, EGF and VEGFD; FGF2, EGF and TGFB1; FGF2, EGF and IL-10;FGF2, EGF and an anti-TNFα antibody; FGF2, TGFA and FGF1; FGF2, TGFA andFGF4; FGF2, TGFA and FGF7; FGF2, TGFA and FGF9; FGF2, TGFA and FGF19;FGF2, TGFA and SCF; FGF2, TGFA and PDGFA; FGF2, TGFA and PDGFB; FGF2,TGFA and PDGFC; FGF2, TGFA and VEGFA; FGF2, TGFA and VEGFB; FGF2, TGFAand VEGFC; FGF2, TGFA and VEGFD; FGF2, TGFA and TGFB1; FGF2, TGFA andIL-10; FGF2, TGFA and an anti-TNFα antibody; FGF2, FGF1 and FGF4; FGF2,FGF1 and FGF7; FGF2, FGF1 and FGF9; FGF2, FGF1 and FGF19; FGF2, FGF1 andSCF; FGF2, FGF1 and PDGFA; FGF2, FGF1 and PDGFB; FGF2, FGF1 and PDGFC;FGF2, FGF1 and VEGFA; FGF2, FGF1 and VEGFB; FGF2, FGF1 and VEGFC; FGF2,FGF1 and VEGFD; FGF2, FGF1 and TGFB1; FGF2, FGF1 and IL-10; FGF2, FGF1and an anti-TNFα antibody; FGF2, FGF4 and FGF7; FGF2, FGF4 and FGF9;FGF2, FGF4 and FGF19; FGF2, FGF4 and SCF; FGF2, FGF4 and PDGFA; FGF2,FGF4 and PDGFB; FGF2, FGF4 and PDGFC; FGF2, FGF4 and VEGFA; FGF2, FGF4and VEGFB; FGF2, FGF4 and VEGFC; FGF2, FGF4 and VEGFD; FGF2, FGF4 andTGFB1; FGF2, FGF4 and IL-10; FGF2, FGF4 and an anti-TNFα antibody; FGF2,FGF7 and FGF9; FGF2, FGF7 and FGF19; FGF2, FGF7 and SCF; FGF2, FGF7 andPDGFA; FGF2, FGF7 and PDGFB; FGF2, FGF7 and PDGFC; FGF2, FGF7 and VEGFA;FGF2, FGF7 and VEGFB; FGF2, FGF7 and VEGFC; FGF2, FGF7 and VEGFD; FGF2,FGF7 and TGFB1; FGF2, FGF7 and IL-10; FGF2, FGF7 and an anti-TNFαantibody; FGF2, FGF9 and FGF19; FGF2, FGF9 and SCF; FGF2, FGF9 andPDGFA; FGF2, FGF9 and PDGFB; FGF2, FGF9 and PDGFC; FGF2, FGF9 and VEGFA;FGF2, FGF9 and VEGFB; FGF2, FGF9 and VEGFC; FGF2, FGF9 and VEGFD; FGF2,FGF9 and TGFB1; FGF2, FGF9 and IL-10; FGF2, FGF9 and an anti-TNFαantibody; FGF2, FGF19 and SCF; FGF2, FGF19 and PDGFA; FGF2, FGF19 andPDGFB; FGF2, FGF19 and PDGFC; FGF2, FGF19 and VEGFA; FGF2, FGF19 andVEGFB; FGF2, FGF19 and VEGFC; FGF2, FGF19 and VEGFD; FGF2, FGF19 andTGFB1; FGF2, FGF19 and IL-10; FGF2, FGF19 and an anti-TNFα antibody;FGF2, SCF and PDGFA; FGF2, SCF and PDGFB; FGF2, SCF and PDGFC; FGF2, SCFand VEGFA; FGF2, SCF and VEGFB; FGF2, SCF and VEGFC; FGF2, SCF andVEGFD; FGF2, SCF and TGFB1; FGF2, SCF and IL-10; FGF2, SCF and ananti-TNFα antibody; FGF2, PDGFA and PDGFB; FGF2, PDGFA and PDGFC; FGF2,PDGFA and VEGFA; FGF2, PDGFA and VEGFB; FGF2, PDGFA and VEGFC; FGF2,PDGFA and VEGFD; FGF2, PDGFA and TGFB1; FGF2, PDGFA and IL-10; FGF2,PDGFA and an anti-TNFα antibody; FGF2, PDGFB and PDGFC; FGF2, PDGFB andVEGFA; FGF2, PDGFB and VEGFB; FGF2, PDGFB and VEGFC; FGF2, PDGFB andVEGFD; FGF2, PDGFB and TGFB1; FGF2, PDGFB and IL-10; FGF2, PDGFB and ananti-TNFα antibody; FGF2, PDGFC and VEGFA; FGF2, PDGFC and VEGFB; FGF2,PDGFC and VEGFC; FGF2, PDGFC and VEGFD; FGF2, PDGFC and TGFB1; FGF2,PDGFC and IL-10; FGF2, PDGFC and an anti-TNFα antibody; FGF2, VEGFA andVEGFB; FGF2, VEGFA and VEGFC; FGF2, VEGFA and VEGFD; FGF2, VEGFA andTGFB1; FGF2, VEGFA and IL-10; FGF2, VEGFA and an anti-TNFα antibody;FGF2, VEGFB and VEGFC; FGF2, VEGFB and VEGFD; FGF2, VEGFB and TGFB1;FGF2, VEGFB and IL-10; FGF2, VEGFB and an anti-TNFα antibody; FGF2,VEGFC and VEGFD; FGF2, VEGFC and TGFB1; FGF2, VEGFC and IL-10; FGF2,VEGFC and an anti-TNFα antibody; FGF2, VEGFD and TGFB1; FGF2, VEGFD andIL-10; FGF2, VEGFD and an anti-TNFα antibody; FGF2, TGFB1 and IL-10;FGF2, TGFB1 and an anti-TNFα antibody; FGF2, IL-10 and an anti-TNFαantibody; FGF4, AREG and EREG; FGF4, AREG and HBEGF; FGF4, AREG and HGF;FGF4, AREG and HRGB; FGF4, AREG and BTC; FGF4, AREG and EGF; FGF4, AREGand TGFA; FGF4, AREG and FGF1; FGF4, AREG and FGF2; FGF4, AREG and FGF4;FGF4, AREG and FGF7; FGF4, AREG and FGF9; FGF4, AREG and FGF19; FGF4,AREG and SCF; FGF4, AREG and PDGFA; FGF4, AREG and PDGFB; FGF4, AREG andPDGFC; FGF4, AREG and VEGFA; FGF4, AREG and VEGFB; FGF4, AREG and VEGFC;FGF4, AREG and VEGFD; FGF4, AREG and TGFB1; FGF4, AREG and IL-10; FGF4,AREG and an anti-TNFα antibody; FGF4, EREG and HBEGF; FGF4, EREG andHGF; FGF4, EREG and HRGB; FGF4, EREG and BTC; FGF4, EREG and EGF; FGF4,EREG and TGFA; FGF4, EREG and FGF1; FGF4, EREG and FGF2; FGF4, EREG andFGF7; FGF4, EREG and FGF9; FGF4, EREG and FGF19; FGF4, EREG and SCF;FGF4, EREG and PDGFA; FGF4, EREG and PDGFB; FGF4, EREG and PDGFC; FGF4,EREG and VEGFA; FGF4, EREG and VEGFB; FGF4, EREG and VEGFC; FGF4, EREGand VEGFD; FGF4, EREG and TGFB1; FGF4, EREG and IL-10; FGF4, EREG and ananti-TNFα antibody; FGF4, HBEGF and HGF; FGF4, HBEGF and HRGB; FGF4,HBEGF and BTC; FGF4, HBEGF and EGF; FGF4, HBEGF and TGFA; FGF4, HBEGFand FGF1; FGF4, HBEGF and FGF2; FGF4, HBEGF and FGF7; FGF4, HBEGF andFGF9; FGF4, HBEGF and FGF19; FGF4, HBEGF and SCF; FGF4, HBEGF and PDGFA;FGF4, HBEGF and PDGFB; FGF4, HBEGF and PDGFC; FGF4, HBEGF and VEGFA;FGF4, HBEGF and VEGFB; FGF4, HBEGF and VEGFC; FGF4, HBEGF and VEGFD;FGF4, HBEGF and TGFB1; FGF4, HBEGF and IL-10; FGF4, HBEGF and ananti-TNFα antibody; FGF4, HGF and HRGB; FGF4, HGF and BTC; FGF4, HGF andEGF; FGF4, HGF and TGFA; FGF4, HGF and FGF1; FGF4, HGF and FGF2; FGF4,HGF and FGF7; FGF4, HGF and FGF9; FGF4, HGF and FGF19; FGF4, HGF andSCF; FGF4, HGF and PDGFA; FGF4, HGF and PDGFB; FGF4, HGF and PDGFC;FGF4, HGF and VEGFA; FGF4, HGF and VEGFB; FGF4, HGF and VEGFC; FGF4, HGFand VEGFD; FGF4, HGF and TGFB1; FGF4, HGF and IL-10; FGF4, HGF and ananti-TNFα antibody; FGF4, HRGB and BTC; FGF4, HRGB and EGF; FGF4, HRGBand TGFA; FGF4, HRGB and FGF1; FGF4, HRGB and FGF2; FGF4, HRGB and FGF7;FGF4, HRGB and FGF9; FGF4, HRGB and FGF19; FGF4, HRGB and SCF; FGF4,HRGB and PDGFA; FGF4, HRGB and PDGFB; FGF4, HRGB and PDGFC; FGF4, HRGBand VEGFA; FGF4, HRGB and VEGFB; FGF4, HRGB and VEGFC; FGF4, HRGB andVEGFD; FGF4, HRGB and TGFB1; FGF4, HRGB and IL-10; FGF4, HRGB and ananti-TNFα antibody; FGF4, BTC and EGF; FGF4, BTC and TGFA; FGF4, BTC andFGF1; FGF4, BTC and FGF2; FGF4, BTC and FGF7; FGF4, BTC and FGF9; FGF4,BTC and FGF19; FGF4, BTC and SCF; FGF4, BTC and PDGFA; FGF4, BTC andPDGFB; FGF4, BTC and PDGFC; FGF4, BTC and VEGFA; FGF4, BTC and VEGFB;FGF4, BTC and VEGFC; FGF4, BTC and VEGFD; FGF4, BTC and TGFB1; FGF4, BTCand IL-10; FGF4, BTC and an anti-TNFα antibody; FGF4, EGF and TGFA;FGF4, EGF and FGF1; FGF4, EGF and FGF2; FGF4, EGF and FGF7; FGF4, EGFand FGF9; FGF4, EGF and FGF19; FGF4, EGF and SCF; FGF4, EGF and PDGFA;FGF4, EGF and PDGFB; FGF4, EGF and PDGFC; FGF4, EGF and VEGFA; FGF4, EGFand VEGFB; FGF4, EGF and VEGFC; FGF4, EGF and VEGFD; FGF4, EGF andTGFB1; FGF4, EGF and IL-10; FGF4, EGF and an anti-TNFα antibody; FGF4,TGFA and FGF1; FGF4, TGFA and FGF2; FGF4, TGFA and FGF7; FGF4, TGFA andFGF9; FGF4, TGFA and FGF19; FGF4, TGFA and SCF; FGF4, TGFA and PDGFA;FGF4, TGFA and PDGFB; FGF4, TGFA and PDGFC; FGF4, TGFA and VEGFA; FGF4,TGFA and VEGFB; FGF4, TGFA and VEGFC; FGF4, TGFA and VEGFD; FGF4, TGFAand TGFB1; FGF4, TGFA and IL-10; FGF4, TGFA and an anti-TNFα antibody;FGF4, FGF1 and FGF2; FGF4, FGF1 and FGF7; FGF4, FGF1 and FGF9; FGF4,FGF1 and FGF19; FGF4, FGF1 and SCF; FGF4, FGF1 and PDGFA; FGF4, FGF1 andPDGFB; FGF4, FGF1 and PDGFC; FGF4, FGF1 and VEGFA; FGF4, FGF1 and VEGFB;FGF4, FGF1 and VEGFC; FGF4, FGF1 and VEGFD; FGF4, FGF1 and TGFB1; FGF4,FGF1 and IL-10; FGF4, FGF1 and an anti-TNFα antibody; FGF4, FGF2 andFGF7; FGF4, FGF2 and FGF9; FGF4, FGF2 and FGF19; FGF4, FGF2 and SCF;FGF4, FGF2 and PDGFA; FGF4, FGF2 and PDGFB; FGF4, FGF2 and PDGFC; FGF4,FGF2 and VEGFA; FGF4, FGF2 and VEGFB; FGF4, FGF2 and VEGFC; FGF4, FGF2and VEGFD; FGF4, FGF2 and TGFB1; FGF4, FGF2 and IL-10; FGF4, FGF2 and ananti-TNFα antibody; FGF4, FGF7 and FGF9; FGF4, FGF7 and FGF19; FGF4,FGF7 and SCF; FGF4, FGF7 and PDGFA; FGF4, FGF7 and PDGFB; FGF4, FGF7 andPDGFC; FGF4, FGF7 and VEGFA; FGF4, FGF7 and VEGFB; FGF4, FGF7 and VEGFC;FGF4, FGF7 and VEGFD; FGF4, FGF7 and TGFB1; FGF4, FGF7 and IL-10; FGF4,FGF7 and an anti-TNFα antibody; FGF4, FGF9 and FGF19; FGF4, FGF9 andSCF; FGF4, FGF9 and PDGFA; FGF4, FGF9 and PDGFB; FGF4, FGF9 and PDGFC;FGF4, FGF9 and VEGFA; FGF4, FGF9 and VEGFB; FGF4, FGF9 and VEGFC; FGF4,FGF9 and VEGFD; FGF4, FGF9 and TGFB1; FGF4, FGF9 and IL-10; FGF4, FGF9and an anti-TNFα antibody; FGF4, FGF19 and SCF; FGF4, FGF19 and PDGFA;FGF4, FGF19 and PDGFB; FGF4, FGF19 and PDGFC; FGF4, FGF19 and VEGFA;FGF4, FGF19 and VEGFB; FGF4, FGF19 and VEGFC; FGF4, FGF19 and VEGFD;FGF4, FGF19 and TGFB1; FGF4, FGF19 and IL-10; FGF4, FGF19 and ananti-TNFα antibody; FGF4, SCF and PDGFA; FGF4, SCF and PDGFB; FGF4, SCFand PDGFC; FGF4, SCF and VEGFA; FGF4, SCF and VEGFB; FGF4, SCF andVEGFC; FGF4, SCF and VEGFD; FGF4, SCF and TGFB1; FGF4, SCF and IL-10;FGF4, SCF and an anti-TNFα antibody; FGF4, PDGFA and PDGFB; FGF4, PDGFAand PDGFC; FGF4, PDGFA and VEGFA; FGF4, PDGFA and VEGFB; FGF4, PDGFA andVEGFC; FGF4, PDGFA and VEGFD; FGF4, PDGFA and TGFB1; FGF4, PDGFA andIL-10; FGF4, PDGFA and an anti-TNFα antibody; FGF4, PDGFB and PDGFC;FGF4, PDGFB and VEGFA; FGF4, PDGFB and VEGFB; FGF4, PDGFB and VEGFC;FGF4, PDGFB and VEGFD; FGF4, PDGFB and TGFB1; FGF4, PDGFB and IL-10;FGF4, PDGFB and an anti-TNFα antibody; FGF4, PDGFC and VEGFA; FGF4,PDGFC and VEGFB; FGF4, PDGFC and VEGFC; FGF4, PDGFC and VEGFD; FGF4,PDGFC and TGFB1; FGF4, PDGFC and IL-10; FGF4, PDGFC and an anti-TNFαantibody; FGF4, VEGFA and VEGFB; FGF4, VEGFA and VEGFC; FGF4, VEGFA andVEGFD; FGF4, VEGFA and TGFB1; FGF4, VEGFA and IL-10; FGF4, VEGFA and ananti-TNFα antibody; FGF4, VEGFB and VEGFC; FGF4, VEGFB and VEGFD; FGF4,VEGFB and TGFB1; FGF4, VEGFB and IL-10; FGF4, VEGFB and an anti-TNFαantibody; FGF4, VEGFC and VEGFD; FGF4, VEGFC and TGFB1; FGF4, VEGFC andIL-10; FGF4, VEGFC and an anti-TNFα antibody; FGF4, VEGFD and TGFB1;FGF4, VEGFD and IL-10; FGF4, VEGFD and an anti-TNFα antibody; FGF4,TGFB1 and IL-10; FGF4, TGFB1 and an anti-TNFα antibody; FGF4, IL-10 andan anti-TNFα antibody; FGF7, AREG and EREG; FGF7, AREG and HBEGF; FGF7,AREG and HGF; FGF7, AREG and HRGB; FGF7, AREG and BTC; FGF7, AREG andEGF; FGF7, AREG and TGFA; FGF7, AREG and FGF1; FGF7, AREG and FGF2;FGF7, AREG and FGF4; FGF7, AREG and FGF9; FGF7, AREG and FGF19; FGF7,AREG and SCF; FGF7, AREG and PDGFA; FGF7, AREG and PDGFB; FGF7, AREG andPDGFC; FGF7, AREG and VEGFA; FGF7, AREG and VEGFB; FGF7, AREG and VEGFC;FGF7, AREG and VEGFD; FGF7, AREG and TGFB1; FGF7, AREG and IL-10; FGF7,AREG and an anti-TNFα antibody; FGF7, EREG and HBEGF; FGF7, EREG andHGF; FGF7, EREG and HRGB; FGF7, EREG and BTC; FGF7, EREG and EGF; FGF7,EREG and TGFA; FGF7, EREG and FGF1; FGF7, EREG and FGF2; FGF7, EREG andFGF4; FGF7, EREG and FGF9; FGF7, EREG and FGF19; FGF7, EREG and SCF;FGF7, EREG and PDGFA; FGF7, EREG and PDGFB; FGF7, EREG and PDGFC; FGF7,EREG and VEGFA; FGF7, EREG and VEGFB; FGF7, EREG and VEGFC; FGF7, EREGand VEGFD; FGF7, EREG and TGFB1; FGF7, EREG and IL-10; FGF7, EREG and ananti-TNFα antibody; FGF7, HBEGF and HGF; FGF7, HBEGF and HRGB; FGF7,HBEGF and BTC; FGF7, HBEGF and EGF; FGF7, HBEGF and TGFA; FGF7, HBEGFand FGF1; FGF7, HBEGF and FGF2; FGF7, HBEGF and FGF4; FGF7, HBEGF andFGF9; FGF7, HBEGF and FGF19; FGF7, HBEGF and SCF; FGF7, HBEGF and PDGFA;FGF7, HBEGF and PDGFB; FGF7, HBEGF and PDGFC; FGF7, HBEGF and VEGFA;FGF7, HBEGF and VEGFB; FGF7, HBEGF and VEGFC; FGF7, HBEGF and VEGFD;FGF7, HBEGF and TGFB1; FGF7, HBEGF and IL-10; FGF7, HBEGF and ananti-TNFα antibody; FGF7, HGF and HRGB; FGF7, HGF and BTC; FGF7, HGF andEGF; FGF7, HGF and TGFA; FGF7, HGF and FGF1; FGF7, HGF and FGF2; FGF7,HGF and FGF4; FGF7, HGF and FGF9; FGF7, HGF and FGF19; FGF7, HGF andSCF; FGF7, HGF and PDGFA; FGF7, HGF and PDGFB; FGF7, HGF and PDGFC;FGF7, HGF and VEGFA; FGF7, HGF and VEGFB; FGF7, HGF and VEGFC; FGF7, HGFand VEGFD; FGF7, HGF and TGFB1; FGF7, HGF and IL-10; FGF7, HGF and ananti-TNFα antibody; FGF7, HRGB and BTC; FGF7, HRGB and EGF; FGF7, HRGBand TGFA; FGF7, HRGB and FGF1; FGF7, HRGB and FGF2; FGF7, HRGB and FGF4;FGF7, HRGB and FGF9; FGF7, HRGB and FGF19; FGF7, HRGB and SCF; FGF7,HRGB and PDGFA; FGF7, HRGB and PDGFB; FGF7, HRGB and PDGFC; FGF7, HRGBand VEGFA; FGF7, HRGB and VEGFB; FGF7, HRGB and VEGFC; FGF7, HRGB andVEGFD; FGF7, HRGB and TGFB1; FGF7, HRGB and IL-10; FGF7, HRGB and ananti-TNFα antibody; FGF7, BTC and EGF; FGF7, BTC and TGFA; FGF7, BTC andFGF1; FGF7, BTC and FGF2; FGF7, BTC and FGF4; FGF7, BTC and FGF9; FGF7,BTC and FGF19; FGF7, BTC and SCF; FGF7, BTC and PDGFA; FGF7, BTC andPDGFB; FGF7, BTC and PDGFC; FGF7, BTC and VEGFA; FGF7, BTC and VEGFB;FGF7, BTC and VEGFC; FGF7, BTC and VEGFD; FGF7, BTC and TGFB1; FGF7, BTCand IL-10; FGF7, BTC and an anti-TNFα antibody; FGF7, EGF and TGFA;FGF7, EGF and FGF1; FGF7, EGF and FGF2; FGF7, EGF and FGF4; FGF7, EGFand FGF9; FGF7, EGF and FGF19; FGF7, EGF and SCF; FGF7, EGF and PDGFA;FGF7, EGF and PDGFB; FGF7, EGF and PDGFC; FGF7, EGF and VEGFA; FGF7, EGFand VEGFB; FGF7, EGF and VEGFC; FGF7, EGF and VEGFD; FGF7, EGF andTGFB1; FGF7, EGF and IL-10; FGF7, EGF and an anti-TNFα antibody; FGF7,TGFA and FGF1; FGF7, TGFA and FGF2; FGF7, TGFA and FGF4; FGF7, TGFA andFGF9; FGF7, TGFA and FGF19; FGF7, TGFA and SCF; FGF7, TGFA and PDGFA;FGF7, TGFA and PDGFB; FGF7, TGFA and PDGFC; FGF7, TGFA and VEGFA; FGF7,TGFA and VEGFB; FGF7, TGFA and VEGFC; FGF7, TGFA and VEGFD; FGF7, TGFAand TGFB1; FGF7, TGFA and IL-10; FGF7, TGFA and an anti-TNFα antibody;FGF7, FGF1 and FGF2; FGF7, FGF1 and FGF4; FGF7, FGF1 and FGF9; FGF7,FGF1 and FGF19; FGF7, FGF1 and SCF; FGF7, FGF1 and PDGFA; FGF7, FGF1 andPDGFB; FGF7, FGF1 and PDGFC; FGF7, FGF1 and VEGFA; FGF7, FGF1 and VEGFB;FGF7, FGF1 and VEGFC; FGF7, FGF1 and VEGFD; FGF7, FGF1 and TGFB1; FGF7,FGF1 and IL-10; FGF7, FGF1 and an anti-TNFα antibody; FGF7, FGF2 andFGF4; FGF7, FGF2 and FGF9; FGF7, FGF2 and FGF19; FGF7, FGF2 and SCF;FGF7, FGF2 and PDGFA; FGF7, FGF2 and PDGFB; FGF7, FGF2 and PDGFC; FGF7,FGF2 and VEGFA; FGF7, FGF2 and VEGFB; FGF7, FGF2 and VEGFC; FGF7, FGF2and VEGFD; FGF7, FGF2 and TGFB1; FGF7, FGF2 and IL-10; FGF7, FGF2 and ananti-TNFα antibody; FGF7, FGF4 and FGF9; FGF7, FGF4 and FGF19; FGF7,FGF4 and SCF; FGF7, FGF4 and PDGFA; FGF7, FGF4 and PDGFB; FGF7, FGF4 andPDGFC; FGF7, FGF4 and VEGFA; FGF7, FGF4 and VEGFB; FGF7, FGF4 and VEGFC;FGF7, FGF4 and VEGFD; FGF7, FGF4 and TGFB1; FGF7, FGF4 and IL-10; FGF7,FGF4 and an anti-TNFα antibody; FGF7, FGF9 and FGF19; FGF7, FGF9 andSCF; FGF7, FGF9 and PDGFA; FGF7, FGF9 and PDGFB; FGF7, FGF9 and PDGFC;FGF7, FGF9 and VEGFA; FGF7, FGF9 and VEGFB; FGF7, FGF9 and VEGFC; FGF7,FGF9 and VEGFD; FGF7, FGF9 and TGFB1; FGF7, FGF9 and IL-10; FGF7, FGF9and an anti-TNFα antibody; FGF7, FGF19 and SCF; FGF7, FGF19 and PDGFA;FGF7, FGF19 and PDGFB; FGF7, FGF19 and PDGFC; FGF7, FGF19 and VEGFA;FGF7, FGF19 and VEGFB; FGF7, FGF19 and VEGFC; FGF7, FGF19 and VEGFD;FGF7, FGF19 and TGFB1; FGF7, FGF19 and IL-10; FGF7, FGF19 and ananti-TNFα antibody; FGF7, SCF and PDGFA; FGF7, SCF and PDGFB; FGF7, SCFand PDGFC; FGF7, SCF and VEGFA; FGF7, SCF and VEGFB; FGF7, SCF andVEGFC; FGF7, SCF and VEGFD; FGF7, SCF and TGFB1; FGF7, SCF and IL-10;FGF7, SCF and an anti-TNFα antibody; FGF7, PDGFA and PDGFB; FGF7, PDGFAand PDGFC; FGF7, PDGFA and VEGFA; FGF7, PDGFA and VEGFB; FGF7, PDGFA andVEGFC; FGF7, PDGFA and VEGFD; FGF7, PDGFA and TGFB1; FGF7, PDGFA andIL-10; FGF7, PDGFA and an anti-TNFα antibody; FGF7, PDGFB and PDGFC;FGF7, PDGFB and VEGFA; FGF7, PDGFB and VEGFB; FGF7, PDGFB and VEGFC;FGF7, PDGFB and VEGFD; FGF7, PDGFB and TGFB1; FGF7, PDGFB and IL-10;FGF7, PDGFB and an anti-TNFα antibody; FGF7, PDGFC and VEGFA; FGF7,PDGFC and VEGFB; FGF7, PDGFC and VEGFC; FGF7, PDGFC and VEGFD; FGF7,PDGFC and TGFB1; FGF7, PDGFC and IL-10; FGF7, PDGFC and an anti-TNFαantibody; FGF7, VEGFA and VEGFB; FGF7, VEGFA and VEGFC; FGF7, VEGFA andVEGFD; FGF7, VEGFA and TGFB1; FGF7, VEGFA and IL-10; FGF7, VEGFA and ananti-TNFα antibody; FGF7, VEGFB and VEGFC; FGF7, VEGFB and VEGFD; FGF7,VEGFB and TGFB1; FGF7, VEGFB and IL-10; FGF7, VEGFB and an anti-TNFαantibody; FGF7, VEGFC and VEGFD; FGF7, VEGFC and TGFB1; FGF7, VEGFC andIL-10; FGF7, VEGFC and an anti-TNFα antibody; FGF7, VEGFD and TGFB1;FGF7, VEGFD and IL-10; FGF7, VEGFD and an anti-TNFα antibody; FGF7,TGFB1 and IL-10; FGF7, TGFB1 and an anti-TNFα antibody; FGF7, IL-10 andan anti-TNFα antibody; FGF9, AREG and EREG; FGF9, AREG and HBEGF; FGF9,AREG and HGF; FGF9, AREG and HRGB; FGF9, AREG and BTC; FGF9, AREG andEGF; FGF9, AREG and TGFA; FGF9, AREG and FGF1; FGF9, AREG and FGF2;FGF9, AREG and FGF4; FGF9, AREG and FGF7; FGF9, AREG and FGF19; FGF9,AREG and SCF; FGF9, AREG and PDGFA; FGF9, AREG and PDGFB; FGF9, AREG andPDGFC; FGF9, AREG and VEGFA; FGF9, AREG and VEGFB; FGF9, AREG and VEGFC;FGF9, AREG and VEGFD; FGF9, AREG and TGFB1; FGF9, AREG and IL-10; FGF9,AREG and an anti-TNFα antibody; FGF9, EREG and HBEGF; FGF9, EREG andHGF; FGF9, EREG and HRGB; FGF9, EREG and BTC; FGF9, EREG and EGF; FGF9,EREG and TGFA; FGF9, EREG and FGF1; FGF9, EREG and FGF2; FGF9, EREG andFGF4; FGF9, EREG and FGF7; FGF9, EREG and FGF19; FGF9, EREG and SCF;FGF9, EREG and PDGFA; FGF9, EREG and PDGFB; FGF9, EREG and PDGFC; FGF9,EREG and VEGFA; FGF9, EREG and VEGFB; FGF9, EREG and VEGFC; FGF9, EREGand VEGFD; FGF9, EREG and TGFB1; FGF9, EREG and IL-10; FGF9, EREG and ananti-TNFα antibody; FGF9, HBEGF and HGF; FGF9, HBEGF and HRGB; FGF9,HBEGF and BTC; FGF9, HBEGF and EGF; FGF9, HBEGF and TGFA; FGF9, HBEGFand FGF1; FGF9, HBEGF and FGF2; FGF9, HBEGF and FGF4; FGF9, HBEGF andFGF7; FGF9, HBEGF and FGF19; FGF9, HBEGF and SCF; FGF9, HBEGF and PDGFA;FGF9, HBEGF and PDGFB; FGF9, HBEGF and PDGFC; FGF9, HBEGF and VEGFA;FGF9, HBEGF and VEGFB; FGF9, HBEGF and VEGFC; FGF9, HBEGF and VEGFD;FGF9, HBEGF and TGFB1; FGF9, HBEGF and IL-10; FGF9, HBEGF and ananti-TNFα antibody; FGF9, HGF and HRGB; FGF9, HGF and BTC; FGF9, HGF andEGF; FGF9, HGF and TGFA; FGF9, HGF and FGF1; FGF9, HGF and FGF2; FGF9,HGF and FGF4; FGF9, HGF and FGF7; FGF9, HGF and FGF19; FGF9, HGF andSCF; FGF9, HGF and PDGFA; FGF9, HGF and PDGFB; FGF9, HGF and PDGFC;FGF9, HGF and VEGFA; FGF9, HGF and VEGFB; FGF9, HGF and VEGFC; FGF9, HGFand VEGFD; FGF9, HGF and TGFB1; FGF9, HGF and IL-10; FGF9, HGF and ananti-TNFα antibody; FGF9, HRGB and BTC; FGF9, HRGB and EGF; FGF9, HRGBand TGFA; FGF9, HRGB and FGF1; FGF9, HRGB and FGF2; FGF9, HRGB and FGF4;FGF9, HRGB and FGF7; FGF9, HRGB and FGF19; FGF9, HRGB and SCF; FGF9,HRGB and PDGFA; FGF9, HRGB and PDGFB; FGF9, HRGB and PDGFC; FGF9, HRGBand VEGFA; FGF9, HRGB and VEGFB; FGF9, HRGB and VEGFC; FGF9, HRGB andVEGFD; FGF9, HRGB and TGFB1; FGF9, HRGB and IL-10; FGF9, HRGB and ananti-TNFα antibody; FGF9, BTC and EGF; FGF9, BTC and TGFA; FGF9, BTC andFGF1; FGF9, BTC and FGF2; FGF9, BTC and FGF4; FGF9, BTC and FGF7; FGF9,BTC and FGF19; FGF9, BTC and SCF; FGF9, BTC and PDGFA; FGF9, BTC andPDGFB; FGF9, BTC and PDGFC; FGF9, BTC and VEGFA; FGF9, BTC and VEGFB;FGF9, BTC and VEGFC; FGF9, BTC and VEGFD; FGF9, BTC and TGFB1; FGF9, BTCand IL-10; FGF9, BTC and an anti-TNFα antibody; FGF9, EGF and TGFA;FGF9, EGF and FGF1; FGF9, EGF and FGF2; FGF9, EGF and FGF4; FGF9, EGFand FGF7; FGF9, EGF and FGF19; FGF9, EGF and SCF; FGF9, EGF and PDGFA;FGF9, EGF and PDGFB; FGF9, EGF and PDGFC; FGF9, EGF and VEGFA; FGF9, EGFand VEGFB; FGF9, EGF and VEGFC; FGF9, EGF and VEGFD; FGF9, EGF andTGFB1; FGF9, EGF and IL-10; FGF9, EGF and an anti-TNFα antibody; FGF9,TGFA and FGF1; FGF9, TGFA and FGF2; FGF9, TGFA and FGF4; FGF9, TGFA andFGF7; FGF9, TGFA and FGF19; FGF9, TGFA and SCF; FGF9, TGFA and PDGFA;FGF9, TGFA and PDGFB; FGF9, TGFA and PDGFC; FGF9, TGFA and VEGFA; FGF9,TGFA and VEGFB; FGF9, TGFA and VEGFC; FGF9, TGFA and VEGFD; FGF9, TGFAand TGFB1; FGF9, TGFA and IL-10; FGF9, TGFA and an anti-TNFα antibody;FGF9, FGF1 and FGF2; FGF9, FGF1 and FGF4; FGF9, FGF1 and FGF7; FGF9,FGF1 and FGF19; FGF9, FGF1 and SCF; FGF9, FGF1 and PDGFA; FGF9, FGF1 andPDGFB; FGF9, FGF1 and PDGFC; FGF9, FGF1 and VEGFA; FGF9, FGF1 and VEGFB;FGF9, FGF1 and VEGFC; FGF9, FGF1 and VEGFD; FGF9, FGF1 and TGFB1; FGF9,FGF1 and IL-10; FGF9, FGF1 and an anti-TNFα antibody; FGF9, FGF2 andFGF4; FGF9, FGF2 and FGF7; FGF9, FGF2 and FGF19; FGF9, FGF2 and SCF;FGF9, FGF2 and PDGFA; FGF9, FGF2 and PDGFB; FGF9, FGF2 and PDGFC; FGF9,FGF2 and VEGFA; FGF9, FGF2 and VEGFB; FGF9, FGF2 and VEGFC; FGF9, FGF2and VEGFD; FGF9, FGF2 and TGFB1; FGF9, FGF2 and IL-10; FGF9, FGF2 and ananti-TNFα antibody; FGF9, FGF4 and FGF7; FGF9, FGF4 and FGF19; FGF9,FGF4 and SCF; FGF9, FGF4 and PDGFA; FGF9, FGF4 and PDGFB; FGF9, FGF4 andPDGFC; FGF9, FGF4 and VEGFA; FGF9, FGF4 and VEGFB; FGF9, FGF4 and VEGFC;FGF9, FGF4 and VEGFD; FGF9, FGF4 and TGFB1; FGF9, FGF4 and IL-10; FGF9,FGF4 and an anti-TNFα antibody; FGF9, FGF7 and FGF19; FGF9, FGF7 andSCF; FGF9, FGF7 and PDGFA; FGF9, FGF7 and PDGFB; FGF9, FGF7 and PDGFC;FGF9, FGF7 and VEGFA; FGF9, FGF7 and VEGFB; FGF9, FGF7 and VEGFC; FGF9,FGF7 and VEGFD; FGF9, FGF7 and TGFB1; FGF9, FGF7 and IL-10; FGF9, FGF7and an anti-TNFα antibody; FGF9, FGF19 and SCF; FGF9, FGF19 and PDGFA;FGF9, FGF19 and PDGFB; FGF9, FGF19 and PDGFC; FGF9, FGF19 and VEGFA;FGF9, FGF19 and VEGFB; FGF9, FGF19 and VEGFC; FGF9, FGF19 and VEGFD;FGF9, FGF19 and TGFB1; FGF9, FGF19 and IL-10; FGF9, FGF19 and ananti-TNFα antibody; FGF9, SCF and PDGFA; FGF9, SCF and PDGFB; FGF9, SCFand PDGFC; FGF9, SCF and VEGFA; FGF9, SCF and VEGFB; FGF9, SCF andVEGFC; FGF9, SCF and VEGFD; FGF9, SCF and TGFB1; FGF9, SCF and IL-10;FGF9, SCF and an anti-TNFα antibody; FGF9, PDGFA and PDGFB; FGF9, PDGFAand PDGFC; FGF9, PDGFA and VEGFA; FGF9, PDGFA and VEGFB; FGF9, PDGFA andVEGFC; FGF9, PDGFA and VEGFD; FGF9, PDGFA and TGFB1; FGF9, PDGFA andIL-10; FGF9, PDGFA and an anti-TNFα antibody; FGF9, PDGFB and PDGFC;FGF9, PDGFB and VEGFA; FGF9, PDGFB and VEGFB; FGF9, PDGFB and VEGFC;FGF9, PDGFB and VEGFD; FGF9, PDGFB and TGFB1; FGF9, PDGFB and IL-10;FGF9, PDGFB and an anti-TNFα antibody; FGF9, PDGFC and VEGFA; FGF9,PDGFC and VEGFB; FGF9, PDGFC and VEGFC; FGF9, PDGFC and VEGFD; FGF9,PDGFC and TGFB1; FGF9, PDGFC and IL-10; FGF9, PDGFC and an anti-TNFαantibody; FGF9, VEGFA and VEGFB; FGF9, VEGFA and VEGFC; FGF9, VEGFA andVEGFD; FGF9, VEGFA and TGFB1; FGF9, VEGFA and IL-10; FGF9, VEGFA and ananti-TNFα antibody; FGF9, VEGFB and VEGFC; FGF9, VEGFB and VEGFD; FGF9,VEGFB and TGFB1; FGF9, VEGFB and IL-10; FGF9, VEGFB and an anti-TNFαantibody; FGF9, VEGFC and VEGFD; FGF9, VEGFC and TGFB1; FGF9, VEGFC andIL-10; FGF9, VEGFC and an anti-TNFα antibody; FGF9, VEGFD and TGFB1;FGF9, VEGFD and IL-10; FGF9, VEGFD and an anti-TNFα antibody; FGF9,TGFB1 and IL-10; FGF9, TGFB1 and an anti-TNFα antibody; FGF9, IL-10 andan anti-TNFα antibody; FGF19, AREG and EREG; FGF19, AREG and HBEGF;FGF19, AREG and HGF; FGF19, AREG and HRGB; FGF19, AREG and BTC; FGF19,AREG and EGF; FGF19, AREG and TGFA; FGF19, AREG and FGF1; FGF19, AREGand FGF2; FGF19, AREG and FGF4; FGF19, AREG and FGF7; FGF19, AREG andFGF9; FGF19, AREG and SCF; FGF19, AREG and PDGFA; FGF19, AREG and PDGFB;FGF19, AREG and PDGFC; FGF19, AREG and VEGFA; FGF19, AREG and VEGFB;FGF19, AREG and VEGFC; FGF19, AREG and VEGFD; FGF19, AREG and TGFB1;FGF19, AREG and IL-10; FGF19, AREG and an anti-TNFα antibody; FGF19,EREG and HBEGF; FGF19, EREG and HGF; FGF19, EREG and HRGB; FGF19, EREGand BTC; FGF19, EREG and EGF; FGF19, EREG and TGFA; FGF19, EREG andFGF1; FGF19, EREG and FGF2; FGF19, EREG and FGF4; FGF19, EREG and FGF7;FGF19, EREG and FGF9; FGF19, EREG and SCF; FGF19, EREG and PDGFA; FGF19,EREG and PDGFB; FGF19, EREG and PDGFC; FGF19, EREG and VEGFA; FGF19,EREG and VEGFB; FGF19, EREG and VEGFC; FGF19, EREG and VEGFD; FGF19,EREG and TGFB1; FGF19, EREG and IL-10; FGF19, EREG and an anti-TNFαantibody; FGF19, HBEGF and HGF; FGF19, HBEGF and HRGB; FGF19, HBEGF andBTC; FGF19, HBEGF and EGF; FGF19, HBEGF and TGFA; FGF19, HBEGF and FGF1;FGF19, HBEGF and FGF2; FGF19, HBEGF and FGF4; FGF19, HBEGF and FGF7;FGF19, HBEGF and FGF9; FGF19, HBEGF and SCF; FGF19, HBEGF and PDGFA;FGF19, HBEGF and PDGFB; FGF19, HBEGF and PDGFC; FGF19, HBEGF and VEGFA;FGF19, HBEGF and VEGFB; FGF19, HBEGF and VEGFC; FGF19, HBEGF and VEGFD;FGF19, HBEGF and TGFB1; FGF19, HBEGF and IL-10; FGF19, HBEGF and ananti-TNFα antibody; FGF19, HGF and HRGB; FGF19, HGF and BTC; FGF19, HGFand EGF; FGF19, HGF and TGFA; FGF19, HGF and FGF1; FGF19, HGF and FGF2;FGF19, HGF and FGF4; FGF19, HGF and FGF7; FGF19, HGF and FGF9; FGF19,HGF and SCF; FGF19, HGF and PDGFA; FGF19, HGF and PDGFB; FGF19, HGF andPDGFC; FGF19, HGF and VEGFA; FGF19, HGF and VEGFB; FGF19, HGF and VEGFC;FGF19, HGF and VEGFD; FGF19, HGF and TGFB1; FGF19, HGF and IL-10; FGF19,HGF and an anti-TNFα antibody; FGF19, HRGB and BTC; FGF19, HRGB and EGF;FGF19, HRGB and TGFA; FGF19, HRGB and FGF1; FGF19, HRGB and FGF2; FGF19,HRGB and FGF4; FGF19, HRGB and FGF7; FGF19, HRGB and FGF9; FGF19, HRGBand SCF; FGF19, HRGB and PDGFA; FGF19, HRGB and PDGFB; FGF19, HRGB andPDGFC; FGF19, HRGB and VEGFA; FGF19, HRGB and VEGFB; FGF19, HRGB andVEGFC; FGF19, HRGB and VEGFD; FGF19, HRGB and TGFB1; FGF19, HRGB andIL-10; FGF19, HRGB and an anti-TNFα antibody; FGF19, BTC and EGF; FGF19,BTC and TGFA; FGF19, BTC and FGF1; FGF19, BTC and FGF2; FGF19, BTC andFGF4; FGF19, BTC and FGF7; FGF19, BTC and FGF9; FGF19, BTC and SCF;FGF19, BTC and PDGFA; FGF19, BTC and PDGFB; FGF19, BTC and PDGFC; FGF19,BTC and VEGFA; FGF19, BTC and VEGFB; FGF19, BTC and VEGFC; FGF19, BTCand VEGFD; FGF19, BTC and TGFB1; FGF19, BTC and IL-10; FGF19, BTC and ananti-TNFα antibody; FGF19, EGF and TGFA; FGF19, EGF and FGF1; FGF19, EGFand FGF2; FGF19, EGF and FGF4; FGF19, EGF and FGF7; FGF19, EGF and FGF9;FGF19, EGF and SCF; FGF19, EGF and PDGFA; FGF19, EGF and PDGFB; FGF19,EGF and PDGFC; FGF19, EGF and VEGFA; FGF19, EGF and VEGFB; FGF19, EGFand VEGFC; FGF19, EGF and VEGFD; FGF19, EGF and TGFB1; FGF19, EGF andIL-10; FGF19, EGF and an anti-TNFα antibody; FGF19, TGFA and FGF1;FGF19, TGFA and FGF2; FGF19, TGFA and FGF4; FGF19, TGFA and FGF7; FGF19,TGFA and FGF9; FGF19, TGFA and SCF; FGF19, TGFA and PDGFA; FGF19, TGFAand PDGFB; FGF19, TGFA and PDGFC; FGF19, TGFA and VEGFA; FGF19, TGFA andVEGFB; FGF19, TGFA and VEGFC; FGF19, TGFA and VEGFD; FGF19, TGFA andTGFB1; FGF19, TGFA and IL-10; FGF19, TGFA and an anti-TNFα antibody;FGF19, FGF1 and FGF2; FGF19, FGF1 and FGF4; FGF19, FGF1 and FGF7; FGF19,FGF1 and FGF9; FGF19, FGF1 and SCF; FGF19, FGF1 and PDGFA; FGF19, FGF1and PDGFB; FGF19, FGF1 and PDGFC; FGF19, FGF1 and VEGFA; FGF19, FGF1 andVEGFB; FGF19, FGF1 and VEGFC; FGF19, FGF1 and VEGFD; FGF19, FGF1 andTGFB1; FGF19, FGF1 and IL-10; FGF19, FGF1 and an anti-TNFα antibody;FGF19, FGF2 and FGF4; FGF19, FGF2 and FGF7; FGF19, FGF2 and FGF9; FGF19,FGF2 and SCF; FGF19, FGF2 and PDGFA; FGF19, FGF2 and PDGFB; FGF19, FGF2and PDGFC; FGF19, FGF2 and VEGFA; FGF19, FGF2 and VEGFB; FGF19, FGF2 andVEGFC; FGF19, FGF2 and VEGFD; FGF19, FGF2 and TGFB1; FGF19, FGF2 andIL-10; FGF19, FGF2 and an anti-TNFα antibody; FGF19, FGF4 and FGF7;FGF19, FGF4 and FGF9; FGF19, FGF4 and SCF; FGF19, FGF4 and PDGFA; FGF19,FGF4 and PDGFB; FGF19, FGF4 and PDGFC; FGF19, FGF4 and VEGFA; FGF19,FGF4 and VEGFB; FGF19, FGF4 and VEGFC; FGF19, FGF4 and VEGFD; FGF19,FGF4 and TGFB1; FGF19, FGF4 and IL-10; FGF19, FGF4 and an anti-TNFαantibody; FGF19, FGF7 and FGF9; FGF19, FGF7 and SCF; FGF19, FGF7 andPDGFA; FGF19, FGF7 and PDGFB; FGF19, FGF7 and PDGFC; FGF19, FGF7 andVEGFA; FGF19, FGF7 and VEGFB; FGF19, FGF7 and VEGFC; FGF19, FGF7 andVEGFD; FGF19, FGF7 and TGFB1; FGF19, FGF7 and IL-10; FGF19, FGF7 and ananti-TNFα antibody; FGF19, FGF9 and SCF; FGF19, FGF9 and PDGFA; FGF19,FGF9 and PDGFB; FGF19, FGF9 and PDGFC; FGF19, FGF9 and VEGFA; FGF19,FGF9 and VEGFB; FGF19, FGF9 and VEGFC; FGF19, FGF9 and VEGFD; FGF19,FGF9 and TGFB1; FGF19, FGF9 and IL-10; FGF19, FGF9 and an anti-TNFαantibody; FGF19, SCF and PDGFA; FGF19, SCF and PDGFB; FGF19, SCF andPDGFC; FGF19, SCF and VEGFA; FGF19, SCF and VEGFB; FGF19, SCF and VEGFC;FGF19, SCF and VEGFD; FGF19, SCF and TGFB1; FGF19, SCF and IL-10; FGF19,SCF and an anti-TNFα antibody; FGF19, PDGFA and PDGFB; FGF19, PDGFA andPDGFC; FGF19, PDGFA and VEGFA; FGF19, PDGFA and VEGFB; FGF19, PDGFA andVEGFC; FGF19, PDGFA and VEGFD; FGF19, PDGFA and TGFB1; FGF19, PDGFA andIL-10; FGF19, PDGFA and an anti-TNFα antibody; FGF19, PDGFB and PDGFC;FGF19, PDGFB and VEGFA; FGF19, PDGFB and VEGFB; FGF19, PDGFB and VEGFC;FGF19, PDGFB and VEGFD; FGF19, PDGFB and TGFB1; FGF19, PDGFB and IL-10;FGF19, PDGFB and an anti-TNFα antibody; FGF19, PDGFC and VEGFA; FGF19,PDGFC and VEGFB; FGF19, PDGFC and VEGFC; FGF19, PDGFC and VEGFD; FGF19,PDGFC and TGFB1; FGF19, PDGFC and IL-10; FGF19, PDGFC and an anti-TNFαantibody; FGF19, VEGFA and VEGFB; FGF19, VEGFA and VEGFC; FGF19, VEGFAand VEGFD; FGF19, VEGFA and TGFB1; FGF19, VEGFA and IL-10; FGF19, VEGFAand an anti-TNFα antibody; FGF19, VEGFB and VEGFC; FGF19, VEGFB andVEGFD; FGF19, VEGFB and TGFB1; FGF19, VEGFB and IL-10; FGF19, VEGFB andan anti-TNFα antibody; FGF19, VEGFC and VEGFD; FGF19, VEGFC and TGFB1;FGF19, VEGFC and IL-10; FGF19, VEGFC and an anti-TNFα antibody; FGF19,VEGFD and TGFB1; FGF19, VEGFD and IL-10; FGF19, VEGFD and an anti-TNFαantibody; FGF19, TGFB1 and IL-10; FGF19, TGFB1 and an anti-TNFαantibody; FGF19, IL-10 and an anti-TNFα antibody; SCF, AREG and EREG;SCF, AREG and HBEGF; SCF, AREG and HGF; SCF, AREG and HRGB; SCF, AREGand BTC; SCF, AREG and EGF; SCF, AREG and TGFA; SCF, AREG and FGF1; SCF,AREG and FGF2; SCF, AREG and FGF4; SCF, AREG and FGF7; SCF, AREG andFGF9; SCF, AREG and FGF19; SCF, AREG and SCF; SCF, AREG and PDGFA; SCF,AREG and PDGFB; SCF, AREG and PDGFC; SCF, AREG and VEGFA; SCF, AREG andVEGFB; SCF, AREG and VEGFC; SCF, AREG and VEGFD; SCF, AREG and TGFB1;SCF, AREG and IL-10; SCF, AREG and an anti-TNFα antibody; SCF, EREG andHBEGF; SCF, EREG and HGF; SCF, EREG and HRGB; SCF, EREG and BTC; SCF,EREG and EGF; SCF, EREG and TGFA; SCF, EREG and FGF1; SCF, EREG andFGF2; SCF, EREG and FGF4; SCF, EREG and FGF7; SCF, EREG and FGF9; SCF,EREG and FGF19; SCF, EREG and PDGFA; SCF, EREG and PDGFB; SCF, EREG andPDGFC; SCF, EREG and VEGFA; SCF, EREG and VEGFB; SCF, EREG and VEGFC;SCF, EREG and VEGFD; SCF, EREG and TGFB1; SCF, EREG and IL-10; SCF, EREGand an anti-TNFα antibody; SCF, HBEGF and HGF; SCF, HBEGF and HRGB; SCF,HBEGF and BTC; SCF, HBEGF and EGF; SCF, HBEGF and TGFA; SCF, HBEGF andFGF1; SCF, HBEGF and FGF2; SCF, HBEGF and FGF4; SCF, HBEGF and FGF7;SCF, HBEGF and FGF9; SCF, HBEGF and FGF19; SCF, HBEGF and PDGFA; SCF,HBEGF and PDGFB; SCF, HBEGF and PDGFC; SCF, HBEGF and VEGFA; SCF, HBEGFand VEGFB; SCF, HBEGF and VEGFC; SCF, HBEGF and VEGFD; SCF, HBEGF andTGFB1; SCF, HBEGF and IL-10; SCF, HBEGF and an anti-TNFα antibody; SCF,HGF and HRGB; SCF, HGF and BTC; SCF, HGF and EGF; SCF, HGF and TGFA;SCF, HGF and FGF1; SCF, HGF and FGF2; SCF, HGF and FGF4; SCF, HGF andFGF7; SCF, HGF and FGF9; SCF, HGF and FGF19; SCF, HGF and PDGFA; SCF,HGF and PDGFB; SCF, HGF and PDGFC; SCF, HGF and VEGFA; SCF, HGF andVEGFB; SCF, HGF and VEGFC; SCF, HGF and VEGFD; SCF, HGF and TGFB1; SCF,HGF and IL-10; SCF, HGF and an anti-TNFα antibody; SCF, HRGB and BTC;SCF, HRGB and EGF; SCF, HRGB and TGFA; SCF, HRGB and FGF1; SCF, HRGB andFGF2; SCF, HRGB and FGF4; SCF, HRGB and FGF7; SCF, HRGB and FGF9; SCF,HRGB and FGF19; SCF, HRGB and PDGFA; SCF, HRGB and PDGFB; SCF, HRGB andPDGFC; SCF, HRGB and VEGFA; SCF, HRGB and VEGFB; SCF, HRGB and VEGFC;SCF, HRGB and VEGFD; SCF, HRGB and TGFB1; SCF, HRGB and IL-10; SCF, HRGBand an anti-TNFα antibody; SCF, BTC and EGF; SCF, BTC and TGFA; SCF, BTCand FGF1; SCF, BTC and FGF2; SCF, BTC and FGF4; SCF, BTC and FGF7; SCF,BTC and FGF9; SCF, BTC and FGF19; SCF, BTC and PDGFA; SCF, BTC andPDGFB; SCF, BTC and PDGFC; SCF, BTC and VEGFA; SCF, BTC and VEGFB; SCF,BTC and VEGFC; SCF, BTC and VEGFD; SCF, BTC and TGFB1; SCF, BTC andIL-10; SCF, BTC and an anti-TNFα antibody; SCF, EGF and TGFA; SCF, EGFand FGF1; SCF, EGF and FGF2; SCF, EGF and FGF4; SCF, EGF and FGF7; SCF,EGF and FGF9; SCF, EGF and FGF19; SCF, EGF and PDGFA; SCF, EGF andPDGFB; SCF, EGF and PDGFC; SCF, EGF and VEGFA; SCF, EGF and VEGFB; SCF,EGF and VEGFC; SCF, EGF and VEGFD; SCF, EGF and TGFB1; SCF, EGF andIL-10; SCF, EGF and an anti-TNFα antibody; SCF, TGFA and FGF1; SCF, TGFAand FGF2; SCF, TGFA and FGF4; SCF, TGFA and FGF7; SCF, TGFA and FGF9;SCF, TGFA and FGF19; SCF, TGFA and PDGFA; SCF, TGFA and PDGFB; SCF, TGFAand PDGFC; SCF, TGFA and VEGFA; SCF, TGFA and VEGFB; SCF, TGFA andVEGFC; SCF, TGFA and VEGFD; SCF, TGFA and TGFB1; SCF, TGFA and IL-10;SCF, TGFA and an anti-TNFα antibody; SCF, FGF1 and FGF2; SCF, FGF1 andFGF4; SCF, FGF1 and FGF7; SCF, FGF1 and FGF9; SCF, FGF1 and FGF19; SCF,FGF1 and PDGFA; SCF, FGF1 and PDGFB; SCF, FGF1 and PDGFC; SCF, FGF1 andVEGFA; SCF, FGF1 and VEGFB; SCF, FGF1 and VEGFC; SCF, FGF1 and VEGFD;SCF, FGF1 and TGFB1; SCF, FGF1 and IL-10; SCF, FGF1 and an anti-TNFαantibody; SCF, FGF2 and FGF4; SCF, FGF2 and FGF7; SCF, FGF2 and FGF9;SCF, FGF2 and FGF19; SCF, FGF2 and PDGFA; SCF, FGF2 and PDGFB; SCF, FGF2and PDGFC; SCF, FGF2 and VEGFA; SCF, FGF2 and VEGFB; SCF, FGF2 andVEGFC; SCF, FGF2 and VEGFD; SCF, FGF2 and TGFB1; SCF, FGF2 and IL-10;SCF, FGF2 and an anti-TNFα antibody; SCF, FGF4 and FGF7; SCF, FGF4 andFGF9; SCF, FGF4 and FGF19; SCF, FGF4 and PDGFA; SCF, FGF4 and PDGFB;SCF, FGF4 and PDGFC; SCF, FGF4 and VEGFA; SCF, FGF4 and VEGFB; SCF, FGF4and VEGFC; SCF, FGF4 and VEGFD; SCF, FGF4 and TGFB1; SCF, FGF4 andIL-10; SCF, FGF4 and an anti-TNFα antibody; SCF, FGF7 and FGF9; SCF,FGF7 and FGF19; SCF, FGF7 and PDGFA; SCF, FGF7 and PDGFB; SCF, FGF7 andPDGFC; SCF, FGF7 and VEGFA; SCF, FGF7 and VEGFB; SCF, FGF7 and VEGFC;SCF, FGF7 and VEGFD; SCF, FGF7 and TGFB1; SCF, FGF7 and IL-10; SCF, FGF7and an anti-TNFαantibody; SCF, FGF9 and FGF19; SCF, FGF9 and PDGFA; SCF,FGF9 and PDGFB; SCF, FGF9 and PDGFC; SCF, FGF9 and VEGFA; SCF, FGF9 andVEGFB; SCF, FGF9 and VEGFC; SCF, FGF9 and VEGFD; SCF, FGF9 and TGFB1;SCF, FGF9 and IL-10; SCF, FGF9 and an anti-TNFα antibody; SCF, FGF19 andPDGFA; SCF, FGF19 and PDGFB; SCF, FGF19 and PDGFC; SCF, FGF19 and VEGFA;SCF, FGF19 and VEGFB; SCF, FGF19 and VEGFC; SCF, FGF19 and VEGFD; SCF,FGF19 and TGFB1; SCF, FGF19 and IL-10; SCF, FGF19 and an anti-TNFαantibody; SCF, PDGFA and PDGFB; SCF, PDGFA and PDGFC; SCF, PDGFA andVEGFA; SCF, PDGFA and VEGFB; SCF, PDGFA and VEGFC; SCF, PDGFA and VEGFD;SCF, PDGFA and TGFB1; SCF, PDGFA and IL-10; SCF, PDGFA and an anti-TNFαantibody; SCF, PDGFB and PDGFC; SCF, PDGFB and VEGFA; SCF, PDGFB andVEGFB; SCF, PDGFB and VEGFC; SCF, PDGFB and VEGFD; SCF, PDGFB and TGFB1;SCF, PDGFB and IL-10; SCF, PDGFB and an anti-TNFα antibody; SCF, PDGFCand VEGFA; SCF, PDGFC and VEGFB; SCF, PDGFC and VEGFC; SCF, PDGFC andVEGFD; SCF, PDGFC and TGFB1; SCF, PDGFC and IL-10; SCF, PDGFC and ananti-TNFα antibody; SCF, VEGFA and VEGFB; SCF, VEGFA and VEGFC; SCF,VEGFA and VEGFD; SCF, VEGFA and TGFB1; SCF, VEGFA and IL-10; SCF, VEGFAand an anti-TNFα antibody; SCF, VEGFB and VEGFC; SCF, VEGFB and VEGFD;SCF, VEGFB and TGFB1; SCF, VEGFB and IL-10; SCF, VEGFB and an anti-TNFαantibody; SCF, VEGFC and VEGFD; SCF, VEGFC and TGFB1; SCF, VEGFC andIL-10; SCF, VEGFC and an anti-TNFα antibody; SCF, VEGFD and TGFB1; SCF,VEGFD and IL-10; SCF, VEGFD and an anti-TNFα antibody; SCF, TGFB1 andIL-10; SCF, TGFB1 and an anti-TNFα antibody; SCF, IL-10 and an anti-TNFαantibody; PDGFA, AREG and EREG; PDGFA, AREG and HBEGF; PDGFA, AREG andHGF; PDGFA, AREG and HRGB; PDGFA, AREG and BTC; PDGFA, AREG and EGF;PDGFA, AREG and TGFA; PDGFA, AREG and FGF1; PDGFA, AREG and FGF2; PDGFA,AREG and FGF4; PDGFA, AREG and FGF7; PDGFA, AREG and FGF9; PDGFA, AREGand FGF19; PDGFA, AREG and SCF; PDGFA, AREG and PDGFA; PDGFA, AREG andPDGFB; PDGFA, AREG and PDGFC; PDGFA, AREG and VEGFA; PDGFA, AREG andVEGFB; PDGFA, AREG and VEGFC; PDGFA, AREG and VEGFD; PDGFA, AREG andTGFB1; PDGFA, AREG and IL-10; PDGFA, AREG and an anti-TNFα antibody;PDGFA, EREG and HBEGF; PDGFA, EREG and HGF; PDGFA, EREG and HRGB; PDGFA,EREG and BTC; PDGFA, EREG and EGF; PDGFA, EREG and TGFA; PDGFA, EREG andFGF1; PDGFA, EREG and FGF2; PDGFA, EREG and FGF4; PDGFA, EREG and FGF7;PDGFA, EREG and FGF9; PDGFA, EREG and FGF19; PDGFA, EREG and SCF; PDGFA,EREG and PDGFA; PDGFA, EREG and PDGFB; PDGFA, EREG and PDGFC; PDGFA,EREG and VEGFA; PDGFA, EREG and VEGFB; PDGFA, EREG and VEGFC; PDGFA,EREG and VEGFD; PDGFA, EREG and TGFB1; PDGFA, EREG and IL-10; PDGFA,EREG and an anti-TNFα antibody; PDGFA, HBEGF and HGF; PDGFA, HBEGF andHRGB; PDGFA, HBEGF and BTC; PDGFA, HBEGF and EGF; PDGFA, HBEGF and TGFA;PDGFA, HBEGF and FGF1; PDGFA, HBEGF and FGF2; PDGFA, HBEGF and FGF4;PDGFA, HBEGF and FGF7; PDGFA, HBEGF and FGF9; PDGFA, HBEGF and FGF19;PDGFA, HBEGF and SCF; PDGFA, HBEGF and PDGFB; PDGFA, HBEGF and PDGFC;PDGFA, HBEGF and VEGFA; PDGFA, HBEGF and VEGFB; PDGFA, HBEGF and VEGFC;PDGFA, HBEGF and VEGFD; PDGFA, HBEGF and TGFB1; PDGFA, HBEGF and IL-10;PDGFA, HBEGF and an anti-TNFα antibody; PDGFA, HGF and HRGB; PDGFA, HGFand BTC; PDGFA, HGF and EGF; PDGFA, HGF and TGFA; PDGFA, HGF and FGF1;PDGFA, HGF and FGF2; PDGFA, HGF and FGF4; PDGFA, HGF and FGF7; PDGFA,HGF and FGF9; PDGFA, HGF and FGF19; PDGFA, HGF and SCF; PDGFA, HGF andPDGFB; PDGFA, HGF and PDGFC; PDGFA, HGF and VEGFA; PDGFA, HGF and VEGFB;PDGFA, HGF and VEGFC; PDGFA, HGF and VEGFD; PDGFA, HGF and TGFB1; PDGFA,HGF and IL-10; PDGFA, HGF and an anti-TNFα antibody; PDGFA, HRGB andBTC; PDGFA, HRGB and EGF; PDGFA, HRGB and TGFA; PDGFA, HRGB and FGF1;PDGFA, HRGB and FGF2; PDGFA, HRGB and FGF4; PDGFA, HRGB and FGF7; PDGFA,HRGB and FGF9; PDGFA, HRGB and FGF19; PDGFA, HRGB and SCF; PDGFA, HRGBand PDGFB; PDGFA, HRGB and PDGFC; PDGFA, HRGB and VEGFA; PDGFA, HRGB andVEGFB; PDGFA, HRGB and VEGFC; PDGFA, HRGB and VEGFD; PDGFA, HRGB andTGFB1; PDGFA, HRGB and IL-10; PDGFA, HRGB and an anti-TNFα antibody;PDGFA, BTC and EGF; PDGFA, BTC and TGFA; PDGFA, BTC and FGF1; PDGFA, BTCand FGF2; PDGFA, BTC and FGF4; PDGFA, BTC and FGF7; PDGFA, BTC and FGF9;PDGFA, BTC and FGF19; PDGFA, BTC and SCF; PDGFA, BTC and PDGFB; PDGFA,BTC and PDGFC; PDGFA, BTC and VEGFA; PDGFA, BTC and VEGFB; PDGFA, BTCand VEGFC; PDGFA, BTC and VEGFD; PDGFA, BTC and TGFB1; PDGFA, BTC andIL-10; PDGFA, BTC and an anti-TNFα antibody; PDGFA, EGF and TGFA; PDGFA,EGF and FGF1; PDGFA, EGF and FGF2; PDGFA, EGF and FGF4; PDGFA, EGF andFGF7; PDGFA, EGF and FGF9; PDGFA, EGF and FGF19; PDGFA, EGF and SCF;PDGFA, EGF and PDGFB; PDGFA, EGF and PDGFC; PDGFA, EGF and VEGFA; PDGFA,EGF and VEGFB; PDGFA, EGF and VEGFC; PDGFA, EGF and VEGFD; PDGFA, EGFand TGFB1; PDGFA, EGF and IL-10; PDGFA, EGF and an anti-TNFα antibody;PDGFA, TGFA and FGF1; PDGFA, TGFA and FGF2; PDGFA, TGFA and FGF4; PDGFA,TGFA and FGF7; PDGFA, TGFA and FGF9; PDGFA, TGFA and FGF19; PDGFA, TGFAand SCF; PDGFA, TGFA and PDGFB; PDGFA, TGFA and PDGFC; PDGFA, TGFA andVEGFA; PDGFA, TGFA and VEGFB; PDGFA, TGFA and VEGFC; PDGFA, TGFA andVEGFD; PDGFA, TGFA and TGFB1; PDGFA, TGFA and IL-10; PDGFA, TGFA and ananti-TNFα antibody; PDGFA, FGF1 and FGF2; PDGFA, FGF1 and FGF4; PDGFA,FGF1 and FGF7; PDGFA, FGF1 and FGF9; PDGFA, FGF1 and FGF19; PDGFA, FGF1and SCF; PDGFA, FGF1 and PDGFB; PDGFA, FGF1 and PDGFC; PDGFA, FGF1 andVEGFA; PDGFA, FGF1 and VEGFB; PDGFA, FGF1 and VEGFC; PDGFA, FGF1 andVEGFD; PDGFA, FGF1 and TGFB1; PDGFA, FGF1 and IL-10; PDGFA, FGF1 and ananti-TNFα antibody; PDGFA, FGF2 and FGF4; PDGFA, FGF2 and FGF7; PDGFA,FGF2 and FGF9; PDGFA, FGF2 and FGF19; PDGFA, FGF2 and SCF; PDGFA, FGF2and PDGFB; PDGFA, FGF2 and PDGFC; PDGFA, FGF2 and VEGFA; PDGFA, FGF2 andVEGFB; PDGFA, FGF2 and VEGFC; PDGFA, FGF2 and VEGFD; PDGFA, FGF2 andTGFB1; PDGFA, FGF2 and IL-10; PDGFA, FGF2 and an anti-TNFα antibody;PDGFA, FGF4 and FGF7; PDGFA, FGF4 and FGF9; PDGFA, FGF4 and FGF19;PDGFA, FGF4 and SCF; PDGFA, FGF4 and PDGFB; PDGFA, FGF4 and PDGFC;PDGFA, FGF4 and VEGFA; PDGFA, FGF4 and VEGFB; PDGFA, FGF4 and VEGFC;PDGFA, FGF4 and VEGFD; PDGFA, FGF4 and TGFB1; PDGFA, FGF4 and IL-10;PDGFA, FGF4 and an anti-TNFα antibody; PDGFA, FGF7 and FGF9; PDGFA, FGF7and FGF19; PDGFA, FGF7 and SCF; PDGFA, FGF7 and PDGFB; PDGFA, FGF7 andPDGFC; PDGFA, FGF7 and VEGFA; PDGFA, FGF7 and VEGFB; PDGFA, FGF7 andVEGFC; PDGFA, FGF7 and VEGFD; PDGFA, FGF7 and TGFB1; PDGFA, FGF7 andIL-10; PDGFA, FGF7 and an anti-TNFα antibody; PDGFA, FGF9 and FGF19;PDGFA, FGF9 and SCF; PDGFA, FGF9 and PDGFB; PDGFA, FGF9 and PDGFC;PDGFA, FGF9 and VEGFA; PDGFA, FGF9 and VEGFB; PDGFA, FGF9 and VEGFC;PDGFA, FGF9 and VEGFD; PDGFA, FGF9 and TGFB1; PDGFA, FGF9 and IL-10;PDGFA, FGF9 and an anti-TNFα antibody; PDGFA, FGF19 and SCF; PDGFA,FGF19 and PDGFB; PDGFA, FGF19 and PDGFC; PDGFA, FGF19 and VEGFA; PDGFA,FGF19 and VEGFB; PDGFA, FGF19 and VEGFC; PDGFA, FGF19 and VEGFD; PDGFA,FGF19 and TGFB1; PDGFA, FGF19 and IL-10; PDGFA, FGF19 and an anti-TNFαantibody; PDGFA, SCF and PDGFB; PDGFA, SCF and PDGFC; PDGFA, SCF andVEGFA; PDGFA, SCF and VEGFB; PDGFA, SCF and VEGFC; PDGFA, SCF and VEGFD;PDGFA, SCF and TGFB1; PDGFA, SCF and IL-10; PDGFA, SCF and an anti-TNFαantibody; PDGFA, PDGFB and PDGFC; PDGFA, PDGFB and VEGFA; PDGFA, PDGFBand VEGFB; PDGFA, PDGFB and VEGFC; PDGFA, PDGFB and VEGFD; PDGFA, PDGFBand TGFB1; PDGFA, PDGFB and IL-10; PDGFA, PDGFB and an anti-TNFαantibody; PDGFA, PDGFC and VEGFA; PDGFA, PDGFC and VEGFB; PDGFA, PDGFCand VEGFC; PDGFA, PDGFC and VEGFD; PDGFA, PDGFC and TGFB1; PDGFA, PDGFCand IL-10; PDGFA, PDGFC and an anti-TNFα antibody; PDGFA, VEGFA andVEGFB; PDGFA, VEGFA and VEGFC; PDGFA, VEGFA and VEGFD; PDGFA, VEGFA andTGFB1; PDGFA, VEGFA and IL-10; PDGFA, VEGFA and an anti-TNFα antibody;PDGFA, VEGFB and VEGFC; PDGFA, VEGFB and VEGFD; PDGFA, VEGFB and TGFB1;PDGFA, VEGFB and IL-10; PDGFA, VEGFB and an anti-TNFα antibody; PDGFA,VEGFC and VEGFD; PDGFA, VEGFC and TGFB1; PDGFA, VEGFC and IL-10; PDGFA,VEGFC and an anti-TNFα antibody; PDGFA, VEGFD and TGFB1; PDGFA, VEGFDand IL-10; PDGFA, VEGFD and an anti-TNFα antibody; PDGFA, TGFB1 andIL-10; PDGFA, TGFB1 and an anti-TNFα antibody; PDGFA, IL-10 and ananti-TNFα antibody; PDGFB, AREG and EREG; PDGFB, AREG and HBEGF; PDGFB,AREG and HGF; PDGFB, AREG and HRGB; PDGFB, AREG and BTC; PDGFB, AREG andEGF; PDGFB, AREG and TGFA; PDGFB, AREG and FGF1; PDGFB, AREG and FGF2;PDGFB, AREG and FGF4; PDGFB, AREG and FGF7; PDGFB, AREG and FGF9; PDGFB,AREG and FGF19; PDGFB, AREG and SCF; PDGFB, AREG and PDGFA; PDGFB, AREGand PDGFC; PDGFB, AREG and VEGFA; PDGFB, AREG and VEGFB; PDGFB, AREG andVEGFC; PDGFB, AREG and VEGFD; PDGFB, AREG and TGFB1; PDGFB, AREG andIL-10; PDGFB, AREG and an anti-TNFα antibody; PDGFB, EREG and HBEGF;PDGFB, EREG and HGF; PDGFB, EREG and HRGB; PDGFB, EREG and BTC; PDGFB,EREG and EGF; PDGFB, EREG and TGFA; PDGFB, EREG and FGF1; PDGFB, EREGand FGF2; PDGFB, EREG and FGF4; PDGFB, EREG and FGF7; PDGFB, EREG andFGF9; PDGFB, EREG and FGF19; PDGFB, EREG and SCF; PDGFB, EREG and PDGFA;PDGFB, EREG and PDGFC; PDGFB, EREG and VEGFA; PDGFB, EREG and VEGFB;PDGFB, EREG and VEGFC; PDGFB, EREG and VEGFD; PDGFB, EREG and TGFB1;PDGFB, EREG and IL-10; PDGFB, EREG and an anti-TNFα antibody; PDGFB,HBEGF and HGF; PDGFB, HBEGF and HRGB; PDGFB, HBEGF and BTC; PDGFB, HBEGFand EGF; PDGFB, HBEGF and TGFA; PDGFB, HBEGF and FGF1; PDGFB, HBEGF andFGF2; PDGFB, HBEGF and FGF4; PDGFB, HBEGF and FGF7; PDGFB, HBEGF andFGF9; PDGFB, HBEGF and FGF19; PDGFB, HBEGF and SCF; PDGFB, HBEGF andPDGFA; PDGFB, HBEGF and PDGFC; PDGFB, HBEGF and VEGFA; PDGFB, HBEGF andVEGFB; PDGFB, HBEGF and VEGFC; PDGFB, HBEGF and VEGFD; PDGFB, HBEGF andTGFB1; PDGFB, HBEGF and IL-10; PDGFB, HBEGF and an anti-TNFα antibody;PDGFB, HGF and HRGB; PDGFB, HGF and BTC; PDGFB, HGF and EGF; PDGFB, HGFand TGFA; PDGFB, HGF and FGF1; PDGFB, HGF and FGF2; PDGFB, HGF and FGF4;PDGFB, HGF and FGF7; PDGFB, HGF and FGF9; PDGFB, HGF and FGF19; PDGFB,HGF and SCF; PDGFB, HGF and PDGFA; PDGFB, HGF and PDGFC; PDGFB, HGF andVEGFA; PDGFB, HGF and VEGFB; PDGFB, HGF and VEGFC; PDGFB, HGF and VEGFD;PDGFB, HGF and TGFB1; PDGFB, HGF and IL-10; PDGFB, HGF and an anti-TNFαantibody; PDGFB, HRGB and BTC; PDGFB, HRGB and EGF; PDGFB, HRGB andTGFA; PDGFB, HRGB and FGF1; PDGFB, HRGB and FGF2; PDGFB, HRGB and FGF4;PDGFB, HRGB and FGF7; PDGFB, HRGB and FGF9; PDGFB, HRGB and FGF19;PDGFB, HRGB and SCF; PDGFB, HRGB and PDGFA; PDGFB, HRGB and PDGFC;PDGFB, HRGB and VEGFA; PDGFB, HRGB and VEGFB; PDGFB, HRGB and VEGFC;PDGFB, HRGB and VEGFD; PDGFB, HRGB and TGFB1; PDGFB, HRGB and IL-10;PDGFB, HRGB and an anti-TNFα antibody; PDGFB, BTC and EGF; PDGFB, BTCand TGFA; PDGFB, BTC and FGF1; PDGFB, BTC and FGF2; PDGFB, BTC and FGF4;PDGFB, BTC and FGF7; PDGFB, BTC and FGF9; PDGFB, BTC and FGF19; PDGFB,BTC and SCF; PDGFB, BTC and PDGFA; PDGFB, BTC and PDGFC; PDGFB, BTC andVEGFA; PDGFB, BTC and VEGFB; PDGFB, BTC and VEGFC; PDGFB, BTC and VEGFD;PDGFB, BTC and TGFB1; PDGFB, BTC and IL-10; PDGFB, BTC and an anti-TNFαantibody; PDGFB, EGF and TGFA; PDGFB, EGF and FGF1; PDGFB, EGF and FGF2;PDGFB, EGF and FGF4; PDGFB, EGF and FGF7; PDGFB, EGF and FGF9; PDGFB,EGF and FGF19; PDGFB, EGF and SCF; PDGFB, EGF and PDGFA; PDGFB, EGF andPDGFB; PDGFB, EGF and PDGFC; PDGFB, EGF and VEGFA; PDGFB, EGF and VEGFB;PDGFB, EGF and VEGFC; PDGFB, EGF and VEGFD; PDGFB, EGF and TGFB1; PDGFB,EGF and IL-10; PDGFB, EGF and an anti-TNFα antibody; PDGFB, TGFA andFGF1; PDGFB, TGFA and FGF2; PDGFB, TGFA and FGF4; PDGFB, TGFA and FGF7;PDGFB, TGFA and FGF9; PDGFB, TGFA and FGF19; PDGFB, TGFA and SCF; PDGFB,TGFA and PDGFA; PDGFB, TGFA and PDGFC; PDGFB, TGFA and VEGFA; PDGFB,TGFA and VEGFB; PDGFB, TGFA and VEGFC; PDGFB, TGFA and VEGFD; PDGFB,TGFA and TGFB1; PDGFB, TGFA and IL-10; PDGFB, TGFA and an anti-TNFαantibody; PDGFB, FGF1 and FGF2; PDGFB, FGF1 and FGF4; PDGFB, FGF1 andFGF7; PDGFB, FGF1 and FGF9; PDGFB, FGF1 and FGF19; PDGFB, FGF1 and SCF;PDGFB, FGF1 and PDGFA; PDGFB, FGF1 and PDGFC; PDGFB, FGF1 and VEGFA;PDGFB, FGF1 and VEGFB; PDGFB, FGF1 and VEGFC; PDGFB, FGF1 and VEGFD;PDGFB, FGF1 and TGFB1; PDGFB, FGF1 and IL-10; PDGFB, FGF1 and ananti-TNFα antibody; PDGFB, FGF2 and FGF4; PDGFB, FGF2 and FGF7; PDGFB,FGF2 and FGF9; PDGFB, FGF2 and FGF19; PDGFB, FGF2 and SCF; PDGFB, FGF2and PDGFA; PDGFB, FGF2 and PDGFC; PDGFB, FGF2 and VEGFA; PDGFB, FGF2 andVEGFB; PDGFB, FGF2 and VEGFC; PDGFB, FGF2 and VEGFD; PDGFB, FGF2 andTGFB1; PDGFB, FGF2 and IL-10; PDGFB, FGF2 and an anti-TNFα antibody;PDGFB, FGF4 and FGF7; PDGFB, FGF4 and FGF9; PDGFB, FGF4 and FGF19;PDGFB, FGF4 and SCF; PDGFB, FGF4 and PDGFA; PDGFB, FGF4 and PDGFB;PDGFB, FGF4 and PDGFC; PDGFB, FGF4 and VEGFA; PDGFB, FGF4 and VEGFB;PDGFB, FGF4 and VEGFC; PDGFB, FGF4 and VEGFD; PDGFB, FGF4 and TGFB1;PDGFB, FGF4 and IL-10; PDGFB, FGF4 and an anti-TNFα antibody; PDGFB,FGF7 and FGF9; PDGFB, FGF7 and FGF19; PDGFB, FGF7 and SCF; PDGFB, FGF7and PDGFA; PDGFB, FGF7 and PDGFB; PDGFB, FGF7 and PDGFC; PDGFB, FGF7 andVEGFA; PDGFB, FGF7 and VEGFB; PDGFB, FGF7 and VEGFC; PDGFB, FGF7 andVEGFD; PDGFB, FGF7 and TGFB1; PDGFB, FGF7 and IL-10; PDGFB, FGF7 and ananti-TNFα antibody; PDGFB, FGF9 and FGF19; PDGFB, FGF9 and SCF; PDGFB,FGF9 and PDGFA; PDGFB, FGF9 and PDGFC; PDGFB, FGF9 and VEGFA; PDGFB,FGF9 and VEGFB; PDGFB, FGF9 and VEGFC; PDGFB, FGF9 and VEGFD; PDGFB,FGF9 and TGFB1; PDGFB, FGF9 and IL-10; PDGFB, FGF9 and an anti-TNFαantibody; PDGFB, FGF19 and SCF; PDGFB, FGF19 and PDGFA; PDGFB, FGF19 andPDGFB; PDGFB, FGF19 and PDGFC; PDGFB, FGF19 and VEGFA; PDGFB, FGF19 andVEGFB; PDGFB, FGF19 and VEGFC; PDGFB, FGF19 and VEGFD; PDGFB, FGF19 andTGFB1; PDGFB, FGF19 and IL-10; PDGFB, FGF19 and an anti-TNFα antibody;PDGFB, SCF and PDGFA, SCF and PDGFC; PDGFB, SCF and VEGFA; PDGFB, SCFand VEGFB; PDGFB, SCF and VEGFC; PDGFB, SCF and VEGFD; PDGFB, SCF andTGFB1; PDGFB, SCF and IL-10; PDGFB, SCF and an anti-TNFα antibody;PDGFB, PDGFA and PDGFC; PDGFB, PDGFA and VEGFA; PDGFB, PDGFA and VEGFB;PDGFB, PDGFA and VEGFC; PDGFB, PDGFA and VEGFD; PDGFB, PDGFA and TGFB1;PDGFB, PDGFA and IL-10; PDGFB, PDGFA and an anti-TNFα antibody; PDGFB,PDGFC and VEGFA; PDGFB, PDGFC and VEGFB; PDGFB, PDGFC and VEGFC; PDGFB,PDGFC and VEGFD; PDGFB, PDGFC and TGFB1; PDGFB, PDGFC and IL-10; PDGFB,PDGFC and an anti-TNFα antibody; PDGFB, VEGFA and VEGFB; PDGFB, VEGFAand VEGFC; PDGFB, VEGFA and VEGFD; PDGFB, VEGFA and TGFB1; PDGFB, VEGFAand IL-10; PDGFB, VEGFA and an anti-TNFα antibody; PDGFB, VEGFB andVEGFC; PDGFB, VEGFB and VEGFD; PDGFB, VEGFB and TGFB1; PDGFB, VEGFB andIL-10; PDGFB, VEGFB and an anti-TNFα antibody; PDGFB, VEGFC and VEGFD;PDGFB, VEGFC and TGFB1; PDGFB, VEGFC and IL-10; PDGFB, VEGFC and ananti-TNFα antibody; PDGFB, VEGFD and TGFB1; PDGFB, VEGFD and IL-10;PDGFB, VEGFD and an anti-TNFα antibody; PDGFB, TGFB1 and IL-10; PDGFB,TGFB1 and an anti-TNFα antibody; PDGFB, IL-10 and an anti-TNFα antibody;PDGFC, AREG and EREG; PDGFC, AREG and HBEGF; PDGFC, AREG and HGF; PDGFC,AREG and HRGB; PDGFC, AREG and BTC; PDGFC, AREG and EGF; PDGFC, AREG andTGFA; PDGFC, AREG and FGF1; PDGFC, AREG and FGF2; PDGFC, AREG and FGF4;PDGFC, AREG and FGF7; PDGFC, AREG and FGF9; PDGFC, AREG and FGF19;PDGFC, AREG and SCF; PDGFC, AREG and PDGFA; PDGFC, AREG and PDGFB;PDGFC, AREG and PDGFC; PDGFC, AREG and VEGFA; PDGFC, AREG and VEGFB;PDGFC, AREG and VEGFC; PDGFC, AREG and VEGFD; PDGFC, AREG and TGFB1;PDGFC, AREG and IL-10; PDGFC, AREG and an anti-TNFα antibody; PDGFC,EREG and HBEGF; PDGFC, EREG and HGF; PDGFC, EREG and HRGB; PDGFC, EREGand BTC; PDGFC, EREG and EGF; PDGFC, EREG and TGFA; PDGFC, EREG andFGF1; PDGFC, EREG and FGF2; PDGFC, EREG and FGF4; PDGFC, EREG and FGF7;PDGFC, EREG and FGF9; PDGFC, EREG and FGF19; PDGFC, EREG and SCF; PDGFC,EREG and PDGFA; PDGFC, EREG and PDGFB; PDGFC, EREG and VEGFA; PDGFC,EREG and VEGFB; PDGFC, EREG and VEGFC; PDGFC, EREG and VEGFD; PDGFC,EREG and TGFB1; PDGFC, EREG and IL-10; PDGFC, EREG and an anti-TNFαantibody; PDGFC, HBEGF and HGF; PDGFC, HBEGF and HRGB; PDGFC, HBEGF andBTC; PDGFC, HBEGF and EGF; PDGFC, HBEGF and TGFA; PDGFC, HBEGF and FGF1;PDGFC, HBEGF and FGF2; PDGFC, HBEGF and FGF4; PDGFC, HBEGF and FGF7;PDGFC, HBEGF and FGF9; PDGFC, HBEGF and FGF19; PDGFC, HBEGF and SCF;PDGFC, HBEGF and PDGFA; PDGFC, HBEGF and PDGFB; PDGFC, HBEGF and VEGFA;PDGFC, HBEGF and VEGFB; PDGFC, HBEGF and VEGFC; PDGFC, HBEGF and VEGFD;PDGFC, HBEGF and TGFB1; PDGFC, HBEGF and IL-10; PDGFC, HBEGF and ananti-TNFα antibody; PDGFC, HGF and HRGB; PDGFC, HGF and BTC; PDGFC, HGFand EGF; PDGFC, HGF and TGFA; PDGFC, HGF and FGF1; PDGFC, HGF and FGF2;PDGFC, HGF and FGF4; PDGFC, HGF and FGF7; PDGFC, HGF and FGF9; PDGFC,HGF and FGF19; PDGFC, HGF and SCF; PDGFC, HGF and PDGFA; PDGFC, HGF andPDGFB; PDGFC, HGF and VEGFA; PDGFC, HGF and VEGFB; PDGFC, HGF and VEGFC;PDGFC, HGF and VEGFD; PDGFC, HGF and TGFB1; PDGFC, HGF and IL-10; PDGFC,HGF and an anti-TNFα antibody; PDGFC, HRGB and BTC; PDGFC, HRGB and EGF;PDGFC, HRGB and TGFA; PDGFC, HRGB and FGF1; PDGFC, HRGB and FGF2; PDGFC,HRGB and FGF4; PDGFC, HRGB and FGF7; PDGFC, HRGB and FGF9; PDGFC, HRGBand FGF19; PDGFC, HRGB and SCF; PDGFC, HRGB and PDGFA; PDGFC, HRGB andPDGFB; PDGFC, HRGB and VEGFA; PDGFC, HRGB and VEGFB; PDGFC, HRGB andVEGFC; PDGFC, HRGB and VEGFD; PDGFC, HRGB and TGFB1; PDGFC, HRGB andIL-10; PDGFC, HRGB and an anti-TNFα antibody; PDGFC, BTC and EGF; PDGFC,BTC and TGFA; PDGFC, BTC and FGF1; PDGFC, BTC and FGF2; PDGFC, BTC andFGF4; PDGFC, BTC and FGF7; PDGFC, BTC and FGF9; PDGFC, BTC and FGF19;PDGFC, BTC and SCF; PDGFC, BTC and PDGFA; PDGFC, BTC and PDGFB; PDGFC,BTC and VEGFA; PDGFC, BTC and VEGFB; PDGFC, BTC and VEGFC; PDGFC, BTCand VEGFD; PDGFC, BTC and TGFB1; PDGFC, BTC and IL-10; PDGFC, BTC and ananti-TNFα antibody; PDGFC, EGF and TGFA; PDGFC, EGF and FGF1; PDGFC, EGFand FGF2; PDGFC, EGF and FGF4; PDGFC, EGF and FGF7; PDGFC, EGF and FGF9;PDGFC, EGF and FGF19; PDGFC, EGF and SCF; PDGFC, EGF and PDGFA; PDGFC,EGF and PDGFB; PDGFC, EGF and VEGFA; PDGFC, EGF and VEGFB; PDGFC, EGFand VEGFC; PDGFC, EGF and VEGFD; PDGFC, EGF and TGFB1; PDGFC, EGF andIL-10; PDGFC, EGF and an anti-TNFα antibody; PDGFC, TGFA and FGF1;PDGFC, TGFA and FGF2; PDGFC, TGFA and FGF4; PDGFC, TGFA and FGF7; PDGFC,TGFA and FGF9; PDGFC, TGFA and FGF19; PDGFC, TGFA and SCF; PDGFC, TGFAand PDGFA; PDGFC, TGFA and PDGFB; PDGFC, TGFA and VEGFA; PDGFC, TGFA andVEGFB; PDGFC, TGFA and VEGFC; PDGFC, TGFA and VEGFD; PDGFC, TGFA andTGFB1; PDGFC, TGFA and IL-10; PDGFC, TGFA and an anti-TNFα antibody;PDGFC, FGF1 and FGF2; PDGFC, FGF1 and FGF4; PDGFC, FGF1 and FGF7; PDGFC,FGF1 and FGF9; PDGFC, FGF1 and FGF19; PDGFC, FGF1 and SCF; PDGFC, FGF1and PDGFA; PDGFC, FGF1 and PDGFB; PDGFC, FGF1 and VEGFA; PDGFC, FGF1 andVEGFB; PDGFC, FGF1 and VEGFC; PDGFC, FGF1 and VEGFD; PDGFC, FGF1 andTGFB1; PDGFC, FGF1 and IL-10; PDGFC, FGF1 and an anti-TNFα antibody;PDGFC, FGF2 and FGF4; PDGFC, FGF2 and FGF7; PDGFC, FGF2 and FGF9; PDGFC,FGF2 and FGF19; PDGFC, FGF2 and SCF; PDGFC, FGF2 and PDGFA; PDGFC, FGF2and PDGFB; PDGFC, FGF2 and VEGFA; PDGFC, FGF2 and VEGFB; PDGFC, FGF2 andVEGFC; PDGFC, FGF2 and VEGFD; PDGFC, FGF2 and TGFB1; PDGFC, FGF2 andIL-10; PDGFC, FGF2 and an anti-TNFα antibody; PDGFC, FGF4 and FGF7;PDGFC, FGF4 and FGF9; PDGFC, FGF4 and FGF19; PDGFC, FGF4 and SCF; PDGFC,FGF4 and PDGFA; PDGFC, FGF4 and PDGFB; PDGFC, FGF4 and VEGFA; PDGFC,FGF4 and VEGFB; PDGFC, FGF4 and VEGFC; PDGFC, FGF4 and VEGFD; PDGFC,FGF4 and TGFB1; PDGFC, FGF4 and IL-10; PDGFC, FGF4 and an anti-TNFαantibody; PDGFC, FGF7 and FGF9; PDGFC, FGF7 and FGF19; PDGFC, FGF7 andSCF; PDGFC, FGF7 and PDGFA; PDGFC, FGF7 and PDGFB; PDGFC, FGF7 andVEGFA; PDGFC, FGF7 and VEGFB; PDGFC, FGF7 and VEGFC; PDGFC, FGF7 andVEGFD; PDGFC, FGF7 and TGFB1; PDGFC, FGF7 and IL-10; PDGFC, FGF7 and ananti-TNFα antibody; PDGFC, FGF9 and FGF19; PDGFC, FGF9 and SCF; PDGFC,FGF9 and PDGFA; PDGFC, FGF9 and PDGFB; PDGFC, FGF9 and VEGFA; PDGFC,FGF9 and VEGFB; PDGFC, FGF9 and VEGFC; PDGFC, FGF9 and VEGFD; PDGFC,FGF9 and TGFB1; PDGFC, FGF9 and IL-10; PDGFC, FGF9 and an anti-TNFαantibody; PDGFC, FGF19 and SCF; PDGFC, FGF19 and PDGFA; PDGFC, FGF19 andPDGFB; PDGFC, FGF19 and VEGFA; PDGFC, FGF19 and VEGFB; PDGFC, FGF19 andVEGFC; PDGFC, FGF19 and VEGFD; PDGFC, FGF19 and TGFB1; PDGFC, FGF19 andIL-10; PDGFC, FGF19 and an anti-TNFα antibody; PDGFC, SCF and PDGFA;PDGFC, SCF and PDGFB; PDGFC, SCF and VEGFA; PDGFC, SCF and VEGFB; PDGFC,SCF and VEGFC; PDGFC, SCF and VEGFD; PDGFC, SCF and TGFB1; PDGFC, SCFand IL-10; PDGFC, SCF and an anti-TNFα antibody; PDGFC, PDGFA and PDGFB;PDGFC, PDGFA and VEGFA; PDGFC, PDGFA and VEGFB; PDGFC, PDGFA and VEGFC;PDGFC, PDGFA and VEGFD; PDGFC, PDGFA and TGFB1; PDGFC, PDGFA and IL-10;PDGFC, PDGFA and an anti-TNFα antibody; PDGFC, PDGFB and VEGFA; PDGFC,PDGFB and VEGFB; PDGFC, PDGFB and VEGFC; PDGFC, PDGFB and VEGFD; PDGFC,PDGFB and TGFB1; PDGFC, PDGFB and IL-10; PDGFC, PDGFB and an anti-TNFαantibody; PDGFC, VEGFA and VEGFB; PDGFC, VEGFA and VEGFC; PDGFC, VEGFAand VEGFD; PDGFC, VEGFA and TGFB1; PDGFC, VEGFA and IL-10; PDGFC, VEGFAand an anti-TNFα antibody; PDGFC, VEGFB and VEGFC; PDGFC, VEGFB andVEGFD; PDGFC, VEGFB and TGFB1; PDGFC, VEGFB and IL-10; PDGFC, VEGFB andan anti-TNFα antibody; PDGFC, VEGFC and VEGFD; PDGFC, VEGFC and TGFB1;PDGFC, VEGFC and IL-10; PDGFC, VEGFC and an anti-TNFα antibody; PDGFC,VEGFD and TGFB1; PDGFC, VEGFD and IL-10; PDGFC, VEGFD and an anti-TNFαantibody; PDGFC, TGFB1 and IL-10; PDGFC, TGFB1 and an anti-TNFαantibody; PDGFC, IL-10 and an anti-TNFα antibody; VEGFA, AREG and EREG;VEGFA, AREG and HBEGF; VEGFA, AREG and HGF; VEGFA, AREG and HRGB; VEGFA,AREG and BTC; VEGFA, AREG and EGF; VEGFA, AREG and TGFA; VEGFA, AREG andFGF1; VEGFA, AREG and FGF2; VEGFA, AREG and FGF4; VEGFA, AREG and FGF7;VEGFA, AREG and FGF9; VEGFA, AREG and FGF19; VEGFA, AREG and SCF; VEGFA,AREG and PDGFA; VEGFA, AREG and PDGFB; VEGFA, AREG and PDGFC; VEGFA,AREG and VEGFA; VEGFA, AREG and VEGFB; VEGFA, AREG and VEGFC; VEGFA,AREG and VEGFD; VEGFA, AREG and TGFB1; VEGFA, AREG and IL-10; VEGFA,AREG and an anti-TNFα antibody; VEGFA, EREG and HBEGF; VEGFA, EREG andHGF; VEGFA, EREG and HRGB; VEGFA, EREG and BTC; VEGFA, EREG and EGF;VEGFA, EREG and TGFA; VEGFA, EREG and FGF1; VEGFA, EREG and FGF2; VEGFA,EREG and FGF4; VEGFA, EREG and FGF7; VEGFA, EREG and FGF9; VEGFA, EREGand FGF19; VEGFA, EREG and SCF; VEGFA, EREG and PDGFA; VEGFA, EREG andPDGFB; VEGFA, EREG and PDGFC; VEGFA, EREG and VEGFB; VEGFA, EREG andVEGFC; VEGFA, EREG and VEGFD; VEGFA, EREG and TGFB1; VEGFA, EREG andIL-10; VEGFA, EREG and an anti-TNFα antibody; VEGFA, HBEGF and HGF;VEGFA, HBEGF and HRGB; VEGFA, HBEGF and BTC; VEGFA, HBEGF and EGF;VEGFA, HBEGF and TGFA; VEGFA, HBEGF and FGF1; VEGFA, HBEGF and FGF2;VEGFA, HBEGF and FGF4; VEGFA, HBEGF and FGF7; VEGFA, HBEGF and FGF9;VEGFA, HBEGF and FGF19; VEGFA, HBEGF and SCF; VEGFA, HBEGF and PDGFA;VEGFA, HBEGF and PDGFB; VEGFA, HBEGF and PDGFC; VEGFA, HBEGF and VEGFB;VEGFA, HBEGF and VEGFC; VEGFA, HBEGF and VEGFD; VEGFA, HBEGF and TGFB1;VEGFA, HBEGF and IL-10; VEGFA, HBEGF and an anti-TNFα antibody; VEGFA,HGF and HRGB; VEGFA, HGF and BTC; VEGFA, HGF and EGF; VEGFA, HGF andTGFA; VEGFA, HGF and FGF1; VEGFA, HGF and FGF2; VEGFA, HGF and FGF4;VEGFA, HGF and FGF7; VEGFA, HGF and FGF9; VEGFA, HGF and FGF19; VEGFA,HGF and SCF; VEGFA, HGF and PDGFA; VEGFA, HGF and PDGFB; VEGFA, HGF andPDGFC; VEGFA, HGF and VEGFB; VEGFA, HGF and VEGFC; VEGFA, HGF and VEGFD;VEGFA, HGF and TGFB1; VEGFA, HGF and IL-10; VEGFA, HGF and an anti-TNFαantibody; VEGFA, HRGB and BTC; VEGFA, HRGB and EGF; VEGFA, HRGB andTGFA; VEGFA, HRGB and FGF1; VEGFA, HRGB and FGF2; VEGFA, HRGB and FGF4;VEGFA, HRGB and FGF7; VEGFA, HRGB and FGF9; VEGFA, HRGB and FGF19;VEGFA, HRGB and SCF; VEGFA, HRGB and PDGFA; VEGFA, HRGB and PDGFB;VEGFA, HRGB and PDGFC; VEGFA, HRGB and VEGFB; VEGFA, HRGB and VEGFC;VEGFA, HRGB and VEGFD; VEGFA, HRGB and TGFB1; VEGFA, HRGB and IL-10;VEGFA, HRGB and an anti-TNFα antibody; VEGFA, BTC and EGF; VEGFA, BTCand TGFA; VEGFA, BTC and FGF1; VEGFA, BTC and FGF2; VEGFA, BTC and FGF4;VEGFA, BTC and FGF7; VEGFA, BTC and FGF9; VEGFA, BTC and FGF19; VEGFA,BTC and SCF; VEGFA, BTC and PDGFA; VEGFA, BTC and PDGFB; VEGFA, BTC andPDGFC; VEGFA, BTC and VEGFB; VEGFA, BTC and VEGFC; VEGFA, BTC and VEGFD;VEGFA, BTC and TGFB1; VEGFA, BTC and IL-10; VEGFA, BTC and an anti-TNFαantibody; VEGFA, EGF and TGFA; VEGFA, EGF and FGF1; VEGFA, EGF and FGF2;VEGFA, EGF and FGF4; VEGFA, EGF and FGF7; VEGFA, EGF and FGF9; VEGFA,EGF and FGF19; VEGFA, EGF and SCF; VEGFA, EGF and PDGFA; VEGFA, EGF andPDGFB; VEGFA, EGF and PDGFC; VEGFA, EGF and VEGFB; VEGFA, EGF and VEGFC;VEGFA, EGF and VEGFD; VEGFA, EGF and TGFB1; VEGFA, EGF and IL-10; VEGFA,EGF and an anti-TNFα antibody; VEGFA, TGFA and FGF1; VEGFA, TGFA andFGF2; VEGFA, TGFA and FGF4; VEGFA, TGFA and FGF7; VEGFA, TGFA and FGF9;VEGFA, TGFA and FGF19; VEGFA, TGFA and SCF; VEGFA, TGFA and PDGFA;VEGFA, TGFA and PDGFB; VEGFA, TGFA and PDGFC; VEGFA, TGFA and VEGFB;VEGFA, TGFA and VEGFC; VEGFA, TGFA and VEGFD; VEGFA, TGFA and TGFB1;VEGFA, TGFA and IL-10; VEGFA, TGFA and an anti-TNFα antibody; VEGFA,FGF1 and FGF2; VEGFA, FGF1 and FGF4; VEGFA, FGF1 and FGF7; VEGFA, FGF1and FGF9; VEGFA, FGF1 and FGF19; VEGFA, FGF1 and SCF; VEGFA, FGF1 andPDGFA; VEGFA, FGF1 and PDGFB; VEGFA, FGF1 and PDGFC; VEGFA, FGF1 andVEGFB; VEGFA, FGF1 and VEGFC; VEGFA, FGF1 and VEGFD; VEGFA, FGF1 andTGFB1; VEGFA, FGF1 and IL-10; VEGFA, FGF1 and an anti-TNFα antibody;VEGFA, FGF2 and FGF4; VEGFA, FGF2 and FGF7; VEGFA, FGF2 and FGF9; VEGFA,FGF2 and FGF19; VEGFA, FGF2 and SCF; VEGFA, FGF2 and PDGFA; VEGFA, FGF2and PDGFB; VEGFA, FGF2 and PDGFC; VEGFA, FGF2 and VEGFB; VEGFA, FGF2 andVEGFC; VEGFA, FGF2 and VEGFD; VEGFA, FGF2 and TGFB1; VEGFA, FGF2 andIL-10; VEGFA, FGF2 and an anti-TNFα antibody; VEGFA, FGF4 and FGF7;VEGFA, FGF4 and FGF9; VEGFA, FGF4 and FGF19; VEGFA, FGF4 and SCF; VEGFA,FGF4 and PDGFA; VEGFA, FGF4 and PDGFB; VEGFA, FGF4 and PDGFC; VEGFA,FGF4 and VEGFB; VEGFA, FGF4 and VEGFC; VEGFA, FGF4 and VEGFD; VEGFA,FGF4 and TGFB1; VEGFA, FGF4 and IL-10; VEGFA, FGF4 and an anti-TNFαantibody; VEGFA, FGF7 and FGF9; VEGFA, FGF7 and FGF19; VEGFA, FGF7 andSCF; VEGFA, FGF7 and PDGFA; VEGFA, FGF7 and PDGFB; VEGFA, FGF7 andPDGFC; VEGFA, FGF7 and VEGFB; VEGFA, FGF7 and VEGFC; VEGFA, FGF7 andVEGFD; VEGFA, FGF7 and TGFB1; VEGFA, FGF7 and IL-10; VEGFA, FGF7 and ananti-TNFα antibody; VEGFA, FGF9 and FGF19; VEGFA, FGF9 and SCF; VEGFA,FGF9 and PDGFA; VEGFA, FGF9 and PDGFB; VEGFA, FGF9 and PDGFC VEGFA, FGF9and VEGFB; VEGFA, FGF9 and VEGFC; VEGFA, FGF9 and VEGFD; VEGFA, FGF9 andTGFB1; VEGFA, FGF9 and IL-10; VEGFA, FGF9 and an anti-TNFα antibody;VEGFA, FGF19 and SCF; VEGFA, FGF19 and PDGFA; VEGFA, FGF19 and PDGFB;VEGFA, FGF19 and PDGFC; VEGFA, FGF19 and VEGFB; VEGFA, FGF19 and VEGFC;VEGFA, FGF19 and VEGFD; VEGFA, FGF19 and TGFB1; VEGFA, FGF19 and IL-10;VEGFA, FGF19 and an anti-TNFα antibody; VEGFA, SCF and PDGFA; VEGFA, SCFand PDGFB; VEGFA, SCF and PDGFC; VEGFA, SCF and VEGFB; VEGFA, SCF andVEGFC; VEGFA, SCF and VEGFD; VEGFA, SCF and TGFB1; VEGFA, SCF and IL-10;VEGFA, SCF and an anti-TNFα antibody; VEGFA, PDGFA and PDGFB; VEGFA,PDGFA and PDGFC; VEGFA, PDGFA and VEGFB; VEGFA, PDGFA and VEGFC; VEGFA,PDGFA and VEGFD; VEGFA, PDGFA and TGFB1; VEGFA, PDGFA and IL-10; VEGFA,PDGFA and an anti-TNFα antibody; VEGFA, PDGFB and PDGFC; VEGFA, PDGFBand VEGFB; VEGFA, PDGFB and VEGFC; VEGFA, PDGFB and VEGFD; VEGFA, PDGFBand TGFB1; VEGFA, PDGFB and IL-10; VEGFA, PDGFB and an anti-TNFαantibody; VEGFA, PDGFC and VEGFB; VEGFA, PDGFC and VEGFC; VEGFA, PDGFCand VEGFD; VEGFA, PDGFC and TGFB1; VEGFA, PDGFC and IL-10; VEGFA, PDGFCand an anti-TNFα antibody; VEGFA, VEGFB and VEGFC; VEGFA, VEGFB andVEGFD; VEGFA, VEGFB and TGFB1; VEGFA, VEGFB and IL-10; VEGFA, VEGFB andan anti-TNFα antibody; VEGFA, VEGFC and VEGFD; VEGFA, VEGFC and TGFB1;VEGFA, VEGFC and IL-10; VEGFA, VEGFC and an anti-TNFα antibody; VEGFA,VEGFD and TGFB1; VEGFA, VEGFD and IL-10; VEGFA, VEGFD and an anti-TNFαantibody; VEGFA, TGFB1 and IL-10; VEGFA, TGFB1 and an anti-TNFαantibody; VEGFA, IL-10 and an anti-TNFα antibody; VEGFB, AREG and EREG;VEGFB, AREG and HBEGF; VEGFB, AREG and HGF; VEGFB, AREG and HRGB; VEGFB,AREG and BTC; VEGFB, AREG and EGF; VEGFB, AREG and TGFA; VEGFB, AREG andFGF1; VEGFB, AREG and FGF2; VEGFB, AREG and FGF4; VEGFB, AREG and FGF7;VEGFB, AREG and FGF9; VEGFB, AREG and FGF19; VEGFB, AREG and SCF; VEGFB,AREG and PDGFA; VEGFB, AREG and PDGFB; VEGFB, AREG and PDGFC; VEGFB,AREG and VEGFA; VEGFB, AREG and VEGFB; VEGFB, AREG and VEGFC; VEGFB,AREG and VEGFD; VEGFB, AREG and TGFB1; VEGFB, AREG and IL-10; VEGFB,AREG and an anti-TNFα antibody; VEGFB, EREG and HBEGF; VEGFB, EREG andHGF; VEGFB, EREG and HRGB; VEGFB, EREG and BTC; VEGFB, EREG and EGF;VEGFB, EREG and TGFA; VEGFB, EREG and FGF1; VEGFB, EREG and FGF2; VEGFB,EREG and FGF4; VEGFB, EREG and FGF7; VEGFB, EREG and FGF9; VEGFB, EREGand FGF19; VEGFB, EREG and SCF; VEGFB, EREG and PDGFA; VEGFB, EREG andPDGFB; VEGFB, EREG and PDGFC; VEGFB, EREG and VEGFA; VEGFB, EREG andVEGFC; VEGFB, EREG and VEGFD; VEGFB, EREG and TGFB1; VEGFB, EREG andIL-10; VEGFB, EREG and an anti-TNFα antibody; VEGFB, HBEGF and HGF;VEGFB, HBEGF and HRGB; VEGFB, HBEGF and BTC; VEGFB, HBEGF and EGF;VEGFB, HBEGF and TGFA; VEGFB, HBEGF and FGF1; VEGFB, HBEGF and FGF2;VEGFB, HBEGF and FGF4; VEGFB, HBEGF and FGF7; VEGFB, HBEGF and FGF9;VEGFB, HBEGF and FGF19; VEGFB, HBEGF and SCF; VEGFB, HBEGF and PDGFA;VEGFB, HBEGF and PDGFB; VEGFB, HBEGF and PDGFC; VEGFB, HBEGF and VEGFA;VEGFB, HBEGF and VEGFC; VEGFB, HBEGF and VEGFD; VEGFB, HBEGF and TGFB1;VEGFB, HBEGF and IL-10; VEGFB, HBEGF and an anti-TNFα antibody; VEGFB,HGF and HRGB; VEGFB, HGF and BTC; VEGFB, HGF and EGF; VEGFB, HGF andTGFA; VEGFB, HGF and FGF1; VEGFB, HGF and FGF2; VEGFB, HGF and FGF4;VEGFB, HGF and FGF7; VEGFB, HGF and FGF9; VEGFB, HGF and FGF19; VEGFB,HGF and SCF; VEGFB, HGF and PDGFA; VEGFB, HGF and PDGFB; VEGFB, HGF andPDGFC; VEGFB, HGF and VEGFA; VEGFB, HGF and VEGFC; VEGFB, HGF and VEGFD;VEGFB, HGF and TGFB1; VEGFB, HGF and IL-10; VEGFB, HGF and an anti-TNFαantibody; VEGFB, HRGB and BTC; VEGFB, HRGB and EGF; VEGFB, HRGB andTGFA; VEGFB, HRGB and FGF1; VEGFB, HRGB and FGF2; VEGFB, HRGB and FGF4;VEGFB, HRGB and FGF7; VEGFB, HRGB and FGF9; VEGFB, HRGB and FGF19;VEGFB, HRGB and SCF; VEGFB, HRGB and PDGFA; VEGFB, HRGB and PDGFB;VEGFB, HRGB and PDGFC; VEGFB, HRGB and VEGFA; VEGFB, HRGB and VEGFC;VEGFB, HRGB and VEGFD; VEGFB, HRGB and TGFB1; VEGFB, HRGB and IL-10;VEGFB, HRGB and an anti-TNFα antibody; VEGFB, BTC and EGF; VEGFB, BTCand TGFA; VEGFB, BTC and FGF1; VEGFB, BTC and FGF2; VEGFB, BTC and FGF4;VEGFB, BTC and FGF7; VEGFB, BTC and FGF9; VEGFB, BTC and FGF19; VEGFB,BTC and SCF; VEGFB, BTC and PDGFA; VEGFB, BTC and PDGFB; VEGFB, BTC andPDGFC; VEGFB, BTC and VEGFA; VEGFB, BTC and VEGFC; VEGFB, BTC and VEGFD;VEGFB, BTC and TGFB1; VEGFB, BTC and IL-10; VEGFB, BTC and an anti-TNFαantibody; VEGFB, EGF and TGFA; VEGFB, EGF and FGF1; VEGFB, EGF and FGF2;VEGFB, EGF and FGF4; VEGFB, EGF and FGF7; VEGFB, EGF and FGF9; VEGFB,EGF and FGF19; VEGFB, EGF and SCF; VEGFB, EGF and PDGFA; VEGFB, EGF andPDGFB; VEGFB, EGF and PDGFC; VEGFB, EGF and VEGFA; VEGFB, EGF and VEGFC;VEGFB, EGF and VEGFD; VEGFB, EGF and TGFB1; VEGFB, EGF and IL-10; VEGFB,EGF and an anti-TNFα antibody; VEGFB, TGFA and FGF1; VEGFB, TGFA andFGF2; VEGFB, TGFA and FGF4; VEGFB, TGFA and FGF7; VEGFB, TGFA and FGF9;VEGFB, TGFA and FGF19; VEGFB, TGFA and SCF; VEGFB, TGFA and PDGFA;VEGFB, TGFA and PDGFB; VEGFB, TGFA and PDGFC; VEGFB, TGFA and VEGFA;VEGFB, TGFA and VEGFC; VEGFB, TGFA and VEGFD; VEGFB, TGFA and TGFB1;VEGFB, TGFA and IL-10; VEGFB, TGFA and an anti-TNFα antibody; VEGFB,FGF1 and FGF2; VEGFB, FGF1 and FGF4; VEGFB, FGF1 and FGF7; VEGFB, FGF1and FGF9; VEGFB, FGF1 and FGF19; VEGFB, FGF1 and SCF; VEGFB, FGF1 andPDGFA; VEGFB, FGF1 and PDGFB; VEGFB, FGF1 and PDGFC; VEGFB, FGF1 andVEGFA; VEGFB, FGF1 and VEGFC; VEGFB, FGF1 and VEGFD; VEGFB, FGF1 andTGFB1; VEGFB, FGF1 and IL-10; VEGFB, FGF1 and an anti-TNFα antibody;VEGFB, FGF2 and FGF4; VEGFB, FGF2 and FGF7; VEGFB, FGF2 and FGF9; VEGFB,FGF2 and FGF19; VEGFB, FGF2 and SCF; VEGFB, FGF2 and PDGFA; VEGFB, FGF2and PDGFB; VEGFB, FGF2 and PDGFC; VEGFB, FGF2 and VEGFA; VEGFB, FGF2 andVEGFC; VEGFB, FGF2 and VEGFD; VEGFB, FGF2 and TGFB1; VEGFB, FGF2 andIL-10; VEGFB, FGF2 and an anti-TNFα antibody; VEGFB, FGF4 and FGF7;VEGFB, FGF4 and FGF9; VEGFB, FGF4 and FGF19; VEGFB, FGF4 and SCF; VEGFB,FGF4 and PDGFA; VEGFB, FGF4 and PDGFB; VEGFB, FGF4 and PDGFC; VEGFB,FGF4 and VEGFA; VEGFB, FGF4 and VEGFC; VEGFB, FGF4 and VEGFD; VEGFB,FGF4 and TGFB1; VEGFB, FGF4 and IL-10; VEGFB, FGF4 and an anti-TNFαantibody; VEGFB, FGF7 and FGF9; VEGFB, FGF7 and FGF19; VEGFB, FGF7 andSCF; VEGFB, FGF7 and PDGFA; VEGFB, FGF7 and PDGFB; VEGFB, FGF7 andPDGFC; VEGFB, FGF7 and VEGFA; VEGFB, FGF7 and VEGFC; VEGFB, FGF7 andVEGFD; VEGFB, FGF7 and TGFB1; VEGFB, FGF7 and IL-10; VEGFB, FGF7 and ananti-TNFα antibody; VEGFB, FGF9 and FGF19; VEGFB, FGF9 and SCF; VEGFB,FGF9 and PDGFA; VEGFB, FGF9 and PDGFB; VEGFB, FGF9 and PDGFC; VEGFB,FGF9 and VEGFA; VEGFB, FGF9 and VEGFC; VEGFB, FGF9 and VEGFD; VEGFB,FGF9 and TGFB1; VEGFB, FGF9 and IL-10; VEGFB, FGF9 and an anti-TNFαantibody; VEGFB, FGF19 and SCF; VEGFB, FGF19 and PDGFA; VEGFB, FGF19 andPDGFB; VEGFB, FGF19 and PDGFC; VEGFB, FGF19 and VEGFA; VEGFB, FGF19 andVEGFC; VEGFB, FGF19 and VEGFD; VEGFB, FGF19 and TGFB1; VEGFB, FGF19 andIL-10; VEGFB, FGF19 and an anti-TNFα antibody; VEGFB, SCF and PDGFA;VEGFB, SCF and PDGFB; VEGFB, SCF and PDGFC; VEGFB, SCF and VEGFA; VEGFB,SCF and VEGFC; VEGFB, SCF and VEGFD; VEGFB, SCF and TGFB1; VEGFB, SCFand IL-10; VEGFB, SCF and an anti-TNFα antibody; VEGFB, PDGFA and PDGFB;VEGFB, PDGFA and PDGFC; VEGFB, PDGFA and VEGFA; VEGFB, PDGFA and VEGFC;VEGFB, PDGFA and VEGFD; VEGFB, PDGFA and TGFB1; VEGFB, PDGFA and IL-10;VEGFB, PDGFA and an anti-TNFα antibody; VEGFB, PDGFB and PDGFC; VEGFB,PDGFB and VEGFA; VEGFB, PDGFB and VEGFC; VEGFB, PDGFB and VEGFD; VEGFB,PDGFB and TGFB1; VEGFB, PDGFB and IL-10; VEGFB, PDGFB and an anti-TNFαantibody; VEGFB, PDGFC and VEGFA; VEGFB, PDGFC and VEGFC; VEGFB, PDGFCand VEGFD; VEGFB, PDGFC and TGFB1; VEGFB, PDGFC and IL-10; VEGFB, PDGFCand an anti-TNFα antibody; VEGFB, VEGFA and VEGFC; VEGFB, VEGFA andVEGFD; VEGFB, VEGFA and TGFB1; VEGFB, VEGFA and IL-10; VEGFB, VEGFA andan anti-TNFα antibody; VEGFB, VEGFC and VEGFD; VEGFB, VEGFC and TGFB1;VEGFB, VEGFC and IL-10; VEGFB, VEGFC and an anti-TNFα antibody; VEGFB,VEGFD and TGFB1; VEGFB, VEGFD and IL-10; VEGFB, VEGFD and an anti-TNFαantibody; VEGFB, TGFB1 and IL-10; VEGFB, TGFB1 and an anti-TNFαantibody; VEGFB, IL-10 and an anti-TNFα antibody; and the like.

VEGFC, AREG and EREG; VEGFC, AREG and HBEGF; VEGFC, AREG and HGF; VEGFC,AREG and HRGB; VEGFC, AREG and BTC; VEGFC, AREG and EGF; VEGFC, AREG andTGFA; VEGFC, AREG and FGF1; VEGFC, AREG and FGF2; VEGFC, AREG and FGF4;VEGFC, AREG and FGF7; VEGFC, AREG and FGF9; VEGFC, AREG and FGF19;VEGFC, AREG and SCF; VEGFC, AREG and PDGFA; VEGFC, AREG and PDGFB;VEGFC, AREG and PDGFC; VEGFC, AREG and VEGFA; VEGFC, AREG and VEGFB;VEGFC, AREG and VEGFC; VEGFC, AREG and VEGFD; VEGFC, AREG and TGFB1;VEGFC, AREG and IL-10; VEGFC, AREG and an anti-TNFα antibody; VEGFC,EREG and HBEGF; VEGFC, EREG and HGF; VEGFC, EREG and HRGB; VEGFC, EREGand BTC; VEGFC, EREG and EGF; VEGFC, EREG and TGFA; VEGFC, EREG andFGF1; VEGFC, EREG and FGF2; VEGFC, EREG and FGF4; VEGFC, EREG and FGF7;VEGFC, EREG and FGF9; VEGFC, EREG and FGF19; VEGFC, EREG and SCF; VEGFC,EREG and PDGFA; VEGFC, EREG and PDGFB; VEGFC, EREG and PDGFC; VEGFC,EREG and VEGFA; VEGFC, EREG and VEGFB; VEGFC, EREG and VEGFD; VEGFC,EREG and TGFB1; VEGFC, EREG and IL-10; VEGFC, EREG and an anti-TNFαantibody; VEGFC, HBEGF and HGF; VEGFC, HBEGF and HRGB; VEGFC, HBEGF andBTC; VEGFC, HBEGF and EGF; VEGFC, HBEGF and TGFA; VEGFC, HBEGF and FGF1;VEGFC, HBEGF and FGF2; VEGFC, HBEGF and FGF4; VEGFC, HBEGF and FGF7;VEGFC, HBEGF and FGF9; VEGFC, HBEGF and FGF19; VEGFC, HBEGF and SCF;VEGFC, HBEGF and PDGFA; VEGFC, HBEGF and PDGFB; VEGFC, HBEGF and PDGFC;VEGFC, HBEGF and VEGFA; VEGFC, HBEGF and VEGFB; VEGFC, HBEGF and VEGFD;VEGFC, HBEGF and TGFB1; VEGFC, HBEGF and IL-10; VEGFC, HBEGF and ananti-TNFα antibody; VEGFC, HGF and HRGB; VEGFC, HGF and BTC; VEGFC, HGFand EGF; VEGFC, HGF and TGFA; VEGFC, HGF and FGF1; VEGFC, HGF and FGF2;VEGFC, HGF and FGF4; VEGFC, HGF and FGF7; VEGFC, HGF and FGF9; VEGFC,HGF and FGF19; VEGFC, HGF and SCF; VEGFC, HGF and PDGFA; VEGFC, HGF andPDGFB; VEGFC, HGF and PDGFC; VEGFC, HGF and VEGFA; VEGFC, HGF and VEGFB;VEGFC, HGF and VEGFD; VEGFC, HGF and TGFB1; VEGFC, HGF and IL-10; VEGFC,HGF and an anti-TNFα antibody; VEGFC, HRGB and BTC; VEGFC, HRGB and EGF;VEGFC, HRGB and TGFA; VEGFC, HRGB and FGF1; VEGFC, HRGB and FGF2; VEGFC,HRGB and FGF4; VEGFC, HRGB and FGF7; VEGFC, HRGB and FGF9; VEGFC, HRGBand FGF19; VEGFC, HRGB and SCF; VEGFC, HRGB and PDGFA; VEGFC, HRGB andPDGFB; VEGFC, HRGB and PDGFC; VEGFC, HRGB and VEGFA; VEGFC, HRGB andVEGFB; VEGFC, HRGB and VEGFD; VEGFC, HRGB and TGFB1; VEGFC, HRGB andIL-10; VEGFC, HRGB and an anti-TNFα antibody; VEGFC, BTC and EGF; VEGFC,BTC and TGFA; VEGFC, BTC and FGF1; VEGFC, BTC and FGF2; VEGFC, BTC andFGF4; VEGFC, BTC and FGF7; VEGFC, BTC and FGF9; VEGFC, BTC and FGF19;VEGFC, BTC and SCF; VEGFC, BTC and PDGFA; VEGFC, BTC and PDGFB; VEGFC,BTC and PDGFC; VEGFC, BTC and VEGFA; VEGFC, BTC and VEGFB; VEGFC, BTCand VEGFD; VEGFC, BTC and TGFB1; VEGFC, BTC and IL-10; VEGFC, BTC and ananti-TNFα antibody; VEGFC, EGF and TGFA; VEGFC, EGF and FGF1; VEGFC, EGFand FGF2; VEGFC, EGF and FGF4; VEGFC, EGF and FGF7; VEGFC, EGF and FGF9;VEGFC, EGF and FGF19; VEGFC, EGF and SCF; VEGFC, EGF and PDGFA; VEGFC,EGF and PDGFB; VEGFC, EGF and PDGFC; VEGFC, EGF and VEGFA; VEGFC, EGFand VEGFB; VEGFC, EGF and VEGFD; VEGFC, EGF and TGFB1; VEGFC, EGF andIL-10; VEGFC, EGF and an anti-TNFα antibody; VEGFC, TGFA and FGF1;VEGFC, TGFA and FGF2; VEGFC, TGFA and FGF4; VEGFC, TGFA and FGF7; VEGFC,TGFA and FGF9; VEGFC, TGFA and FGF19; VEGFC, TGFA and SCF; VEGFC, TGFAand PDGFA; VEGFC, TGFA and PDGFB; VEGFC, TGFA and PDGFC; VEGFC, TGFA andVEGFA; VEGFC, TGFA and VEGFB; VEGFC, TGFA and VEGFD; VEGFC, TGFA andTGFB1; VEGFC, TGFA and IL-10; VEGFC, TGFA and an anti-TNFα antibody;VEGFC, FGF1 and FGF2; VEGFC, FGF1 and FGF4; VEGFC, FGF1 and FGF7; VEGFC,FGF1 and FGF9; VEGFC, FGF1 and FGF19; VEGFC, FGF1 and SCF; VEGFC, FGF1and PDGFA; VEGFC, FGF1 and PDGFB; VEGFC, FGF1 and PDGFC; VEGFC, FGF1 andVEGFA; VEGFC, FGF1 and VEGFB; VEGFC, FGF1 and VEGFD; VEGFC, FGF1 andTGFB1; VEGFC, FGF1 and IL-10; VEGFC, FGF1 and an anti-TNFα antibody;VEGFC, FGF2 and FGF4; VEGFC, FGF2 and FGF7; VEGFC, FGF2 and FGF9; VEGFC,FGF2 and FGF19; VEGFC, FGF2 and SCF; VEGFC, FGF2 and PDGFA; VEGFC, FGF2and PDGFB; VEGFC, FGF2 and PDGFC; VEGFC, FGF2 and VEGFA; VEGFC, FGF2 andVEGFB; VEGFC, FGF2 and VEGFD; VEGFC, FGF2 and TGFB1; VEGFC, FGF2 andIL-10; VEGFC, FGF2 and an anti-TNFα antibody; VEGFC, FGF4 and FGF7;VEGFC, FGF4 and FGF9; VEGFC, FGF4 and FGF19; VEGFC, FGF4 and SCF; VEGFC,FGF4 and PDGFA; VEGFC, FGF4 and PDGFB; VEGFC, FGF4 and PDGFC; VEGFC,FGF4 and VEGFA; VEGFC, FGF4 and VEGFB; VEGFC, FGF4 and VEGFD; VEGFC,FGF4 and TGFB1; VEGFC, FGF4 and IL-10; VEGFC, FGF4 and an anti-TNFαantibody; VEGFC, FGF7 and FGF9; VEGFC, FGF7 and FGF19; VEGFC, FGF7 andSCF; VEGFC, FGF7 and PDGFA; VEGFC, FGF7 and PDGFB; VEGFC, FGF7 andPDGFC; VEGFC, FGF7 and VEGFA; VEGFC, FGF7 and VEGFB; VEGFC, FGF7 andVEGFD; VEGFC, FGF7 and TGFB1; VEGFC, FGF7 and IL-10; VEGFC, FGF7 and ananti-TNFα antibody; VEGFC, FGF9 and FGF19; VEGFC, FGF9 and SCF; VEGFC,FGF9 and PDGFA; VEGFC, FGF9 and PDGFB; VEGFC, FGF9 and PDGFC; VEGFC,FGF9 and VEGFA; VEGFC, FGF9 and VEGFB; VEGFC, FGF9 and VEGFD; VEGFC,FGF9 and TGFB1; VEGFC, FGF9 and IL-10; VEGFC, FGF9 and an anti-TNFαantibody; VEGFC, FGF19 and SCF; VEGFC, FGF19 and PDGFA; VEGFC, FGF19 andPDGFB; VEGFC, FGF19 and PDGFC; VEGFC, FGF19 and VEGFA; VEGFC, FGF19 andVEGFB; VEGFC, FGF19 and VEGFD; VEGFC, FGF19 and TGFB1; VEGFC, FGF19 andIL-10; VEGFC, FGF19 and an anti-TNFα antibody; VEGFC, SCF and PDGFA;VEGFC, SCF and PDGFB; VEGFC, SCF and PDGFC; VEGFC, SCF and VEGFA; VEGFC,SCF and VEGFB; VEGFC, SCF and VEGFD; VEGFC, SCF and TGFB1; VEGFC, SCFand IL-10; VEGFC, SCF and an anti-TNFα antibody; VEGFC, PDGFA and PDGFB;VEGFC, PDGFA and PDGFC; VEGFC, PDGFA and VEGFA; VEGFC, PDGFA and VEGFB;VEGFC, PDGFA and VEGFD; VEGFC, PDGFA and TGFB1; VEGFC, PDGFA and IL-10;VEGFC, PDGFA and an anti-TNFα antibody; VEGFC, PDGFB and PDGFC; VEGFC,PDGFB and VEGFA; VEGFC, PDGFB and VEGFB; VEGFC, PDGFB and VEGFD; VEGFC,PDGFB and TGFB1; VEGFC, PDGFB and IL-10; VEGFC, PDGFB and an anti-TNFαantibody; VEGFC, PDGFC and VEGFA; VEGFC, PDGFC and VEGFB; VEGFC, PDGFCand VEGFD; VEGFC, PDGFC and TGFB1; VEGFC, PDGFC and IL-10; VEGFC, PDGFCand an anti-TNFα antibody; VEGFC, VEGFA and VEGFB; VEGFC, VEGFA andVEGFD; VEGFC, VEGFA and TGFB1; VEGFC, VEGFA and IL-10; VEGFC, VEGFA andan anti-TNFα antibody; VEGFC, VEGFB and VEGFD; VEGFC, VEGFB and TGFB1;VEGFC, VEGFB and IL-10; VEGFC, VEGFB and an anti-TNFα antibody; VEGFC,VEGFD and TGFB1; VEGFC, VEGFD and IL-10; VEGFC, VEGFD and an anti-TNFαantibody; VEGFC, TGFB1 and IL-10; VEGFC, TGFB1 and an anti-TNFαantibody; VEGFC, IL-10 and an anti-TNFα antibody; VEGFD, AREG and EREG;VEGFD, AREG and HBEGF; VEGFD, AREG and HGF; VEGFD, AREG and HRGB; VEGFD,AREG and BTC; VEGFD, AREG and EGF; VEGFD, AREG and TGFA; VEGFD, AREG andFGF1; VEGFD, AREG and FGF2; VEGFD, AREG and FGF4; VEGFD, AREG and FGF7;VEGFD, AREG and FGF9; VEGFD, AREG and FGF19; VEGFD, AREG and SCF; VEGFD,AREG and PDGFA; VEGFD, AREG and PDGFB; VEGFD, AREG and PDGFC; VEGFD,AREG and VEGFA; VEGFD, AREG and VEGFB; VEGFD, AREG and VEGFC; VEGFD,AREG and TGFB1; VEGFD, AREG and IL-10; VEGFD, AREG and an anti-TNFαantibody; VEGFD, EREG and HBEGF; VEGFD, EREG and HGF; VEGFD, EREG andHRGB; VEGFD, EREG and BTC; VEGFD, EREG and EGF; VEGFD, EREG and TGFA;VEGFD, EREG and FGF1; VEGFD, EREG and FGF2; VEGFD, EREG and FGF4; VEGFD,EREG and FGF7; VEGFD, EREG and FGF9; VEGFD, EREG and FGF19; VEGFD, EREGand SCF; VEGFD, EREG and PDGFA; VEGFD, EREG and PDGFB; VEGFD, EREG andPDGFC; VEGFD, EREG and VEGFA; VEGFD, EREG and VEGFB; VEGFD, EREG andVEGFC; VEGFD, EREG and TGFB1; VEGFD, EREG and IL-10; VEGFD, EREG and ananti-TNFα antibody; VEGFD, HBEGF and HGF; VEGFD, HBEGF and HRGB; VEGFD,HBEGF and BTC; VEGFD, HBEGF and EGF; VEGFD, HBEGF and TGFA; VEGFD, HBEGFand FGF1; VEGFD, HBEGF and FGF2; VEGFD, HBEGF and FGF4; VEGFD, HBEGF andFGF7; VEGFD, HBEGF and FGF9; VEGFD, HBEGF and FGF19; VEGFD, HBEGF andSCF; VEGFD, HBEGF and PDGFA; VEGFD, HBEGF and PDGFB; VEGFD, HBEGF andPDGFC; VEGFD, HBEGF and VEGFA; VEGFD, HBEGF and VEGFB; VEGFD, HBEGF andVEGFC; VEGFD, HBEGF and TGFB1; VEGFD, HBEGF and IL-10; VEGFD, HBEGF andan anti-TNFα antibody; VEGFD, HGF and HRGB; VEGFD, HGF and BTC; VEGFD,HGF and EGF; VEGFD, HGF and TGFA; VEGFD, HGF and FGF1; VEGFD, HGF andFGF2; VEGFD, HGF and FGF4; VEGFD, HGF and FGF7; VEGFD, HGF and FGF9;VEGFD, HGF and FGF19; VEGFD, HGF and SCF; VEGFD, HGF and PDGFA; VEGFD,HGF and PDGFB; VEGFD, HGF and PDGFC; VEGFD, HGF and VEGFA; VEGFD, HGFand VEGFB; VEGFD, HGF and VEGFC; VEGFD, HGF and TGFB1; VEGFD, HGF andIL-10; VEGFD, HGF and an anti-TNFα antibody; VEGFD, HRGB and BTC; VEGFD,HRGB and EGF; VEGFD, HRGB and TGFA; VEGFD, HRGB and FGF1; VEGFD, HRGBand FGF2; VEGFD, HRGB and FGF4; VEGFD, HRGB and FGF7; VEGFD, HRGB andFGF9; VEGFD, HRGB and FGF19; VEGFD, HRGB and SCF; VEGFD, HRGB and PDGFA;VEGFD, HRGB and PDGFB; VEGFD, HRGB and PDGFC; VEGFD, HRGB and VEGFA;VEGFD, HRGB and VEGFB; VEGFD, HRGB and VEGFC; VEGFD, HRGB and TGFB1;VEGFD, HRGB and IL-10; VEGFD, HRGB and an anti-TNFα antibody; VEGFD, BTCand EGF; VEGFD, BTC and TGFA; VEGFD, BTC and FGF1; VEGFD, BTC and FGF2;VEGFD, BTC and FGF4; VEGFD, BTC and FGF7; VEGFD, BTC and FGF9; VEGFD,BTC and FGF19; VEGFD, BTC and SCF; VEGFD, BTC and PDGFA; VEGFD, BTC andPDGFB; VEGFD, BTC and PDGFC; VEGFD, BTC and VEGFA; VEGFD, BTC and VEGFB;VEGFD, BTC and VEGFC; VEGFD, BTC and TGFB1; VEGFD, BTC and IL-10; VEGFD,BTC and an anti-TNFα antibody; VEGFD, EGF and TGFA; VEGFD, EGF and FGF1;VEGFD, EGF and FGF2; VEGFD, EGF and FGF4; VEGFD, EGF and FGF7; VEGFD,EGF and FGF9; VEGFD, EGF and FGF19; VEGFD, EGF and SCF; VEGFD, EGF andPDGFA; VEGFD, EGF and PDGFB; VEGFD, EGF and PDGFC; VEGFD, EGF and VEGFA;VEGFD, EGF and VEGFB; VEGFD, EGF and VEGFC; VEGFD, EGF and TGFB1; VEGFD,EGF and IL-10; VEGFD, EGF and an anti-TNFα antibody; VEGFD, TGFA andFGF1; VEGFD, TGFA and FGF2; VEGFD, TGFA and FGF4; VEGFD, TGFA and FGF7;VEGFD, TGFA and FGF9; VEGFD, TGFA and FGF19; VEGFD, TGFA and SCF; VEGFD,TGFA and PDGFA; VEGFD, TGFA and PDGFB; VEGFD, TGFA and PDGFC; VEGFD,TGFA and VEGFA; VEGFD, TGFA and VEGFB; VEGFD, TGFA and VEGFC; VEGFD,TGFA and TGFB1; VEGFD, TGFA and IL-10; VEGFD, TGFA and an anti-TNFαantibody; VEGFD, FGF1 and FGF2; VEGFD, FGF1 and FGF4; VEGFD, FGF1 andFGF7; VEGFD, FGF1 and FGF9; VEGFD, FGF1 and FGF19; VEGFD, FGF1 and SCF;VEGFD, FGF1 and PDGFA; VEGFD, FGF1 and PDGFB; VEGFD, FGF1 and PDGFC;VEGFD, FGF1 and VEGFA; VEGFD, FGF1 and VEGFB; VEGFD, FGF1 and VEGFC;VEGFD, FGF1 and TGFB1; VEGFD, FGF1 and IL-10; VEGFD, FGF1 and ananti-TNFα antibody; VEGFD, FGF2 and FGF4; VEGFD, FGF2 and FGF7; VEGFD,FGF2 and FGF9; VEGFD, FGF2 and FGF19; VEGFD, FGF2 and SCF; VEGFD, FGF2and PDGFA; VEGFD, FGF2 and PDGFB; VEGFD, FGF2 and PDGFC; VEGFD, FGF2 andVEGFA; VEGFD, FGF2 and VEGFB; VEGFD, FGF2 and VEGFC; VEGFD, FGF2 andTGFB1; VEGFD, FGF2 and IL-10; VEGFD, FGF2 and an anti-TNFα antibody;VEGFD, FGF4 and FGF7; VEGFD, FGF4 and FGF9; VEGFD, FGF4 and FGF19;VEGFD, FGF4 and SCF; VEGFD, FGF4 and PDGFA; VEGFD, FGF4 and PDGFB;VEGFD, FGF4 and PDGFC; VEGFD, FGF4 and VEGFA; VEGFD, FGF4 and VEGFB;VEGFD, FGF4 and VEGFC; VEGFD, FGF4 and TGFB1; VEGFD, FGF4 and IL-10;VEGFD, FGF4 and an anti-TNFα antibody; VEGFD, FGF7 and FGF9; VEGFD, FGF7and FGF19; VEGFD, FGF7 and SCF; VEGFD, FGF7 and PDGFA; VEGFD, FGF7 andPDGFB; VEGFD, FGF7 and PDGFC; VEGFD, FGF7 and VEGFA; VEGFD, FGF7 andVEGFB; VEGFD, FGF7 and VEGFC; VEGFD, FGF7 and TGFB1; VEGFD, FGF7 andIL-10; VEGFD, FGF7 and an anti-TNFα antibody; VEGFD, FGF9 and FGF19;VEGFD, FGF9 and SCF; VEGFD, FGF9 and PDGFA; VEGFD, FGF9 and PDGFB;VEGFD, FGF9 and PDGFC; VEGFD, FGF9 and VEGFA; VEGFD, FGF9 and VEGFB;VEGFD, FGF9 and VEGFC; VEGFD, FGF9 and TGFB1; VEGFD, FGF9 and IL-10;VEGFD, FGF9 and an anti-TNFα antibody; VEGFD, FGF19 and SCF; VEGFD,FGF19 and PDGFA; VEGFD, FGF19 and PDGFB; VEGFD, FGF19 and PDGFC; VEGFD,FGF19 and VEGFA; VEGFD, FGF19 and VEGFB; VEGFD, FGF19 and VEGFC; VEGFD,FGF19 and TGFB1; VEGFD, FGF19 and IL-10; VEGFD, FGF19 and an anti-TNFαantibody; VEGFD, SCF and PDGFA; VEGFD, SCF and PDGFB; VEGFD, SCF andPDGFC; VEGFD, SCF and VEGFA; VEGFD, SCF and VEGFB; VEGFD, SCF and VEGFC;VEGFD, SCF and TGFB1; VEGFD, SCF and IL-10; VEGFD, SCF and an anti-TNFαantibody; VEGFD, PDGFA and PDGFB; VEGFD, PDGFA and PDGFC; VEGFD, PDGFAand VEGFA; VEGFD, PDGFA and VEGFB; VEGFD, PDGFA and VEGFC; VEGFD, PDGFAand TGFB1; VEGFD, PDGFA and IL-10; VEGFD, PDGFA and an anti-TNFαantibody; VEGFD, PDGFB and PDGFC; VEGFD, PDGFB and VEGFA; VEGFD, PDGFBand VEGFB; VEGFD, PDGFB and VEGFC; VEGFD, PDGFB and TGFB1; VEGFD, PDGFBand IL-10; VEGFD, PDGFB and an anti-TNFα antibody; VEGFD, PDGFC andVEGFA; VEGFD, PDGFC and VEGFB; VEGFD, PDGFC and VEGFC; VEGFD, PDGFC andTGFB1; VEGFD, PDGFC and IL-10; VEGFD, PDGFC and an anti-TNFα antibody;VEGFD, VEGFA and VEGFB; VEGFD, VEGFA and VEGFC; VEGFD, VEGFA and TGFB1;VEGFD, VEGFA and IL-10; VEGFD, VEGFA and an anti-TNFα antibody; VEGFD,VEGFB and VEGFC; VEGFD, VEGFB and TGFB1; VEGFD, VEGFB and IL-10; VEGFD,VEGFB and an anti-TNFα antibody; VEGFD, VEGFC and TGFB1; VEGFD, VEGFCand IL-10; VEGFD, VEGFC and an anti-TNFα antibody; VEGFD, TGFB1 andIL-10; VEGFD, TGFB1 and an anti-TNFα antibody; VEGFD, IL-10 and ananti-TNFα antibody; TGFB1, AREG and EREG; TGFB1, AREG and HBEGF; TGFB1,AREG and HGF; TGFB1, AREG and HRGB; TGFB1, AREG and BTC; TGFB1, AREG andEGF; TGFB1, AREG and TGFA; TGFB1, AREG and FGF1; TGFB1, AREG and FGF2;TGFB1, AREG and FGF4; TGFB1, AREG and FGF7; TGFB1, AREG and FGF9; TGFB1,AREG and FGF19; TGFB1, AREG and SCF; TGFB1, AREG and PDGFA; TGFB1, AREGand PDGFB; TGFB1, AREG and PDGFC; TGFB1, AREG and VEGFA; TGFB1, AREG andVEGFB; TGFB1, AREG and VEGFC; TGFB1, AREG and VEGFD; TGFB1, AREG andIL-10; TGFB1, AREG and an anti-TNFα antibody; TGFB1, EREG and HBEGF;TGFB1, EREG and HGF; TGFB1, EREG and HRGB; TGFB1, EREG and BTC; TGFB1,EREG and EGF; TGFB1, EREG and TGFA; TGFB1, EREG and FGF1; TGFB1, EREGand FGF2; TGFB1, EREG and FGF4; TGFB1, EREG and FGF7; TGFB1, EREG andFGF9; TGFB1, EREG and FGF19; TGFB1, EREG and SCF; TGFB1, EREG and PDGFA;TGFB1, EREG and PDGFB; TGFB1, EREG and PDGFC; TGFB1, EREG and VEGFA;TGFB1, EREG and VEGFB; TGFB1, EREG and VEGFC; TGFB1, EREG and VEGFD;TGFB1, EREG and IL-10; TGFB1, EREG and an anti-TNFα antibody; TGFB1,HBEGF and HGF; TGFB1, HBEGF and HRGB; TGFB1, HBEGF and BTC; TGFB1, HBEGFand EGF; TGFB1, HBEGF and TGFA; TGFB1, HBEGF and FGF1; TGFB1, HBEGF andFGF2; TGFB1, HBEGF and FGF4; TGFB1, HBEGF and FGF7; TGFB1, HBEGF andFGF9; TGFB1, HBEGF and FGF19; TGFB1, HBEGF and SCF; TGFB1, HBEGF andPDGFA; TGFB1, HBEGF and PDGFB; TGFB1, HBEGF and PDGFC; TGFB1, HBEGF andVEGFA; TGFB1, HBEGF and VEGFB; TGFB1, HBEGF and VEGFC; TGFB1, HBEGF andVEGFD; TGFB1, HBEGF and IL-10; TGFB1, HBEGF and an anti-TNFα antibody;TGFB1, HGF and HRGB; TGFB1, HGF and BTC; TGFB1, HGF and EGF; TGFB1, HGFand TGFA; TGFB1, HGF and FGF1; TGFB1, HGF and FGF2; TGFB1, HGF and FGF4;TGFB1, HGF and FGF7; TGFB1, HGF and FGF9; TGFB1, HGF and FGF19; TGFB1,HGF and SCF; TGFB1, HGF and PDGFA; TGFB1, HGF and PDGFB; TGFB1, HGF andPDGFC; TGFB1, HGF and VEGFA; TGFB1, HGF and VEGFB; TGFB1, HGF and VEGFC;TGFB1, HGF and VEGFD; TGFB1, HGF and IL-10; TGFB1, HGF and an anti-TNFαantibody; TGFB1, HRGB and BTC; TGFB1, HRGB and EGF; TGFB1, HRGB andTGFA; TGFB1, HRGB and FGF1; TGFB1, HRGB and FGF2; TGFB1, HRGB and FGF4;TGFB1, HRGB and FGF7; TGFB1, HRGB and FGF9; TGFB1, HRGB and FGF19;TGFB1, HRGB and SCF; TGFB1, HRGB and PDGFA; TGFB1, HRGB and PDGFB;TGFB1, HRGB and PDGFC; TGFB1, HRGB and VEGFA; TGFB1, HRGB and VEGFB;TGFB1, HRGB and VEGFC; TGFB1, HRGB and VEGFD; TGFB1, HRGB and IL-10;TGFB1, HRGB and an anti-TNFα antibody; TGFB1, BTC and EGF; TGFB1, BTCand TGFA; TGFB1, BTC and FGF1; TGFB1, BTC and FGF2; TGFB1, BTC and FGF4;TGFB1, BTC and FGF7; TGFB1, BTC and FGF9; TGFB1, BTC and FGF19; TGFB1,BTC and SCF; TGFB1, BTC and PDGFA; TGFB1, BTC and PDGFB; TGFB1, BTC andPDGFC; TGFB1, BTC and VEGFA; TGFB1, BTC and VEGFB; TGFB1, BTC and VEGFC;TGFB1, BTC and VEGFD; TGFB1, BTC and IL-10; TGFB1, BTC and an anti-TNFαantibody; TGFB1, EGF and TGFA; TGFB1, EGF and FGF1; TGFB1, EGF and FGF2;TGFB1, EGF and FGF4; TGFB1, EGF and FGF7; TGFB1, EGF and FGF9; TGFB1,EGF and FGF19; TGFB1, EGF and SCF; TGFB1, EGF and PDGFA; TGFB1, EGF andPDGFB; TGFB1, EGF and PDGFC; TGFB1, EGF and VEGFA; TGFB1, EGF and VEGFB;TGFB1, EGF and VEGFC; TGFB1, EGF and VEGFD; TGFB1, EGF and IL-10; TGFB1,EGF and an anti-TNFα antibody; TGFB1, TGFA and FGF1; TGFB1, TGFA andFGF2; TGFB1, TGFA and FGF4; TGFB1, TGFA and FGF7; TGFB1, TGFA and FGF9;TGFB1, TGFA and FGF19; TGFB1, TGFA and SCF; TGFB1, TGFA and PDGFA;TGFB1, TGFA and PDGFB; TGFB1, TGFA and PDGFC; TGFB1, TGFA and VEGFA;TGFB1, TGFA and VEGFB; TGFB1, TGFA and VEGFC; TGFB1, TGFA and VEGFD;TGFB1, TGFA and IL-10; TGFB1, TGFA and an anti-TNFα antibody; TGFB1,FGF1 and FGF2; TGFB1, FGF1 and FGF4; TGFB1, FGF1 and FGF7; TGFB1, FGF1and FGF9; TGFB1, FGF1 and FGF19; TGFB1, FGF1 and SCF; TGFB1, FGF1 andPDGFA; TGFB1, FGF1 and PDGFB; TGFB1, FGF1 and PDGFC; TGFB1, FGF1 andVEGFA; TGFB1, FGF1 and VEGFB; TGFB1, FGF1 and VEGFC; TGFB1, FGF1 andVEGFD; TGFB1, FGF1 and IL-10; TGFB1, FGF1 and an anti-TNFα antibody;TGFB1, FGF2 and FGF4; TGFB1, FGF2 and FGF7; TGFB1, FGF2 and FGF9; TGFB1,FGF2 and FGF19; TGFB1, FGF2 and SCF; TGFB1, FGF2 and PDGFA; TGFB1, FGF2and PDGFB; TGFB1, FGF2 and PDGFC; TGFB1, FGF2 and VEGFA; TGFB1, FGF2 andVEGFB; TGFB1, FGF2 and VEGFC; TGFB1, FGF2 and VEGFD; TGFB1, FGF2 andIL-10; TGFB1, FGF2 and an anti-TNFα antibody; TGFB1, FGF4 and FGF7;TGFB1, FGF4 and FGF9; TGFB1, FGF4 and FGF19; TGFB1, FGF4 and SCF; TGFB1,FGF4 and PDGFA; TGFB1, FGF4 and PDGFB; TGFB1, FGF4 and PDGFC; TGFB1,FGF4 and VEGFA; TGFB1, FGF4 and VEGFB; TGFB1, FGF4 and VEGFC; TGFB1,FGF4 and VEGFD; TGFB1, FGF4 and IL-10; TGFB1, FGF4 and an anti-TNFαantibody; TGFB1, FGF7 and FGF9; TGFB1, FGF7 and FGF19; TGFB1, FGF7 andSCF; TGFB1, FGF7 and PDGFA; TGFB1, FGF7 and PDGFB; TGFB1, FGF7 andPDGFC; TGFB1, FGF7 and VEGFA; TGFB1, FGF7 and VEGFB; TGFB1, FGF7 andVEGFC; TGFB1, FGF7 and VEGFD; TGFB1, FGF7 and IL-10; TGFB1, FGF7 and ananti-TNFα antibody; TGFB1, FGF9 and FGF19; TGFB1, FGF9 and SCF; TGFB1,FGF9 and PDGFA; TGFB1, FGF9 and PDGFB; TGFB1, FGF9 and PDGFC; TGFB1,FGF9 and VEGFA; TGFB1, FGF9 and VEGFB; TGFB1, FGF9 and VEGFC; TGFB1,FGF9 and VEGFD; TGFB1, FGF9 and IL-10; TGFB1, FGF9 and an anti-TNFαantibody; TGFB1, FGF19 and SCF; TGFB1, FGF19 and PDGFA; TGFB1, FGF19 andPDGFB; TGFB1, FGF19 and PDGFC; TGFB1, FGF19 and VEGFA; TGFB1, FGF19 andVEGFB; TGFB1, FGF19 and VEGFC; TGFB1, FGF19 and VEGFD; TGFB1, FGF19 andIL-10; TGFB1, FGF19 and an anti-TNFα antibody; TGFB1, SCF and PDGFA;TGFB1, SCF and PDGFB; TGFB1, SCF and PDGFC; TGFB1, SCF and VEGFA; TGFB1,SCF and VEGFB; TGFB1, SCF and VEGFC; TGFB1, SCF and VEGFD; TGFB1, SCFand IL-10; TGFB1, SCF and an anti-TNFα antibody; TGFB1, PDGFA and PDGFB;TGFB1, PDGFA and PDGFC; TGFB1, PDGFA and VEGFA; TGFB1, PDGFA and VEGFB;TGFB1, PDGFA and VEGFC; TGFB1, PDGFA and VEGFD; TGFB1, PDGFA and IL-10;TGFB1, PDGFA and an anti-TNFα antibody; TGFB1, PDGFB and PDGFC; TGFB1,PDGFB and VEGFA; TGFB1, PDGFB and VEGFB; TGFB1, PDGFB and VEGFC; TGFB1,PDGFB and VEGFD; TGFB1, PDGFB and IL-10; TGFB1, PDGFB and an anti-TNFαantibody; TGFB1, PDGFC and VEGFA; TGFB1, PDGFC and VEGFB; TGFB1, PDGFCand VEGFC; TGFB1, PDGFC and VEGFD; TGFB1, PDGFC and IL-10; TGFB1, PDGFCand an anti-TNFα antibody; TGFB1, VEGFA and VEGFB; TGFB1, VEGFA andVEGFC; TGFB1, VEGFA and VEGFD; TGFB1, VEGFA and IL-10; TGFB1, VEGFA andan anti-TNFα antibody; TGFB1, VEGFB and VEGFC; TGFB1, VEGFB and VEGFD;TGFB1, VEGFB and IL-10; TGFB1, VEGFB and an anti-TNFα antibody; TGFB1,VEGFC and VEGFD; TGFB1, VEGFC and IL-10; TGFB1, VEGFC and an anti-TNFαantibody; TGFB1, VEGFD and IL-10; TGFB1, VEGFD and an anti-TNFαantibody; TGFB1, IL-10 and an anti-TNFα antibody; IL-10, AREG and EREG;IL-10, AREG and HBEGF; IL-10, AREG and HGF; IL-10, AREG and HRGB; IL-10,AREG and BTC; IL-10, AREG and EGF; IL-10, AREG and TGFA; IL-10, AREG andFGF1; IL-10, AREG and FGF2; IL-10, AREG and FGF4; IL-10, AREG and FGF7;IL-10, AREG and FGF9; IL-10, AREG and FGF19; IL-10, AREG and SCF; IL-10,AREG and PDGFA; IL-10, AREG and PDGFB; IL-10, AREG and PDGFC; IL-10,AREG and VEGFA; IL-10, AREG and VEGFB; IL-10, AREG and VEGFC; IL-10,AREG and VEGFD; IL-10, AREG and TGFB1; IL-10, AREG and IL-10; IL-10,AREG and an anti-TNFα antibody; IL-10, EREG and HBEGF; IL-10, EREG andHGF; IL-10, EREG and HRGB; IL-10, EREG and BTC; IL-10, EREG and EGF;IL-10, EREG and TGFA; IL-10, EREG and FGF1; IL-10, EREG and FGF2; IL-10,EREG and FGF4; IL-10, EREG and FGF7; IL-10, EREG and FGF9; IL-10, EREGand FGF19; IL-10, EREG and SCF; IL-10, EREG and PDGFA; IL-10, EREG andPDGFB; IL-10, EREG and PDGFC; IL-10, EREG and VEGFA; IL-10, EREG andVEGFB; IL-10, EREG and VEGFC; IL-10, EREG and VEGFD; IL-10, EREG andTGFB1; IL-10, EREG and an anti-TNFα antibody; IL-10, HBEGF and HGF;IL-10, HBEGF and HRGB; IL-10, HBEGF and BTC; IL-10, HBEGF and EGF;IL-10, HBEGF and TGFA; IL-10, HBEGF and FGF1; IL-10, HBEGF and FGF2;IL-10, HBEGF and FGF4; IL-10, HBEGF and FGF7; IL-10, HBEGF and FGF9;IL-10, HBEGF and FGF19; IL-10, HBEGF and SCF; IL-10, HBEGF and PDGFA;IL-10, HBEGF and PDGFB; IL-10, HBEGF and PDGFC; IL-10, HBEGF and VEGFA;IL-10, HBEGF and VEGFB; IL-10, HBEGF and VEGFC; IL-10, HBEGF and VEGFD;IL-10, HBEGF and TGFB1; IL-10, HBEGF and an anti-TNFα antibody; IL-10,HGF and HRGB; IL-10, HGF and BTC; IL-10, HGF and EGF; IL-10, HGF andTGFA; IL-10, HGF and FGF1; IL-10, HGF and FGF2; IL-10, HGF and FGF4;IL-10, HGF and FGF7; IL-10, HGF and FGF9; IL-10, HGF and FGF19; IL-10,HGF and SCF; IL-10, HGF and PDGFA; IL-10, HGF and PDGFB; IL-10, HGF andPDGFC; IL-10, HGF and VEGFA; IL-10, HGF and VEGFB; IL-10, HGF and VEGFC;IL-10, HGF and VEGFD; IL-10, HGF and TGFB1; IL-10, HGF and an anti-TNFαantibody; IL-10, HRGB and BTC; IL-10, HRGB and EGF; IL-10, HRGB andTGFA; IL-10, HRGB and FGF1; IL-10, HRGB and FGF2; IL-10, HRGB and FGF4;IL-10, HRGB and FGF7; IL-10, HRGB and FGF9; IL-10, HRGB and FGF19;IL-10, HRGB and SCF; IL-10, HRGB and PDGFA; IL-10, HRGB and PDGFB;IL-10, HRGB and PDGFC; IL-10, HRGB and VEGFA; IL-10, HRGB and VEGFB;IL-10, HRGB and VEGFC; IL-10, HRGB and VEGFD; IL-10, HRGB and TGFB1;IL-10, HRGB and an anti-TNFα antibody; IL-10, BTC and EGF; IL-10, BTCand TGFA; IL-10, BTC and FGF1; IL-10, BTC and FGF2; IL-10, BTC and FGF4;IL-10, BTC and FGF7; IL-10, BTC and FGF9; IL-10, BTC and FGF19; IL-10,BTC and SCF; IL-10, BTC and PDGFA; IL-10, BTC and PDGFB; IL-10, BTC andPDGFC; IL-10, BTC and VEGFA; IL-10, BTC and VEGFB; IL-10, BTC and VEGFC;IL-10, BTC and VEGFD; IL-10, BTC and TGFB1; IL-10, BTC and an anti-TNFαantibody; IL-10, EGF and TGFA; IL-10, EGF and FGF1; IL-10, EGF and FGF2;IL-10, EGF and FGF4; IL-10, EGF and FGF7; IL-10, EGF and FGF9; IL-10,EGF and FGF19; IL-10, EGF and SCF; IL-10, EGF and PDGFA; IL-10, EGF andPDGFB; IL-10, EGF and PDGFC; IL-10, EGF and VEGFA; IL-10, EGF and VEGFB;IL-10, EGF and VEGFC; IL-10, EGF and VEGFD; IL-10, EGF and TGFB1; IL-10,EGF and an anti-TNFα antibody; IL-10, TGFA and FGF1; IL-10, TGFA andFGF2; IL-10, TGFA and FGF4; IL-10, TGFA and FGF7; IL-10, TGFA and FGF9;IL-10, TGFA and FGF19; IL-10, TGFA and SCF; IL-10, TGFA and PDGFA;IL-10, TGFA and PDGFB; IL-10, TGFA and PDGFC; IL-10, TGFA and VEGFA;IL-10, TGFA and VEGFB; IL-10, TGFA and VEGFC; IL-10, TGFA and VEGFD;IL-10, TGFA and TGFB1; IL-10, TGFA and an anti-TNFα antibody; IL-10,FGF1 and FGF2; IL-10, FGF1 and FGF4; IL-10, FGF1 and FGF7; IL-10, FGF1and FGF9; IL-10, FGF1 and FGF19; IL-10, FGF1 and SCF; IL-10, FGF1 andPDGFA; IL-10, FGF1 and PDGFB; IL-10, FGF1 and PDGFC; IL-10, FGF1 andVEGFA; IL-10, FGF1 and VEGFB; IL-10, FGF1 and VEGFC; IL-10, FGF1 andVEGFD; IL-10, FGF1 and TGFB1; IL-10, FGF1 and an anti-TNFα antibody;IL-10, FGF2 and FGF4; IL-10, FGF2 and FGF7; IL-10, FGF2 and FGF9; IL-10,FGF2 and FGF19; IL-10, FGF2 and SCF; IL-10, FGF2 and PDGFA; IL-10, FGF2and PDGFB; IL-10, FGF2 and PDGFC; IL-10, FGF2 and VEGFA; IL-10, FGF2 andVEGFB; IL-10, FGF2 and VEGFC; IL-10, FGF2 and VEGFD; IL-10, FGF2 andTGFB1; IL-10, FGF2 and an anti-TNFα antibody; IL-10, FGF4 and FGF7;IL-10, FGF4 and FGF9; IL-10, FGF4 and FGF19; IL-10, FGF4 and SCF; IL-10,FGF4 and PDGFA; IL-10, FGF4 and PDGFB; IL-10, FGF4 and PDGFC; IL-10,FGF4 and VEGFA; IL-10, FGF4 and VEGFB; IL-10, FGF4 and VEGFC; IL-10,FGF4 and VEGFD; IL-10, FGF4 and TGFB1; IL-10, FGF4 and an anti-TNFαantibody; IL-10, FGF7 and FGF9; IL-10, FGF7 and FGF19; IL-10, FGF7 andSCF; IL-10, FGF7 and PDGFA; IL-10, FGF7 and PDGFB; IL-10, FGF7 andPDGFC; IL-10, FGF7 and VEGFA; IL-10, FGF7 and VEGFB; IL-10, FGF7 andVEGFC; IL-10, FGF7 and VEGFD; IL-10, FGF7 and TGFB1; IL-10, FGF7 and ananti-TNFα antibody; IL-10, FGF9 and FGF19; IL-10, FGF9 and SCF; IL-10,FGF9 and PDGFA; IL-10, FGF9 and PDGFB; IL-10, FGF9 and PDGFC; IL-10,FGF9 and VEGFA; IL-10, FGF9 and VEGFB; IL-10, FGF9 and VEGFC; IL-10,FGF9 and VEGFD; IL-10, FGF9 and TGFB1; IL-10, FGF9 and an anti-TNFαantibody; IL-10, FGF19 and SCF; IL-10, FGF19 and PDGFA; IL-10, FGF19 andPDGFB; IL-10, FGF19 and PDGFC; IL-10, FGF19 and VEGFA; IL-10, FGF19 andVEGFB; IL-10, FGF19 and VEGFC; IL-10, FGF19 and VEGFD; IL-10, FGF19 andTGFB1; IL-10, FGF19 and an anti-TNFα antibody; IL-10, SCF and PDGFA;IL-10, SCF and PDGFB; IL-10, SCF and PDGFC; IL-10, SCF and VEGFA; IL-10,SCF and VEGFB; IL-10, SCF and VEGFC; IL-10, SCF and VEGFD; IL-10, SCFand TGFB1; IL-10, SCF and an anti-TNFα antibody; IL-10, PDGFA and PDGFB;IL-10, PDGFA and PDGFC; IL-10, PDGFA and VEGFA; IL-10, PDGFA and VEGFB;IL-10, PDGFA and VEGFC; IL-10, PDGFA and VEGFD; IL-10, PDGFA and TGFB1;IL-10, PDGFA and an anti-TNFα antibody; IL-10, PDGFB and PDGFC; IL-10,PDGFB and VEGFA; IL-10, PDGFB and VEGFB; IL-10, PDGFB and VEGFC; IL-10,PDGFB and VEGFD; IL-10, PDGFB and TGFB1; IL-10, PDGFB and an anti-TNFαantibody; IL-10, PDGFC and VEGFA; IL-10, PDGFC and VEGFB; IL-10, PDGFCand VEGFC; IL-10, PDGFC and VEGFD; IL-10, PDGFC and TGFB1; IL-10, PDGFCand an anti-TNFα antibody; IL-10, VEGFA and VEGFB; IL-10, VEGFA andVEGFC; IL-10, VEGFA and VEGFD; IL-10, VEGFA and TGFB1; IL-10, VEGFA andan anti-TNFα antibody; IL-10, VEGFB and VEGFC; IL-10, VEGFB and VEGFD;IL-10, VEGFB and TGFB1; IL-10, VEGFB and an anti-TNFα antibody; IL-10,VEGFC and VEGFD; IL-10, VEGFC and TGFB1; IL-10, VEGFC and an anti-TNFαantibody; IL-10, VEGFD and TGFB1; IL-10, VEGFD and an anti-TNFαantibody; IL-10, TGFB1 and an anti-TNFα antibody; an anti-TNFα antibody,AREG and EREG; an anti-TNFα antibody, AREG and HBEGF; an anti-TNFαantibody, AREG and HGF; an anti-TNFα antibody, AREG and HRGB; ananti-TNFα antibody, AREG and BTC; an anti-TNFα antibody, AREG and EGF;an anti-TNFα antibody, AREG and TGFA; an anti-TNFα antibody, AREG andFGF1; an anti-TNFα antibody, AREG and FGF2; an anti-TNFα antibody, AREGand FGF4; an anti-TNFα antibody, AREG and FGF7; an anti-TNFα antibody,AREG and FGF9; an anti-TNFα antibody, AREG and FGF19; an anti-TNFαantibody, AREG and SCF; an anti-TNFα antibody, AREG and PDGFA; ananti-TNFα antibody, AREG and PDGFB; an anti-TNFα antibody, AREG andPDGFC; an anti-TNFα antibody, AREG and VEGFA; an anti-TNFα antibody,AREG and VEGFB; an anti-TNFα antibody, AREG and VEGFC; an anti-TNFαantibody, AREG and VEGFD; an anti-TNFα antibody, AREG and TGFB1; ananti-TNFα antibody, AREG and IL-10; an anti-TNFα antibody, EREG andHBEGF; an anti-TNFα antibody, EREG and HGF; an anti-TNFα antibody, EREGand HRGB; an anti-TNFα antibody, EREG and BTC; an anti-TNFα antibody,EREG and EGF; an anti-TNFα antibody, EREG and TGFA; an anti-TNFαantibody, EREG and FGF1; an anti-TNFα antibody, EREG and FGF2; ananti-TNFα antibody, EREG and FGF4; an anti-TNFα antibody, EREG and FGF7;an anti-TNFα antibody, EREG and FGF9; an anti-TNFα antibody, EREG andFGF19; an anti-TNFα antibody, EREG and SCF; an anti-TNFα antibody, EREGand PDGFA; an anti-TNFα antibody, EREG and PDGFB; an anti-TNFα antibody,EREG and PDGFC; an anti-TNFα antibody, EREG and VEGFA; an anti-TNFαantibody, EREG and VEGFB; an anti-TNFα antibody, EREG and VEGFC; ananti-TNFα antibody, EREG and VEGFD; an anti-TNFα antibody, EREG andTGFB1; an anti-TNFα antibody, EREG and IL-10; an anti-TNFα antibody,HBEGF and HGF; an anti-TNFα antibody, HBEGF and HRGB; an anti-TNFαantibody, HBEGF and BTC; an anti-TNFα antibody, HBEGF and EGF; ananti-TNFα antibody, HBEGF and TGFA; an anti-TNFα antibody, HBEGF andFGF1; an anti-TNFα antibody, HBEGF and FGF2; an anti-TNFα antibody,HBEGF and FGF4; an anti-TNFα antibody, HBEGF and FGF7; an anti-TNFαantibody, HBEGF and FGF9; an anti-TNFα antibody, HBEGF and FGF19; ananti-TNFα antibody, HBEGF and SCF; an anti-TNFα antibody, HBEGF andPDGFA; an anti-TNFα antibody, HBEGF and PDGFB; an anti-TNFα antibody,HBEGF and PDGFC; an anti-TNFα antibody, HBEGF and VEGFA; an anti-TNFαantibody, HBEGF and VEGFB; an anti-TNFα antibody, HBEGF and VEGFC; ananti-TNFα antibody, HBEGF and VEGFD; an anti-TNFα antibody, HBEGF andTGFB1; an anti-TNFα antibody, HBEGF and IL-10; an anti-TNFα antibody,HGF and HRGB; an anti-TNFα antibody, HGF and BTC; an anti-TNFα antibody,HGF and EGF; an anti-TNFα antibody, HGF and TGFA; an anti-TNFα antibody,HGF and FGF1; an anti-TNFα antibody, HGF and FGF2; an anti-TNFαantibody, HGF and FGF4; an anti-TNFα antibody, HGF and FGF7; ananti-TNFα antibody, HGF and FGF9; an anti-TNFα antibody, HGF and FGF19;an anti-TNFα antibody, HGF and SCF; an anti-TNFα antibody, HGF andPDGFA; an anti-TNFα antibody, HGF and PDGFB; an anti-TNFα antibody, HGFand PDGFC; an anti-TNFα antibody, HGF and VEGFA; an anti-TNFα antibody,HGF and VEGFB; an anti-TNFα antibody, HGF and VEGFC; an anti-TNFαantibody, HGF and VEGFD; an anti-TNFα antibody, HGF and TGFB1; ananti-TNFα antibody, HGF and IL-10; an anti-TNFα antibody, HRGB and BTC;an anti-TNFα antibody, HRGB and EGF; an anti-TNFα antibody, HRGB andTGFA; an anti-TNFα antibody, HRGB and FGF1; an anti-TNFα antibody, HRGBand FGF2; an anti-TNFα antibody, HRGB and FGF4; an anti-TNFα antibody,HRGB and FGF7; an anti-TNFα antibody, HRGB and FGF9; an anti-TNFαantibody, HRGB and FGF19; an anti-TNFα antibody, HRGB and SCF; ananti-TNFα antibody, HRGB and PDGFA; an anti-TNFα antibody, HRGB andPDGFB; an anti-TNFα antibody, HRGB and PDGFC; an anti-TNFα antibody,HRGB and VEGFA; an anti-TNFα antibody, HRGB and VEGFB; an anti-TNFαantibody, HRGB and VEGFC; an anti-TNFα antibody, HRGB and VEGFD; ananti-TNFα antibody, HRGB and TGFB1; an anti-TNFα antibody, HRGB andIL-10; an anti-TNFα antibody, BTC and EGF; an anti-TNFα antibody, BTCand TGFA; an anti-TNFα antibody, BTC and FGF1; an anti-TNFα antibody,BTC and FGF2; an anti-TNFα antibody, BTC and FGF4; an anti-TNFαantibody, BTC and FGF7; an anti-TNFα antibody, BTC and FGF9; ananti-TNFα antibody, BTC and FGF19; an anti-TNFα antibody, BTC and SCF;an anti-TNFα antibody, BTC and PDGFA; an anti-TNFα antibody, BTC andPDGFB; an anti-TNFα antibody, BTC and PDGFC; an anti-TNFα antibody, BTCand VEGFA; an anti-TNFα antibody, BTC and VEGFB; an anti-TNFα antibody,BTC and VEGFC; an anti-TNFα antibody, BTC and VEGFD; an anti-TNFαantibody, BTC and TGFB1; an anti-TNFα antibody, BTC and IL-10; ananti-TNFα antibody, EGF and TGFA; an anti-TNFα antibody, EGF and FGF1;an anti-TNFα antibody, EGF and FGF2; an anti-TNFα antibody, EGF andFGF4; an anti-TNFα antibody, EGF and FGF7; an anti-TNFα antibody, EGFand FGF9; an anti-TNFα antibody, EGF and FGF19; an anti-TNFα antibody,EGF and SCF; an anti-TNFα antibody, EGF and PDGFA; an anti-TNFαantibody, EGF and PDGFB; an anti-TNFα antibody, EGF and PDGFC; ananti-TNFα antibody, EGF and VEGFA; an anti-TNFα antibody, EGF and VEGFB;an anti-TNFα antibody, EGF and VEGFC; an anti-TNFα antibody, EGF andVEGFD; an anti-TNFα antibody, EGF and TGFB1; an anti-TNFα antibody, EGFand IL-10; an anti-TNFα antibody, TGFA and FGF1; an anti-TNFα antibody,TGFA and FGF2; an anti-TNFα antibody, TGFA and FGF4; an anti-TNFαantibody, TGFA and FGF7; an anti-TNFα antibody, TGFA and FGF9; ananti-TNFα antibody, TGFA and FGF19; an anti-TNFα antibody, TGFA and SCF;an anti-TNFα antibody, TGFA and PDGFA; an anti-TNFα antibody, TGFA andPDGFB; an anti-TNFα antibody, TGFA and PDGFC; an anti-TNFα antibody,TGFA and VEGFA; an anti-TNFα antibody, TGFA and VEGFB; an anti-TNFαantibody, TGFA and VEGFC; an anti-TNFα antibody, TGFA and VEGFD; ananti-TNFα antibody, TGFA and TGFB1; an anti-TNFα antibody, TGFA andIL-10; an anti-TNFα antibody, FGF1 and FGF2; an anti-TNFα antibody, FGF1and FGF4; an anti-TNFα antibody, FGF1 and FGF7; an anti-TNFα antibody,FGF1 and FGF9; an anti-TNFα antibody, FGF1 and FGF19; an anti-TNFαantibody, FGF1 and SCF; an anti-TNFα antibody, FGF1 and PDGFA; ananti-TNFα antibody, FGF1 and PDGFB; an anti-TNFα antibody, FGF1 andPDGFC; an anti-TNFα antibody, FGF1 and VEGFA; an anti-TNFα antibody,FGF1 and VEGFB; an anti-TNFα antibody, FGF1 and VEGFC; an anti-TNFαantibody, FGF1 and VEGFD; an anti-TNFα antibody, FGF1 and TGFB1; ananti-TNFα antibody, FGF1 and IL-10; an anti-TNFα antibody, FGF2 andFGF4; an anti-TNFα antibody, FGF2 and FGF7; an anti-TNFα antibody, FGF2and FGF9; an anti-TNFα antibody, FGF2 and FGF19; an anti-TNFα antibody,FGF2 and SCF; an anti-TNFα antibody, FGF2 and PDGFA; an anti-TNFαantibody, FGF2 and PDGFB; an anti-TNFα antibody, FGF2 and PDGFC; ananti-TNFα antibody, FGF2 and VEGFA; an anti-TNFα antibody, FGF2 andVEGFB; an anti-TNFα antibody, FGF2 and VEGFC; an anti-TNFα antibody,FGF2 and VEGFD; an anti-TNFα antibody, FGF2 and TGFB1; an anti-TNFαantibody, FGF2 and IL-10; an anti-TNFα antibody, FGF4 and FGF7; ananti-TNFα antibody, FGF4 and FGF9; an anti-TNFα antibody, FGF4 andFGF19; an anti-TNFα antibody, FGF4 and SCF; an anti-TNFα antibody, FGF4and PDGFA; an anti-TNFα antibody, FGF4 and PDGFB; an anti-TNFα antibody,FGF4 and PDGFC; an anti-TNFα antibody, FGF4 and VEGFA; an anti-TNFαantibody, FGF4 and VEGFB; an anti-TNFα antibody, FGF4 and VEGFC; ananti-TNFα antibody, FGF4 and VEGFD; an anti-TNFα antibody, FGF4 andTGFB1; an anti-TNFα antibody, FGF4 and IL-10; an anti-TNFα antibody,FGF7 and FGF9; an anti-TNFα antibody, FGF7 and FGF19; an anti-TNFαantibody, FGF7 and SCF; an anti-TNFα antibody, FGF7 and PDGFA; ananti-TNFα antibody, FGF7 and PDGFB; an anti-TNFα antibody, FGF7 andPDGFC; an anti-TNFα antibody, FGF7 and VEGFA; an anti-TNFα antibody,FGF7 and VEGFB; an anti-TNFα antibody, FGF7 and VEGFC; an anti-TNFαantibody, FGF7 and VEGFD; an anti-TNFα antibody, FGF7 and TGFB1; ananti-TNFα antibody, FGF7 and IL-10; an anti-TNFα antibody, FGF9 andFGF19; an anti-TNFα antibody, FGF9 and SCF; an anti-TNFα antibody, FGF9and PDGFA; an anti-TNFα antibody, FGF9 and PDGFB; an anti-TNFα antibody,FGF9 and PDGFC; an anti-TNFα antibody, FGF9 and VEGFA; an anti-TNFαantibody, FGF9 and VEGFB; an anti-TNFα antibody, FGF9 and VEGFC; ananti-TNFα antibody, FGF9 and VEGFD; an anti-TNFα antibody, FGF9 andTGFB1; an anti-TNFα antibody, FGF9 and IL-10; an anti-TNFα antibody,FGF19 and SCF; an anti-TNFα antibody, FGF19 and PDGFA; an anti-TNFαantibody, FGF19 and PDGFB; an anti-TNFα antibody, FGF19 and PDGFC; ananti-TNFα antibody, FGF19 and VEGFA; an anti-TNFα antibody, FGF19 andVEGFB; an anti-TNFα antibody, FGF19 and VEGFC; an anti-TNFα antibody,FGF19 and VEGFD; an anti-TNFα antibody, FGF19 and TGFB1; an anti-TNFαantibody, FGF19 and IL-10; an anti-TNFα antibody, SCF and PDGFA; ananti-TNFα antibody, SCF and PDGFB; an anti-TNFα antibody, SCF and PDGFC;an anti-TNFα antibody, SCF and VEGFA; an anti-TNFα antibody, SCF andVEGFB; an anti-TNFα antibody, SCF and VEGFC; an anti-TNFα antibody, SCFand VEGFD; an anti-TNFα antibody, SCF and TGFB1; an anti-TNFα antibody,SCF and IL-10; an anti-TNFα antibody, PDGFA and PDGFB; an anti-TNFαantibody, PDGFA and PDGFC; an anti-TNFα antibody, PDGFA and VEGFA; ananti-TNFα antibody, PDGFA and VEGFB; an anti-TNFα antibody, PDGFA andVEGFC; an anti-TNFα antibody, PDGFA and VEGFD; an anti-TNFα antibody,PDGFA and TGFB1; an anti-TNFα antibody, PDGFA and IL-10; an anti-TNFαantibody, PDGFB and PDGFC; an anti-TNFα antibody, PDGFB and VEGFA; ananti-TNFα antibody, PDGFB and VEGFB; an anti-TNFα antibody, PDGFB andVEGFC; an anti-TNFα antibody, PDGFB and VEGFD; an anti-TNFα antibody,PDGFB and TGFB1; an anti-TNFα antibody, PDGFB and IL-10; an anti-TNFαantibody, PDGFC and VEGFA; an anti-TNFα antibody, PDGFC and VEGFB; ananti-TNFα antibody, PDGFC and VEGFC; an anti-TNFα antibody, PDGFC andVEGFD; an anti-TNFα antibody, PDGFC and TGFB1; an anti-TNFα antibody,PDGFC and IL-10; an anti-TNFα antibody, VEGFA and VEGFB; an anti-TNFαantibody, VEGFA and VEGFC; an anti-TNFα antibody, VEGFA and VEGFD; ananti-TNFα antibody, VEGFA and TGFB1; an anti-TNFα antibody, VEGFA andIL-10; an anti-TNFα antibody, VEGFB and VEGFC; an anti-TNFα antibody,VEGFB and VEGFD; an anti-TNFα antibody, VEGFB and TGFB1; an anti-TNFαantibody, VEGFB and IL-10; an anti-TNFα antibody, VEGFC and VEGFD; ananti-TNFα antibody, VEGFC and TGFB1; an anti-TNFα antibody, VEGFC andIL-10; an anti-TNFα antibody, VEGFD and TGFB1; an anti-TNFα antibody,VEGFD and IL-10; an anti-TNFα antibody, TGFB1 and IL-10; and the like.In some instances, the combination of at least three markers can furtherinclude at least 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16,17, 18, 19, 20, 21, or 22 of the other markers selected from the secondset of markers to form a proliferation phase marker score.

In certain instances, the presence or level of various markers such asan inflammatory phase marker, a growth factor marker, a repair factormarker, an anti-inflammatory marker, a proliferation phase marker, or aserology marker is detected at the level of mRNA expression with anassay such as, for example, a hybridization assay or anamplification-based assay.

In other instances, the presence or level of various markers such as aninflammatory phase marker, a growth factor marker, a repair factormarker, an anti-inflammatory marker, an anti-drug antibody (ADA), aproliferation phase marker, a serology marker, or an anti-TNFα antibodyis detected at the level of protein expression using, for example, animmunoassay (e.g., ELISA or CEER), a homogeneous mobility shift assay(HMSA) or an immunohistochemical assay.

Suitable ELISA kits for determining the presence or level of a growthfactor, an inflammatory marker, or an anti-inflammatory marker in aserum, plasma, saliva, or urine sample are available from, e.g.,Antigenix America Inc. (Huntington Station, N.Y.), Promega (Madison,Wis.), R&D Systems, Inc. (Minneapolis, Minn.), Invitrogen (Camarillo,Calif.), CHEMICON International, Inc. (Temecula, Calif.), Neogen Corp.(Lexington, Ky.), PeproTech (Rocky Hill, N.J.), Alpco Diagnostics(Salem, N.H.), Pierce Biotechnology, Inc. (Rockford, Ill.), and/orAbazyme (Needham, Mass.).

In other instances, the presence or level of various markers such as aninflammatory phase marker, a growth factor marker, a repair factormarker, an anti-inflammatory marker, a proliferation phase marker, or aserology marker is detected using a multiplexed immunoarray, such as aCollaborative Enzyme Enhanced Reactive ImmunoAssay (CEER), also known asthe Collaborative Proximity Immunoassay (COPIA). CEER is described inthe following patent documents which are herein incorporated byreference in their entirety for all purposes: PCT Publication Nos. WO2008/036802, WO 2009/012140, WO 2009/108637, WO 2010/132723, WO2011/008990, WO 2011/050069; WO 2012/088337; WO 2012/119113; and WO2013/033623.

Suitable anti-repair factor antibodies useful in determining the levelof a selected growth factor in a sample include, without limitation, anantibody that recognizes (binds to, forms a complex with, is specificfor) a selected growth factor protein, a growth factor polypeptidehaving substantially the same amino acid sequence as the selected growthfactor protein, or a fragment thereof such as an immunoreactive fragmentthereof. A growth factor polypeptide generally describes polypeptideshaving an amino acid sequence with greater than about 50% identity,preferably greater than about 60% identity, more preferably greater thanabout 70% identity, still more preferably greater than about 80%, 85%,90%, 95%, 96%, 97%, 98%, or 99% amino acid sequence identity with agrowth factor protein, with the amino acid identity determined using asequence alignment program such as CLUSTALW. Suitable antibodies fordetermining the level of a growth factor are available from, e.g.,Promega (Madison, Wis.), R&D Systems, Inc. (Minneapolis, Minn.),Invitrogen (Camarillo, Calif.), CHEMICON International, Inc. (Temecula,Calif.), Abcam (Cambridge, Mass.), Santa Cruz Biotechnology (Santa Cruz,Calif.), and Dako (Carpinteria, Calif.).

C. Inflammatory Phase Markers

In certain aspects, any of a variety of inflammatory phase markers,including but not limited to biochemical markers, serological markers,protein markers, and/or other clinical characteristics, are useful inthe methods of the present invention. In particular embodiments, themethods herein facilitate predicting the likelihood of mucosal healingand monitoring the progression of mucosal healing based upon one or moreinflammatory phase markers. In other embodiments, the methods hereinfacilitate selecting therapy, optimizing therapy, reducing toxicity,and/or monitoring the efficacy of therapeutic treatment with one or moretherapeutic agents such as biologics (e.g., anti-TNF drugs). Inpreferred embodiments, the methods herein utilize the determination ofan inflammatory phase marker score based upon one or more (a pluralityof) inflammatory phase markers (e.g., alone or in combination withbiomarkers from other categories) to aid or assist in predicting thelikelihood of mucosal healing, monitoring the progression of mucosalhealing, predicting disease course, selecting an appropriate anti-TNFdrug therapy, optimizing anti-TNF drug therapy, reducing toxicityassociated with anti-TNF drug therapy, and/or monitoring the efficacy oftherapeutic treatment with an anti-TNF drug.

Non-limiting examples of inflammatory phase markers include cytokines,chemokines, acute phase proteins, cellular adhesion molecules, S100proteins, serology markers, and/or other inflammatory markers.

Inflammatory phase markers that can be used to establish a marker scoreinclude, but are not limited to, at least one or a plurality (e.g., atleast 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19,20, or 21, such as, e.g., a panel or an array) of the following markers:TNF-α, IL-12p70, IL-1β, IL-2, IL-6, IL8, SDF-1, GM-CSF, IL-13, IFN-γ,SAA, CRP, ICAM, VCAM, TWEAK, ASCA-A, ASCA-G, Cbir, Fla2, FlaX, OmpC, andcombinations thereof. In preferred embodiments, the inflammatory phasemarkers include one or more of GM-CSF, IL-2, VCAM, and combinationsthereof.

1. Cytokines

The determination of the presence or level of at least one cytokine orchemokine in a sample is particularly useful in the present invention.As used herein, the term “cytokine” includes any of a variety ofpolypeptides or proteins secreted by immune cells that regulate a rangeof immune system functions and encompasses small cytokines such aschemokines. The term “cytokine” also includes adipocytokines, whichcomprise a group of cytokines secreted by adipocytes that function, forexample, in the regulation of body weight, hematopoiesis, angiogenesis,wound healing, insulin resistance, the immune response, and theinflammatory response.

In certain embodiments, the presence or level of at least one cytokineincluding, but not limited to, granulocyte-macrophage colony-stimulatingfactor (GM-CSF), IFN-γ, IL-1β, IL-2, IL-6, IL-8, TNF-α, soluble tumornecrosis factor-α receptor II (sTNF RII), TNF-related weak inducer ofapoptosis (TWEAK), osteoprotegerin (OPG), IFN-α, IFN-β, IL-1α, IL-1receptor antagonist (IL-1ra), IL-4, IL-5, soluble IL-6 receptor(sIL-6R), IL-7, IL-9, IL-12, IL-13, IL-15, IL-17, IL-23, and IL-27 isdetermined in a sample.

In certain other embodiments, the presence or level of at least onechemokine such as, for example, CXCL1/GRO1/GROα, CXCL2/GRO2, CXCL3/GRO3,CXCL4/PF-4, CXCL5/ENA-78, CXCL6/GCP-2, CXCL7/NAP-2, CXCL9/MIG,CXCL10/IP-10, CXCL11/I-TAC, CXCL12/SDF-1, CXCL13/BCA-1, CXCL14/BRAK,CXCL15, CXCL16, CXCL17/DMC, CCL1, CCL2/MCP-1, CCL3/MIP-1α, CCL4/MIP-1β,CCL5/RANTES, CCL6/C10, CCL7/MCP-3, CCL8/MCP-2, CCL9/CCL10,CCL11/Eotaxin, CCL12/MCP-5, CCL13/MCP-4, CCL14/HCC-1, CCL15/MIP-5,CCL16/LEC, CCL17/TARC, CCL18/MIP-4, CCL19/MIP-3β, CCL20/MIP-3α,CCL21/SLC, CCL22/MDC, CCL23/MPIF1, CCL24/Eotaxin-2, CCL25/TECK,CCL26/Eotaxin-3, CCL27/CTACK, CCL28/MEC, CL1, CL2, and CX₃CL1 isdetermined in a sample. In certain further embodiments, the presence orlevel of at least one adipocytokine including, but not limited to,leptin, adiponectin, resistin, active or total plasminogen activatorinhibitor-1 (PAI-1), visfatin, and retinol binding protein 4 (RBP4) isdetermined in a sample. Preferably, the presence or level of SDF-1,GM-CSF, IFN-γ, IL-1β, IL-2, IL-6, IL-8, TNF-α, sTNF RII, and/or othercytokines or chemokines is determined.

In certain instances, the presence or level of a particular cytokine orchemokine marker is detected at the level of mRNA expression with anassay such as, for example, a hybridization assay or anamplification-based assay. In certain other instances, the presence orlevel of a particular cytokine or chemokine is detected at the level ofprotein expression using, for example, an immunoassay (e.g., ELISA), animmunohistochemical assay, or a multiplexed immunoarray, such as aCollaborative Enzyme Enhanced Reactive ImmunoAssay (CEER), also known asthe Collaborative Proximity Immunoassay (COPIA). Suitable ELISA kits fordetermining the presence or level of a cytokine or chemokine of interestin a serum, plasma, saliva, or urine sample are available from, e.g.,R&D Systems, Inc. (Minneapolis, Minn.), Neogen Corp. (Lexington, Ky.),Alpco Diagnostics (Salem, N.H.), Assay Designs, Inc. (Ann Arbor, Mich.),BD Biosciences Pharmingen (San Diego, Calif.), Invitrogen (Camarillo,Calif.), Calbiochem (San Diego, Calif.), CHEMICON International, Inc.(Temecula, Calif.), Antigenix America Inc. (Huntington Station, N.Y.),QIAGEN Inc. (Valencia, Calif.), Bio-Rad Laboratories, Inc. (Hercules,Calif.), and/or Bender MedSystems Inc. (Burlingame, Calif.).

The human IL-1β polypeptide sequence is set forth in, e.g., GenbankAccession No. NP_(—)000567. The human IL-1β mRNA (coding) sequence isset forth in, e.g., Genbank Accession No. NM_(—)000576. One skilled inthe art will appreciate that IL-1β is also known as IL1F2 and IL-1beta.

The human IL-2 polypeptide sequence is set forth in, e.g., GenbankAccession No. NP_(—)000577. The human IL-2 mRNA (coding) sequence is setforth in, e.g., Genbank Accession No. NM_(—)000586. One skilled in theart will appreciate that IL-2 is also known as TCGF and lymphokine.

The human IL-6 polypeptide sequence is set forth in, e.g., GenbankAccession No. NP_(—)000591. The human IL-6 mRNA (coding) sequence is setforth in, e.g., Genbank Accession No. NM_(—)000600. One skilled in theart will appreciate that IL-6 is also known as interferon beta 2(IFNB2), HGF, HSF, and BSF2.

The human IL-8 polypeptide sequence is set forth in, e.g., GenbankAccession No. NP_(—)000575. The human IL-8 mRNA (coding) sequence is setforth in, e.g., Genbank Accession No. NM_(—)000584. One skilled in theart will appreciate that IL-8 is also known as CXCL8, K60, NAF, GCP1,LECT, LUCT, NAP1, 3-10C, GCP-1, LYNAP, MDNCF, MONAP, NAP-1, SCYB8,TSG-1, AMCF-I, and b-ENAP.

The human GM-CSF polypeptide sequence is set forth in, e.g., GenbankAccession No. NP_(—)000749. The human GM-CSF mRNA (coding) sequence isset forth in, e.g., Genbank Accession No. NM_(—)000758. One skilled inthe art will appreciate that GM-CSF is also known asgranulocyte-macrophage colony stimulating factor, colony stimulatingfactor 2 (granulocyte-macrophage), GSF2 and GMCSF.

The human IFNγ polypeptide sequence is set forth in, e.g., GenbankAccession No. NP_(—)000610. The human IFNγ mRNA (coding) sequence is setforth in, e.g., Genbank Accession No. NM_(—)000619. One skilled in theart will appreciate that GM-CSF is also known as interferon gamma, IFNG,IFG, IFI, and IFN gamma.

The human TNFα polypeptide sequence is set forth in, e.g., GenbankAccession No. NP_(—)000585. The human TNFα mRNA (coding) sequence is setforth in, e.g., Genbank Accession No. NM_(—)000594. One skilled in theart will appreciate that TNFα is also known as tumor necrosis factor,TNF, DIF, TNF-alpha, TNFA, and TNFSF2.

The human TNF-related weak inducer of apoptosis (TWEAK) polypeptidesequence is set forth in, e.g., Genbank Accession No. NP_(—)003800.1.The human TWEAK mRNA (coding) sequence is set forth in, e.g., GenbankAccession No. NM_(—)003809.2. One skilled in the art will appreciatethat TWEAK is also known as TNF12, APO3 ligand, APO3L, DR3LG, andUNQ181/PRO207.

2. Acute Phase Proteins

The determination of the presence or level of one or more acute-phaseproteins in a sample is also useful in the present invention.Acute-phase proteins are a class of proteins whose plasma concentrationsincrease (positive acute-phase proteins) or decrease (negativeacute-phase proteins) in response to inflammation. This response iscalled the acute-phase reaction (also called acute-phase response).Examples of positive acute-phase proteins include, but are not limitedto, C-reactive protein (CRP), D-dimer protein, mannose-binding protein,alpha 1-antitrypsin, alpha 1-antichymotrypsin, alpha 2-macroglobulin,fibrinogen, prothrombin, factor VIII, von Willebrand factor,plasminogen, complement factors, ferritin, serum amyloid P component,serum amyloid A (SAA), orosomucoid (alpha 1-acid glycoprotein, AGP),ceruloplasmin, haptoglobin, and combinations thereof. Non-limitingexamples of negative acute-phase proteins include albumin, transferrin,transthyretin, transcortin, retinol-binding protein, and combinationsthereof. Preferably, the presence or level of CRP and/or SAA isdetermined.

In certain instances, the presence or level of a particular acute-phaseprotein is detected at the level of mRNA expression with an assay suchas, for example, a hybridization assay or an amplification-based assay.In certain other instances, the presence or level of a particularacute-phase protein is detected at the level of protein expressionusing, for example, an immunoassay (e.g., ELISA), an immunohistochemicalassay, or a multiplexed immunoarray, such as a Collaborative EnzymeEnhanced Reactive ImmunoAssay (CEER), also known as the CollaborativeProximity Immunoassay (COPIA). For example, a sandwich colorimetricELISA assay available from Alpco Diagnostics (Salem, N.H.) can be usedto determine the level of CRP in a serum, plasma, urine, or stoolsample. Similarly, an ELISA kit available from Biomeda Corporation(Foster City, Calif.) can be used to detect CRP levels in a sample.Other methods for determining CRP levels in a sample are described in,e.g., U.S. Pat. Nos. 6,838,250; 6,406,862; 7,439,019; and U.S. PatentPublication No. 20060019410. Additional methods for determining CRPlevels include, e.g., immunoturbidimetry assays, rapid immunodiffusionassays, and visual agglutination assays. Suitable ELISA kits fordetermining the presence or level of SAA in a sample such as serum,plasma, saliva, urine, or stool are available from, e.g., AntigenixAmerica Inc. (Huntington Station, N.Y.), Abazyme (Needham, Mass.), USCNLife (Missouri City, Tex.), and/or U.S. Biological (Swampscott, Mass.).

C-reactive protein (CRP) is a protein found in the blood in response toinflammation (an acute-phase protein). CRP is typically produced by theliver and by fat cells (adipocytes). It is a member of the pentraxinfamily of proteins. The human CRP polypeptide sequence is set forth in,e.g., Genbank Accession No. NP_(—)000558. The human CRP mRNA (coding)sequence is set forth in, e.g., Genbank Accession No. NM_(—)000567. Oneskilled in the art will appreciate that CRP is also known as PTX1,MGC88244, and MGC149895.

Serum amyloid A (SAA) proteins are a family of apolipoproteinsassociated with high-density lipoprotein (HDL) in plasma. Differentisoforms of SAA are expressed constitutively (constitutive SAAs) atdifferent levels or in response to inflammatory stimuli (acute phaseSAAs). These proteins are predominantly produced by the liver. Theconservation of these proteins throughout invertebrates and vertebratessuggests SAAs play a highly essential role in all animals. Acute phaseserum amyloid A proteins (A-SAAs) are secreted during the acute phase ofinflammation. The human SAA polypeptide sequence is set forth in, e.g.,Genbank Accession No. NP_(—)000322. The human SAA mRNA (coding) sequenceis set forth in, e.g., Genbank Accession No. NM_(—)000331. One skilledin the art will appreciate that SAA is also known as PIG4, TP53I4,MGC111216, and SAA1.

3. Immunoglobulin Proteins

The determination of the presence or level of one or more immunoglobulinsuperfamily cellular adhesion molecules in a sample is also useful inthe present invention. As used herein, the term “immunoglobulinsuperfamily cellular adhesion molecule” (IgSF CAM) includes any of avariety of polypeptides or proteins located on the surface of a cellthat have one or more immunoglobulin-like fold domains, and whichfunction in intercellular adhesion and/or signal transduction. In manycases, IgSF CAMs are transmembrane proteins. Non-limiting examples ofIgSF CAMs include Neural Cell Adhesion Molecules (NCAMs; e.g., NCAM-120,NCAM-125, NCAM-140, NCAM-145, NCAM-180, NCAM-185, etc.), IntercellularAdhesion Molecules (ICAMs, e.g., ICAM-1, ICAM-2, ICAM-3, ICAM-4, andICAM-5), Vascular Cell Adhesion Molecule-1 (VCAM-1),Platelet-Endothelial Cell Adhesion Molecule-1 (PECAM-1), L1 CellAdhesion Molecule (L1CAM), cell adhesion molecule with homology to L1CAM(close homolog of L1) (CHL1), sialic acid binding Ig-like lectins(SIGLECs; e.g., SIGLEC-1, SIGLEC-2, SIGLEC-3, SIGLEC-4, etc.), Nectins(e.g., Nectin-1, Nectin-2, Nectin-3, etc.), and Nectin-like molecules(e.g., Nec1-1, Nec1-2, Nec1-3, Nec1-4, and Nec1-5). Preferably, thepresence or level of ICAM-1 and/or VCAM-1 is determined.

ICAM-1 (ICAM) is a transmembrane cellular adhesion protein that iscontinuously present in low concentrations in the membranes ofleukocytes and endothelial cells. Upon cytokine stimulation, theconcentrations greatly increase. ICAM-1 can be induced by IL-1 and TNFαand is expressed by the vascular endothelium, macrophages, andlymphocytes. In IBD, proinflammatory cytokines cause inflammation byupregulating expression of adhesion molecules such as ICAM-1 and VCAM-1.The increased expression of adhesion molecules recruit more lymphocytesto the infected tissue, resulting in tissue inflammation (see, Goke etal., J., Gastroenterol., 32:480 (1997); and Rijcken et al., Gut, 51:529(2002)). ICAM-1 is encoded by the intercellular adhesion molecule 1 gene(ICAM1; Entrez GeneID:3383; Genbank Accession No. NM_(—)000201) and isproduced after processing of the intercellular adhesion molecule 1precursor polypeptide (Genbank Accession No. NP_(—)000192).

VCAM-1 (VCAM) is a transmembrane cellular adhesion protein that mediatesthe adhesion of lymphocytes, monocytes, eosinophils, and basophils tovascular endothelium. Upregulation of VCAM-1 in endothelial cells bycytokines occurs as a result of increased gene transcription (e.g., inresponse to tumor necrosis factor-alpha (TNFα) and Interleukin-1(IL-1)). VCAM-1 is encoded by the vascular cell adhesion molecule 1 gene(VCAM1; Entrez GeneID:7412) and is produced after differential splicingof the transcript (Genbank Accession No. NM_(—)001078 (variant 1) orNM_(—)080682 (variant 2)), and processing of the precursor polypeptidesplice isoform (Genbank Accession No. NP_(—)001069 (isoform a) orNP_(—)542413 (isoform b)).

In certain instances, the presence or level of an IgSF CAM is detectedat the level of mRNA expression with an assay such as, for example, ahybridization assay or an amplification-based assay. In certain otherinstances, the presence or level of an IgSF CAM is detected at the levelof protein expression using, for example, an immunoassay (e.g., ELISA),an immunohistochemical assay, or a multiplexed immunoarray, such as aCollaborative Enzyme Enhanced Reactive ImmunoAssay (CEER), also known asthe Collaborative Proximity Immunoassay (COPIA). Suitable antibodiesand/or ELISA kits for determining the presence or level of ICAM-1 and/orVCAM-1 in a sample such as a tissue sample, biopsy, serum, plasma,saliva, urine, or stool are available from, e.g., Invitrogen (Camarillo,Calif.), Santa Cruz Biotechnology, Inc. (Santa Cruz, Calif.), and/orAbcam Inc. (Cambridge, Mass.).

4. Anti-Inflammatory Markers

In certain embodiments, a variety of anti-inflammatory markers areparticularly useful in the methods of the present invention. Inparticular embodiments, the methods herein utilize the determination ofan inflammatory phase marker score based upon one or more (a pluralityof) anti-inflammatory markers (e.g., alone or in combination withbiomarkers from other categories) to aid or assist in predicting thelikelihood of mucosal healing, monitoring the progression of mucosalhealing, predicting disease course, selecting an appropriate anti-TNFdrug therapy, optimizing anti-TNF drug therapy, reducing toxicityassociated with anti-TNF drug therapy, and/or monitoring the efficacy oftherapeutic treatment with an anti-TNF drug.

In certain instances, the presence or level of a particularanti-inflammatory marker is detected at the level of mRNA expressionwith an assay such as, for example, a hybridization assay or anamplification-based assay. In certain other instances, the presence orlevel of a particular anti-inflammatory marker is detected at the levelof protein expression using, for example, an immunoassay (e.g., ELISA),an immunohistochemical assay, or a multiplexed immunoarray, such as aCollaborative Enzyme Enhanced Reactive ImmunoAssay (CEER), also known asthe Collaborative Proximity Immunoassay (COPIA).

The human IL-12p70 polypeptide is a heterodimer made up of two subunitsof IL-12 proteins: one is 40 kDa (IL-12p40) and one is 35 kDa(IL-12p35). Suitable ELISA kits for determining the presence or level ofIL-12p70 in a serum, plasma, saliva, or urine sample are available from,e.g., Gen-Probe Diaclone SAS (France), Abazyme (Needham, Mass.), BDBiosciences Pharmingen (San Diego, Calif.), Cell Sciences (Canton,Mass.), eBioscience (San Diego, Calif.), Invitrogen (Camarillo, Calif.),R&D Systems, Inc. (Minneapolis, Minn.), and Thermo Scientific PierceProtein Research Products (Rockford, Ill.).

5. Serology Markers

In certain aspects, the methods of the present invention utilize thedetermination of an inflammatory phase marker score based upon one ormore (a plurality of) serological immune markers (e.g., alone or incombination with biomarkers from other categories) to aid or assist inpredicting the likelihood of mucosal healing, monitoring the progressionof mucosal healing, predicting disease course, selecting an appropriateanti-TNF drug therapy, optimizing anti-TNF drug therapy, reducingtoxicity associated with anti-TNF drug therapy, and/or monitoring theefficacy of therapeutic treatment with an anti-TNF drug.

Non-limiting examples of serological immune markers suitable for use inthe present invention include anti-neutrophil antibodies,anti-Saccharomyces cerevisiae antibodies, and/or other anti-microbialantibodies. Mucosal healing can also result in a decrease in theantibody titer of antibodies to bacterial antigens such as, e.g., OmpC,flagellins (cBir-1, Fla-A, Fla-X, etc.), 12, and others (pANCA, ASCA,etc.).

The determination of ASCA (e.g., ASCA-IgA and/or ASCA-IgG) levels in asample is useful in the present invention. As used herein, the term“anti-Saccharomyces cerevisiae immunoglobulin A” or “ASCA-IgA” includesantibodies of the immunoglobulin A isotype that react specifically withS. cerevisiae. Similarly, the term “anti-Saccharomyces cerevisiaeimmunoglobulin G” or “ASCA-IgG” includes antibodies of theimmunoglobulin G isotype that react specifically with S. cerevisiae.

The determination of whether a sample is positive for ASCA-IgA orASCA-IgG is made using an antigen specific for ASCA. Such an antigen canbe any antigen or mixture of antigens that is bound specifically byASCA-IgA and/or ASCA-IgG. Although ASCA antibodies were initiallycharacterized by their ability to bind S. cerevisiae, those of skill inthe art will understand that an antigen that is bound specifically byASCA can be obtained from S. cerevisiae or from a variety of othersources so long as the antigen is capable of binding specifically toASCA antibodies. Accordingly, exemplary sources of an antigen specificfor ASCA, which can be used to determine the levels of ASCA-IgA and/orASCA-IgG in a sample, include, without limitation, whole killed yeastcells such as Saccharomyces or Candida cells; yeast cell wall mannansuch as phosphopeptidomannan (PPM); oligosachharides such asoligomannosides; neoglycolipids; anti-ASCA idiotypic antibodies; and thelike. Different species and strains of yeast, such as S. cerevisiaestrain Su1, Su2, CBS 1315, or BM 156, or Candida albicans strain VW32,are suitable for use as an antigen specific for ASCA-IgA and/orASCA-IgG. Purified and synthetic antigens specific for ASCA are alsosuitable for use in determining the levels of ASCA-IgA and/or ASCA-IgGin a sample. Examples of purified antigens include, without limitation,purified oligosaccharide antigens such as oligomannosides. Examples ofsynthetic antigens include, without limitation, syntheticoligomannosides such as those described in U.S. Patent Publication No.20030105060, e.g., D-Man β(1-2) D-Man β(1-2) D-Man β(1-2) D-Man-OR,D-Man α(1-2) D-Man α(1-2) D-Man α(1-2) D-Man-OR, and D-Man α(1-3) D-Manα(1-2) D-Man α(1-2) D-Man-OR, wherein R is a hydrogen atom, a C₁ to C₂₀alkyl, or an optionally labeled connector group.

Preparations of yeast cell wall mannans, e.g., PPM, can be used indetermining the levels of ASCA-IgA and/or ASCA-IgG in a sample. Suchwater-soluble surface antigens can be prepared by any appropriateextraction technique known in the art, including, for example, byautoclaving, or can be obtained commercially (see, e.g., Lindberg etal., Gut, 33:909-913 (1992)). The acid-stable fraction of PPM is alsouseful in the present invention (Sendid et al., Clin. Diag. Lab.Immunol., 3:219-226 (1996)). An exemplary PPM that is useful indetermining ASCA levels in a sample is derived from S. uvarum strainATCC #38926.

Purified oligosaccharide antigens such as oligomannosides can also beuseful in determining the levels of ASCA-IgA and/or ASCA-IgG in asample. The purified oligomannoside antigens are preferably convertedinto neoglycolipids as described in, for example, Faille et al., Eur. J.Microbiol. Infect. Dis., 11:438-446 (1992). One skilled in the artunderstands that the reactivity of such an oligomannoside antigen withASCA can be optimized by varying the mannosyl chain length (Frosh etal., Proc Natl. Acad. Sci. USA, 82:1194-1198 (1985)); the anomericconfiguration (Fukazawa et al., In “Immunology of Fungal Disease,” E.Kurstak (ed.), Marcel Dekker Inc., New York, pp. 37-62 (1989); Nishikawaet al., Microbiol. Immunol., 34:825-840 (1990); Poulain et al., Eur. J.Clin. Microbiol., 23:46-52 (1993); Shibata et al., Arch. Biochem.Biophys., 243:338-348 (1985); Trinel et al., Infect. Immun.,60:3845-3851 (1992)); or the position of the linkage (Kikuchi et al.,Planta, 190:525-535 (1993)).

Suitable oligomannosides for use in the methods of the present inventioninclude, without limitation, an oligomannoside having the mannotetraoseMan(1-3) Man(1-2) Man(1-2) Man. Such an oligomannoside can be purifiedfrom PPM as described in, e.g., Faille et al., supra. An exemplaryneoglycolipid specific for ASCA can be constructed by releasing theoligomannoside from its respective PPM and subsequently coupling thereleased oligomannoside to 4-hexadecylaniline or the like.

The determination of anti-OmpC antibody levels in a sample is alsouseful in the present invention. As used herein, the term “anti-outermembrane protein C antibody” or “anti-OmpC antibody” includes antibodiesdirected to a bacterial outer membrane porin as described in, e.g., PCTPatent Publication No. WO 01/89361. The term “outer membrane protein C”or “OmpC” refers to a bacterial porin that is immunoreactive with ananti-OmpC antibody.

The level of anti-OmpC antibody present in a sample from an individualcan be determined using an OmpC protein or a fragment thereof such as animmunoreactive fragment thereof. Suitable OmpC antigens useful indetermining anti-OmpC antibody levels in a sample include, withoutlimitation, an OmpC protein, an OmpC polypeptide having substantiallythe same amino acid sequence as the OmpC protein, or a fragment thereofsuch as an immunoreactive fragment thereof. As used herein, an OmpCpolypeptide generally describes polypeptides having an amino acidsequence with greater than about 50% identity, preferably greater thanabout 60% identity, more preferably greater than about 70% identity,still more preferably greater than about 80%, 85%, 90%, 95%, 96%, 97%,98%, or 99% amino acid sequence identity with an OmpC protein, with theamino acid identity determined using a sequence alignment program suchas CLUSTALW. Such antigens can be prepared, for example, by purificationfrom enteric bacteria such as E. coli, by recombinant expression of anucleic acid such as Genbank Accession No. K00541, by synthetic meanssuch as solution or solid phase peptide synthesis, or by using phagedisplay.

The determination of anti-flagellin antibody levels in a sample is alsouseful in the present invention. As used herein, the term“anti-flagellin antibody” includes antibodies directed to a proteincomponent of bacterial flagella as described in, e.g., PCT PatentPublication Nos. WO 03/053220 and WO 07/087576; and U.S. Pat. Nos.7,361,733 and 7,868,139. The term “flagellin” refers to a bacterialflagellum protein that is immunoreactive with an anti-flagellinantibody. Microbial flagellins are proteins found in bacterial flagellumthat arrange themselves in a hollow cylinder to form the filament.

The level of anti-flagellin antibody present in a sample from anindividual can be determined using a flagellin protein or a fragmentthereof such as an immunoreactive fragment thereof. Suitable flagellinantigens useful in determining anti-flagellin antibody levels in asample include, without limitation, a flagellin protein such as CBir-1flagellin, flagellin X (FlaX), flagellin A, flagellin B, Fla2 (A4-Fla2),FliC, fragments thereof such as immunoreactive fragments thereof,flagellin polypeptides having substantially the same amino acid sequenceas a flagellin protein, and combinations thereof. As used herein, aflagellin polypeptide generally describes polypeptides having an aminoacid sequence with greater than about 50% identity, preferably greaterthan about 60% identity, more preferably greater than about 70%identity, still more preferably greater than about 80%, 85%, 90%, 95%,96%, 97%, 98%, or 99% amino acid sequence identity with anaturally-occurring flagellin protein, with the amino acid identitydetermined using a sequence alignment program such as CLUSTALW. Suchflagellin antigens can be prepared, e.g., by purification from bacteriumsuch as Helicobacter Bilis, Helicobacter mustelae, Helicobacter pylori,Butyrivibrio fibrisolvens, and bacterium found in the cecum, byrecombinant expression of a nucleic acid encoding a flagellin antigen,by synthetic means such as solution or solid phase peptide synthesis, orby using phage display.

D. Proliferation Phase Markers

In certain aspects, the determination of the presence and/or level of atleast one or more proliferation phase markers (e.g., repair factormarkers, anti-inflammatory markers, anti-TNFαantibody) in a sample isuseful in the present invention. As used herein, the term “repairfactor” includes any of a variety of peptides, polypeptides, or proteinscapable of stimulating cellular proliferation and/or cellulardifferentiation.

In particular embodiments, at least one or a plurality (e.g., at least2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21,22, 23, or 24, such as, e.g., a panel or an array) of the followingrepair factor markers can be detected or measured (e.g., alone or incombination with biomarkers from other categories) and used to form aproliferation phase marker score to aid or assist in predicting thelikelihood of mucosal healing, monitoring the progression of mucosalhealing, predicting disease course, and/or to improve the accuracy ofselecting therapy, optimizing therapy, reducing toxicity, and/ormonitoring the efficacy of therapeutic treatment to anti-TNF drugtherapy: EGF, AREG, EREG, HBEGF, HGF, HRGB, BTC, TGFA, FGF1, FGF2, FGF4,FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC, VEGFD,TGFB1, TWEAK, and combinations thereof.

Non-limiting examples of repair factors include epidermal growth factor(EGF), heparin binding epidermal growth factor (HB-EGF), amphiregulin(AREG), betacellulin (BTC), epiregulin (EREG), heregulin and variantsthereof (HRGα, HRGβ1, HRGβ2, HRGβ3, HRGγ), neuregulin 1 (NRG1) andisoforms thereof (e.g. type I NRG1 (also known as neu differentiationfactor (NDF), heregulin, or acetylcholine receptor inducing activity),type II NRG1 (also known as glial growth factor 2 (GGF2)), type III NRG1(also knowns as sensory and motor neuron-derived factor (SMDF)), type IVNRG1, type V NRG1, type VI NRG1), neuregulin 2 (NRG2), neuregulin 3(NRG3), neuregulin 4 (NRG4), vascular endothelial growth factors(VEGF-A, VEGF-B, VEGF-C, VEGF-D), platelet derived growth factors(PDGF-A, PDGF-B, PDGF-C, PDGF-D), fibroblast growth factors (FGF1, FGF2,FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGF10, FGF11, FGF12, FGF13,FGF14, FGF16, FGF17, FGF18, FGF19, FGF20, FGF21, FGF22, FGF23, etc.),stem cell factor (SCF), transforming growth factor (TGFα, TGFβ (TGFB)),endothelin 3 (EDN3), hepatocyte growth factor (HGF), insulin growthfactor-1 (IGF-1), interleukin 10 (IL-10) and combinations thereof.

In other embodiments, repair factors also include platelet-derivedgrowth factor (PDGF), soluble fms-like tyrosine kinase 1 (sFlt1),placenta growth factor (PIGF, PLGF or PGF), pigment epithelium-derivedfactor (PEDF, also known as SERPINF1), endothelin-1 (ET-1), keratinocytegrowth factor (KGF), bone morphogenetic proteins (e.g., BMP1-BMP15),platelet-derived growth factor (PDGF), nerve growth factor (NGF),β-nerve growth factor (β-NGF), neurotrophic factors (e.g., brain-derivedneurotrophic factor (BDNF), neurotrophin 3 (NT3), neurotrophin 4 (NT4),etc.), growth differentiation factor-9 (GDF-9), granulocyte-colonystimulating factor (G-CSF), myostatin (GDF-8), erythropoietin (EPO),thrombopoietin (TPO), and combinations thereof.

The human amphiregulin (AREG) polypeptide sequence is set forth in,e.g., NCBI Accession No. AAA51781.1. The human AREG mRNA (coding)sequence is set forth in, e.g., Genbank Accession Nos. NM_(—)001657.2and XM_(—)001125684.3. One skilled in the art will appreciate that AREGis also known as AR, colorectum cell-derived growth factor, CRDGF, SDGF,and AREGB.

The human epiregulin (EREG) polypeptide sequence is set forth in, e.g.,NCBI Accession No. BAA22146.1. The human EREG mRNA (coding) sequence isset forth in, e.g., Genbank Accession No. NM_(—)001432.2. One skilled inthe art will appreciate that EREG is also known as EPR.

The human heparin-binding EGF-like growth factor (HB-EGF) polypeptidesequence is set forth in, e.g., NCBI Accession No. AAA35956.1. The humanHB-EGF mRNA (coding) sequence is set forth in, e.g., Genbank AccessionNo. NM_(—)001945.2. One skilled in the art will appreciate that HB-EGFis also known as diphtheria toxin receptor, DT-R, HBEGF, DTR, DTS, andHEGFL.

The human hepatocyte growth factor (HGF) polypeptide sequence is setforth in, e.g., ncbi Accession No. NP_(—)000592.3. The human HGF mRNA(coding) sequence is set forth in, e.g., Genbank Accession Nos.NM_(—)000601.4, NM_(—)001010931.1, NM_(—)001010932.1, NM_(—)001010933.1and NM_(—)001010934.1. One skilled in the art will appreciate that HGFis also known as scatter factor, SF, HPTA and hepatopoietin-A. One ofskill will also appreciate that HGF includes all isoform variants.

The human heregulin β (HRGβ) polypeptide sequence is set forth in, e.g.,NCBI Accession No. ABY70644.1. One of skill will also appreciate thatHRGβ includes all isoform variants.

The human betacellulin (BTC) polypeptide sequence is set forth in, e.g.,NCBI Accession No. AAB25452.1. The human BTC mRNA (coding) sequence isset forth in, e.g., Genbank Accession No. NM_(—)001729.2. One skilled inthe art will appreciate that BTC includes all isoform variants.

The human epidermal growth factor (EGF) polypeptide sequence is setforth in, e.g., Genbank Accession No. AAI13462.1. The human EGF mRNA(coding) sequence is set forth in, e.g., Genbank Accession Nos.NM_(—)001963.4 and NM_(—)001178131.1. One skilled in the art willappreciate that EGF is also known as beta-urogastrone, urogastrone, URG,and HOMG4. One skilled in the art will appreciate that EGF includes allisoform variants.

The human transforming growth factor alpha (TGF-α) polypeptide sequenceis set forth in, e.g., NCBI Accession No. AAA61159.1. The human TGF-αmRNA (coding) sequence is set forth in, e.g., Genbank Accession Nos.NM_(—)003236.3 and NM_(—)001099691.2. One skilled in the art willappreciate that TGF-α includes all isoform variants. One skilled in theart will also appreciate that TGF-α is also known as TGFA, EGF-like TGF,ETGF, and TGF type 1.

The human transforming growth factor alpha (TGF-β or TGFB) polypeptidesequence is set forth in, e.g., NCBI Accession No. AAH00125.1. Oneskilled in the art will appreciate that TGF-β includes all isoformvariants.

The human vascular endothelial growth factor (VEGF-A) polypeptidesequence is set forth in, e.g., NCBI Accession No. AAA35789.1. The humanVEGF-A mRNA (coding) sequence is set forth in, e.g., Genbank AccessionNo. NM_(—)001025366, NM_(—)001025367, NM_(—)001025368, NM_(—)001025369,NM_(—)001025370, NM_(—)001033756, and NM_(—)003376. One skilled in theart will appreciate that VEGF-A is also known as VPF, VEGFA, VEGF, andMGC70609. One skilled in the art will appreciate that VEGF-A includesall isoform variants.

The human vascular endothelial growth factor (VEGF-B) polypeptidesequence is set forth in, e.g., NCBI Accession No. AAH08818.1. The humanVEGF-B mRNA (coding) sequence is set forth in, e.g., Genbank AccessionNos. NM_(—)001243733 and NM_(—)003377. One skilled in the art willappreciate that VEGF-B is also known as VEGFB, VEGF-related factor, andVRF. One skilled in the art will appreciate that VEGF-B includes allisoform variants.

The human vascular endothelial growth factor (VEGF-C) polypeptidesequence is set forth in, e.g., NCBI Accession No. AAH63685.1. The humanVEGF-C mRNA (coding) sequence is set forth in, e.g., Genbank AccessionNo. NM_(—)005429. One skilled in the art will appreciate that VEGF-C isalso known as VEGFC, Flt4 ligand, Flt4-L, VRP and vascular endothelialgrowth factor-related protein. One skilled in the art will appreciatethat VEGF-C includes all isoform variants.

The human vascular endothelial growth factor (VEGF-D) polypeptidesequence is set forth in, e.g., NCBI Accession No. NP_(—)004460.1. Oneskilled in the art will appreciate that VEGF-D is also known as VEGFD,c-Fos induced growth factor or FIGF. One skilled in the art willappreciate that VEGF-D includes all isoform variants.

The human platelet-derived growth factor subunit A (PDGF-A) polypeptidesequence is set forth in, e.g., NCBI Accession No. AAI09247.1. Oneskilled in the art will appreciate that PDGF-A is also known as PDGFA,PDGF subunit A, PDGF-1, platelet-derived growth factor A chain, andplatelet-derived growth factor alpha polypeptide. One skilled in the artwill appreciate that PDGF-A includes all isoform variants.

The human platelet-derived growth factor subunit B (PDGF-B) polypeptidesequence is set forth in, e.g., NCBI Accession No. NP_(—)002599.1. Oneskilled in the art will appreciate that PDGF-B is also known as PDGFB,PDGF subunit B, PDGF-2, platelet-derived growth factor B chain,proto-oncogene c-Sos, and platelet-derived growth factor betapolypeptide. One skilled in the art will appreciate that PDGF-B includesall isoform variants.

The human platelet-derived growth factor subunit C (PDGF-C) polypeptidesequence is set forth in, e.g., NCBI Accession No. AAK51637.1. Oneskilled in the art will appreciate that PDGF-C is also known as PDGFC,PDGF subunit C, fallotein, spinal cord-derived growth factor, SCDGF, andVEGF-E. One skilled in the art will appreciate that PDGF-C includes allisoform variants.

The human platelet-derived growth factor subunit D (PDGF-D) polypeptidesequence is set forth in, e.g., NCBI Accession No. AAK38840.1. Oneskilled in the art will appreciate that PDGF-D is also known as PDGFD,PDGF subunit D, iris-expressed growth factor, spinal cord-derived growthfactor B, and SCDGF-B. One skilled in the art will appreciate thatPDGF-D includes all isoform variants.

The human fibroblast growth factor 1 (FGF1) polypeptide sequence is setforth in, e.g., NCBI Accession No. AAH32697.1. The human FGF1 mRNA(coding) sequence is set forth in, e.g., Genbank Accession Nos.NM_(—)000800, NM_(—)001144892, NM_(—)001144934, NM_(—)001144934,NM_(—)001144935, NM_(—)033136 and NM_(—)033137. One skilled in the artwill appreciate that FGF1 is also known as FGFA, FGF-1, acidicfibroblast growth factor, aFGF, endothelial cell growth factor, ECGF,heparin-binding growth factor 1, and HB-EGF1. One skilled in the artwill appreciate that FGF1 includes all isoform variants.

The human fibroblast growth factor (FGF2) polypeptide sequence is setforth in, e.g., Genbank Accession No. NP_(—)001997.5. The human FGF2mRNA (coding) sequence is set forth in, e.g., Genbank Accession No.NM_(—)002006.4. One skilled in the art will appreciate that FGF2 is alsoknown as basic FGF, bFGF, and FGFB.

The human fibroblast growth factor (FGF4) polypeptide sequence is setforth in, e.g., Genbank Accession No. NP_(—)001998.1. One skilled in theart will appreciate that FGF4 is also known as heparin-secretorytransforming protein 1, HST, HST-1, HSTF-1, heparin-binding growthfactor 4, HBGF-4, and KS3.

The human fibroblast growth factor 7 (FGF7) polypeptide sequence is setforth in, e.g., NCBI Accession No. CAG46799.1. The human FGF7 mRNA(coding) sequence is set forth in, e.g., Genbank Accession No.NM_(—)002009.3. One skilled in the art will appreciate that FGF7 is alsoknown as FGF-7, heparin-binding growth factor 7, HBGF-7 and keratinocytegrowth factor.

The human fibroblast growth factor 9 (FGF9) polypeptide sequence is setforth in, e.g., NCBI Accession No. AAT74624.1. The human FGF9 mRNA(coding) sequence is set forth in, e.g., Genbank Accession No.NM_(—)002010.2. One skilled in the art will appreciate that FGF9 is alsoknown as heparin-binding growth factor 9, GAF, and HBGF-9.

The human fibroblast growth factor 19 (FGF19) polypeptide sequence isset forth in, e.g., NCBI Accession No. AAQ88669.1. One skilled in theart will appreciate that FGF19 is also known as zFGF5. One skilled inthe art will appreciate that FGF19 includes all isoform variants.

The human stem cell factor (SCF) polypeptide sequence is set forth in,e.g., NCBI Accession No. AAI26167.1. One skilled in the art willappreciate that PDGF-A is also known as kit ligand, c-kit ligand, mastcell growth factor and MGF. One skilled in the art will appreciate thatSCF includes all isoform variants.

The interleukin 10 (IL-10) polypeptide sequence is set forth in, e.g.,NCBI Accession No. AAI04253.1. One skilled in the art will appreciatethat IL-10 includes all isoform variants.

E. Anti-TNF Drug Levels & Anti-Drug Antibody (ADA) Levels

In some embodiments, the method comprises determining the presenceand/or level of a drug analyte in a patient sample (e.g., a serum samplefrom a patient on anti-TNF drug therapy) to form an inflammatory phasemarker score and/or proliferation phase marker score. In certaininstances, the measurements can be made at multiple time points, e.g.,before, during, and/or after the course of therapy. In some embodiments,the drug analyte is an anti-TNF drug (e.g., level of free anti-TNFαtherapeutic antibody such as infliximab) and/or an anti-drug antibody(ADA) (e.g., level of autoantibody to the anti-TNF drug such as HACA,HAHA, HAMA, and combinations thereof).

In particular embodiments, the presence and/or level of an anti-TNF drugand/or ADA is determined with a homogeneous mobility shift assay usingsize exclusion chromatography. These methods and related technology aredescribed in PCT Publication Nos. WO 2011/056590, WO 2012/054532, WO2012/154253 and WO 2013/006810, and in U.S. Provisional Application No.61/683,681, filed Aug. 15, 2012, the disclosures of which areincorporated by reference in their entirety for all purposes. Thesemethods are particularly advantageous for measuring the presence orlevel of TNFα inhibitors as well as autoantibodies (e.g., HACA, HAHA,etc.) that are generated against them.

The method for determining the presence or level of an anti-TNFα drug ina sample can comprise: (a) contacting a labeled TNFα with a samplehaving an anti-TNFα drug to form a labeled complex with the anti-TNFαdrug; (b) subjecting the labeled complex to size exclusionchromatography to separate the labeled complex from free labeled TNFαand to detect an amount of the labeled complex and an amount of the freelabeled TNFα; and (c) comparing the amount of the labeled complex andthe amount of the free labeled TNFα detected in step (b) to a standardcurve of known amounts of the anti-TNFα drug, thereby determining thepresence or level of the anti-TNFα drug.

The method for determining the presence or level of an autoantibody toan anti-TNFα drug in a sample can comprise: (a) contacting a labeledanti-TNFα drug with the sample to form a labeled complex with theautoantibody; (b) subjecting the labeled complex to size exclusionchromatography to separate the labeled complex from free labeledanti-TNFα drug and to detect an amount of the labeled complex and anamount of the free labeled anti-TNFα drug; and (c) comparing the amountof the labeled complex and the amount of the free labeled anti-TNFα drugdetected in step (b) to a standard curve of known amounts of theautoantibody, thereby determining the presence or level of theautoantibody.

In certain embodiments, the methods are especially useful for thefollowing anti-TNFα drugs: REMICADE™ (infliximab), ENBREL™ (etanercept),HUMIRA™ (adalimvumab), and CIMZIA® (certolizumab pegol).

In other embodiments, the methods are especially useful for thefollowing anti-drug antibodies (ADA): human anti-chimeric antibody(HACA), human anti-humanized antibody (HAHA), and human anti-mouseantibody (HAMA).

In some embodiments, the method of detecting an anti-drug antibodyincludes determining the presence or level of anti-drug antibody (ADA)isotypes in ADA-positive patients receiving anti-TNF drug therapy.Non-limiting examples of antibody isotypes include IgA, IgD, IgE, IgG,and IgM. In certain aspects, the detection of the presence or level of aspecific ADA isotype or a particular combination of ADA isotypes isassociated with different clinical outcomes.

Non-limiting examples of other methods for determining the presenceand/or level of a drug analyte (e.g., anti-TNF drug and/or anti-drugantibodies (ADA)) include enzyme-linked immunosorbent assays (ELISAs)such as bridging ELISAs. For example, the Infliximab ELISA from MatriksBiotek Laboratories detects free infliximab in serum and plasma samples,and the HACA ELISA from PeaceHealth Laboratories detects HACA in serumsamples.

F. Generating a Marker Score

In some embodiments, the methods of predicting the presence of mucosalhealing and/or monitoring the progression of mucosal healing in anindividual utilize an empirically derived score (e.g., inflammatoryphase score and proliferation phase score).

In addition, the methods of selecting an appropriate therapy, optimizingtherapeutic efficiency and the like, include the use of the marker scoreto select, for example, a dose of drug, an appropriate drug, a course orlength of therapy, a therapy regimen, or the maintenance of an existingdrug or dose. In certain aspects, a derived or measured score can beused for selecting an appropriate therapeutic regimen that promotesmucosal healing.

In certain aspects, each marker is assigned a value based upon theconcentration and level of the marker relative to a standard or a set ofstandards. In some embodiments, the value is selected from 0 to 6, e.g.,0, 1, 2, 3, 4, 5, or 6. For example, if the level of a marker is belowthe level of the lowest standard, the marker is assigned a value of 0.If the level of a marker is between the first lowest standard and thesecond standard (from low to high), the marker is given a value of 1. Ifthe level of a marker is between the second standard and the thirdstandard, the marker is given a value of 2. If the level of a marker isbetween the third standard and the fourth standard, the marker is givena value of 3. If the level of a marker is between the fourth standardand the fifth standard, the marker is given a value of 4. If the levelof a marker is between the fifth standard and the sixth standard, themarker is given a value of 5. If the level of a marker is even with thesixth standard or higher, the marker is given a value of 6. In certainembodiments, each marker can be assigned a value selected from 0 to 1,2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25,30, or any range therein (e.g., from 1 to 6).

In certain aspects, each marker is assigned a value based upon thequantile level of the marker. In some embodiments, the value is selectedfrom 0 to 6, e.g., 0, 1, 2, 3, 4, 5, or 6. For instance, the values aresplit into 7 groups (“a septile”) and the markers are assigned a valuefrom 0 to 6 based on its quantile group. In certain embodiments, eachmarker can be assigned a value selected from 0 to 1, 2, 3, 4, 5, 6, 7,8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, 30, or any rangetherein (e.g., from 1 to 6). For instance, the values are split into 12groups and the markers are assigned a value from 0 to 11 based on itsquantile group.

In some aspects, the concentration or level of each marker is relativeto the level of the same marker in a control patient population, e.g., apopulation or group of IBD patients that do not exhibit mucosal healing.

In some embodiments, the inflammatory phase marker score is thesummation of the value of each marker in the first set of markers, suchas one or more of TWEAK, CRP, ICAM, SAA, VCAM, IL-2, IL-8, IL-12p70,IL-1β, GMCSF, IFNγ, IL-6, TNFα, ASCA-A, ASCA-G, CBir1, Fla2, FlaX, OmpC,and an anti-drug antibody (ADA). In other embodiments, the value of eachmarker in the first set of markers includes one or more of GMCSF, IL-2,and VCAM.

In some embodiments, the proliferation phase marker score is thesummation of the value of each marker in the second set of markers, suchas one or more of AREG, EREG, HBEGF, HGF, HRGB, BTC, EGF, TGFA, FGF1,FGF2, FGF4, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB,VEGFC, VEGFD, TGFB1, IL-10, and an anti-TNFα antibody. In otherembodiments, the value of the marker in the second set of markersincludes HGF.

In some embodiments, an algorithm is applied to the inflammatory markerscore and the proliferation phase marker score. In particularembodiments, the algorithm allows for the comparison of the inflammatorymarker score and the proliferation phase marker score to form orgenerate a biomarker score. As a non-limiting example, the biomarkerscore comprises the proliferation phase marker score (e.g., sum of theproliferation phase marker values) minus the inflammatory phase markerscore (e.g., sum of the inflammatory phase marker values).

In some embodiments, the algorithm predicts the likelihood of mucosalhealing and/or monitors the progression of mucosal healing independentof clinical confounders. For instance, one or more of the clinicalconfounders, e.g., age of diagnosis, age of last sample, diseaselocation, anal involvement, smoking, and surgery does not contribute tothe algorithm for determining the likelihood of mucosal healing.

In some embodiments, the algorithm predicts the likelihood of mucosalhealing and/or monitors the progression of mucosal healing without oneor more serology markers, e.g., ASCA-A, RSCA-G, CBir1, Fla2, FlaX, andOmpC, that are used to form the inflammatory phase marker score. Thealgorithm remains predictive with the exclusion of one or more serologymarkers, e.g., ASCA-A, ASCA-G, CBir1, Fla2, FlaX, and OmpC.

In some embodiments, the subject's biomarker score is compared to thebiomarker score of a control patient population, such as a populationwherein the patients have not undergone the inflammatory phase ofmucosal healing, the proliferation phase of mucosal healing, aprogression of mucosal healing, incomplete improvement of mucosalhealing, and/or complete improvement of mucosal healing. For instance,if a subject's biomarker score is higher than the biomarker score of apatient population without mucosal healing, then the subject has anincreased likelihood of having complete improvement of mucosal healingwithout relapse. If a subject's biomarker score is lower than thebiomarker score of a patient population without mucosal healing, thenthe subject has a decreased likelihood of having complete improvement ofmucosal healing without relapse, thereby indicating the need forselecting an appropriate therapy (e.g., an increase in dose of anti-TNFαtherapy, surgery, combination therapy, and the like) for effectivetreatment.

G. Statistical Algorithms for Mucosal Healing

In certain aspects, the present invention provides an algorithmic-basedanalysis that incorporates the inflammatory phase marker score and theproliferation phase marker score to improve the sensitivity,specificity, and/or accuracy of predicting and/or monitoring mucosalhealing, selecting therapy, optimizing therapy, reducing toxicity,and/or monitoring the efficacy of therapeutic treatment to anti-TNFαdrug therapy.

In some aspects, the present invention provides methods for identifyingthe phase of mucosal healing, monitoring mucosal healing, predicting thelikelihood of mucosal healing and/or selecting a therapeutic regimen fora subject by applying a statistical algorithm to a proliferation phasemarker score and an inflammatory phase marker score to generate amucosal healing measurement.

The term “statistical analysis” or “statistical algorithm” or“statistical process” includes any of a variety of statistical methodsand models used to determine relationships between variables. In thepresent invention, the variables are the presence and/or level of atleast one marker of interest. Any number of markers can be analyzedusing a statistical analysis described herein. For example, the presenceor level of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17,18, 19, 20, 25, 30, 35, 40, 45, 50, 55, 60, or more markers can beincluded in a statistical analysis. In one embodiment, logisticregression is used. In another embodiment, linear regression is used. Inyet another embodiment, ordinary least squares regression orunconditional logistic regression is used.

In some embodiments, the statistical analyses of the present inventioncomprise a quantile measurement of one or more markers, e.g., within agiven population, as a variable. Quantiles are a set of “cut points”that divide a sample of data into groups containing (as far as possible)equal numbers of observations. For example, quartiles are values thatdivide a sample of data into four groups containing (as far as possible)equal numbers of observations. The lower quartile is the data value aquarter way up through the ordered data set; the upper quartile is thedata value a quarter way down through the ordered data set. Quintilesare values that divide a sample of data into five groups containing (asfar as possible) equal numbers of observations. The present inventioncan also include the use of percentile ranges of marker levels (e.g.,tertiles, quartile, quintiles, etc.), or their cumulative indices (e.g.,quartile sums of marker levels to obtain quartile sum scores (QSS),etc.) as variables in the statistical analyses (just as with continuousvariables).

In some embodiments, the statistical analyses of the present inventioncomprise one or more learning statistical classifier systems. As usedherein, the term “learning statistical classifier system” includes amachine learning algorithmic technique capable of adapting to complexdata sets (e.g., panel of markers of interest) and making decisionsbased upon such data sets. In some embodiments, a single learningstatistical classifier system such as a decision/classification tree(e.g., random forest (RF) or classification and regression tree (C&RT))is used. In other embodiments, a combination of 2, 3, 4, 5, 6, 7, 8, 9,10, or more learning statistical classifier systems are used, preferablyin tandem. Examples of learning statistical classifier systems include,but are not limited to, those using inductive learning (e.g.,decision/classification trees such as random forests, classification andregression trees (C&RT), boosted trees, etc.), Probably ApproximatelyCorrect (PAC) learning, connectionist learning (e.g., neural networks(NN), artificial neural networks (ANN), neuro fuzzy networks (NFN),network structures, the Cox Proportional-Hazards Model (CPHM),perceptrons such as multi-layer perceptrons, multi-layer feed-forwardnetworks, applications of neural networks, Bayesian learning in beliefnetworks, etc.), reinforcement learning (e.g., passive learning in aknown environment such as naïve learning, adaptive dynamic learning, andtemporal difference learning, passive learning in an unknownenvironment, active learning in an unknown environment, learningaction-value functions, applications of reinforcement learning, etc.),and genetic algorithms and evolutionary programming. Other learningstatistical classifier systems include support vector machines (e.g.,Kernel methods), multivariate adaptive regression splines (MARS),Levenberg-Marquardt algorithms, Gauss-Newton algorithms, mixtures ofGaussians, gradient descent algorithms, and learning vector quantization(LVQ).

Random forests are learning statistical classifier systems that areconstructed using an algorithm developed by Leo Breiman and AdeleCutler. Random forests use a large number of individual decision treesand decide the class by choosing the mode (i.e., most frequentlyoccurring) of the classes as determined by the individual trees. Randomforest analysis can be performed, e.g., using the RandomForests softwareavailable from Salford Systems (San Diego, Calif.). See, e.g., Breiman,Machine Learning, 45:5-32 (2001); andhttp://stat-www.berkeley.edu/users/breiman/RandomForests/cc_home.htm,for a description of random forests.

Classification and regression trees represent a computer intensivealternative to fitting classical regression models and are typicallyused to determine the best possible model for a categorical orcontinuous response of interest based upon one or more predictors.Classification and regression tree analysis can be performed, e.g.,using the C&RT software available from Salford Systems or the Statisticadata analysis software available from StatSoft, Inc. (Tulsa, Okla.). Adescription of classification and regression trees is found, e.g., inBreiman et al. “Classification and Regression Trees,” Chapman and Hall,New York (1984); and Steinberg et al., “CART: Tree-StructuredNon-Parametric Data Analysis,” Salford Systems, San Diego, (1995).

Neural networks are interconnected groups of artificial neurons that usea mathematical or computational model for information processing basedon a connectionist approach to computation. Typically, neural networksare adaptive systems that change their structure based on external orinternal information that flows through the network. Specific examplesof neural networks include feed-forward neural networks such asperceptrons, single-layer perceptrons, multi-layer perceptrons,backpropagation networks, ADALINE networks, MADALINE networks,Learnmatrix networks, radial basis function (RBF) networks, andself-organizing maps or Kohonen self-organizing networks; recurrentneural networks such as simple recurrent networks and Hopfield networks;stochastic neural networks such as Boltzmann machines; modular neuralnetworks such as committee of machines and associative neural networks;and other types of networks such as instantaneously trained neuralnetworks, spiking neural networks, dynamic neural networks, andcascading neural networks. Neural network analysis can be performed,e.g., using the Statistica data analysis software available fromStatSoft, Inc. See, e.g., Freeman et al., In “Neural Networks:Algorithms, Applications and Programming Techniques,” Addison-WesleyPublishing Company (1991); Zadeh, Information and Control, 8:338-353(1965); Zadeh, “IEEE Trans. on Systems, Man and Cybernetics,” 3:28-44(1973); Gersho et al., In “Vector Quantization and Signal Compression,”Kluywer Academic Publishers, Boston, Dordrecht, London (1992); andHassoun, “Fundamentals of Artificial Neural Networks,” MIT Press,Cambridge, Mass., London (1995), for a description of neural networks.

Support vector machines are a set of related supervised learningtechniques used for classification and regression and are described,e.g., in Cristianini et al., “An Introduction to Support Vector Machinesand Other Kernel-Based Learning Methods,” Cambridge University Press(2000). Support vector machine analysis can be performed, e.g., usingthe SVM^(light) software developed by Thorsten Joachims (CornellUniversity) or using the LIBSVM software developed by Chih-Chung Changand Chih-Jen Lin (National Taiwan University).

The various statistical methods and models described herein can betrained and tested using a cohort of samples (e.g., serological samples)from healthy or non-IBD individuals and patients with a TNFα-mediateddisease or disorder such as, e.g., IBD (e.g., CD and/or UC). Forexample, samples from patients diagnosed by a physician, preferably by agastroenterologist, as having IBD or a clinical subtype thereof using abiopsy, colonoscopy, or an immunoassay as described in, e.g., U.S. Pat.No. 6,218,129, are suitable for use in training and testing thestatistical methods and models of the present invention. Samples frompatients diagnosed with IBD can also be stratified into Crohn's diseaseor ulcerative colitis using an immunoassay as described in, e.g., U.S.Pat. Nos. 5,750,355 and 5,830,675. Samples from healthy individuals caninclude those that were not identified as IBD samples. One skilled inthe art will know of additional techniques and diagnostic criteria forobtaining a cohort of patient samples that can be used in training andtesting the statistical methods and models of the present invention.

H. Predicting Therapeutic Response/Therapeutic Efficacy

The present invention provides non-invasive methods for predicting thelikelihood of mucosal healing and/or monitoring mucosal healing inpatients, such as patients receiving anti-TNF therapy. In addition, thepresent invention provides methods of predicting therapeutic response,risk of relapse, and risk of surgery in patients with IBD (e.g., Crohn'sdisease and ulcerative colitis) based upon the progression of mucosalhealing in the subject. In particular, the methods of the presentinvention find utility for selecting an appropriate anti-TNFα therapyfor continued treatment, for determining when or how to adjust or modify(e.g., increase or decrease) the subsequent dose of an anti-TNFα drug tooptimize therapeutic efficacy and/or to reduce toxicity, for determiningwhen or how to combine an anti-TNFα drug (e.g., at an initial,increased, decreased, or same dose) with one or more immunosuppressiveagents such as methotrexate (MTX) or azathioprine (AZA), and/or fordetermining when or how to change the current course of therapy (e.g.,switch to a different anti-TNFα drug or to a drug that targets adifferent mechanism). The present invention also provides methods forselecting an appropriate therapy for patients diagnosed with IBD,wherein the therapy promotes mucosal healing (e.g., complete improvementof mucosal healing without relapse).

In some embodiments, selecting an appropriate therapy comprisesmaintaining, increasing, or decreasing a subsequent dose of the courseof therapy for the subject. In other embodiments, the method furthercomprises determining a different course of therapy for the subject. Incertain instances, the different course of therapy comprises treatmentwith a different anti-TNFα antibody. In other instances, the differentcourse of therapy comprises the current course of therapy along withanother therapeutic agent, such as, but not limited to, animmunosuppressive agent, a corticosteroid, a drug that targets adifferent mechanism, nutrition therapy, and combinations thereof.

In some embodiments, selecting an appropriate therapy comprisesselecting an appropriate therapy for initial treatment. In someinstances, the therapy comprises an anti-TNFα antibody therapy.

In certain embodiments, the methods disclosed herein can be used asconfirmation that a proposed new drug or therapeutic is the same as oris sufficiently or substantially similar to an approved drug product,such that the proposed new drug or therapeutic can be used as a“biosimilar” therapeutic. For example, if the proposed new drug has onlya slightly different disease activity profile compared to the brandeddrug product, this would be apparent using the methods disclosed herein.If the proposed new drug has a significantly different disease activityprofile compared to the branded drug product, then the new drug wouldnot be biosimilar. Advantageously, the methods disclosed herein can beused in clinical trials of proposed new drugs in order to assess theeffective therapeutic value of the drug.

In some embodiments, selecting an appropriate therapy comprisesmaintaining, increasing, or decreasing a subsequent dose of the courseof therapy for the subject. In other embodiments, the method furthercomprises determining a different course of therapy for the subject. Incertain instances, the different course of therapy comprises treatmentwith a different anti-TNFα antibody. In other instances, the differentcourse of therapy comprises the current course of therapy along withanother therapeutic agent, such as, but not limited to, animmunosuppressive agent, a corticosteroid, a drug that targets adifferent mechanism, nutrition therapy, and combinations thereof).

Accordingly, in some aspects, the methods of the invention provideinformation useful for guiding treatment decisions for patientsreceiving or about to receive anti-TNFα drug therapy, e.g., by selectingan appropriate anti-TNFα therapy for initial treatment, by determiningwhen or how to adjust or modify (e.g., increase or decrease) thesubsequent dose of an anti-TNFα drug, by determining when or how tocombine an anti-TNFα drug (e.g., at an initial, increased, decreased, orsame dose) with one or more immunosuppressive agents such asmethotrexate (MTX) or azathioprine (AZA), and/or by determining when orhow to change the current course of therapy (e.g., switch to a differentanti-TNFα drug or to a drug that targets a different mechanism such asan IL-6 receptor-inhibiting monoclonal antibody, anti-integrin molecule(e.g., Tysabri, Vedaluzamab), JAK-2 inhibitor, and tyrosine kinaseinhibitor, or to a nutrition therapy (e.g., special carbohydrate diet)).

In other embodiments, the methods of the present invention can be usedto predict responsiveness to a TNFα inhibitor, especially to ananti-TNFα antibody in a subject having an autoimmune disorder (e.g.,rheumatoid arthritis, Crohn's disease, ulcerative colitis and thelike.). In this method, by assaying the subject for the correct ortherapeutic dose of anti-TNFα antibody, i.e., the therapeuticconcentration level, it is possible to predict whether the individualwill be responsive to the therapy.

In another embodiment, the present invention provides methods formonitoring IBD (e.g., Crohn's disease and ulcerative colitis) in asubject having the IBD disorder, wherein the method comprises assayingthe subject for the correct or therapeutic dose of anti-TNFα antibody,i.e., the therapeutic concentration level, over time. In this manner, itis possible to predict whether the individual will be responsive to thetherapy over the given time period.

Once the diagnosis or prognosis of a subject receiving anti-TNFα drugtherapy has been determined or the likelihood of response to ananti-TNFα drug has been predicted in a subject diagnosed with a diseasein which TNFα has been implicated in the pathophysiology, including, butnot limited to, IBD (e.g., Crohn's disease and ulcerative colitis),shock, sepsis, infections, autoimmune diseases, RA, transplant rejectionand graft-versus-host disease, according to the methods describedherein, the present invention may further comprise recommending a courseof therapy based upon the diagnosis, prognosis, or prediction. Incertain instances, the present invention may further compriseadministering to a subject a therapeutically effective amount of ananti-TNFα drug useful for treating one or more symptoms associated withthe TNF-mediated disease or disorder. For therapeutic applications, theanti-TNF drug can be administered alone or co-administered incombination with one or more additional anti-TNF drugs and/or one ormore drugs that reduce the side-effects associated with the anti-TNFdrug (e.g., an immunosuppressive agent). As such, the present inventionadvantageously enables a clinician to practice “personalized medicine”by guiding treatment decisions and informing therapy selection andoptimization for anti-TNFα drugs such that the right drug is given tothe right patient at the right time.

Understanding the clinical course of the disease enables physicians tomake better informed treatment decisions for their inflammatory diseasepatients (e.g., IBD (e.g., Crohn's disease and ulcerative colitis),rheumatoid arthritis (RA), others) and helps to direct new drugdevelopment. The biomarkers described herein are able to detect mucosalhealing phases and monitor the effect of treatment; and have apredictive value towards healing or recurrence of the disease. Thepresent invention is particularly advantageous because it providesindicators of the phases of mucosal healing and enables a prediction ofmucosal improvement in patients. In addition, the inflammatory phasescore and the proliferation phase score of the present invention haveenormous implications for patient management, as well as therapeuticdecision-making, and aid or assist in directing the appropriate therapyto patients who most likely will benefit from it and avoid the expenseand potential toxicity of chronic maintenance therapy in those who havea low risk of recurrence.

V. Examples

The following examples are offered for illustrative purposes, and arenot intended to limit the invention in any manner. Those of skill in theart will readily recognize a variety of noncritical parameters which canbe changed or modified to yield essentially the same results.

Example 1 Per-Marker Analysis and Individual Patient Analysis of MucosalHealing

This example illustrates that the phases of mucosal healing (e.g.,inflammatory phase, proliferation phase, and remodeling phase) in an IBDpatient are associated with the levels of various inflammatory markersand repair markers. Described herein is a biomarker analysis of IBDpatients who showed either complete healing or no healing.

In this study serum samples were obtained from 197 IBD patients withrepeated endoscopic scores. At least one sample from each patient wasavailable for evaluation. 131 patients had more than 1 sample availablefor testing and 49 subjects has more than 2 samples. In total, 386samples were analyzed.

Endoscopy remains the standard method for determining the clinicalstatus of patients with IBD. It is used to assess mucosal changes (e.g.,improvements) and to determine whether a patient exhibits completeimprovement. Unfortunately, some patients with an endoscopic score ofcomplete improvement can relapse (FIG. 2A). This suggests thatendoscopic scoring does not provide an adequate assessment of mucosalhealing in IBD patients. In one aspect, this study investigated whethermucosal healing and its three phases (e.g., inflammatory, proliferation,and remodeling) can be detected in serum samples from IBD patients. Twodistinct populations were analyzed: patients who showed complete healing(FIG. 3A); and patients who never healed (FIG. 3B).

To further investigate the differences between the phases of mucosalhealing, biomarker profiles were compared between the two patientpopulations. In particular, forty-five markers were measured including22 repair factors (e.g., 7 HER ligands, 14 angiogenesis ligands, and 1hematopoiesis ligand), 15 inflammatory markers (e.g., 13pro-inflammatory markers and 2 anti-inflammatory markers), 6 serologicalmarkers, infliximab (IFX), and anti-infliximab antibodies (ATI).

The markers EGF, AREG, EREG, HBEGF, HGF, HRGB, BTC, TGFA, FGF1, FGF2,FGF, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC,VEGFD, TGFB1, and TWEAK were measured by CEER. IFX and ATI levels weremeasured by HMSA. IL10, CRP, ICAM, SAA, VCAM, IL2, IL8, IL12p70, IL1B,GMCSF, IFNgamma, IL6, TNF alpha were measured by ELISA array (e.g., MesoScale Discovery assay kit). And, the markers ASCAA, ASCAG, CBir1, Fla2,FLAX, OmpC were measured by ELISA (e.g., Prometheus IBD sgi Diagnostictest).

59 samples were analyzed from patients who healed and never relapsed. 52samples were from patients who never healed. Samples used in the studywere obtained within 3 years before and no more than 30 days after thepatient's last endoscopy.

FIG. 4 shows the distribution of the markers in patients who neverhealed (left bar in each plot) and those who had complete healing (rightbar in each plot).

Logistic regression of per-marker analysis was performed to determine ifa particular marker was associated with a clinical outcome. Adjustmentswere made for various clinical variables, such as, location of disease,anal involvement in disease, age of patient at the time of sampling, ageat diagnosis, smoking, and surgery. The associations of GM-CSF, IL2,VCAM and HGF with clinical outcome were significant (FIG. 5). Thesemarkers were significantly associated with mucosal healing aftercontrolling for clinical variables related to severity. Lower values ofthe markers were predictive of mucosal healing. The value of each markerin a patient sample was relative to the level of the same marker inpatients with inflammatory bowel disease (IBD) but no mucosal healing.

To further elucidate the marker association with mucosal healing, anindividual patient analysis strategy was employed (see, FIG. 6A-D). 4“true” healed individuals (Patients #1-4) were compared to 4 not healedindividuals (Patients #5-8). “True” healed individuals were selectedaccording to the following criteria: 1) having low or decreasinginflammation over time and 2) having samples characterized as being fromone “no improvement” scope followed by two “complete improvement”scopes. Not healed individuals were selected according to the followingcriteria: 1) having samples paired with three “no improvement” scopesand 2) having a length of time between first and second events similarto the “true” healed individuals.

FIG. 7 A-F shows representative data from the individuals in the study.Each box represents one patient. The top line shows the clinical data(e.g., ATI and IFX status) and the plots at the bottom show the markerdata, e.g., data of VCAM, ICAM, SAA, CRP, IL2, and IL8. The markervalues were scaled to the highest non-outlier value for each marker. Theplots are used to determine if the marker value is increasing ordecreasing with time (e.g., years since diagnosis).

Patients #1-4 showed decreasing or low inflammation over time,indicating that these patients were more likely to be healed (FIG. 7A-D). Patients A and B (FIGS. 7E & 7F) were determined to be completelyhealed by endoscopic scoring, yet these patients showed increasinginflammation in the marker analysis. The study revealed that Patients Aand B were not completely healed and may be in the inflammatory phase ofmucosal healing (FIG. 7).

FIGS. 8-9 show the marker profile for Patient #1. Repair factors (e.g.,HER ligands and FGFs) (FIG. 8 A-D) and serologic markers (FIG. 9 A-D)increased over time. TWEAK spiked when Patient #1 was ATI negative andIFX negative at time point 2 (t2). The patient was ATI−, IFX+ at timepoint 1 (t1) and time point 3 (t3). The data shows that the patient islikely in the proliferation phase of healing.

FIGS. 10-11 show the marker profile for Patient #2. Repair factors (FIG.10 A-D) and serological markers increased over time as inflammatorymarkers decreased (FIG. 11 A-D). Patient #2 was ATI− at t1 and ATI−,IFX+ at t2 and t3. The results indicated that the patient is not fullyhealed and is likely in the proliferation phase of mucosal healing.

The marker profile for Patient #3 is shown in FIGS. 12-13. Repairfactors (FIG. 12 A-D) and serolocial markers increased over time asinflammatory markers decreased (FIG. 13 A-D). Patient #3 was ATI− at t1and t2, and progressed to ATI−, IFX+ at t3. As with Patients #1 and 2,this patient is likely in the proliferation phase of mucosal healing andshould not be considered to be completely healed.

FIGS. 14-15 show the marker profile for Patient #4. Compared to theprofile of Patient #3, the repair factors (FIG. 14 A-D), serologicmarkers and inflammatory markers (FIG. 15 A-D) were lower for Patient#4, indicating that this patient is closer to being fully healed.Patient #4 was ATI− at t1, and progressed to ATI−, IFX+ at t2 and t3.

FIGS. 16-17 show the marker profile for Patient #5. The repair factors,serological markers (FIG. 16 A-D) and inflammatory markers (FIG. 17 A-D)increased or remained high over time. For instance, IL8 and TWEAK werestill high when the repair factors and the flagellin markers (e.g.,CBir1, Fla2 and FLAX) were high. At t1, Patient #5 was ATI− and ATI−,IFX− at t2. By t3, the patient was ATI−, IFX+.

FIGS. 18-19 show the marker profile for Patient #6. The repair factorswere not increased (FIG. 18 A-D), but some of the inflammatory markersand serological markers were high (FIG. 19 A-D). By the time the secondsample was obtained, the patient developed ATI and elevated levels ofTNFα (FIG. 18).

FIGS. 20-21 show the marker profile for Patient #7. Several repairfactors (e.g., AREG, HBEGF, TGFA and PDGFB) are high in the first twosamples from the patient, but these markers decreased at the third timepoint (FIG. 20 A-D) when the inflammation markers IL1β and IL2increased. OmpC levels were very high in all samples tested (FIG. 21A-D). The patient was ATI− at all time points.

FIGS. 22-23 show the marker profile for Patient #8. In this patient,repair factors were high at times (FIG. 22 A-D), while some inflammationmarkers and serologic markers were always high (FIG. 23 A-D). Patient #8was ATI− at t1, ATI−, IFX+ at t2, and ATI−, IFX+ at t3.

The individual patient comparison analysis showed that even whenendoscopic analysis reported complete improvement, some patientsexpressed high levels of repair factors and low inflammation. Theresults indicate that these patients were still in the proliferationphase of mucosal healing. Furthermore, patients with high levels ofrepair factors and high levels of inflammatory markers were determinedto be not completely healed.

The data illustrates that marker expression in a patient's serum changesduring progression through the phases of healing. As a patient goes frominflammatory phase (year 1) to proliferation phase (year 2), the levelsof inflammatory markers decrease even though the patient is not fullyhealed (FIG. 25 A-C). Repair factors and inflammatory markers increaseas the patient progresses from the inflammatory phase to theproliferation phase (FIG. 24 A-D). In the remodeling phase (year 3),repair factors and inflammatory markers decrease (FIGS. 24-25).

In summary, this example shows that measuring inflammatory markers,serology markers, and repair markers can indicate when a patient'sintestinal mucosa is undergoing mucosal healing. Likewise, these markerscan be used to determine whether the patient is healed and in theremodeling phase.

Example 2 Combined Marker Analysis for Predicting Phases of MucosalHealing

This example shows a method for selecting markers that are predictive ofthe different phases of mucosal healing. In this study two sets ofmarkers (e.g., proliferation phase markers and inflammatory phasemarkers) was analyzed in two patient populations, e.g., individuals withcomplete improvement without relapse and individuals who never healed.Statistical analysis was conducted to determine whether the marker sets(or a subset of the marker sets) were associated with a particularclinical outcome. Initially, the full marker sets were analyzed.Secondly, the analysis was serially repeated with the selectiveexclusion of one marker in each round until each marker was tested.

Samples from 111 individuals who showed either complete improvement(remodeling phase of mucosal healing) or no healing (inflammatory phase)were obtained and assayed. The markers used included proliferation phasemarkers such as proliferation markers, anti-inflammatory markers and IFX(e.g., AREG, EREG, HBEGF, HGF, HRGB, BTC, EGF, TGFA, FGF1, FGF2, FGF4,FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC, VEGFD,TGFB1, IL10, and IFX) and inflammatory phase markers such asinflammatory markers, serology markers and ATI (e.g., TWEAK, CRP, ICAM,SAA, VCAM, IL2, IL8, IL12p70, IL1β, GMCSF, IFNγ, IL6, TNFα, ASCAA,ASCAG, CBir1, Fla2, FlaX, OmpC, and ATI). The levels (e.g.,concentrations) of the markers were assayed by CEER or other methods,such as, ELISA, HMSA, and protein array. Each marker value was assigneda score of 0 to 6, depending on the level detected relative to either aseries of standards or quantiles.

For CEER markers (e.g., EGF, AREG, EREG, HBEGF, HGF, HRGB, BTC, TGFA,FGF1, FGF2, FGF, FGF7, FGF9, FGF19, SCF, PDGFA, PDGFB, PDGFC, VEGFA,VEGFB, VEGFC, VEGFD, TGFB1, and TWEAK), the score was based on theindividual's marker value relative to six standards. For example, if thevalue was below the lowest standard, the marker was given a 0 score. Ifthe value was between the lowest standard and the second loweststandard, the marker was given a 1 score. For some markers, the scorewas determined using a lower dilution factor such as, e.g., 1:5, 1:25,1:100, 1:260, or 1:1250.

For non-CEER markers, the score was based on the quantiles of eachmarker in the data set. The samples are split into 7 groups and assigneda score of 0 to 6 based on the group that the marker value wasassociated with. It was assumed that there was a wide distribution ofeach marker in the data set.

If an individual was missing data for a particular marker, theindividual was given the average value of the marker. FIG. 26 shows thenumber of individuals with missing biomarker values. A biomarker scorewas calculated as the sum of the scores for all the proliferation phasemarkers minus the sum of the scores for all the inflammatory markers.The distribution of the biomarker scores is presented in FIG. 27.

Logistic regression of mucosal improvement status on the biomarker scorewas used to test for association. The data shows that the biomarkerscore is significantly associated with an increased odds of havingcomplete improvement without relapse (FIG. 28).

The analysis was also performed by controlling for potential clinicalconfounders, such as age of diagnosis, age of last sample, diseaselocation, anal involvement, smoking and surgery. Data from 79individuals were used, in particular, 41 individuals who never healedand 38 patient who showed complete improvement with no relapse). Evenwith the adjustment, the biomarker score was significantly associatedwith an increased odds of having complete improvement without relapse(FIG. 29). Thus, the proliferation phase markers and inflammatory phasemarkers are predictive of mucosal healing and independent of clinicalvariables. FIG. 30 shows the distribution of the biomarker scoresegregated by mucosal healing status.

Next, the analysis of the biomarker score was performed by excluding theserology markers. Once again, the biomarker score was significantlyassociated with an increased odd of having complete improvement (FIG.31). This was also the case when the data was adjusted to control forpotential clinical confounders (FIG. 32). FIG. 33 shows the distributionof the biomarker score without serology markers and partitioned bymucosal healing status.

This example describes a biomarker score approach that can be used whenmultivariate modeling cannot be used with the dataset. The methodinvolves the following steps: 1) selecting an experimental biomarker set(e.g., proliferation phase markers and inflammatory phase markers exceptATI and IFX) to be tested; 2) calculating the p-value, OR and ROC AUC ofthe biomarker score as a single marker is excluded from the analysis; 3)eliminating any marker from the experimental biomarker set if thatmarker results in the lowest p-value when excluded in the analysis; 4)plotting the biomarker score, p-value, OR and ROC AUC; and 5) repeatingsteps 1-4. The trends in the statistical analysis can be used todetermine which markers of the set are more predictive of the remodelingphase of mucosal healing (e.g., complete improvement without relapse)(FIG. 34 A-C). This example provides a method for selecting informativemarkers that are predictive of the different phases of mucosal healing.

Although the foregoing invention has been described in some detail byway of illustration and example for purposes of clarity ofunderstanding, one of skill in the art will appreciate that certainchanges and modifications may be practiced within the scope of theappended claims. In addition, each reference provided herein isincorporated by reference in its entirety to the same extent as if eachreference was individually incorporated by reference.

1-21. (canceled)
 22. A method for monitoring the progression of mucosalhealing in a subject, the method comprising: (a) measuring a first setof markers at a plurality of time points to form a plurality ofinflammatory phase marker scores; (b) measuring a second set of markersat a plurality of time points to form a plurality of proliferation phasemarker scores; (c) comparing the inflammatory phase marker score to theproliferation phase marker score at each time point and across theplurality of time points; and (d) monitoring the progression of mucosalhealing based upon the comparison in step (c).
 23. The method of claim22, wherein the subject has an inflammatory bowel disease (IBD).
 24. Themethod of claim 23, wherein the inflammatory bowel disease is Crohn'sdisease or ulcerative colitis.
 25. The method of claim 22, wherein thefirst set of markers comprises one or more of TWEAK, CRP, ICAM, SAA,VCAM, IL-2, IL-8, IL-12p70, IL-1β, GMCSF, IFNγ, IL-6, TNFα, ASCA-A,ASCA-G, CBir1, Fla2, FlaX, OmpC, and an anti-drug antibody (ADA). 26.The method of claim 25, wherein the first set of markers comprises oneor more of GMCSF, IL-2, and VCAM.
 27. The method of claim 22, whereinthe second set of markers comprises one or more of AREG, EREG, HBEGF,HGF, HRGB, BTC, EGF, TGFA, FGF1, FGF2, FGF4, FGF7, FGF9, FGF19, SCF,PDGFA, PDGFB, PDGFC, VEGFA, VEGFB, VEGFC, VEGFD, TGFB1, IL-10, and ananti-TNFα antibody.
 28. The method of claim 27, wherein the second setof markers comprises HGF.
 29. The method of claim 22, wherein eachmarker is assigned a value of from 0 to 6 based upon the concentrationor level of the marker.
 30. The method of claim 29, wherein theconcentration or level of the marker is relative to the level of thesame marker in a patient population without mucosal healing.
 31. Themethod of claim 22, wherein the value for each marker in the first setof markers is summed to form the inflammatory phase marker score. 32.The method of claim 22, wherein the value for each marker in the secondset of markers is summed to form the proliferation phase marker score.33. The method of claim 22, wherein the comparison in step (c) comprisesapplying an algorithm incorporating the inflammatory phase marker scoreand the proliferation phase marker score.
 34. The method of claim 33,wherein the algorithm comprises subtracting the inflammatory phasemarker score from the proliferation phase marker score to form abiomarker score of the subject at each time point.
 35. The method ofclaim 34, wherein the subject is progressing through the phases ofmucosal healing when the biomarker score of the subject increases ateach time point over the plurality of time points.
 36. The method ofclaim 35, wherein the subject is progressing from a phase of mucosalhealing selected from an inflammatory phase and a proliferation phaseonto the next phase of mucosal healing.
 37. The method of claim 33,wherein the algorithm monitors the progression of mucosal healingindependent of clinical confounders.
 38. The method of claim 37, whereinthe clinical confounders comprise one or more selected from the groupconsisting of age of diagnosis, age of last sample, disease location,anal involvement, smoking, and surgery.
 39. The method of claim 33,wherein the algorithm monitors the progression of mucosal healingexcluding serology markers.
 40. The method of claim 39, wherein theexcluded serology markers comprise one or more selected from the groupconsisting of ASCA-A, ASCA-G, CBir1, Flat, FlaX, and OmpC.
 41. Themethod of claim 22, wherein the subject is receiving an anti-TNFαantibody.
 42. The method of claim 41, wherein the anti-TNFα antibodycomprises one or more of REMICADE™ (infliximab), ENBREL™ (etanercept),HUMIRA™ (adalimumab), and CIMZIA® (certolizumab pegol).
 43. The methodof claim 22, wherein the marker at each time point is measured in asample selected from the group consisting of serum, plasma, whole blood,stool, peripheral blood mononuclear cells (PBMC), polymorphonuclear(PMN) cells, and a tissue biopsy.
 44. The method of claim 22, furthercomprising optimizing therapeutic efficacy of an anti-TNFα antibodytherapy based upon the progression of mucosal healing in the subject.45. The method of claim 22, further comprising selecting an appropriatetherapeutic regimen based upon the progression of mucosal healing in thesubject.